{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:48:52Z","timestamp":1768693732130,"version":"3.49.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation (ZA)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South African Medical Council"},{"name":"Wits\/NIH Non-Communicable Diseases Leadership Program"},{"name":"Fogarty International Centre of NIH Promise Awards: Non-Communicable Chronic Diseases Research Training Program","award":["1D43TW008330-01A1"],"award-info":[{"award-number":["1D43TW008330-01A1"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","nrjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.nutres.2017.03.003","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T10:34:00Z","timestamp":1489487640000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Review of a causal role of fructose-containing sugars in myocardial susceptibility to ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"42","author":[{"given":"Gerald J.","family":"Maarman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Mendham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Lamont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2017.03.003_bb0005","series-title":"Global status report on noncommunicable diseases","author":"WHO","year":"2014"},{"key":"10.1016\/j.nutres.2017.03.003_bb0010","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/ajcn.81.2.536a","article-title":"Diet and risk of ischemic heart disease in India","volume":"81","author":"Chacko","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0015","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/ajcn\/77.4.814","article-title":"A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men","volume":"77","author":"Al-Delaimy","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0020","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ajcn\/59.4.935","article-title":"Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes","volume":"59","author":"Marckmann","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0025","doi-asserted-by":"crossref","first-page":"F625","DOI":"10.1152\/ajprenal.00140.2005","article-title":"A causal role for uric acid in fructose-induced metabolic syndrome","volume":"290","author":"Nakagawa","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1471-2261-14-185","article-title":"Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause","volume":"14","author":"Conti","year":"2014","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.nutres.2017.03.003_bb0035","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2337\/dc13-2085","article-title":"Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes? Health be damned! Pour on the sugar","volume":"37","author":"Bray","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nutres.2017.03.003_bb0040","doi-asserted-by":"crossref","first-page":"E658","DOI":"10.1152\/ajpendo.00511.2013","article-title":"Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat","volume":"306","author":"Warren","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.nutres.2017.03.003_bb0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/1056-8719(94)00063-A","article-title":"Fructose-induced hypertension in rats is concentration- and duration-dependent","volume":"33","author":"Dai","year":"1995","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.nutres.2017.03.003_bb0050","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1139\/y06-080","article-title":"Fructose-induced hypertension in Wistar-Kyoto rats: interaction with moderately high dietary salt","volume":"85","author":"Vasdev","year":"2007","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"10.1016\/j.nutres.2017.03.003_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00394-014-0826-5","article-title":"Early developmental exposure to high fructose intake in rats with NaCl stimulation causes cardiac damage","volume":"55","author":"Araujo","year":"2016","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1475-2840-12-89","article-title":"Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model","volume":"12","author":"Morvan","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0065","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.2174\/138161281939131127122054","article-title":"Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia","volume":"19","author":"Tanguy","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.nutres.2017.03.003_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1289\/ehp.1307085","article-title":"Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome","volume":"122","author":"Wagner","year":"2014","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.nutres.2017.03.003_bb0075","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.metabol.2014.04.002","article-title":"Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity","volume":"63","author":"Bostick","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.nutres.2017.03.003_bb0080","doi-asserted-by":"crossref","first-page":"H1126","DOI":"10.1152\/ajpheart.00898.2014","article-title":"Mineralocorticoid receptor blockade prevents Western diet\u2013induced diastolic dysfunction in female mice","volume":"308","author":"Bostick","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0085","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11745-014-3909-4","article-title":"Gender differences in the expression and cellular localization of lipin 1 in the hearts of fructose-fed rats","volume":"49","author":"Romic","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.nutres.2017.03.003_bb0090","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1748-1716.2012.02420.x","article-title":"Early cardiac dysfunction is rescued by upregulation of SERCA2a pump activity in a rat model of metabolic syndrome","volume":"205","author":"Miklos","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.nutres.2017.03.003_bb0095","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3892\/etm.2014.1886","article-title":"Interdependency of selected metabolic variables in an animal model of metabolic syndrome","volume":"8","author":"Mellouk","year":"2014","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.nutres.2017.03.003_bb0100","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4103\/0253-7613.132156","article-title":"Development