{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:31:48Z","timestamp":1786995108570,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.nutres.2015.08.001","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T06:56:51Z","timestamp":1439017011000},"page":"921-929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Probiotic  Pediococcus pentosaceus  strain GS4 alleviates azoxymethane-induced toxicity in mice"],"prefix":"10.1016","volume":"35","author":[{"given":"Vinay","family":"Dubey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asit R.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kausik","family":"Bishayee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisur R.","family":"Khuda-Bukhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2015.08.001_bb0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0029-1242458","article-title":"Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors","volume":"22","author":"Haggar","year":"2009","journal-title":"Clin Colon Rectal Surg"},{"key":"10.1016\/j.nutres.2015.08.001_bb0010","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000323926","article-title":"Colon cancer: a civilization disorder","volume":"29","author":"Watson","year":"2011","journal-title":"Dig Dis"},{"key":"10.1016\/j.nutres.2015.08.001_bb0015","first-page":"2727","article-title":"Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies","volume":"29","author":"Triantafillidis","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.nutres.2015.08.001_bb0020","first-page":"18","article-title":"Diet and colorectal cancer: current evidence for etiology and prevention","volume":"20","author":"Campos","year":"2005","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.nutres.2015.08.001_bb0025","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/sj.bjc.6603033","article-title":"Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies","volume":"94","author":"Simmonds","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.nutres.2015.08.001_bb0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nm.1889","article-title":"MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis","volume":"15","author":"Stein","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.nutres.2015.08.001_bb0035","first-page":"3387","article-title":"Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process","volume":"59","author":"Reddy","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.nutres.2015.08.001_bb0040","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6603990","article-title":"Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study","volume":"97","author":"\u00d6sterlund","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.nutres.2015.08.001_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/scitranslmed.3010473","article-title":"Cancer and the gut microbiota: an unexpected link","volume":"7","author":"Zitvogel","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.nutres.2015.08.001_bb0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0463.2004.apm1120601.x","article-title":"Secondary effects induced by the colon carcinogen azoxymethane in BDIX rats","volume":"112","author":"Kobaek-Larsen","year":"2004","journal-title":"APMIS"},{"key":"10.1016\/j.nutres.2015.08.001_bb0055","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.foodchem.2013.10.101","article-title":"Attenuation of histopathological alterations of colon, liver and lung by dietary fibre of barley Rihane in azoxymethane-treated rats","volume":"149","author":"Lahouar","year":"2014","journal-title":"Food Chem"},{"key":"10.1016\/j.nutres.2015.08.001_bb0060","first-page":"3123","article-title":"Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: similarity to the microsomal metabolism of N-nitrosodimethylamine","volume":"47","author":"Sohn","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.nutres.2015.08.001_bb0065","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.neuint.2005.11.022","article-title":"Neurobiological characterization of an azoxymethane mouse model of acute liver failure","volume":"48","author":"Be\u00b4langer","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.nutres.2015.08.001_bb0070","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/S0016-5085(98)70028-9","article-title":"Expression of G protein a subunits in normal rat colon and in azoxymethane-induced colonic neoplasms","volume":"115","author":"Bolt","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nutres.2015.08.001_bb0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s004320050231","article-title":"Expression of sucrase and intestinal-type alkaline phosphatase in colorectal carcinomas in rats treated with methylazoxymethanol acetate","volume":"124","author":"Yoshida","year":"1998","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0080","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/MIB.0b013e318281330a","article-title":"Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor\u2013associated kinase M deficient mice","volume":"19","author":"Klimesova","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.nutres.2015.08.001_bb0085","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1756283X13482996","article-title":"Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ","volume":"6","author":"Guinane","year":"2013","journal-title":"Ther Adv Gastroenterol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0090","doi-asserted-by":"crossref","first-page":"e7521","DOI":"10.5812\/hepatmon.7521","article-title":"Probiotic as a novel treatment strategy against liver disease","volume":"13","author":"Imani Fooladi","year":"2013","journal-title":"Hepat Mon"},{"key":"10.1016\/j.nutres.2015.08.001_bb0095","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/ajcn\/83.5.1199","article-title":"Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China","volume":"83","author":"El-Nezami","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.08.001_bb0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.nut.2011.02.012","article-title":"Probiotic Enterococcus lactis IITRHR1 protects against acetaminophen-induced hepatotoxicity","volume":"28","author":"Sharma","year":"2012","journal-title":"Nutrition"},{"key":"10.1016\/j.nutres.2015.08.001_bb0105","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s11274-013-1268-6","article-title":"Lactobacillus rhamnosus GG antagonizes Giardia intestinalis induced oxidative stress and intestinal disaccharide enzymes: an experimental study","volume":"29","author":"Goyal","year":"2013","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0110","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1016\/j.fct.2012.07.070","article-title":"Lactobacillus reuteri CRL 1098 and Lactobacillus acidophilus CRL 1014 differently reduce in vitro immunotoxic effect induced by Ochratoxin A","volume":"50","author":"Mechoud","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0115","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3748\/wjg.v16.i4.403","article-title":"Probiotics and gut health: a special focus on liver diseases","volume":"16","author":"Gratz","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0120","first-page":"597","article-title":"Pediococcus spp.