{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:35:34Z","timestamp":1791423334949,"version":"4.3.3"},"reference-count":196,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["21320061330000"],"award-info":[{"award-number":["21320061330000"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.nutres.2021.08.007","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:13:14Z","timestamp":1631146394000},"page":"1-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review"],"prefix":"10.1016","volume":"95","author":[{"given":"Mingbao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-6510","authenticated-orcid":false,"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8065-663X","authenticated-orcid":false,"given":"Xianqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-6449","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-544X","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2021.08.007_bib0001","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2004.02.005","article-title":"Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases","volume":"93","author":"Tlaskalova-Hogenova","year":"2004","journal-title":"Immuno Lett"},{"key":"10.1016\/j.nutres.2021.08.007_bib0002","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.clnu.2005.02.009","article-title":"Aetiology of inflammatory bowel disease (IBD): role of intestinal microbiota and gut associated lymphoid tissue immune response","volume":"24","author":"Thompson-Chagoy\u00e1n","year":"2005","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0003","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/ajcn\/78.4.675","article-title":"The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium \u201cThe Intelligent Intestine,\u201d held in Paris, June 14, 2002","volume":"78","author":"Bourlioux","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0005","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1038\/ncomms7956","article-title":"Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis","volume":"6","author":"Deng","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.nutres.2021.08.007_bib0006","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/BSR20110062","article-title":"Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells","volume":"32","author":"Sun","year":"2012","journal-title":"Biosci Rep"},{"key":"10.1016\/j.nutres.2021.08.007_bib0007","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/cmi.2010.67","article-title":"The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases","volume":"8","author":"Tlaskalova-Hogenova","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0008","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/18715273113126660147","article-title":"Role of gut microbiota in obesity, type 2 diabetes and Alzheimer's disease","volume":"13","author":"Naseer","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.nutres.2021.08.007_bib0009","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.anaerobe.2010.02.004","article-title":"Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut","volume":"16","author":"Solis","year":"2010","journal-title":"Anaerobe"},{"key":"10.1016\/j.nutres.2021.08.007_bib0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.clp.2011.03.008","article-title":"Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis","volume":"38","author":"Neu","year":"2011","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0011","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.nutres.2021.08.007_bib0012","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0013","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cmet.2012.10.007","article-title":"Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk","volume":"16","author":"Holmes","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.nutres.2021.08.007_bib0014","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0015","first-page":"3238","article-title":"Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats","volume":"37","author":"Reddy","year":"1977","journal-title":"Cancer Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0016","doi-asserted-by":"crossref","first-page":"e95268","DOI":"10.1371\/journal.pone.0095268","article-title":"The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2021.08.007_bib0017","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1258\/acb.2010.010047","article-title":"Measurement of short-chain fatty acids in human faeces using high-performance liquid chromatography: specimen stability","volume":"47","author":"Torii","year":"2010","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0018","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00426337","article-title":"Short chain fatty acid and glucose metabolism in isolated pig colonocytes: modulation by NH4+","volume":"156","author":"Darcy-Vrillon","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0019","first-page":"1052","article-title":"Effect of dietary fiber in the quantitative expression of butyrate receptor GPR43 in rats colon","volume":"26","author":"Corte Osorio","year":"2011","journal-title":"Nutri Hosp"},{"key":"10.1016\/j.nutres.2021.08.007_bib0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1079\/PNS2002207","article-title":"Regulation of short-chain fatty acid production","volume":"62","author":"Macfarlane","year":"2003","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.nutres.2021.08.007_bib0021","doi-asserted-by":"crossref","first-page":"fnz153","DOI":"10.1093\/femsle\/fnz153","article-title":"Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice","volume":"366","author":"Zhai","year":"2019","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.nutres.2021.08.007_bib0022","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/BF02236937","article-title":"Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial","volume":"42","author":"Pinto","year":"1999","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.nutres.2021.08.007_bib0023","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/00365529609094568","article-title":"Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease","volume":"216","author":"Mortensen","year":"1996","journal-title":"Scand J Gastroenterol Suppl"},{"issue":"9","key":"10.1016\/j.nutres.2021.08.007_bib0024","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.3748\/wjg.v21.i9.2759","article-title":"Fecal microbes, short chain fatty