of an experimental diet model in rats to study hyperlipidemia and insulin resistance, markers for coronary heart disease","volume":"46","author":"Munshi","year":"2014","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0105","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.HYP.10.5.512","article-title":"Fructose-induced insulin resistance and hypertension in rats","volume":"10","author":"Hwang","year":"1987","journal-title":"Hypertension"},{"key":"10.1016\/j.nutres.2017.03.003_bb0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jn\/107.1.147","article-title":"Insulin sensitivity and adipose tissue weight of rats fed starch or sucrose diets ad libitum or in meals","volume":"107","author":"Reiser","year":"1977","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0115","first-page":"4A","article-title":"Insulin sensitivity of adipose tissue of rats fed with various carbohydrates","volume":"33","author":"Bruckdorfer","year":"1974","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.nutres.2017.03.003_bb0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/01.HYP.5.2.218","article-title":"Chronic sucrose ingestion induces mild hypertension and tachycardia in rats","volume":"5","author":"Bunag","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/j.nutres.2017.03.003_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01851984","article-title":"Influence of feeding fructose on fructose and glucose absorption in rat jejunum and ileum","volume":"179","author":"Bode","year":"1981","journal-title":"Res Exp Med (Berl)"},{"key":"10.1016\/j.nutres.2017.03.003_bb0130","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/jn\/118.9.1061","article-title":"Hepatic fatty acid synthesis and triglyceride secretion in rats fed fructose- or glucose-based diets containing corn oil, tallow or marine oil","volume":"118","author":"Herzberg","year":"1988","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0135","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1001\/jama.1986.03380230065027","article-title":"Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects","volume":"256","author":"Bantle","year":"1986","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2017.03.003_bb0140","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ajh\/2.6.424","article-title":"Effect of fructose-induced hypertension on the renin-angiotensin-aldosterone system and atrial natriuretic factor","volume":"2","author":"Hwang","year":"1989","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.nutres.2017.03.003_bb0145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/ajcn\/33.2.273","article-title":"Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects","volume":"33","author":"Beck-Nielsen","year":"1980","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0150","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/jn\/113.9.1819","article-title":"Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men","volume":"113","author":"Hallfrisch","year":"1983","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0155","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ajcn\/37.5.740","article-title":"Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose","volume":"37","author":"Hallfrisch","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0160","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mvr.2014.02.012","article-title":"Aerobic exercise improves microvascular dysfunction in fructose fed hamsters","volume":"93","author":"Boa","year":"2014","journal-title":"Microvasc Res"},{"key":"10.1016\/j.nutres.2017.03.003_bb0165","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1681\/ASN.2007121304","article-title":"Fructose induces the inflammatory molecule ICAM-1 in endothelial cells","volume":"19","author":"Glushakova","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4103\/0250-474X.151604","article-title":"Protective effect of sitagliptin and rosuvastatin combination on vascular endothelial dysfunction in type-2 diabetes","volume":"77","author":"Nade","year":"2015","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.nutres.2017.03.003_bb0175","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10557-011-6312-x","article-title":"Atorvastatin protects against ischemia-reperfusion injury in fructose-induced insulin resistant rats","volume":"25","author":"Prakash","year":"2011","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.nutres.2017.03.003_bb0180","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00210-012-0830-3","article-title":"Fenofibrate attenuates impaired ischemic preconditioning-mediated cardioprotection in the fructose-fed hypertriglyceridemic rat heart","volume":"386","author":"Babbar","year":"2013","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0185","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1017\/S1368980014002122","article-title":"Sugar-sweetened beverages, vascular risk factors and events: a systematic literature review","volume":"18","author":"Keller","year":"2015","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0190","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.mayocp.2015.04.017","article-title":"Fructose as a driver of diabetes: an incomplete view of the evidence","volume":"90","author":"Sievenpiper","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.nutres.2017.03.003_bb0195","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1017\/S000711451200013X","article-title":"'Catalytic' doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: a small meta-analysis of randomised controlled feeding trials","volume":"108","author":"Sievenpiper","year":"2012","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0200","article-title":"Sugar consumption, metabolic disease and obesity: the state of the controversy","volume":"1-16","author":"Stanhope","year":"2015","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.nutres.2017.03.003_bb0205","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001700","article-title":"Effect of fructose on established lipid targets: a systematic review and meta-analysis of controlled feeding