{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:17:42Z","timestamp":1791836262710,"version":"4.3.4"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.nutres.2020.03.002","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T20:47:09Z","timestamp":1583786829000},"page":"11-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":183,"special_numbering":"C","title":["A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health"],"prefix":"10.1016","volume":"78","author":[{"given":"Melissa J.","family":"Banez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew I.","family":"Geluz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesnim","family":"Hamdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia S.","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan S.","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst R.","family":"Von Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2020.03.002_bb0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.7326\/M19-0341","article-title":"Effects of nutritional supplements and dietary interventions on cardiovascular outcomes: an umbrella review and evidence map","volume":"171","author":"Khan","year":"2019","journal-title":"Ann Intern Med"},{"issue":"12","key":"10.1016\/j.nutres.2020.03.002_bb0010","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/jch.12211","article-title":"Nutrition and nutraceutical supplements for the treatment of hypertension: part I","volume":"15","author":"Houston","year":"2013","journal-title":"J Clin Hypertens"},{"issue":"1a","key":"10.1016\/j.nutres.2020.03.002_bb0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1079\/PHN2003587","article-title":"Diet, nutrition and the prevention of hypertension and cardiovascular diseases","volume":"7","author":"Reddy","year":"2004","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.nutres.2020.03.002_bb0020","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1111\/j.1755-5922.2010.00211.x","article-title":"Nutraceuticals and prevention of atherosclerosis: focus on omega-3 polyunsaturated fatty acids and Mediterranean diet polyphenols","volume":"28","author":"Massaro","year":"2010","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.nutres.2020.03.002_bb0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nutres.2020.03.002_bb0030","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1113\/jphysiol.2013.262956","article-title":"Recent data do not provide evidence that resveratrol causes \u2018mainly negative\u2019 or \u2018adverse\u2019 effects on exercise training in humans","volume":"591","author":"Smoliga","year":"2013","journal-title":"J Physiol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0035","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.2174\/13816128113199990407","article-title":"Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence","volume":"19","author":"Tom\u00e9-Carneiro","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.nutres.2020.03.002_bb0040","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.3390\/nu10121856","article-title":"Study of potential anti-inflammatory effects of red wine extract and resveratrol through a modulation of interleukin-1-beta in macrophages","volume":"10","author":"Chalons","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2020.03.002_bb0045","first-page":"331","article-title":"Resveratrol in prevention and treatment of common clinical conditions of aging","volume":"3","author":"Markus","year":"2008","journal-title":"J Clin Interv Aging"},{"key":"10.1016\/j.nutres.2020.03.002_bb0050","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1139\/Y09-013","article-title":"Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease","volume":"87","author":"Penumathsa","year":"2009","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.niox.2011.12.006","article-title":"Cardiovascular effects and molecular targets of resveratrol","volume":"26","author":"Li","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.nutres.2020.03.002_bb0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cardiores.2006.10.004","article-title":"Dietary polyphenols: good, bad, or indifferent for your health?","volume":"73","author":"Halliwell","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0065","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.phymed.2018.08.002","article-title":"The natural phenolic compounds as modulators of NADPH oxidases in hypertension","volume":"55","author":"Yousefian","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.nutres.2020.03.002_bb0070","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/01.CIR.0000029925.18593.5C","article-title":"Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase","volume":"106","author":"Wallerath","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2020.03.002_bb0075","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1161\/01.CIR.0000034445.31543.43","article-title":"Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells","volume":"106","author":"Leikert","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2020.03.002_bb0080","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2141.2007.06788.x","article-title":"Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO\/cyclic GMP","volume":"139","author":"Shen","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2174\/187152807781696464","article-title":"Anti-inflammatory responses of resveratrol","volume":"6","author":"Das","year":"2007","journal-title":"Inflamm Allergy Drug Targ"},{"issue":"11","key":"10.1016\/j.nutres.2020.03.002_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111813","article-title":"Beneficial effects of resveratrol administration-focus on potential biochemical mechanisms in cardiovascular conditions","volume":"10","author":"Wici\u0144ski","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2020.03.002_bb0095","first-page":"8731","article-title":"Resveratrol pretreatment protects rat hearts from ischemia\/reperfusion injury partly via a NALP3 inflammasome