acids, and colorectal cancer across racial\/ethnic groups","volume":"21","author":"Hester","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0025","doi-asserted-by":"crossref","first-page":"2493S","DOI":"10.1093\/jn\/137.11.2493S","article-title":"Inulin-type fructans: functional food ingredients","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0026","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2036.1998.00337.x","article-title":"Review article: short chain fatty acids in health and disease","volume":"12","author":"Cook","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nutres.2021.08.007_bib0027","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/gut.28.10.1221","article-title":"Short chain fatty acids in human large intestine, portal, hepatic and venous blood","volume":"28","author":"Cummings","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2021.08.007_bib0028","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1099\/ijs.0.02764-0","article-title":"Propionicimonas paludicola gen. nov., sp. nov., a novel facultatively anaerobic, gram-positive, propionate-producing bacterium isolated from plant residue in irrigated rice-field soil","volume":"53","author":"Akasaka","year":"2003","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0029","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrmicro1817","article-title":"Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis","volume":"6","author":"Flint","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0030","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1462-2920.2006.01186.x","article-title":"Selective colonization of insoluble substrates by human faecal bacteria","volume":"9","author":"Leitch","year":"2007","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0031","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J Lipid Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0032","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0033","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13068-016-0549-3","article-title":"Production of medium-chain carboxylic acids by Megasphaera sp. MH with supplemental electron acceptors","volume":"9","author":"Jeon","year":"2016","journal-title":"Biotechnol Biofuels"},{"issue":"2","key":"10.1016\/j.nutres.2021.08.007_bib0034","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4291\/wjgp.v9.i2.47","article-title":"Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans","volume":"9","author":"Farhana","year":"2018","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"1","key":"10.1016\/j.nutres.2021.08.007_bib0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.clnu.2008.11.002","article-title":"Butyrate modulates oxidative stress in the colonic mucosa of healthy humans","volume":"28","author":"Hamer","year":"2009","journal-title":"Clin Nutr (Edinburgh, Scotland)"},{"key":"10.1016\/j.nutres.2021.08.007_bib0036","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3109\/00365529409094878","article-title":"Absorption of short-chain fatty acids from the in-situ-perfused caecum and colon of the guinea pig","volume":"29","author":"Oltmer","year":"1994","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0037","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/ajcn\/39.2.338","article-title":"The contribution of the large intestine to energy supplies in man","volume":"39","author":"McNeil","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0038","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/jn\/137.11.2493S","article-title":"Inulin-type fructans: functional food ingredients","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0039","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/gut.19.9.819","article-title":"Short chain fatty acid absorption by the human large intestine","volume":"19","author":"McNeil","year":"1978","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2021.08.007_bib0040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF01312224","article-title":"Effect of short-chain fatty-acid on sodium-absorption in isolated human-colon perfused through the vascular bed","volume":"26","author":"Roediger","year":"1981","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.nutres.2021.08.007_bib0041","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0026-0495(97)90127-X","article-title":"Time of day and glucose tolerance status affect serum short-chain fatty acid concentrations in humans","volume":"46","author":"Wolever","year":"1997","journal-title":"Metabolism"},{"key":"10.1016\/j.nutres.2021.08.007_bib0042","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/jn\/121.11.1787","article-title":"Absorption of short-chain fatty acids from the rat cecum in vivo","volume":"121","author":"Fleming","year":"1991","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0043","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00232873","article-title":"Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon","volume":"141","author":"Rajendran","year":"1994","journal-title":"J Membarin Biol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0044","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1152\/ajpgi.1996.271.3.G415","article-title":"Transport of n-butyrate into human colonic luminal membrane vesicles","volume":"271","author":"Harig","year":"1996","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0045","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1093\/jn\/133.10.3145","article-title":"Fecal acetate is inversely related to acetate absorption from the human rectum and distal colon","volume":"133","author":"Vogt","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0046","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1002\/art.21258","article-title":"Butyrate suppresses tumor necrosis factor \u03b1 production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element","volume":"52","author":"Fukae","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.nutres.2021.08.007_bib0047","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nutres.2008.02.012","article-title":"Butyrate and trichostatin A attenuate nuclear factor \u03baB activation and tumor necrosis factor \u03b1 secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells","volume":"28","author":"Usami","year":"2008","journal-title":"Nutr Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0048","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1079\/PNS2002215","article-title":"Molecular