{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:03:34Z","timestamp":1779386614735,"version":"3.53.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Canadian Foundation for Innovation: Leaders Opportunity Fund"},{"name":"Faculty of Health Professions Research Development"},{"name":"Nova Scotia Graduate Scholarship"},{"name":"Nova Scotia Health Research Foundation Scotia Scholar Award"},{"name":"Heart & Stroke BrightRed Award"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Women's Heart Health Student Traineeship (Canadian Institutes of Health Research)"},{"name":"Nova Scotia Health Research Foundation Scotia Scholar Award"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.nutres.2019.03.016","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:05:44Z","timestamp":1554116744000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Short-term supplement of virgin coconut oil improves endothelial-dependent dilation but not exercise-mediated hyperemia in young adults"],"prefix":"10.1016","volume":"67","author":[{"given":"Susan A.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles W.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Grandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Heinze-Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek S.","family":"Kimmerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2019.03.016_bb0005","first-page":"71","article-title":"Endothelial dysfunction and antioxidants","volume":"72","author":"Duvall","year":"2005","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.nutres.2019.03.016_bb0010","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00424-010-0808-2","article-title":"Nitric oxide and oxidative stress in vascular disease","volume":"459","author":"Forstermann","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.nutres.2019.03.016_bb0015","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1113\/jphysiol.2012.240762","article-title":"Vasodilator interactions in skeletal muscle blood flow regulation","volume":"590","author":"Hellsten","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0020","first-page":"H1951","article-title":"Nitric oxide in the regulation of vasomotor tone in human skeletal muscle","volume":"276","author":"Radegran","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1113\/jphysiol.2006.127423","article-title":"Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg","volume":"581","author":"Mortensen","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0030","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1113\/jphysiol.2011.225136","article-title":"Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training","volume":"590","author":"Nyberg","year":"2012","journal-title":"J Physiol"},{"issue":"Suppl. 2","key":"10.1016\/j.nutres.2019.03.016_bb0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/09637480802549127","article-title":"Antioxidant capacity and phenolic acids of virgin coconut oil","volume":"60","author":"Marina","year":"2009","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.nutres.2019.03.016_bb0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vph.2014.10.006","article-title":"Mechanisms of endothelial cell protection by hydroxycinnamic acids","volume":"63","author":"Fuentes","year":"2014","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0045","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.clinbiochem.2004.04.010","article-title":"Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation","volume":"37","author":"Nevin","year":"2004","journal-title":"Clin Biochem"},{"key":"10.1016\/j.nutres.2019.03.016_bb0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.foodchem.2005.06.056","article-title":"Virgin coconut oil supplemented diet increases the antioxidant status in rats","volume":"99","author":"Nevin","year":"2006","journal-title":"Food Chem"},{"key":"10.1016\/j.nutres.2019.03.016_bb0055","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s13197-015-2040-8","article-title":"Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats","volume":"53","author":"Narayanankutty","year":"2016","journal-title":"J Food Sci Technol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0060","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1080\/13880209.2017.1280688","article-title":"Enhanced memory in Wistar rats by virgin coconut oil is associated with increased antioxidative, cholinergic activities and reduced oxidative stress","volume":"55","author":"Rahim","year":"2017","journal-title":"Pharm Biol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0065","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/19390211.2017.1346031","article-title":"Dietary supplementation with virgin coconut oil improves lipid profile and hepatic antioxidant status and has potential benefits on cardiovascular risk indices in normal rats","volume":"15","author":"Famurewa","year":"2018","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.nutres.2019.03.016_bb0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0960327115578867","article-title":"Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice","volume":"35","author":"Nair","year":"2016","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0075","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/629329","article-title":"Virgin coconut oil prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil","volume":"2013","author":"Nurul-Iman","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.nutres.2019.03.016_bb0080","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1139\/apnm-2016-0029","article-title":"Renoprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats","volume":"41","author":"Kamisah","year":"2016","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.nutres.2019.03.016_bb0085","doi-asserted-by":"crossref","DOI":"10.5402\/2011\/949686","article-title":"An open-label pilot study to assess the efficacy and safety of virgin coconut oil in reducing visceral adiposity","volume":"2011","author":"Liau","year":"2011","journal-title":"ISRN Pharmacol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/jmf.2016.0114","article-title":"The impact of virgin coconut oil and high-oleic safflower oil on body composition, lipids, and inflammatory markers in postmenopausal women","volume":"20","author":"Harris","year":"2017","journal-title":"J Med Food"},{"key":"10.1016\/j.nutres.2019.03.016_bb0095","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G* Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.nutres.2019.03.016_bb0100","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1161\/01.CIR.92.12.3431","article-title":"Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle","volume":"92","author":"Hashimoto","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2019.03.016_bb0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2165\/00007256-198805050-00002","article-title":"Heart rate and exercise intensity during sports activities. Practical application","volume":"5","author":"Karvonen","year":"1988","journal-title":"Sports Med"},{"key":"10.1016\/j.nutres.2019.03.016_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0735-1097(00)01054-8","article-title":"Age-predicted maximal heart rate revisited","volume":"37","author":"Tanaka","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0115","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1017\/S0007114510002229","article-title":"Genotoxic and carcinogenic risks associated with the dietary consumption of repeatedly heated coconut oil","volume":"104","author":"Srivastava","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nutres.2019.03.016_bb0120","doi-asserted-by":"crossref","first-page":"H2","DOI":"10.1152\/ajpheart.00471.2010","article-title":"Assessment of flow-mediated dilation in humans: a methodological and physiological