{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:21:21Z","timestamp":1778653281308,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.nutres.2013.04.008","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T08:30:55Z","timestamp":1368865855000},"page":"487-493","source":"Crossref","is-referenced-by-count":21,"title":["Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model"],"prefix":"10.1016","volume":"33","author":[{"given":"Joshua C.","family":"Neuman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey A.","family":"Albright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L.","family":"Schalinske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2013.04.008_bb0005","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nutres.2013.04.008_bb0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8","article-title":"Total serum homocysteine in senile dementia of Alzheimer type","volume":"13","author":"McCaddon","year":"1998","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.nutres.2013.04.008_bb0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/jmg.21.5.325","article-title":"Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland","volume":"21","author":"Seller","year":"1984","journal-title":"J Med Genet"},{"key":"10.1016\/j.nutres.2013.04.008_bb0020","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.nutres.2013.04.008_bb0025","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","article-title":"Hyperhomocysteinemia: an independent risk factor for vascular disease","volume":"324","author":"Clarke","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2013.04.008_bb0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jn\/137.2.311","article-title":"New insights into the regulation of methyl group and homocysteine metabolism","volume":"137","author":"Williams","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0035","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/00005768-200006000-00004","article-title":"Training in hypoxia: modulation of metabolic and cardiovascular risk factors in men","volume":"32","author":"Bailey","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.nutres.2013.04.008_bb0040","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1600-0838.1999.tb00245.x","article-title":"Influence of exercise and menstrual cycle phase on plasma homocyst(e)ine levels in young women\u2014a prospective study","volume":"9","author":"De Cree","year":"1999","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.nutres.2013.04.008_bb0045","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/ajcn\/73.2.338","article-title":"Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning","volume":"73","author":"de Jong","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0050","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ypmed.2004.03.012","article-title":"Effects of exercise on emerging and traditional cardiovascular risk factors","volume":"39","author":"Duncan","year":"2004","journal-title":"Prev Med"},{"key":"10.1016\/j.nutres.2013.04.008_bb0055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000085536","article-title":"Physical training decreases total plasma homocysteine and cysteine in middle-aged subjects","volume":"49","author":"Gaume","year":"2005","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0060","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1515\/CCLM.2003.233","article-title":"Homocysteine increases during endurance exercise","volume":"41","author":"Herrmann","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.nutres.2013.04.008_bb0065","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000070032","article-title":"Influence of training volume and acute physical exercise on the homocysteine levels in endurance-trained men: interactions with plasma folate and vitamin B12","volume":"47","author":"Konig","year":"2003","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0070","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1210\/jc.2001-012056","article-title":"Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome","volume":"87","author":"Randeva","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0075","first-page":"262","article-title":"Effect of acute exercise on plasma homocysteine","volume":"38","author":"Wright","year":"1998","journal-title":"J Sports Med Phys Fitness"},{"key":"10.1016\/j.nutres.2013.04.008_bb0080","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/sj.ejcn.1601942","article-title":"Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)","volume":"58","author":"Husemoen","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1123\/ijsnem.16.4.341","article-title":"Exercise, nutrition, and homocysteine","volume":"16","author":"Joubert","year":"2006","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0090","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI107645","article-title":"Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids","volume":"53","author":"Ahlborg","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2013.04.008_bb0095","doi-asserted-by":"crossref","first-page":"E365","DOI":"10.1152\/ajpendo.2001.281.2.E365","article-title":"BCAA intake affects protein metabolism in muscle after but not during exercise in humans","volume":"281","author":"Blomstrand","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1152\/jappl.1981.50.1.41","article-title":"Influence of exercise on free amino acid concentrations in rat tissues","volume":"50","author":"Dohm","year":"1981","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nutres.2013.04.008_bb0105","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1152\/japplphysiol.00571.2005","article-title":"Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids","volume":"100","author":"Mourtzakis","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nutres.2013.04.008_bb0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1123\/ijsnem.16.5.453","article-title":"B-vitamins and exercise: does exercise alter requirements?","volume":"16","author":"Woolf","year":"2006","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0115","doi-asserted-by":"crossref","first-page":"E1235","DOI":"10.1152\/ajpendo.00237.2006","article-title":"Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats","volume":"291","author":"Nieman","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0120","doi-asserted-by":"crossref","first-page":"45708","DOI":"10.1074\/jbc.M408664200","article-title":"Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid","volume":"279","author":"Nieman","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2013.04.008_bb0125","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1093\/jn\/133.11.3392","article-title":"Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells","volume":"133","author":"Rowling","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0130","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.3945\/jn.108.094144","article-title":"Type 1 diabetes leads to tissue-specific DNA hypomethylation in male