analysis of the effect of short-chain fatty acids on intestinal cell proliferation","volume":"62","author":"Blottiere","year":"2003","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.nutres.2021.08.007_bib0049","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00424-003-1067-2","article-title":"The SLC16 gene family\u2014from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond","volume":"447","author":"Halestrap","year":"2004","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/j.nutres.2021.08.007_bib0050","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/modpathol.3800261","article-title":"Progressive methylation during the serrated neoplasia pathway of the colorectum","volume":"18","author":"Dong","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0051","doi-asserted-by":"crossref","first-page":"994","DOI":"10.2174\/1389200211314090006","article-title":"Butyrate and colorectal cancer: the role of butyrate transport","volume":"14","author":"Goncalves","year":"2013","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.nutres.2021.08.007_bib0052","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/BJ20150242","article-title":"Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions","volume":"469","author":"Gurav","year":"2015","journal-title":"Biochem J"},{"key":"10.1016\/j.nutres.2021.08.007_bib0053","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/ibd.21108","article-title":"Butyrate utilization by the colonic mucosa in inflammatory bowel diseases: a transport deficiency","volume":"16","author":"Thibault","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0054","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00428-007-0558-5","article-title":"Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas","volume":"452","author":"Pinheiro","year":"2008","journal-title":"Virchows Arch"},{"issue":"1","key":"10.1016\/j.nutres.2021.08.007_bib0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10863-012-9418-3","article-title":"Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate","volume":"44","author":"Queir\u00f3s","year":"2012","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0056","doi-asserted-by":"crossref","first-page":"C984","DOI":"10.1152\/ajpcell.00146.2011","article-title":"The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein","volume":"301","author":"Goncalves","year":"2011","journal-title":"Am J Physiol-Cell Ph"},{"key":"10.1016\/j.nutres.2021.08.007_bib0057","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ibd.20030","article-title":"Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)","volume":"13","author":"Englund","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0058","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/hep.21596","article-title":"Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate","volume":"45","author":"Shin","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0059","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jnutbio.2007.02.009","article-title":"Effects of dietary fibers on disturbances clustered in the metabolic syndrome","volume":"19","author":"Galisteo","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0060","first-page":"871","article-title":"Treatment of diversion colitis with short-chain fatty acids. Bacteriological study","volume":"19","author":"Neut","year":"1995","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0061","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev-physiol-021909-135817","article-title":"Role of colonic short-chain fatty acid transport in diarrhea","volume":"72","author":"Binder","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0062","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1365-2036.2005.02639.x","article-title":"Oral butyrate for mildly to moderately active Crohn's disease","volume":"22","author":"Di Sabatino","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.nutres.2021.08.007_bib0063","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/1750-1172-8-194","volume":"8","author":"Canani","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0064","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004836-200603000-00015","article-title":"Colonic health: fermentation and short chain fatty acids","volume":"40","author":"Wong","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0065","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0115426506021004351","article-title":"Short-chain fatty acids: ready for prime time?","volume":"21","author":"Roy","year":"2006","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.nutres.2021.08.007_bib0066","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jnutbio.2010.07.009","article-title":"Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils","volume":"22","author":"Vinolo","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0067","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","article-title":"Short-chain fatty acids in control of body weight and insulin sensitivity","volume":"11","author":"Canfora","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0068","doi-asserted-by":"crossref","first-page":"25481","DOI":"10.1074\/jbc.M301403200","article-title":"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation","volume":"278","author":"Le Poul","year":"2003","journal-title":"J Bio Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0069","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J Bio Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0070","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-291X(03)00488-1","article-title":"Identification of a free fatty acid receptor, FFA(2)R, expressed on leukocytes and activated by short-chain fatty acids","volume":"303","author":"Nilsson","year":"2003","journal-title":"Biochem Biophys Res Com"},{"key":"10.1016\/j.nutres.2021.08.007_bib0071","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/350516a0","article-title":"Activation of the \u03b21 isozyme of phospholipase C by \u03b1 subunits of the Gq class of G proteins","volume":"11","author":"Taylor","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0072","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1016\/S0021-9258(18)67553-2","article-title":"Molecular basis for two forms of the G protein that stimulates adenylate cyclase","volume":"261","author":"Robishaw","year":"1986","journal-title":"J