{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:57:00Z","timestamp":1791482220370,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.nutres.2011.12.005","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T16:48:46Z","timestamp":1329497326000},"page":"107-115","source":"Crossref","is-referenced-by-count":31,"title":["Iron deficiency reduces serum and in vitro secretion of interleukin-4 in mice independent of altered spleen cell proliferation"],"prefix":"10.1016","volume":"32","author":[{"given":"Solo R.","family":"Kuvibidila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Penugonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrance C.","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lolie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2011.12.005_bb0005","series-title":"Cellular and molecular immunology","first-page":"267","year":"1997"},{"key":"10.1016\/j.nutres.2011.12.005_bb0010","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.1365-2249.2002.01932.x","article-title":"IL-10 enhances B-cell IgE synthesis by promoting differentiation into plasma cells, a process that is inhibited by CD27\/CD70 interaction","volume":"129","author":"Kobayashi","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0015","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1084\/jem.168.3.853","article-title":"Interleukin-4 causes isotype switching to IgE in T cell\u2013stimulated clonal B cell cultures","volume":"168","author":"Lebman","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/j.nutres.2011.12.005_bb0020","doi-asserted-by":"crossref","first-page":"6880","DOI":"10.1073\/pnas.85.18.6880","article-title":"IgE production by normal human lymphocytes is induced by interleukin-4 and suppressed by interferon-gamma and alpha and prostaglandin E2","volume":"85","author":"Pene","year":"1988","journal-title":"Proc of the Natl Acad Scie (USA)"},{"key":"10.1016\/j.nutres.2011.12.005_bb0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1164\/rccm.200310-1416OC","article-title":"Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma","volume":"171","author":"Cho","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.nutres.2011.12.005_bb0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3347\/kjp.2000.38.4.209","article-title":"Mucosal immunity against parasitic gastrointestinal nematodes","volume":"38","author":"Onah","year":"2000","journal-title":"Korean J Parasitol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0035","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.4049\/jimmunol.148.7.2142","article-title":"Reciprocal regulatory effects of IFN-gamma and IL-4 on in vitro development of Th1 and Th2 clones","volume":"148","author":"Maggi","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cyto.2003.12.010","article-title":"Differential effects of iron deficiency and underfeeding on serum levels of interleukin-10, interleukin-12p40, and interferon-gamma in mice","volume":"26","author":"Kuvibidila","year":"2004","journal-title":"Cytokine"},{"key":"10.1016\/j.nutres.2011.12.005_bb0045","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jcb.10627","article-title":"Effects of iron deficiency on the secretion of interleukin-10 by mitogen-treated and non-treated in mice","volume":"90","author":"Kuvibidila","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.nutres.2011.12.005_bb0050","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1079\/BJN19940094","article-title":"The effects of iron deficiency and iron overload on cell mediated immunity in the mouse","volume":"72","author":"Omar","year":"1994","journal-title":"Br J Nutr"},{"issue":"3","key":"10.1016\/j.nutres.2011.12.005_bb0055","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cyto.2010.08.004","article-title":"Iron deficiency, but not underfeeding reduces the secretion of interferon-gamma by mitogen-activated murine spleen cells","volume":"52","author":"Kuvibidila","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.nutres.2011.12.005_bb0060","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1086\/422331","article-title":"Iron deficiency and malaria among children living on the coast of Kenya","volume":"190","author":"Nyakeriga","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nutres.2011.12.005_bb0065","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-3083.2005.01573.x","article-title":"Cytokine mRNA expression and iron status in children living in a malaria endemic area","volume":"61","author":"Nyakeriga","year":"2005","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0070","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1046\/j.1365-2249.2001.01707.x","article-title":"The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost","volume":"126","author":"Jason","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0075","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.4049\/jimmunol.169.7.3700","article-title":"Altered IL-4 mRNA stability correlates with TH1 and TH2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice","volume":"169","author":"Butler","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0080","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/sj.gene.6363819","article-title":"Linkage analysis of variations in CD4:CD8 T cell subsets between C57BL\/6 and DBA\/2","volume":"3","author":"Myrick","year":"2002","journal-title":"Genes Immun"},{"key":"10.1016\/j.nutres.2011.12.005_bb0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jtra.10047","article-title":"An overview of role of iron on T cell activation","volume":"16","author":"Kuvibidila","year":"2003","journal-title":"J Trace Elem Exp Med"},{"key":"10.1016\/j.nutres.2011.12.005_bb0090","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2011.12.005_bb0095","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/jn\/128.7.1077","article-title":"Iron deficiency reduces the hydrolysis of cell membrane phosphatidyl-inositol 4,5 bis-phosphate during splenic lymphocyte activation in C57BL\/6 mice","volume":"128","author":"Kuvibidila","year":"1998","journal-title":"J Nut"},{"issue":"1","key":"10.1016\/j.nutres.2011.12.005_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/14.1.1","article-title":"The IL-4 production capability of different strains of na\u00efve CD4+ T cells controls the direction of the Th cell response","volume":"14","author":"Yagi","year":"2002","journal-title":"Intern Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0105","first-page":"99","article-title":"Differences among group means: one-way analysis of variance","author":"Munro","year":"1993"},{"issue":"4","key":"10.1016\/j.nutres.2011.12.005_bb0110","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1142\/S0192415X05003247","article-title":"Long-term oral administration of ginger extract modulates humoral immune response and spleen cell functions","volume":"33","author":"Liou","year":"2005","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.nutres.2011.12.005_bb0115","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/ajcn\/51.2.228","article-title":"Influence of iron deficiency anemia on selected thymus functions in mice: thymulin biological activity, T cell subsets, and thymocyte proliferation","volume":"51","author":"Kuvibidila","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2011.12.005_bb0120","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/jn\/121.9.1418","article-title":"Lymphocyte subpopulations in the thymus, lymph nodes, and spleen of iron-deficient and rehabilitated mice","volume":"121","author":"Dhur","year":"1991","journal-title":"J Nutr"},{"issue":"2","key":"10.1016\/j.nutres.2011.12.005_bb0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12288-009-0017-3","article-title":"Effect of iron deficiency anemia and its treatment on cell mediated immunity","volume":"25","author":"Attia","year":"2009","journal-title":"Indian J Hem Blood Transfus"},{"key":"10.1016\/j.nutres.2011.12.005_bb0130","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0271-5317(05)80499-3","article-title":"Moderate and severe iron deficiency lower numbers of spleen T lymphocyte and B lymphocyte subsets in C57BL\/6 mice","volume":"12","author":"Helyar","year":"1992","journal-title":"Nut Res"},{"key":"10.1016\/j.nutres.2011.12.005_bb0135","first-page":"861","article-title":"Generation of plaque-forming cells in iron deficient anemic mice","volume":"26","author":"Kuvibidila","year":"1982","journal-title":"Nutr Rep Intern"},{"issue":"4","key":"10.1016\/j.nutres.2011.12.005_bb0140","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1084\/jem.20040598","article-title":"Basophils initiate IL-4 production during a memory T-dependent response","volume":"200","author":"Khodoun","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.nutres.2011.12.005_bb0145","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0091-6749(97)70276-8","article-title":"The relative contribution of IL4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells","volume":"100","author":"Punnonen","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.nutres.2011.12.005_bb0150","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1365-2249.1998.00471.x","article-title":"The role of IL-13 in IgE synthesis by allergic asthma patients","volume":"111","author":"Van Der Pouw Kraan","year":"1998","journal-title":"Clin Exp Immunol"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531711002697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531711002697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T20:30:58Z","timestamp":1686774658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531711002697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0271531711002697"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2011.12.005","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}