{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:42:26Z","timestamp":1769085746785,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["24591171"],"award-info":[{"award-number":["24591171"]}]},{"name":"Grant-in-Aid for challenging Exploratory Research","award":["24659406"],"award-info":[{"award-number":["24659406"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Labour Sciences Research Grant for Clinical Research Translational Research General","award":["002"],"award-info":[{"award-number":["002"]}]},{"name":"Japan Intractable Diseases Research Foundation"},{"name":"Tsumura and Co"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.nutres.2014.08.014","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T04:45:37Z","timestamp":1409892337000},"page":"876-885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion"],"prefix":"10.1016","volume":"34","author":[{"given":"Hironobu","family":"Tsubouchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehisa","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-4928","authenticated-orcid":false,"given":"Sachiko","family":"Mogami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-884X","authenticated-orcid":false,"given":"Seiichi","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamitsu","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2014.08.014_bb0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.nutres.2014.08.014_bb0010","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1152\/japplphysiol.00790.2012","article-title":"The mechanisms of cachexia underlying muscle dysfunction in COPD","volume":"114","author":"Remels","year":"2013","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nutres.2014.08.014_bb0015","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1378\/chest.121.5.1434","article-title":"Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD","volume":"121","author":"Nishimura","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.nutres.2014.08.014_bb0020","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1183\/09031936.00152609","article-title":"A simple assessment of dyspnoea as a prognostic indicator in idiopathic pulmonary fibrosis","volume":"36","author":"Nishiyama","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.nutres.2014.08.014_bb0025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1164\/ajrccm\/142.3.631","article-title":"Resting energy expenditure in interstitial lung disease","volume":"142","author":"Fitting","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.nutres.2014.08.014_bb0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1475-2891-11-37","article-title":"Resting energy expenditure and carbohydrate oxidation are higher in elderly patients with COPD: a case control study","volume":"11","author":"Ramires","year":"2012","journal-title":"Nutr J"},{"key":"10.1016\/j.nutres.2014.08.014_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/thx.2006.062026","article-title":"Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease","volume":"62","author":"Swallow","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.nutres.2014.08.014_bb0040","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1378\/chest.06-2784","article-title":"Body mass index and mortality in patients with idiopathic pulmonary fibrosis","volume":"131","author":"Alakhras","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.nutres.2014.08.014_bb0045","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1378\/chest.126.2.540","article-title":"C-reactive protein and body mass index predict outcome in end-stage respiratory failure","volume":"126","author":"Cano","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.nutres.2014.08.014_bb0050","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone\u2013releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2014.08.014_bb0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2014.08.014_bb0060","first-page":"611","article-title":"Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice","volume":"123","author":"Porporato","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2014.08.014_bb0065","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1378\/chest.128.3.1187","article-title":"Treatment of cachexia with ghrelin in patients with COPD","volume":"128","author":"Nagaya","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.nutres.2014.08.014_bb0070","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00383-003-1053-y","article-title":"The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectric activity in post-operative dyspeptic children after gastrointestinal surgery","volume":"19","author":"Yagi","year":"2004","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.nutres.2014.08.014_bb0075","first-page":"62","article-title":"Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin","volume":"59","author":"Arai","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.nutres.2014.08.014_bb0080","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1038\/tp.2011.25","article-title":"Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival","volume":"1","author":"Fujitsuka","year":"2011","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.nutres.2014.08.014_bb0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejphar.2011.09.183","article-title":"Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation","volume":"672","author":"Imazu","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nutres.2014.08.014_bb0090","doi-asserted-by":"crossref","first-page":"L233","DOI":"10.1152\/ajplung.00096.2013","article-title":"Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner","volume":"306","author":"Tsubouchi","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.nutres.2014.08.014_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.regpep.2007.09.010","article-title":"Ghrelin deficiency does not influence feeding performance","volume":"145","author":"Sato","year":"2008","journal-title":"Regul