{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:13:19Z","timestamp":1781651599903,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","content-domain":{"domain":["patient-research.elsevier.com","nrjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.nutres.2014.04.007","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:30:36Z","timestamp":1398119436000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Olive leaf extract suppresses messenger RNA expression of proinflammatory cytokines and enhances insulin receptor substrate 1 expression in the rats with streptozotocin and high-fat diet\u2013induced diabetes"],"prefix":"10.1016","volume":"34","author":[{"given":"Ya-Nan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hye","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HyunSook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2014.04.007_bb0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.nutres.2014.04.007_bb0010","doi-asserted-by":"crossref","first-page":"e59153","DOI":"10.1371\/journal.pone.0059153","article-title":"Waist circumference independently associates with the risk of insulin resistance and type 2 diabetes in Mexican American families","volume":"8","author":"Mamtani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2014.04.007_bb0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/YCO.0b013e32835a4206","article-title":"Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults","volume":"26","author":"Deuschle","year":"2013","journal-title":"Curr Opin Psychiatry"},{"issue":"Suppl 4","key":"10.1016\/j.nutres.2014.04.007_bb0020","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1038\/sj.ijo.0801497","article-title":"Molecular mechanisms of insulin resistance and the role of the adipocyte","volume":"24","author":"Hotamisligil","year":"2000","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.nutres.2014.04.007_bb0025","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3803\/jkes.2006.21.5.352","article-title":"NF-kB pathway in metabolic\/endocrine diseases","volume":"21","author":"Lee","year":"2006","journal-title":"J Korean Endocr Soc"},{"key":"10.1016\/j.nutres.2014.04.007_bb0030","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11130-012-0294-0","article-title":"Renal protective effects of extracts from guava fruit (Psidium guajava L.) in diabetic mice","volume":"67","author":"Lin","year":"2012","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1016\/j.nutres.2014.04.007_bb0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1254\/jphs.11184FP","article-title":"Syzygium cumini ameliorates insulin resistance and beta-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-alpha in type 2 diabetic rats","volume":"119","author":"Sharma","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.nutres.2014.04.007_bb0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","article-title":"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB","volume":"11","author":"Cai","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.nutres.2014.04.007_bb0045","first-page":"436","article-title":"The combination of insulin and GLP-1 analogues in the treatment of type 2 diabetes","volume":"70","author":"van der Klauw","year":"2012","journal-title":"Neth J Med"},{"key":"10.1016\/j.nutres.2014.04.007_bb0050","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3746\/jkfn.2006.35.2.150","article-title":"Effect of combined extract of safflower seed with herbs on blood glucose level and biochemical parameters in streptozotocin-induced diabetic rats","volume":"35","author":"Yang","year":"2006","journal-title":"J Kor Soc Food Sci Nutr"},{"key":"10.1016\/j.nutres.2014.04.007_bb0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4163\/kjn.2010.43.4.333","article-title":"Effects of fermented yacon (smallamthus sonchifolius) leaves tea on blood glucose levels and glucose metabolism in high-fat diet and streptozotocin-induced type 2 diabetic mice","volume":"43","author":"Kim","year":"2010","journal-title":"Korean J Nutr"},{"key":"10.1016\/j.nutres.2014.04.007_bb0060","first-page":"48","article-title":"Effects of Opuntia ficus-indica complexes B(OCB) on blood glucose and lipid metabolism in streptozotocin-induced diabetic rats","volume":"21","author":"Yoon","year":"2009","journal-title":"Korean J Food Nutr"},{"key":"10.1016\/j.nutres.2014.04.007_bb0065","doi-asserted-by":"crossref","first-page":"564972","DOI":"10.5402\/2011\/564972","article-title":"Chloroformic and methanolic extracts of Olea europaea L. Leaves present anti-inflammatory and analgesic activities","volume":"2011","author":"Chebbi Mahjoub","year":"2011","journal-title":"ISRN Pharmacol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0070","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0924-8579(02)00181-4","article-title":"In vitro antimycoplasmal activity of oleuropein","volume":"20","author":"Furneri","year":"2002","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.nutres.2014.04.007_bb0075","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1016\/j.biortech.2009.12.052","article-title":"Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract","volume":"101","author":"Lee","year":"2010","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0080","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1089\/jmf.2011.0243","article-title":"Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats","volume":"15","author":"Wainstein","year":"2012","journal-title":"J Med Food"},{"key":"10.1016\/j.nutres.2014.04.007_bb0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00394-008-0717-8","article-title":"The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis","volume":"47","author":"Wang","year":"2008","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nutres.2014.04.007_bb0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.18388\/abp.2011_2284","article-title":"Effects of olive leaf polyphenols against H(2)O(2) toxicity in insulin secreting beta-cells","volume":"58","author":"Cumaoglu","year":"2011","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0095","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.nutres.2014.04.007_bb0100","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1016\/j.biortech.2009.06.059","article-title":"Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities","volume":"100","author":"Lee","year":"2009","journal-title":"Bioresour Technol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0105","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1016\/j.chroma.2011.04.053","article-title":"New possibilities for the valorization of olive oil by-products","volume":"1218","author":"Herrero","year":"2011","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.nutres.2014.04.007_bb0110","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jep.2010.12.018","article-title":"Antidiabetic effect of Symplocos cochinchinensis (Lour.) S. Moore. in type 2 diabetic rats","volume":"134","author":"Sunil","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.nutres.2014.04.007_bb0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2011.07.001","article-title":"Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats","volume":"668","author":"Makni","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0125","first-page":"972","article-title":"Expression