rats","volume":"138","author":"Williams","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0135","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jn\/129.5.919","article-title":"Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement","volume":"129","author":"Bailey","year":"1999","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0140","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1093\/jn\/132.9.2545","article-title":"Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats","volume":"132","author":"Rowling","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0145","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0378-4347(91)80407-4","article-title":"Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum","volume":"565","author":"Ubbink","year":"1991","journal-title":"J Chromatogr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/dmrr.1281","article-title":"Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat","volume":"28","author":"Williams","year":"2012","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.nutres.2013.04.008_bb0155","doi-asserted-by":"crossref","first-page":"22831","DOI":"10.1074\/jbc.271.37.22831","article-title":"Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase","volume":"271","author":"Garrow","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2013.04.008_bb0160","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/cs0690287","article-title":"Demonstration of methionine synthetase in intestinal mucosal cells of the rat","volume":"69","author":"Keating","year":"1985","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.nutres.2013.04.008_bb0165","series-title":"Statistical methods","author":"Snedecor","year":"1980"},{"key":"10.1016\/j.nutres.2013.04.008_bb0170","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.107.729939","article-title":"Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms","volume":"116","author":"Mora","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2013.04.008_bb0175","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ajcn\/72.2.324","article-title":"The controversy over homocysteine and cardiovascular risk","volume":"72","author":"Ueland","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0180","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/hh1101.092180","article-title":"Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice","volume":"88","author":"Dayal","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.nutres.2013.04.008_bb0185","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/j.1538-7836.2003.00482.x","article-title":"Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice","volume":"1","author":"Wilson","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.nutres.2013.04.008_bb0190","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"Bonaa","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2013.04.008_bb0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1182\/blood-2006-04-014654","article-title":"Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial","volume":"109","author":"den Heijer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.nutres.2013.04.008_bb0200","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2013.04.008_bb0205","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2013.04.008_bb0210","doi-asserted-by":"crossref","first-page":"1563S","DOI":"10.1093\/ajcn\/86.5.1563S","article-title":"Homocysteine, vitamins, and vascular disease prevention","volume":"86","author":"McCully","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0215","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1017\/S0029665108007076","article-title":"Homocysteine, B-vitamins and CVD","volume":"67","author":"McNulty","year":"2008","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.nutres.2013.04.008_bb0220","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/ATVBAHA.108.164830","article-title":"The homocysteine paradox","volume":"28","author":"Rodionov","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.nutres.2013.04.008_bb0225","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3177\/jnsv.55.22","article-title":"High casein diet decreases plasma homocysteine concentration in rats","volume":"55","author":"Ohuchi","year":"2009","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1016\/j.nutres.2013.04.008_bb0230","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/0026-0495(93)90198-W","article-title":"Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism","volume":"42","author":"Allen","year":"1993","journal-title":"Metabolism"},{"key":"10.1016\/j.nutres.2013.04.008_bb0235","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/abbi.2001.2474","article-title":"Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney","volume":"393","author":"Delgado-Reyes","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.nutres.2013.04.008_bb0240","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/ki.2009.117","article-title":"The kidney is the major site of S-adenosylhomocysteine disposal in humans","volume":"76","author":"Garibotto","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.nutres.2013.04.008_bb0245","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.2337\/diabetes.47.12.1967","article-title":"Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat","volume":"47","author":"Jacobs","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.nutres.2013.04.008_bb0250","doi-asserted-by":"crossref","first-page":"43740","DOI":"10.1074\/jbc.M107553200","article-title":"Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver","volume":"276","author":"Jacobs","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2013.04.008_bb0255","doi-asserted-by":"crossref","first-page":"42912","DOI":"10.1074\/jbc.M206588200","article-title":"Hormonal regulation of cystathionine \u03b2-synthase expression in liver","volume":"277","author":"Ratnam","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2013.04.008_bb0260","doi-asserted-by":"crossref","first-page":"E933","DOI":"10.1152\/ajpendo.00498.2005","article-title":"Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver","volume":"290","author":"Ratnam","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nutres.2013.04.008_bb0265","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev.nutr.24.012003.132418","article-title":"Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine","volume":"24","author":"Stipanuk","year":"2004","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.nutres.2013.04.008_bb0270","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00726-004-0147-8","article-title":"Effect of a swim training on homocysteine and cysteine levels in rats","volume":"28","author":"Gaume","year":"2005","journal-title":"Amino Acids"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531713000821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531713000821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T23:15:48Z","timestamp":1563059748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531713000821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0271531713000821"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2013.04.008","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}