trials","volume":"4","author":"Chiavaroli","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.nutres.2017.03.003_bb0210","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/jch.12457","article-title":"Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption","volume":"17","author":"Angelopoulos","year":"2015","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"10.1016\/j.nutres.2017.03.003_bb0215","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1053\/j.gastro.2013.07.012","article-title":"No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men","volume":"145","author":"Johnston","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nutres.2017.03.003_bb0220","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3945\/jn.115.218016","article-title":"Consumption of honey, sucrose, and high-fructose corn syrup produces similar metabolic effects in glucose-tolerant and -intolerant individuals","volume":"145","author":"Raatz","year":"2015","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0225","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1097\/MPG.0000000000000704","article-title":"Overstated associations between fructose and nonalcoholic fatty liver disease","volume":"60","author":"Chiavaroli","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0230","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnut.2015.00012","article-title":"The ecologic validity of fructose feeding trials: supraphysiological feeding of fructose in human trials requires careful consideration when drawing conclusions on cardiometabolic risk","volume":"2","author":"Choo","year":"2015","journal-title":"Front Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0235","first-page":"1128","article-title":"The effect of normally consumed amounts of sucrose or high fructose corn syrup on lipid profiles, body composition and related parameters in overweight\/obese subjects","volume":"6","author":"Lowndes","year":"2014","journal-title":"Forum Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0240","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.pcad.2015.11.006","article-title":"The evidence for saturated fat and for sugar related to coronary heart disease","volume":"58","author":"DiNicolantonio","year":"2016","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.nutres.2017.03.003_bb0245","doi-asserted-by":"crossref","first-page":"983814","DOI":"10.1155\/2012\/983814","article-title":"Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions","volume":"2012","author":"Snel","year":"2012","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0250","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/nutrit\/nuv047","article-title":"Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials","volume":"74","author":"Ma","year":"2016","journal-title":"Nutr Rev"},{"key":"10.1016\/j.nutres.2017.03.003_bb0255","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2017.03.003_bb0260","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1160\/TH14-08-0703","article-title":"RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-alpha in cardiac ischaemia\/reperfusion injury","volume":"112","author":"Cabrera-Fuentes","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.nutres.2017.03.003_bb0265","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00395-015-0527-0","article-title":"Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside","volume":"111","author":"Cabrera-Fuentes","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0270","first-page":"15","article-title":"Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants","volume":"7","author":"Sayols-Baixeras","year":"2014","journal-title":"Appl Clin Genet"},{"key":"10.1016\/j.nutres.2017.03.003_bb0275","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2017.03.003_bb0280","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/wvn.12027","article-title":"Sugar or high fructose corn syrup\u2014what should nurses teach patients and families?","volume":"11","author":"Sobel","year":"2014","journal-title":"Worldviews Evid-Based Nurs"},{"key":"10.1016\/j.nutres.2017.03.003_bb0285","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1476-511X-12-136","article-title":"Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats","volume":"12","author":"de Castro","year":"2013","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.nutres.2017.03.003_bb0290","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3109\/10715762.2015.1031662","article-title":"Fructose-induced ROS generation impairs glucose utilization in L6 skeletal muscle cells","volume":"49","author":"Jaiswal","year":"2015","journal-title":"Free Radic Res"},{"key":"10.1016\/j.nutres.2017.03.003_bb0295","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/joim.12071","article-title":"Ectopic lipid storage and insulin resistance: a harmful relationship","volume":"274","author":"Boren","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.nutres.2017.03.003_bb0300","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1161\/CIRCULATIONAHA.111.077602","article-title":"Ectopic fat depots and cardiovascular disease","volume":"124","author":"Britton","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2017.03.003_bb0305","doi-asserted-by":"crossref","first-page":"H2336","DOI":"10.1152\/ajpheart.00481.2007","article-title":"Myocardial susceptibility to ischemic-reperfusion injury in a prediabetic model of dietary-induced obesity","volume":"294","author":"du Toit","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0310","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1631\/jzus.B1100090","article-title":"Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats","volume":"13","author":"Tranchida","year":"2012","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.nutres.2017.03.003_bb0315","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.nut.2009.08.017","article-title":"High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy","volume":"26","author":"Mellor","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.nutres.2017.03.003_bb0320","doi-asserted-by":"crossref","first-page":"e25204","DOI":"10.1371\/journal.pone.0025204","article-title":"Fructose modulates cardiomyocyte excitation-contraction coupling and Ca(2)(+) handling in