of insulin receptor substrates in pancreas of rats with intrauterine growth retardation","volume":"12","author":"Li","year":"2010","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"10.1016\/j.nutres.2014.04.007_bb0130","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3945\/jn.109.117812","article-title":"Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats","volume":"140","author":"Poudyal","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2014.04.007_bb0135","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5507\/bp.2012.103","article-title":"Comparison of a low-glycemic index vs standard diabetic diet","volume":"158","author":"Visek","year":"2014","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.nutres.2014.04.007_bb0140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2119\/2007-00119.Tilg","article-title":"Inflammatory mechanisms in the regulation of insulin resistance","volume":"14","author":"Tilg","year":"2008","journal-title":"Mol Med"},{"key":"10.1016\/j.nutres.2014.04.007_bb0145","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm1185","article-title":"IKK-beta links inflammation to obesity-induced insulin resistance","volume":"11","author":"Arkan","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.nutres.2014.04.007_bb0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/en.2006-0692","article-title":"Interleukin-1beta\u2013induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression","volume":"148","author":"Jager","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.nutres.2014.04.007_bb0155","doi-asserted-by":"crossref","first-page":"E749","DOI":"10.1152\/ajpendo.00363.2011","article-title":"Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria","volume":"301","author":"Coletta","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nutres.2014.04.007_bb0160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0168-8227(00)00247-3","article-title":"Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with type 2 diabetes mellitus","volume":"52","author":"Mishima","year":"2001","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.nutres.2014.04.007_bb0165","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1016\/j.fct.2012.08.012","article-title":"The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide\u2013induced type 2 diabetic rats","volume":"50","author":"Arya","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.nutres.2014.04.007_bb0170","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.biochi.2010.11.002","article-title":"Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium","volume":"93","author":"Deqiu","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.nutres.2014.04.007_bb0175","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/jf901280r","article-title":"Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats","volume":"57","author":"Jemai","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nutres.2014.04.007_bb0180","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ptr.2629","article-title":"Antidiabetic effect of Olea europaea L. in normal and diabetic rats","volume":"23","author":"Eidi","year":"2009","journal-title":"Phytother Res"},{"key":"10.1016\/j.nutres.2014.04.007_bb0185","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2337\/diacare.25.7.1135","article-title":"HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: prospective data from the Verona Diabetes Complications Study","volume":"25","author":"Bonora","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nutres.2014.04.007_bb0190","first-page":"84","article-title":"Metabolic factors that affect beta-cell function and survival","volume":"13","author":"Purrello","year":"2000","journal-title":"Diabetes Nutr Metab"},{"key":"10.1016\/j.nutres.2014.04.007_bb0195","doi-asserted-by":"crossref","first-page":"281","DOI":"10.7326\/0003-4819-131-4-199908170-00008","article-title":"Pharmacologic therapy for type 2 diabetes mellitus","volume":"131","author":"DeFronzo","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nutres.2014.04.007_bb0200","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2337\/diabetes.50.8.1771","article-title":"Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation","volume":"50","author":"Cnop","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.nutres.2014.04.007_bb0205","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2337\/diab.43.6.735","article-title":"Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?","volume":"43","author":"Taylor","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.nutres.2014.04.007_bb0210","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF00401208","article-title":"Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview","volume":"35","author":"DeFronzo","year":"1992","journal-title":"Diabetologia"},{"key":"10.1016\/j.nutres.2014.04.007_bb0215","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.diabet.2009.05.005","article-title":"Early-stage atherosclerosis in newly diagnosed, untreated type 2 diabetes mellitus and impaired glucose tolerance","volume":"35","author":"Gong","year":"2009","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.nutres.2014.04.007_bb0220","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2337\/diacare.25.3.579","article-title":"Hypertriglyceridemic hyperapoB in type 2 diabetes","volume":"25","author":"Sniderman","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nutres.2014.04.007_bb0225","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.metabol.2007.04.021","article-title":"Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat","volume":"56","author":"Sahin","year":"2007","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.nutres.2014.04.007_bb0230","doi-asserted-by":"crossref","first-page":"820786","DOI":"10.1155\/2013\/820786","article-title":"Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kutzing extract in experimental type 2 diabetic rats","volume":"2013","author":"Ontawong","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.nutres.2014.04.007_bb0235","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.foodchem.2011.04.066","article-title":"Beneficial effect of Ficus religiosa Linn. on high-fat-diet\u2013induced hypercholesterolemia in rats","volume":"129","author":"Hamed","year":"2011","journal-title":"Food Chem"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531714000621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531714000621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T19:24:38Z","timestamp":1565378678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531714000621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0271531714000621"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2014.04.007","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Olive leaf extract suppresses messenger RNA expression of proinflammatory cytokines and enhances insulin receptor substrate 1 expression in the rats with streptozotocin and high-fat diet\u2013induced diabetes","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2014.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}