Bio Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0073","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1073\/pnas.77.5.2533","article-title":"A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids","volume":"77","author":"Hirata","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2021.08.007_bib0074","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1073\/pnas.97.9.4826","article-title":"Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy","volume":"97","author":"Redfern","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2021.08.007_bib0075","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1210\/en.2005-0545","article-title":"Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43","volume":"146","author":"Hong","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0076","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1038\/oncsis.2016.38","article-title":"An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis","volume":"5","author":"Sivaprakasam","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0077","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.peptides.2014.11.009","article-title":"Regulation of nutrition-associated receptors in blood monocytes of normal weight and obese humans","volume":"65","author":"Pivovarova","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.nutres.2021.08.007_bib0078","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","article-title":"Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice","volume":"145","author":"Kim","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0079","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00441-005-0140-x","article-title":"Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine","volume":"324","author":"Karaki","year":"2006","journal-title":"Cell and Tissue Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10735-010-9304-4","article-title":"Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide","volume":"42","author":"Kaji","year":"2011","journal-title":"J Mol Histol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0081","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2220\/biomedres.30.149","article-title":"Expression of short-chain fatty acid receptor GPR41 in the human colon","volume":"30","author":"Tazoe","year":"2009","journal-title":"Biomed Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0082","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1210\/en.2013-1142","article-title":"GPR41\/FFAR3 and GPR43\/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes","volume":"154","author":"N\u00f8hr","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0084","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.nutres.2021.08.007_bib0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.immuni.2019.06.022","article-title":"The Inflammasome: More Than a Protective Innate Immune Mechanism","volume":"51","author":"Stoilova","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.nutres.2021.08.007_bib0086","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0087","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1158\/0008-5472.CAN-13-1451","article-title":"The niacin\/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival","volume":"74","author":"Elangovan","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0088","doi-asserted-by":"crossref","first-page":"26649","DOI":"10.1074\/jbc.C500213200","article-title":"D)-\u03b2-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G","volume":"280","author":"Taggart","year":"2005","journal-title":"J Bio Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0089","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micpath.2009.04.006","article-title":"Sodium butyrate inhibits Staphylococcus aureus internalization in bovine mammary epithelial cells and induces the expression of antimicrobial peptide genes","volume":"47","author":"Ochoa-Zarzosa","year":"2009","journal-title":"Microb Pathog"},{"key":"10.1016\/j.nutres.2021.08.007_bib0090","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1167\/iovs.11-8447","article-title":"GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy","volume":"53","author":"Gambhir","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.nutres.2021.08.007_bib0091","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nm824","article-title":"PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect","volume":"9","author":"Tunaru","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.nutres.2021.08.007_bib0092","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0093","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0006-291X(03)00342-5","article-title":"Molecular identification of nicotinic acid receptor","volume":"303","author":"Soga","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.nutres.2021.08.007_bib0094","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/nu7042839","article-title":"Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation","volume":"7","author":"Kasubuchi","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2021.08.007_bib0095","doi-asserted-by":"crossref","first-page":"F439","DOI":"10.1152\/ajprenal.00252.2013","article-title":"Renal and cardiovascular sensory receptors and blood pressure regulation","volume":"305","author":"Pluznick","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0096","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4161\/gmic.27492","article-title":"A novel SCFA receptor, the microbiota, and blood pressure regulation","volume":"5","author":"Pluznick","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.nutres.2021.08.007_bib0097","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0959-437X(02)00279-4","article-title":"Histone modifications in transcriptional regulation","volume":"12","author":"Berger","year":"2002","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.nutres.2021.08.007_bib0098","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0099","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01080","article-title":"Active genes are tri-methylated at K4 of histone H3","volume":"419","author":"Santos-Rosa","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0100","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1126\/science.1064413","article-title":"Correlation between histone lysine methylation and developmental changes at the chicken \u03b2-globin