{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:44:49Z","timestamp":1782297889796,"version":"3.54.5"},"reference-count":78,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","nrjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.nutres.2015.10.003","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T22:44:26Z","timestamp":1445726666000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"title":["Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-1098","authenticated-orcid":false,"given":"J. David","family":"Spence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2015.10.003_bb0005","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1161\/STR.0b013e31829734f2","article-title":"Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association","volume":"44","author":"Ovbiagele","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0010","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1474-4422(13)70203-5","article-title":"The road map to integrated dementia prevention and care","volume":"12","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0015","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.3945\/ajcn.111.013243","article-title":"Biomarkers of vitamin B-12 status in NHANES: a roundtable summary","volume":"94","author":"Yetley","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2796.2011.02485.x","article-title":"Do we need to reconsider the desirable blood level of vitamin B12?","volume":"271","author":"Smith","year":"2012","journal-title":"J Intern Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0025","doi-asserted-by":"crossref","first-page":"359S","DOI":"10.3945\/ajcn.111.013458","article-title":"Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility","volume":"94","author":"Nexo","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0030","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1373\/clinchem.2006.080382","article-title":"Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin","volume":"53","author":"Clarke","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.nutres.2015.10.003_bb0035","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/bjh.12959","article-title":"British Committee for Standards in H. Guidelines for the diagnosis and treatment of cobalamin and folate disorders","volume":"166","author":"Devalia","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0040","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1515\/cclm-2014-0784","article-title":"A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population","volume":"53","author":"Aparicio-Ugarriza","year":"2015","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1503\/cmaj.1031155","article-title":"Vitamin B12 (cobalamin) deficiency in elderly patients","volume":"171","author":"Andres","year":"2004","journal-title":"CMAJ"},{"key":"10.1016\/j.nutres.2015.10.003_bb0050","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1373\/clinchem.2009.128678","article-title":"Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status","volume":"55","author":"Vogiatzoglou","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.nutres.2015.10.003_bb0055","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000096149","article-title":"Tutorial in biostatistics: analyzing associations between total plasma homocysteine and B vitamins using optimal categorization and segmented regression","volume":"27","author":"Bang","year":"2006","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.nutres.2015.10.003_bb0060","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3945\/ajcn.113.061234","article-title":"Modeling a methylmalonic acid\u2013derived change point for serum vitamin B-12 for adults in NHANES","volume":"98","author":"Bailey","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0065","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1161\/01.STR.0000236633.40160.ee","article-title":"Nutrition and stroke prevention","volume":"37","author":"Spence","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0070","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1046\/j.1532-5415.2002.50506.x","article-title":"Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults","volume":"50","author":"Rajan","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.nutres.2015.10.003_bb0075","doi-asserted-by":"crossref","first-page":"19995","DOI":"10.1073\/pnas.0709487104","article-title":"In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations","volume":"104","author":"Selhub","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2015.10.003_bb0080","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3945\/ajcn.2009.27514","article-title":"Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate","volume":"90","author":"Miller","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0085","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3945\/ajcn.2009.28671","article-title":"Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors","volume":"91","author":"Morris","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0090","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1532-5415.2012.04076.x","article-title":"Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study","volume":"60","author":"Morris","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.nutres.2015.10.003_bb0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-131265","article-title":"Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts","volume":"39","author":"Moore","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.nutres.2015.10.003_bb0100","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/bmj.281.6247.1036","article-title":"The neuropsychiatry of megaloblastic anaemia","volume":"281","author":"Shorvon","year":"1980","journal-title":"Br Med J"},{"key":"10.1016\/j.nutres.2015.10.003_bb0105","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(06)70598-1","article-title":"Vitamin B12, folic acid, and the nervous system","volume":"5","author":"Reynolds","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0110","doi-asserted-by":"crossref","first-page":"707S","DOI":"10.3945\/ajcn.2008.26947D","article-title":"Vitamin B-12 and cognition in the elderly","volume":"89","author":"Smith","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2796.2011.02484.x","article-title":"Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study","volume":"271","author":"Hooshmand","year":"2012","journal-title":"J Intern Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0120","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/1471-2458-14-643","article-title":"Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis","volume":"14","author":"Beydoun","year":"2014","journal-title":"BMC Public