pathway","volume":"8","author":"Dong","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0100","doi-asserted-by":"crossref","first-page":"540","DOI":"10.12659\/MSM.910996","article-title":"Resveratrol effects on a diabetic rat model with coronary heart disease","volume":"25","author":"Huo","year":"2019","journal-title":"Med Sci Monit"},{"issue":"12","key":"10.1016\/j.nutres.2020.03.002_bb0105","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.nutres.2020.03.002_bb0110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0009-9120(02)00397-1","article-title":"Absorption of three wine-related polyphenols in three different matrices by healthy subjects","volume":"36","author":"Goldberg","year":"2013","journal-title":"Clin Biochem"},{"key":"10.1016\/j.nutres.2020.03.002_bb0115","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1158\/0008-5472.CAN-10-2364","article-title":"Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis","volume":"70","author":"Brown","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.2010.05853.x","article-title":"Clinical trials of resveratrol","volume":"1215","author":"Patel","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.nutres.2020.03.002_bb0125","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S0007114511000316","article-title":"Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients","volume":"106","author":"Brasnyo","year":"2011","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nutres.2020.03.002_bb0130","first-page":"122","article-title":"The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: a pilot randomized, placebo-controlled clinical trial","volume":"4","author":"Walker","year":"2019","journal-title":"J Clin Transl Res"},{"issue":"11","key":"10.1016\/j.nutres.2020.03.002_bb0135","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.nutres.2011.09.028","article-title":"Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment","volume":"31","author":"Fujitaka","year":"2011","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0140","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/mnfr.201100673","article-title":"Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow up, placebo-controlled, randomized trial","volume":"56","author":"Tom\u00e9-Carneiro","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0145","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.amjcard.2012.03.030","article-title":"One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease","volume":"110","author":"Tom\u00e9-Carneiro","year":"2012","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.nutres.2020.03.002_bb0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/CH-2011-1424","article-title":"Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease","volume":"50","author":"Magyar","year":"2012","journal-title":"Clin Hemorheol Microcirc"},{"issue":"2","key":"10.1016\/j.nutres.2020.03.002_bb0155","first-page":"81","article-title":"Follow-up of hemorheological parameters and platelet aggregation in patients with acute coronary syndromes","volume":"29","author":"Marton","year":"2003","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.nutres.2020.03.002_bb0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clnu.2014.03.009","article-title":"Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials","volume":"34","author":"Liu","year":"2015","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nutres.2020.03.002_bb0165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41430-018-0253-4","article-title":"Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials","volume":"73","author":"Haghighatdoost","year":"2019","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.nutres.2020.03.002_bb0170","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.cmet.2012.09.015","article-title":"Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance","volume":"16","author":"Yoshino","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.nutres.2020.03.002_bb0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/13813450802033958","article-title":"Role of curcumin in health and disease","volume":"114","author":"Pari","year":"2008","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.nutres.2020.03.002_bb0180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/2210315511202010069","article-title":"Anti-oxidative effect of curcumin against tertbutylhydroperoxide induced oxidative stress in human erythrocytes","volume":"2","author":"Singh","year":"2012","journal-title":"The Natural Products Journal"},{"key":"10.1016\/j.nutres.2020.03.002_bb0185","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0190","first-page":"7500","article-title":"Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR","volume":"22","author":"Liu","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.nutres.2020.03.002_bb0195","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1164\/ajrccm.163.2.2007102","article-title":"Normal responses to injury prevent systemic inflammation and can be immunosuppressive","volume":"163","author":"Munford","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nutres.2020.03.002_bb0200","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0891-5849(00)00294-X","article-title":"Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress","volume":"28","author":"Motterlini","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nutres.2020.03.002_bb0205","doi-asserted-by":"crossref","first-page":"112051","DOI":"10.18632\/oncotarget.23002","article-title":"Curcumin attenuates myocardial ischemia-reperfusion injury","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.nutres.2020.03.002_bb0210","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0049-3848(85)90276-2","article-title":"Anti-thrombotic effect of