locus","volume":"293","author":"Litt","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.nutres.2021.08.007_bib0101","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fphys.2013.00284","article-title":"Alterations in muscle mass and contractile phenotype in response to unloading models: role of transcriptional\/pretranslational mechanisms","volume":"4","author":"Baldwin","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0102","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tins.2009.06.002","article-title":"Multiple roles of HDAC inhibition in neurodegenerative conditions","volume":"32","author":"Chuang","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.nutres.2021.08.007_bib0103","first-page":"4561","article-title":"Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer","volume":"60","author":"Mariadason","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0104","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/jn\/132.5.1012","article-title":"The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation","volume":"132","author":"Hinnebusch","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0105","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jnutbio.2007.08.002","article-title":"Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon","volume":"19","author":"Waldecker","year":"2008","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0106","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","article-title":"The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control","volume":"134","author":"Nakahata","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.nutres.2021.08.007_bib0107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1022923508198","article-title":"SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing","volume":"117","author":"Schotta","year":"2003","journal-title":"Genetica"},{"key":"10.1016\/j.nutres.2021.08.007_bib0108","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1073\/pnas.95.18.10866","article-title":"A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus","volume":"95","author":"Sun","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2021.08.007_bib0109","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0092-8674(78)90305-7","article-title":"Sodium butyrate inhibits histone deacetylation in cultured cells","volume":"14","author":"Candido","year":"1978","journal-title":"Cell"},{"key":"10.1016\/j.nutres.2021.08.007_bib0110","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0092-8674(78)90306-9","article-title":"The effect of sodium butyrate on histone modification","volume":"14","author":"Sealy","year":"1978","journal-title":"Cell"},{"key":"10.1016\/j.nutres.2021.08.007_bib0111","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/S0021-9258(17)37831-6","article-title":"Different accessibilities in chromatin to histone acetylase","volume":"254","author":"Cousens","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0112","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nutres.2021.08.007_bib0113","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11010-011-0751-3","article-title":"Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression","volume":"352","author":"Soliman","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0114","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1016\/j.bmc.2011.06.030","article-title":"Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors","volume":"19","author":"Whitehead","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0115","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1158\/1078-0432.CCR-13-2483","article-title":"Molecular pathways: gene-environment interactions regulating dietary fiber induction of proliferation and apoptosis via butyrate for cancer prevention","volume":"20","author":"Bultman","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0116","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02796360","article-title":"Effect of sodium butyrate on mammalian cells in culture: a review","volume":"12","author":"Prasad","year":"1976","journal-title":"In Vitro"},{"key":"10.1016\/j.nutres.2021.08.007_bib0117","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.freeradbiomed.2004.11.020","article-title":"Human fecal water content of phenolics: the extent of colonic exposure to aromatic compounds","volume":"38","author":"Jenner","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nutres.2021.08.007_bib0118","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/gut.42.1.42","article-title":"Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study","volume":"42","author":"Bearcroft","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2021.08.007_bib0119","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/01.hjr.0000114707.27531.48","article-title":"International Obesity Task Force. The obesity epidemic, metabolic syndrome and future prevention strategies","volume":"11","author":"James","year":"2004","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.nutres.2021.08.007_bib0120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/BJ20081132","article-title":"Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1\/HDAC3","volume":"417","author":"Thangaraju","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.nutres.2021.08.007_bib0121","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1152\/ajpgi.00543.2011","article-title":"Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells","volume":"302","author":"Zimmerman","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0122","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1016\/S0021-9258(19)37144-3","article-title":"Effect of sodium-butyrate on estrogen-receptor and epidermal growth-factor receptor gene-expression in human breast-cancer cell-lines","volume":"267","author":"Defazio","year":"1992","journal-title":"J Bio Chem"},{"key":"10.1016\/j.nutres.2021.08.007_bib0123","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1590\/S0100-879X2012007500103","article-title":"Efficacy of the dietary histone deacetylase inhibitor butyrate alone or in combination with vitamin A against proliferation of MCF-7 human breast cancer cells","volume":"45","author":"Andrade","year":"2012","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0124","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/d5030627","article-title":"Untangling the genetic basis of