vitro","volume":"6","author":"Mellor","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2017.03.003_bb0325","doi-asserted-by":"crossref","first-page":"H964","DOI":"10.1152\/ajpheart.00797.2011","article-title":"Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness","volume":"302","author":"Mellor","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0330","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1475-2840-12-133","article-title":"Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats","volume":"12","author":"Li","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0335","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1081\/CEH-120004228","article-title":"Myocardial function and effect of serum in isolated heart from hypertriglyceridemic and hypertensive rats","volume":"24","author":"Carvajal","year":"2002","journal-title":"Clin Exp Hypertens"},{"key":"10.1016\/j.nutres.2017.03.003_bb0340","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10557-012-6377-1","article-title":"Effect of chronic CPT-1 inhibition on myocardial ischemia-reperfusion injury (I\/R) in a model of diet-induced obesity","volume":"26","author":"Maarman","year":"2012","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.nutres.2017.03.003_bb0345","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.amjcard.2010.03.032","article-title":"Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy","volume":"106","author":"Turer","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0350","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-079X.2010.00826.x","article-title":"Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemia and reperfusion injury in a prediabetic model of diet-induced obesity","volume":"50","author":"Nduhirabandi","year":"2011","journal-title":"J Pineal Res"},{"key":"10.1016\/j.nutres.2017.03.003_bb0355","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11010-015-2501-4","article-title":"T3 and T4 decrease ROS levels and increase endothelial nitric oxide synthase expression in the myocardium of infarcted rats","volume":"408","author":"de Castro","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nutres.2017.03.003_bb0360","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199807233390404","article-title":"Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction","volume":"339","author":"Haffner","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nutres.2017.03.003_bb0365","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s001250050581","article-title":"Insulin resistance and coronary artery disease","volume":"39","author":"Bressler","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.nutres.2017.03.003_bb0370","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0735-1097(02)02044-2","article-title":"The impact of diabetes mellitus and prior myocardial infarction on mortality from all causes and from coronary heart disease in men","volume":"40","author":"Cho","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0375","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1007\/s00125-002-0882-x","article-title":"Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1","volume":"45","author":"Marfella","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.nutres.2017.03.003_bb0380","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1124\/jpet.103.055970","article-title":"Fructose-fed rats are protected against ischemia\/reperfusion injury","volume":"307","author":"Jordan","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.nutres.2017.03.003_bb0385","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/153537020623100411","article-title":"Fructose-fed rat hearts are protected against ischemia-reperfusion injury","volume":"231","author":"Joyeux-Faure","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.nutres.2017.03.003_bb0390","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/CIRCHEARTFAILURE.113.000521","article-title":"Plasma free fatty acids and risk of heart failure: the Cardiovascular Health Study","volume":"6","author":"Djousse","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.nutres.2017.03.003_bb0395","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0021-9150(01)00588-3","article-title":"Plasma free fatty acid levels and the risk of ischemic heart disease in men: prospective results from the Quebec Cardiovascular Study","volume":"160","author":"Pirro","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.nutres.2017.03.003_bb0400","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0939-4753(03)80029-7","article-title":"Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) study","volume":"13","author":"Wang","year":"2003","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.nutres.2017.03.003_bb0405","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.106.171016","volume":"113","author":"Poirier","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2017.03.003_bb0410","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/01.ATV.0000216787.85457.f3","article-title":"Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss","volume":"26","author":"Poirier","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0415","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1073\/pnas.97.4.1784","article-title":"Lipotoxic heart disease in obese rats: implications for human obesity","volume":"97","author":"Zhou","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl. 2","key":"10.1016\/j.nutres.2017.03.003_bb0420","doi-asserted-by":"crossref","first-page":"S371","DOI":"10.2337\/dc11-s250","article-title":"Myocardial, perivascular, and epicardial fat","volume":"34","author":"Iozzo","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.nutres.2017.03.003_bb0425","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/hrt.71.3.293","article-title":"Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study","volume":"71","author":"Yarnell","year":"1994","journal-title":"Br Heart J"},{"key":"10.1016\/j.nutres.2017.03.003_bb0430","first-page":"365","article-title":"Transgenic mouse models for cardiac dysfunction by a specific gene manipulation","volume":"112","author":"Babu","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.nutres.2017.03.003_bb0435","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jacc.2010.10.068","article-title":"Abnormal