Pept"},{"key":"10.1016\/j.nutres.2014.08.014_bb0100","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1073\/pnas.0305930101","article-title":"Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor","volume":"101","author":"Sun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2014.08.014_bb0105","doi-asserted-by":"crossref","first-page":"L152","DOI":"10.1152\/ajplung.00313.2007","article-title":"Murine models of pulmonary fibrosis","volume":"294","author":"Moore","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.nutres.2014.08.014_bb0110","doi-asserted-by":"crossref","first-page":"E1076","DOI":"10.1152\/ajpendo.00211.2012","article-title":"Effect of vertical sleeve gastrectomy on food selection and satiation in rats","volume":"303","author":"Chambers","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nutres.2014.08.014_bb0115","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1053\/j.gastro.2008.02.078","article-title":"Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism","volume":"134","author":"Takeda","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nutres.2014.08.014_bb0120","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1038\/emboj.2011.292","article-title":"C\/EBPbeta mediates tumour-induced ubiquitin ligase atrogin1\/MAFbx upregulation and muscle wasting","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.nutres.2014.08.014_bb0125","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1096\/fj.08-128843","article-title":"Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect","volume":"23","author":"Cao","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.nutres.2014.08.014_bb0130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.nutres.2014.08.014_bb0135","first-page":"S1","article-title":"Skeletal muscle dysfunction in chronic obstructive pulmonary disease. A statement of the American Thoracic Society and European Respiratory Society","volume":"159","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nutres.2014.08.014_bb0140","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/resp.12181","article-title":"Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia","volume":"19","author":"Mendoza","year":"2014","journal-title":"Respirology"},{"key":"10.1016\/j.nutres.2014.08.014_bb0145","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1183\/09031936.02.00532002","article-title":"Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study","volume":"20","author":"Prescott","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.nutres.2014.08.014_bb0150","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1164\/rccm.2107031","article-title":"Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease","volume":"166","author":"Marquis","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nutres.2014.08.014_bb0155","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1136\/gut.52.7.947","article-title":"Antagonism of ghrelin receptor reduces food intake and body weight gain in mice","volume":"52","author":"Asakawa","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2014.08.014_bb0160","doi-asserted-by":"crossref","first-page":"R674","DOI":"10.1152\/ajpregu.00104.2006","article-title":"IGF-1 is downregulated in experimental cancer cachexia","volume":"291","author":"Costelli","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.nutres.2014.08.014_bb0165","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00424-010-0919-9","article-title":"The role and regulation of MAFbx\/atrogin-1 and MuRF1 in skeletal muscle atrophy","volume":"461","author":"Foletta","year":"2011","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.nutres.2014.08.014_bb0170","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.regpep.2012.06.003","article-title":"Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II\u2013induced cachexia in mice","volume":"178","author":"Sugiyama","year":"2012","journal-title":"Regul Pept"},{"key":"10.1016\/j.nutres.2014.08.014_bb0175","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/B978-0-12-410473-0.00012-X","article-title":"Cisplatin-induced anorexia and ghrelin","volume":"92","author":"Hattori","year":"2013","journal-title":"Vitam Horm"},{"key":"10.1016\/j.nutres.2014.08.014_bb0180","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1248\/bpb.b13-00364","article-title":"Pathophysiologic basis of anorexia: focus on the interaction between ghrelin dynamics and the serotonergic system","volume":"36","author":"Takeda","year":"2013","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.nutres.2014.08.014_bb0185","doi-asserted-by":"crossref","first-page":"792940","DOI":"10.1155\/2013\/792940","article-title":"Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model","volume":"2013","author":"Yamada","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.nutres.2014.08.014_bb0190","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/gast.2002.35954","article-title":"The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats","volume":"123","author":"Date","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nutres.2014.08.014_bb0195","doi-asserted-by":"crossref","first-page":"e45048","DOI":"10.1371\/journal.pone.0045048","article-title":"Prevention of disuse muscle atrophy by dietary ingestion of 8-prenylnaringenin in denervated mice","volume":"7","author":"Mukai","year":"2012","journal-title":"PLoS One"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531714001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531714001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:46:50Z","timestamp":1759448810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531714001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0271531714001651"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2014.08.014","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2014.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}