Health"},{"key":"10.1016\/j.nutres.2015.10.003_bb0125","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0130","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/01.wnl.0000325581.26991.f2","article-title":"Vitamin B12 status and rate of brain volume loss in community-dwelling elderly","volume":"71","author":"Vogiatzoglou","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nutres.2015.10.003_bb0135","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1212\/WNL.0b013e3182315a33","article-title":"Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination","volume":"77","author":"Tangney","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nutres.2015.10.003_bb0140","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jnnp.2008.149286","article-title":"Plasma vitamin B12 status and cerebral white-matter lesions","author":"de Lau","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nutres.2015.10.003_bb0145","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3945\/ajcn.113.076349","article-title":"Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals","author":"Clarke","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2015.10.003_bb0150","doi-asserted-by":"crossref","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","author":"Smith","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2015.10.003_bb0155","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/gps.2758","article-title":"Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial","author":"de Jager","year":"2012","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.nutres.2015.10.003_bb0160","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment","author":"Douaud","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2015.10.003_bb0165","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(09)70236-4","article-title":"Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis","volume":"8","author":"Pendlebury","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nrneurol.2012.255","article-title":"Antihypertensive treatment can prevent stroke and cognitive decline","author":"Soros","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0175","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1161\/STROKEAHA.107.486068","article-title":"B vitamin plasma levels and the risk of ischemic stroke and transient ischemic attack in a German cohort","author":"Weikert","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0180","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S1474-4422(07)70219-3","article-title":"Homocysteine-lowering therapy: a role in stroke prevention?","author":"Spence","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0185","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1503\/cmaj.045055","article-title":"Increased importance of vitamin B12 for total homocysteine and carotid plaque in the era of folate fortification of the grain supply","volume":"172","author":"Robertson","year":"2005","journal-title":"CMAJ"},{"key":"10.1016\/j.nutres.2015.10.003_bb0190","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1161\/01.STR.0000183620.06179.7b","article-title":"Culprit factors for the failure of well-conducted warfarin therapy to prevent ischemic events in patients with atrial fibrillation: the role of homocysteine","volume":"36","author":"Poli","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0195","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1172\/JCI72606","article-title":"Vitamin B(12)-dependent taurine synthesis regulates growth and bone mass","author":"Roman-Garcia","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2015.10.003_bb0200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00726-012-1432-6","article-title":"Taurine and atherosclerosis","author":"Murakami","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.nutres.2015.10.003_bb0205","doi-asserted-by":"crossref","first-page":"s6","DOI":"10.1186\/1423-0127-17-S1-S6","article-title":"Taurine in health and diseases: consistent evidence from experimental and epidemiological studies","author":"Yamori","year":"2010","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.nutres.2015.10.003_bb0210","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1186\/1423-0127-17-S1-S21","article-title":"Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world","author":"Yamori","year":"2010","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.nutres.2015.10.003_bb0215","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3390\/brainsci3020877","article-title":"Neuroprotective mechanisms of taurine against ischemic stroke","author":"Menzie","year":"2013","journal-title":"Brain Sci"},{"key":"10.1016\/j.nutres.2015.10.003_bb0220","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: the Framingham Study","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0225","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1161\/STROKEAHA.114.006536","article-title":"Secular trends in ischemic stroke subtypes and stroke risk factors","volume":"45","author":"Bogiatzi","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0230","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0140-6736(09)60604-8","article-title":"Mechanisms of thrombogenesis in atrial fibrillation","volume":"373","author":"Spence","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.nutres.2015.10.003_bb0235","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jns.2008.08.018","article-title":"Cryptogenic stroke and patent foramen ovale: clinical clues to paradoxical embolism","author":"Ozdemir","year":"2008","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nutres.2015.10.003_bb0240","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1161\/01.STR.0000185922.49809.46","article-title":"Absence of microemboli on transcranial Doppler identifies low-risk patients with asymptomatic carotid stenosis","author":"Spence","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0245","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1212\/WNL.0b013e31822b0090","article-title":"High-risk asymptomatic carotid stenosis: ulceration on 3D ultrasound vs TCD microemboli","author":"Madani","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nutres.2015.10.003_bb0250","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0255","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/jama.2015.1961","article-title":"Folate supplements for stroke prevention: targeted trial trumps the rest","volume":"313","author":"Stampfer","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0260","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering plasma total homocysteine to prevent recurrent stroke, myocardial infarction, and death in ischemic stroke patients: results of the Vitamin Intervention for Stroke Prevention (VISP) randomized trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0265","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(02)07439-1","article-title":"Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease","volume":"359","author":"Quinlivan","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.nutres.2015.10.003_bb0270","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1503\/cmaj.045055","article-title":"Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products","volume":"172","author":"Robertson","year":"2005","journal-title":"CMAJ"},{"key":"10.1016\/j.nutres.2015.10.003_bb0275","first-page":"1567","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0280","doi-asserted-by":"crossref","first-page":"e6273","DOI":"10.1136\/bmj.c6273","article-title":"Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled, trial","author":"Galan","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.nutres.2015.10.003_bb0285","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S1474-4422(12)70091-1","article-title":"Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial","author":"Hankey","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0290","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.STR.0000185929.38534.f3","article-title":"Vitamin Intervention for Stroke Prevention trial: an efficacy analysis","author":"Spence","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.nutres.2015.10.003_bb0295","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1001\/jama.2010.490","article-title":"Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled, trial","author":"House","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0300","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2010.1106","article-title":"B-vitamin therapy for diabetic nephropathy: reply","volume":"304","author":"Spence","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0305","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1001\/jama.2011.1834","article-title":"Understanding the complexity of homocysteine lowering with vitamins: the potential role of subgroup analyses","author":"Spence","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0315","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2141.2005.05913.x","article-title":"Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap","volume":"132","author":"Smulders","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0320","doi-asserted-by":"crossref","first-page":"55008","DOI":"10.1074\/jbc.M410818200","article-title":"A mathematical model of the folate cycle: new insights into folate homeostasis","volume":"279","author":"Nijhout","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2015.10.003_bb0325","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/ndt\/12.8.1622","article-title":"Abnormal cyanide metabolism in uraemic patients","author":"Koyama","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nutres.2015.10.003_bb0330","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1053\/j.ajkd.2009.12.035","article-title":"Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis","author":"Koyama","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.nutres.2015.10.003_bb0335","doi-asserted-by":"crossref","first-page":"e64774","DOI":"10.1371\/journal.pone.0064774","article-title":"The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine","author":"Loland","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2015.10.003_bb0340","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1177\/014107689208501110","article-title":"Cyanocobalamin\u2014a case for withdrawal: discussion paper","author":"Freeman","year":"1992","journal-title":"J R Soc Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0345","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1001\/jama.2011.1834","article-title":"Understanding the complexity of homocysteine lowering with vitamins: the potential role of subgroup analyses","volume":"306","author":"Spence","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2015.10.003_bb0350","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/ATVBAHA.108.180190","article-title":"Is H2S a stinky remedy for atherosclerosis?","author":"Wang","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.nutres.2015.10.003_bb0355","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2004.04.039","article-title":"Thiocyanate catalyzes myeloperoxidase-initiated lipid oxidation in LDL","author":"Exner","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0360","series-title":"Folic acid and renal function in the China Stroke Primary Prevention Trial Personal communication","author":"Huo","year":"2015"},{"key":"10.1016\/j.nutres.2015.10.003_bb0365","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10286-004-0142-x","article-title":"Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement","volume":"14","author":"Moore","year":"2004","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.nutres.2015.10.003_bb0370","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Clinical practice. Vitamin B12 deficiency","author":"Stabler","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0375","first-page":"79","article-title":"Vitamin B12 injections versus oral supplements. How much money could be saved by switching from injection Physician","volume":"47","author":"van Walraven","year":"2001"},{"key":"10.1016\/j.nutres.2015.10.003_bb0380","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1046\/j.1532-5415.2002.50506.x","article-title":"Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults","author":"Rajan","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.nutres.2015.10.003_bb0385","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJM196709142771101","article-title":"Mucosa of the small intestine in pernicious anemia","author":"Foroozan","year":"1967","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2015.10.003_bb0390","first-page":"313","article-title":"Functional and morphological abnormalities of the small intestinal mucosa in pernicious anemia\u2014a prospective study","author":"Arvanitakis","year":"1978","journal-title":"Acta Hepatogastroenterol (Stuttg)"},{"key":"10.1016\/j.nutres.2015.10.003_bb0395","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMoa032739","article-title":"Homocysteine as a predictive factor for hip fracture in older persons","volume":"350","author":"McLean","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531715002511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531715002511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T16:08:23Z","timestamp":1692115703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531715002511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0271531715002511"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2015.10.003","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2015.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}