fibrolytic specialization by Lachnospiraceae and Ruminococcaceae in diverse gut communities","volume":"5","author":"Biddle","year":"2013","journal-title":"Diversity"},{"issue":"2","key":"10.1016\/j.nutres.2021.08.007_bib0125","doi-asserted-by":"crossref","first-page":"i46","DOI":"10.1136\/annrheumdis-2011-200593","article-title":"HDAC inhibitor therapy in autoimmunity and transplantation","volume":"71","author":"Hancock","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0126","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0305-0491(90)90290-A","article-title":"Pyruvate sparing by butyrate and propionate in proliferating colonic epithelium","volume":"97","author":"Butler","year":"1990","journal-title":"Comp Biochem Physiol B"},{"key":"10.1016\/j.nutres.2021.08.007_bib0127","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12934-017-0691-z","article-title":"Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria","volume":"16","author":"LeBlanc","year":"2017","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.nutres.2021.08.007_bib0128","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/gut.21.9.793","article-title":"Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man","volume":"21","author":"Roediger","year":"1980","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2021.08.007_bib0129","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.1016088108","article-title":"Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)","volume":"108","author":"Kimura","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2021.08.007_bib0130","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.2637002100","article-title":"Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41","volume":"101","author":"Xiong","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2021.08.007_bib0131","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1172\/JCI104079","article-title":"Studies on the site of the feedback control of cholesterol synthesis","volume":"39","author":"Siperstein","year":"1960","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2021.08.007_bib0132","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/physrev.2001.81.3.1031","article-title":"Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides","volume":"81","author":"Topping","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.nutres.2021.08.007_bib0133","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2362.2011.02590.x","article-title":"Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects","volume":"42","author":"Al-Lahham","year":"2012","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"10.1016\/j.nutres.2021.08.007_bib0134","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/gut.37.5.684","article-title":"Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis","volume":"37","author":"Clausen","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2021.08.007_bib0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1053\/rvsc.2002.0548","article-title":"Effect of diet on markers of intestinal health in dogs","volume":"72","author":"Martineau","year":"2002","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.nutres.2021.08.007_bib0136","first-page":"177","article-title":"Correlation between faecal iso-butyric and iso-valeric acids in different species","volume":"17","author":"Cardona","year":"2005","journal-title":"Microb Ecol Health Dis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0137","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.nutres.2021.08.007_bib0138","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.celrep.2014.10.032","article-title":"Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells","volume":"9","author":"Chimerel","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.nutres.2021.08.007_bib0139","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1128\/AEM.70.6.3582-3587.2004","article-title":"Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis","volume":"70","author":"Van Immerseel","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.5551\/jat.15065","article-title":"Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages","volume":"20","author":"Ohira","year":"2013","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.nutres.2021.08.007_bib0141","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s10753-012-9484-z","article-title":"Short-chain fatty acids suppress lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines through inhibition of NF-\u03baB pathway in RAW264.7 cells","volume":"35","author":"Liu","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.nutres.2021.08.007_bib0142","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3109\/09637486.2015.1088935","article-title":"Short-chain fatty acids produced by synbiotic mixtures in skim milk differentially regulate proliferation and cytokine production in peripheral blood mononuclear cells","volume":"66","author":"Asarat","year":"2015","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0143","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aimed.2014.12.007","article-title":"The gut\u2013brain axis: the role of melatonin in linking psychiatric, inflammatory and neurodegenerative conditions","volume":"2","author":"Anderson","year":"2015","journal-title":"Adv Integr Med"},{"key":"10.1016\/j.nutres.2021.08.007_bib0144","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/BJ20150242","article-title":"Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions","volume":"469","author":"Gurav","year":"2015","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.nutres.2021.08.007_bib0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ecco-jcc\/jjw125","article-title":"Gut inflammation in mice triggers proliferation and function of mucosal Foxp3+ regulatory T Cells but impairs their conversion from CD4+ T Cells","volume":"11","author":"Boschetti","year":"2017","journal-title":"J Crohns Colitis"},{"issue":"1","key":"10.1016\/j.nutres.2021.08.007_bib0146","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1038\/cti.2015.46","article-title":"Histone deacetylases in monocyte\/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases","volume":"5","author":"Das Gupta","year":"2016","journal-title":"Clin Transl Immunology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0147","doi-asserted-by":"crossref","first-page":"2485S","DOI":"10.1093\/jn\/133.7.2485S","article-title":"Inhibition