\u2014a potential probiotic isolated from Khadi (an Indian fermented food) and identified by 16S rDNA sequence analysis","volume":"4","author":"Sukumar","year":"2010","journal-title":"Afr J Food Sci"},{"key":"10.1016\/j.nutres.2015.08.001_bb0125","first-page":"983","article-title":"Anti-oxidative potential of probiotic bacteria from Indian fermented food","volume":"2","author":"Sukumar","year":"2011","journal-title":"Int J Res Ayurv Pharm"},{"key":"10.1016\/j.nutres.2015.08.001_bb0130","first-page":"233","article-title":"Determination of viability of Pediococcus spp. After storage into hard gelatin capsule and its survival under in vitro simulated gastrointestinal condition","volume":"3","author":"Bagad","year":"2012","journal-title":"Int J Res Ayurv Pharm"},{"key":"10.1016\/j.nutres.2015.08.001_bb0135","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s12010-012-9855-9","article-title":"Appraisal of conjugated linoleic acid production by probiotic potential of Pediococcus spp. GS4","volume":"168","author":"Dubey","year":"2012","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0140","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1462-5822.2008.01137.x","article-title":"Probiotic Lactobacillus reuteri promotes TNF induced apoptosis in human myeloid leukemia derived cells by modulation of NF-kappa B and MAPK signalling","volume":"10","author":"Iyer","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0145","series-title":"World Gastroenterol Organization Practice Guidelines","article-title":"Probiotics and prebiotics","author":"Guarner","year":"2008"},{"key":"10.1016\/j.nutres.2015.08.001_bb0150","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/mc.20637","article-title":"Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase","volume":"49","author":"Hosono","year":"2010","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.nutres.2015.08.001_bb0155","series-title":"Histological techniques","author":"Carleton","year":"1980"},{"key":"10.1016\/j.nutres.2015.08.001_bb0160","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.nutres.2015.08.001_bb0165","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0003-2697(64)90115-0","article-title":"Method for assay of intestinal disaccharides","volume":"7","author":"Dahlqvist","year":"1964","journal-title":"Anal Biochem"},{"key":"10.1016\/j.nutres.2015.08.001_bb0170","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1128\/AEM.01054-09","article-title":"Survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG in the human gastrointestinal tract with daily consumption of a low-fat probiotic spread","volume":"75","author":"Dommels","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0175","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ilar.43.4.244","article-title":"Guidelines for the design and statistical analysis of experiments using laboratory animals","volume":"43","author":"Festing","year":"2002","journal-title":"ILAR J"},{"key":"10.1016\/j.nutres.2015.08.001_bb0180","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.intimp.2012.10.026","article-title":"Protective effects of probiotic Lactobacillus casei Zhang against endotoxin- and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities","volume":"15","author":"Wang","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0185","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s10620-008-0275-1","article-title":"Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats","volume":"53","author":"Southcott","year":"2008","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.nutres.2015.08.001_bb0190","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.nutres.2007.02.003","article-title":"Protective effects of Lactobacillus delbrueckii subsp bulgaricus B3 on intestinal enzyme activities after abdominal irradiation in rats","volume":"27","author":"Demirera","year":"2007","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2015.08.001_bb0195","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.nutres.2007.08.002","article-title":"Intestinal beneficial effects of kefir-supplemented diet in rats","volume":"27","author":"Urdaneta","year":"2007","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2015.08.001_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2007.10.001","article-title":"Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial","volume":"28","author":"Diop","year":"2008","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2015.08.001_bb0205","doi-asserted-by":"crossref","first-page":"e17996","DOI":"10.1371\/journal.pone.0017996","article-title":"Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression","volume":"6","author":"Reikvam","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2015.08.001_bb0210","doi-asserted-by":"crossref","first-page":"582048","DOI":"10.1155\/2015\/582048","article-title":"Clostridium butyricum combined with bifidobacterium infantis probiotic mixture restores fecal microbiota and attenuates systemic inflammation in mice with antibiotic-associated diarrhea","volume":"2015","author":"Ling","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.nutres.2015.08.001_bb0215","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fcimb.2014.00028","article-title":"The gut microbiota in mouse models of inflammatory bowel disease","volume":"4","author":"Gkouskou","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.nutres.2015.08.001_bb0220","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0271-5317(03)00134-9","article-title":"Effects of the consumption of Bifidobacterium lactis HN019 (DR10\u2122) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects","volume":"23","author":"Gopal","year":"2003","journal-title":"Nutr Res"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531715001839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531715001839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T13:39:59Z","timestamp":1529933999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531715001839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0271531715001839"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2015.08.001","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probiotic Pediococcus pentosaceus strain GS4 alleviates azoxymethane-induced toxicity in mice","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2015.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}