guideline","volume":"300","author":"Thijssen","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0125","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1073\/pnas.122225199","article-title":"Identification of the enzymatic mechanism of nitroglycerin bioactivation","volume":"99","author":"Chen","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2019.03.016_bb0130","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1476-7120-6-44","article-title":"Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus","volume":"6","author":"Padilla","year":"2008","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.nutres.2019.03.016_bb0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.atherosclerosis.2012.11.027","article-title":"Allometric scaling of diameter change in the original flow-mediated dilation protocol","volume":"226","author":"Atkinson","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.nutres.2019.03.016_bb0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/cs0970291","article-title":"Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress","volume":"97","author":"Harms","year":"1999","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.nutres.2019.03.016_bb0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10554-010-9616-1","article-title":"Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis","volume":"26","author":"Inaba","year":"2010","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.nutres.2019.03.016_bb0150","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/cs1010629","article-title":"Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide","volume":"101","author":"Doshi","year":"2001","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.nutres.2019.03.016_bb0155","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/01.RES.88.2.145","article-title":"Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia","volume":"88","author":"Mullen","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.nutres.2019.03.016_bb0160","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/01.CIR.91.5.1314","article-title":"Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo","volume":"91","author":"Joannides","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2019.03.016_bb0165","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1113\/jphysiol.2007.145722","article-title":"Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans","volume":"586","author":"Kooijman","year":"2008","journal-title":"J Physiol"},{"issue":"10","key":"10.1016\/j.nutres.2019.03.016_bb0170","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1113\/EP086918","article-title":"Brief periods of inactivity reduce leg microvascular, but not macrovascular, function in healthy young men","volume":"103","author":"Vranish","year":"2018","journal-title":"Exp Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0175","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1152\/japplphysiol.00837.2013","article-title":"Impact of reduced daily physical activity on conduit artery flow-mediated dilation and circulating endothelial microparticles","volume":"115","author":"Boyle","year":"2013","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0180","doi-asserted-by":"crossref","first-page":"H177","DOI":"10.1152\/ajpheart.00297.2016","article-title":"Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting","volume":"311","author":"Morishima","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0185","doi-asserted-by":"crossref","first-page":"H648","DOI":"10.1152\/ajpheart.00943.2015","article-title":"Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress","volume":"310","author":"Restaino","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/cs1020553","article-title":"Low-protein diet impairs vascular relaxation in virgin and pregnant rats","volume":"102","author":"Koumentaki","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.nutres.2019.03.016_bb0195","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1139\/apnm-2014-0351","article-title":"Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats","volume":"40","author":"Alves","year":"2015","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.nutres.2019.03.016_bb0200","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/bcpt.12700","article-title":"Acute treatment with lauric acid reduces blood pressure and oxidative stress in spontaneously hypertensive rats","volume":"120","author":"Alves","year":"2017","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0205","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3109\/13880209.2014.971383","article-title":"Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats","volume":"53","author":"Kamisah","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.nutres.2019.03.016_bb0210","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.nutres.2015.07.005","article-title":"Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults","volume":"35","author":"Jokura","year":"2015","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2019.03.016_bb0215","article-title":"The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2019.03.016_bb0220","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1039\/C6FO00248J","article-title":"Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women","volume":"7","author":"Ward","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.nutres.2019.03.016_bb0225","first-page":"8306","article-title":"Chemistry of wine","volume":"99","author":"Cheynier","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2019.03.016_bb0230","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.nut.2016.07.008","article-title":"Natural antioxidant ice cream acutely reduces oxidative stress and improves vascular function and physical performance in healthy individuals","volume":"33","author":"Sanguigni","year":"2017","journal-title":"Nutrition"},{"key":"10.1016\/j.nutres.2019.03.016_bb0235","doi-asserted-by":"crossref","first-page":"230s","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2019.03.016_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/nu9020163","article-title":"Cinnamic acid and its derivatives: mechanisms for prevention and management of diabetes and its complications","volume":"9","author":"Adisakwattana","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2019.03.016_bb0245","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1186\/bcr752","article-title":"Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action","volume":"6","author":"Kampa","year":"2004","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.nutres.2019.03.016_bb0250","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/nutrit\/nuw002","article-title":"Coconut oil consumption and cardiovascular risk factors in humans","volume":"74","author":"Eyres","year":"2016","journal-title":"Nutr Rev"},{"key":"10.1016\/j.nutres.2019.03.016_bb0255","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1152\/physrev.00035.2013","article-title":"Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs","volume":"95","author":"Joyner","year":"2015","journal-title":"Physiol Rev"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531718309394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531718309394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T17:25:10Z","timestamp":1569345910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531718309394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":51,"alternative-id":["S0271531718309394"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2019.03.016","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-term supplement of virgin coconut oil improves endothelial-dependent dilation but not exercise-mediated hyperemia in young adults","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2019.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}