calcium homeostasis: one mechanism in diastolic heart failure","volume":"58","author":"Zile","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0440","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1006\/jmcc.2000.1101","article-title":"Cardiac unloading alters contractility and calcium homeostasis in ventricular myocytes","volume":"32","author":"Ritter","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0445","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fphys.2015.00078","article-title":"Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study","volume":"6","author":"Adeniran","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0450","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.RES.66.1.135","article-title":"Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart","volume":"66","author":"Steenbergen","year":"1990","journal-title":"Circ Res"},{"key":"10.1016\/j.nutres.2017.03.003_bb0455","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11010-005-4778-1","article-title":"Early pre-diabetic state alters adaptation of myocardial glucose metabolism during ischemia in rats","volume":"272","author":"Morel","year":"2005","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nutres.2017.03.003_bb0460","doi-asserted-by":"crossref","first-page":"e000167","DOI":"10.1136\/openhrt-2014-000167","article-title":"The wrong white crystals: not salt but sugar as aetiological in hypertension and cardiometabolic disease","volume":"1","author":"DiNicolantonio","year":"2014","journal-title":"Open Heart"},{"key":"10.1016\/j.nutres.2017.03.003_bb0465","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ajcn\/86.4.899","article-title":"Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease","volume":"86","author":"Johnson","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0470","article-title":"Baseline consumption and changes in sugar-sweetened beverage consumption and the incidence of hypertension: the SUN project","author":"Sayon-Orea","year":"2014","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.nutres.2017.03.003_bb0475","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/HYPERTENSIONAHA.115.06015","article-title":"Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females","volume":"66","author":"Jia","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.nutres.2017.03.003_bb0480","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2014.01.038","article-title":"Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat","volume":"727","author":"Prakash","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0485","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4103\/0253-7613.103248","article-title":"Effect of bromocriptine on cardiovascular complications associated with metabolic syndrome in fructose fed rats","volume":"44","author":"Nade","year":"2012","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0490","doi-asserted-by":"crossref","first-page":"1236S","DOI":"10.3945\/jn.109.106641","article-title":"Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans","volume":"139","author":"Stanhope","year":"2009","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0495","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-015-1128-y","article-title":"Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress","author":"Jaiswal","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.nutres.2017.03.003_bb0500","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1017\/S0007114508066774","article-title":"Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols","volume":"101","author":"de Moura","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0505","doi-asserted-by":"crossref","first-page":"351982","DOI":"10.1155\/2011\/351982","article-title":"Rodent models for metabolic syndrome research","volume":"2011","author":"Panchal","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.nutres.2017.03.003_bb0510","first-page":"R1117","article-title":"Model of spontaneous obesity in aging male Wistar rats","volume":"259","author":"Newby","year":"1990","journal-title":"Am J Phys"},{"key":"10.1016\/j.nutres.2017.03.003_bb0515","first-page":"1","article-title":"High-fat diet-induced obesity rat model: a comparison between Wistar and Sprague-Dawley rat","author":"Marques","year":"2015","journal-title":"Adipocyte"},{"key":"10.1016\/j.nutres.2017.03.003_bb0520","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1258\/0023677052886457","article-title":"Housing-related activity in rats: effects on body weight, urinary corticosterone levels, muscle properties and performance","volume":"39","author":"Spangenberg","year":"2005","journal-title":"Lab Anim"},{"issue":"3","key":"10.1016\/j.nutres.2017.03.003_bb0525","article-title":"A dose-response study of consuming high-fructose corn syrup\u2013sweetened beverages on lipid\/lipoprotein risk factors for cardiovascular disease in young adults","volume":"105","author":"Stanhope","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2017.03.003_bb0530","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1172\/JCI37385","article-title":"Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight\/obese humans","volume":"119","author":"Stanhope","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2017.03.003_bb0535","first-page":"jc20143678","article-title":"Effect of a high-fructose weight-maintaining diet on lipogenesis and liver fat","author":"Schwarz","year":"2015","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531716305966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531716305966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T23:37:34Z","timestamp":1719099454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531716305966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":107,"alternative-id":["S0271531716305966"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2017.03.003","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review of a causal role of fructose-containing sugars in myocardial susceptibility to ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2017.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}