of histone deacetylase activity by butyrate","volume":"133","author":"Davie","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0148","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.7717\/peerj.611","article-title":"Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes","volume":"2","author":"Rumberger","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.nutres.2021.08.007_bib0149","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cellimm.2009.03.004","article-title":"Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors","volume":"257","author":"Lucas","year":"2009","journal-title":"Cell Immunol"},{"issue":"9","key":"10.1016\/j.nutres.2021.08.007_bib0150","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1128\/AEM.68.9.4689-4693.2002","article-title":"Cholesterol assimilation by lactic acid bacteria and bifidobacteria isolated from the human gut","volume":"68","author":"Pereira","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0151","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1874091X01004010053","article-title":"The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects","volume":"4","author":"Huda-Faujan","year":"2010","journal-title":"Open Biochem J"},{"key":"10.1016\/j.nutres.2021.08.007_bib0152","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nutres.2021.08.007_bib0153","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10620-012-2526-4","article-title":"Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer","volume":"58","author":"Ohigashi","year":"2013","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.nutres.2021.08.007_bib0154","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/BF02236937","article-title":"Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial","volume":"42","author":"Pinto","year":"1999","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.nutres.2021.08.007_bib0155","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00384-013-1807-5","article-title":"Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis\u2013a prospective randomized study","volume":"29","author":"Krokowicz","year":"2014","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.nutres.2021.08.007_bib0156","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1053\/j.gastro.2004.03.071","article-title":"Butyrate as an effective treatment of congenital chloride diarrhea","volume":"127","author":"Canani","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0157","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.clnu.2008.11.002","article-title":"Butyrate modulates oxidative stress in the colonic mucosa of healthy humans","volume":"28","author":"Hamer","year":"2009","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0158","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1158\/2159-8290.CD-14-0501","article-title":"A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner","volume":"4","author":"Donohoe","year":"2014","journal-title":"Cancer Discov"},{"key":"10.1016\/j.nutres.2021.08.007_bib0159","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fimmu.2012.00286","article-title":"DAMP signaling in fungal infections and diseases","volume":"3","author":"Cunha","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0160","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1021\/pr1011125","article-title":"Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response","volume":"10","author":"Fung","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0161","doi-asserted-by":"crossref","first-page":"24339","DOI":"10.18632\/oncotarget.8248","article-title":"Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein","volume":"7","author":"Ortega","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.nutres.2021.08.007_bib0162","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/jcmm.12850","article-title":"Vimentin, colon cancer progression and resistance to butyrate and other HDACis","volume":"20","author":"Lazarova","year":"2016","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.nutres.2021.08.007_bib0163","doi-asserted-by":"crossref","first-page":"8238","DOI":"10.3748\/wjg.v21.i27.8238","article-title":"CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer","volume":"21","author":"Bordonaro","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0164","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.fct.2013.10.028","article-title":"Butyrate suppresses proliferation and migration of RKO colon cancer cells though regulating endocan expression by MAPK signaling pathway","volume":"62","author":"Zuo","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0165","doi-asserted-by":"crossref","first-page":"e20487","DOI":"10.1371\/journal.pone.0020487","article-title":"Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation","volume":"6","author":"Bermudez","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2021.08.007_bib0166","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nut.2010.09.006","article-title":"Antiobesity activities of indole-3-carbinol in high-fat-diet\u2013induced obese mice","volume":"27","author":"Chang","year":"2011","journal-title":"Nutrition"},{"key":"10.1016\/j.nutres.2021.08.007_bib0167","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.molcel.2012.08.033","article-title":"The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation","volume":"48","author":"Donohoe","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.nutres.2021.08.007_bib0168","article-title":"Sodium butyrate induces endoplasmic reticulum stress and autophagy in colorectal cells: implications for apoptosis","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nutres.2021.08.007_bib0169","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1152\/ajpgi.2001.281.2.G405","article-title":"Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease","volume":"281","author":"J\u00f8rgensen","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0170","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1136\/gut.34.11.1552","article-title":"Ileal and Colonic Epithelial metabolism in quiescent ulcerative-colitis-increased glutamine-metabolism in distal colon but no defect in butyrate metabolism","volume":"34","author":"Finnie","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.nutres.2021.08.007_bib0171","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/jn\/127.5.717","article-title":"Acarbose enhances