curcumin","volume":"40","author":"Srivastava","year":"1985","journal-title":"Thromb Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0215","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1111\/j.1476-5381.2012.02109.x","article-title":"Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction","volume":"167","author":"Wang","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0220","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00395-012-0263-7","article-title":"The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2\/STAT3 signaling pathway","volume":"107","author":"Duan","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0225","doi-asserted-by":"crossref","first-page":"21556","DOI":"10.1007\/s11356-019-05433-2","article-title":"Could curcumin ameliorate titanium dioxide nanoparticles effect on the heart? A histopathological, immunohistochemical, and genotoxic study","volume":"21","author":"El-Din","year":"2019","journal-title":"Environ Sci Pollut Res Int"},{"issue":"7","key":"10.1016\/j.nutres.2020.03.002_bb0230","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s13238-012-2053-2","article-title":"Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway","volume":"3","author":"Mujoo","year":"2012","journal-title":"Protein Cell"},{"issue":"4","key":"10.1016\/j.nutres.2020.03.002_bb0235","first-page":"201","article-title":"The effect of curcumin on lipid level in patients with acute coronary syndrome","volume":"40","author":"Alwi","year":"2008","journal-title":"Acta Med Indones"},{"issue":"4","key":"10.1016\/j.nutres.2020.03.002_bb0240","first-page":"273","article-title":"Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers","volume":"36","author":"Soni","year":"1992","journal-title":"Indian J Physiol Pharmacol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0245","doi-asserted-by":"crossref","unstructured":"Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging (Albany NY) 2017;9:187\u2013208. 10.18632\/aging.101149","DOI":"10.18632\/aging.101149"},{"key":"10.1016\/j.nutres.2020.03.002_bb0250","first-page":"1","article-title":"The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: a randomized clinical trial","volume":"1","author":"Dastani","year":"2019","journal-title":"Avicenna J Phytomed"},{"key":"10.1016\/j.nutres.2020.03.002_bb0255","doi-asserted-by":"crossref","first-page":"172471","DOI":"10.1016\/j.ejphar.2019.172471","article-title":"Curcumin for the prevention of myocardial injury following elective percutaneous coronary intervention; a pilot randomized clinical trial","volume":"858","author":"Aslanabadi","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0260","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.bi.63.070194.001135","article-title":"Nitric oxide: a physiologic messenger molecule","volume":"63","author":"Bredt","year":"1994","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.nutres.2020.03.002_bb0265","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-6147(91)90510-Y","article-title":"Modulation of platelet aggregation by an l-arginine-nitric oxide pathway","volume":"12","author":"Radomski","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.nutres.2020.03.002_bb0270","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1161\/01.RES.84.12.1416","article-title":"Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene","volume":"84","author":"Freedman","year":"1999","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.nutres.2020.03.002_bb0275","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/j.2040-4603.2019.tb00084.x","article-title":"Shen Xi, Glawe J, Kolluru G, Kevil C. Nitric oxide and hydrogen sulfide regulation of ischemic vascular growth and remodeling","volume":"9","author":"Rajendran","year":"2019","journal-title":"Compr Physiol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0280","first-page":"19","article-title":"Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice","volume":"77","author":"Liu","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0285","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrd4623","article-title":"Strategies to increase nitric oxide signalling in cardiovascular disease","volume":"14","author":"Lundberg","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nutres.2020.03.002_bb0290","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nutres.2020.03.002_bb0295","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.niox.2014.03.162","article-title":"Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health","volume":"38","author":"Kapil","year":"2014","journal-title":"Nitric Oxide."},{"key":"10.1016\/j.nutres.2020.03.002_bb0300","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/ars.2010.3502","article-title":"Critical role of the nitric oxide\/reactive oxygen species balance in endothelial progenitor dysfunction","volume":"15","author":"Fleissner","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.nutres.2020.03.002_bb0305","first-page":"7","article-title":"Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy? Microvasc","volume":"119","author":"Yuyun","year":"2018","journal-title":"Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0310","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.3390\/nu6115224","article-title":"Nitrate ingestion: a review of the health and physical performance effects","volume":"6","author":"Clements","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2020.03.002_bb0315","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1113\/jphysiol.2012.243121","article-title":"Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats","volume":"591","author":"Ferguson","year":"2013","journal-title":"J Physiol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0320","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-319-55330-6_18","article-title":"Nitrite-nitric oxide signaling and cardioprotection","volume":"982","author":"Totzeck","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0325","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/cvr\/cvy039","article-title":"Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate\u2013elevating agents involves cardiomyocyte nitric oxide\u2013sensitive guanylyl cyclase","volume":"114","author":"Frankenreiter","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"17","key":"10.1016\/j.nutres.2020.03.002_bb0330","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100938","article-title":"Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition","volume":"38","author":"Siragusa","year":"2019","journal-title":"EMBO J"},{"key":"10.1016\/j.nutres.2020.03.002_bb0335","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fphys.2018.00479","article-title":"Connexins and nitric oxide inside and outside mitochondria: significance for cardiac protection and adaptation","volume":"9","author":"Shvedova","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.nutres.2020.03.002_bb0340","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/14728222.2017.1310840","article-title":"The potential of stimulating nitric oxide formation in the treatment of hypertension","volume":"21","author":"Pinheiro","year":"2017","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.nutres.2020.03.002_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.11.003","article-title":"Inorganic nitrite and nitrate in cardiovascular therapy: a better alternative to organic nitrates as nitric oxide donors?","volume":"102","author":"Munzel","year":"2018","journal-title":"Vascul Pharmacol"},{"issue":"14","key":"10.1016\/j.nutres.2020.03.002_bb0350","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14183","article-title":"Pattern of sympathetic vasomotor activity in a model of hypertension induced by nitric oxide synthase blockade","volume":"7","author":"Zambrano","year":"2019","journal-title":"Physiol Rep"},{"key":"10.1016\/j.nutres.2020.03.002_bb0355","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/TA.0000000000001325","article-title":"Acute right heart failure after hemorrhagic shock and trauma pneumonectomy\u2014a management approach: a blinded randomized controlled animal trial using inhaled nitric oxide","volume":"82","author":"Lubitz","year":"2017","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.nutres.2020.03.002_bb0360","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/HYPERTENSIONAHA.111.00933","article-title":"Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential","volume":"61","author":"Ghosh","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.nutres.2020.03.002_bb0365","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/1074248414539563","article-title":"Effects of an oral nitric oxide supplement on functional capacity and blood pressure in adults with prehypertension","volume":"20","author":"Biswas","year":"2015","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.nutres.2020.03.002_bb0370","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/jch.12352","article-title":"Acute effects of an oral nitric oxide supplement on blood pressure, endothelial function, and vascular compliance in hypertensive patients","volume":"16","author":"Houston","year":"2014","journal-title":"J Clin Hypertens"},{"key":"10.1016\/j.nutres.2020.03.002_bb0375","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.nutres.2011.03.008","article-title":"All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans","volume":"31","author":"Zand","year":"2011","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2020.03.002_bb0380","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ajhg.2012.03.018","article-title":"Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria","volume":"90","author":"Nagamani","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nutres.2020.03.002_bb0385","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2016.06.007","article-title":"Effects of acute dietary nitrate supplementation on aortic blood pressure and aortic augmentation index in young and older adults","volume":"59","author":"Hughes","year":"2016","journal-title":"Nitric Oxide."},{"issue":"11","key":"10.1016\/j.nutres.2020.03.002_bb0390","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1017\/S0007114512000190","article-title":"Blood pressure\u2013lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects","volume":"108","author":"Hobbs","year":"2012","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nutres.2020.03.002_bb0395","doi-asserted-by":"crossref","unstructured":"Asgary S, Afshani MR, Sahebkar A, Keshvari M, Taheri M, Jahanian E, Rafieian-Kopaei M, Malekian F, Sarrafzadegan N. Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study. J. Hum. Hypertens. 2016;30:627\u2013632. https:\/\/doi.org\/10.1038\/jhh.2016.34","DOI":"10.1038\/jhh.2016.34"},{"issue":"7","key":"10.1016\/j.nutres.2020.03.002_bb0400","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3390\/nu11071683","article-title":"Acute supplementation with nitrate-rich beetroot juice causes a greater increase in plasma nitrite and reduction in blood pressure of older compared to younger adults","volume":"11","author":"Stanaway","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2020.03.002_bb0405","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006478","article-title":"Inorganic nitrate in angina study: a randomized double-blind placebo-controlled trial","volume":"6","author":"Schwarz","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"10.1016\/j.nutres.2020.03.002_bb0410","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCRESAHA.116.309832","article-title":"Pharmacokinetics and pharmacodynamics of inorganic nitrate in heart failure with preserved ejection fraction","volume":"120","author":"Zamani","year":"2017","journal-title":"Circ Res"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531719308802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531719308802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:49:06Z","timestamp":1759448946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531719308802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":82,"alternative-id":["S0271531719308802"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2020.03.002","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2020.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}