human colonic butyrate production","volume":"127","author":"Weaver","year":"1997","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0172","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S0007114500001239","article-title":"Acarbose raises serum butyrate in human subjects with impaired glucose tolerance","volume":"84","author":"Wolever","year":"2000","journal-title":"Br J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0173","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/003655200451180","article-title":"The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats","volume":"35","author":"Araki","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0174","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1093\/jn\/135.12.2878","article-title":"Oral administration of butyrivibrio fibrisolvens, a butyrate-producing bacterium, decreases the formation of aberrant crypt foci in the colon and rectum of mice","volume":"135","author":"Ohkawara","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.nutres.2021.08.007_bib0175","first-page":"577","article-title":"Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats","volume":"13","author":"Araki","year":"2004","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.nutres.2021.08.007_bib0176","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s12010-012-9995-y","article-title":"Potential probiotic lactic acid bacteria of human origin induce antiproliferation of colon cancer cells via synergic actions in adhesion to cancer cells and short-chain fatty acid bioproduction","volume":"169","author":"Thirabunyanon","year":"2013","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0177","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.intimp.2006.08.015","article-title":"Anti-inflammatory effects of short chain fatty acids in IFN-gamma-stimulated RAW 264.7 murine macrophage cells: involvement of NF-kappaB and ERK signaling pathways","volume":"7","author":"Park","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.nutres.2021.08.007_bib0178","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/09680519000060030501","article-title":"The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7 murine macrophage cells","volume":"6","author":"Chakravortty","year":"2000","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0179","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1002\/hep.23572","article-title":"Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis","volume":"51","author":"Kendrick","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.nutres.2021.08.007_bib0180","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1096\/fj.00-0359fje","article-title":"Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production","volume":"14","author":"Saemann","year":"2000","journal-title":"Faseb J"},{"key":"10.1016\/j.nutres.2021.08.007_bib0181","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.3748\/wjg.15.5549","article-title":"Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E-2 and cytokines","volume":"15","author":"Cox","year":"2009","journal-title":"World J Gastroentero"},{"key":"10.1016\/j.nutres.2021.08.007_bib0182","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/sj.bjp.0705682","article-title":"Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids","volume":"141","author":"Huuskonen","year":"2004","journal-title":"Br J Pharm"},{"key":"10.1016\/j.nutres.2021.08.007_bib0183","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1365\/s10337-007-0193-y","article-title":"Simultaneous HPLC determination of four key metabolites in the metabolic pathway for production of 1,3-propanediol from glycerol","volume":"65","author":"Chen","year":"2007","journal-title":"Chroma"},{"key":"10.1016\/j.nutres.2021.08.007_bib0184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jsre.1998.5316","article-title":"Sodium butyrate upregulates Kupffer cell PGE(2) production and modulates immune function","volume":"78","author":"Perez","year":"1998","journal-title":"J Surg Res"},{"key":"10.1016\/j.nutres.2021.08.007_bib0185","doi-asserted-by":"crossref","first-page":"16148","DOI":"10.1038\/srep16148","article-title":"The effect of short-chain fatty acids on human monocyte-derived dendritic cells","volume":"5","author":"Nastasi","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.nutres.2021.08.007_bib0186","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.nut.2004.11.011","article-title":"Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules","volume":"21","author":"Miller","year":"2005","journal-title":"Nutrition"},{"issue":"2","key":"10.1016\/j.nutres.2021.08.007_bib0187","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1089\/jmf.2018.0080","article-title":"Effect of daily consumption of orange juice on the levels of blood glucose, lipids, and gut microbiota metabolites: controlled clinical trials","volume":"22","author":"Lima","year":"2019","journal-title":"J Med Food"},{"key":"10.1016\/j.nutres.2021.08.007_bib0188","doi-asserted-by":"crossref","first-page":"e4195","DOI":"10.7717\/peerj.4195","article-title":"Effect of dark sweet cherry powder consumption on the gut microbiota, short-chain fatty acids, and biomarkers of gut health in obese db\/db mice","volume":"6","author":"Garcia-Mazcorro","year":"2018","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.nutres.2021.08.007_bib0189","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212586","article-title":"Apple consumption is associated with a distinctive microbiota, proteomics and metabolomics profile in the gut of Dawley Sprague rats fed a high-fat diet","volume":"14","author":"Garcia-Mazcorro","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.nutres.2021.08.007_bib0190","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5650\/jos.ess18221","article-title":"Effect of oat and tartary buckwheat-based food on cholesterol-lowering and gut microbiota in hypercholesterolemic hamsters","volume":"68","author":"Sun","year":"2019","journal-title":"J Oleo Sci"},{"key":"10.1016\/j.nutres.2021.08.007_bib0191","article-title":"Modulation of gut microbiota profile and short-chain fatty acids of rats fed with taro flour or taro starch","volume":"8893283","author":"Surono","year":"2020","journal-title":"Int J Microbiol"},{"issue":"8","key":"10.1016\/j.nutres.2021.08.007_bib0192","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1111\/1750-3841.15324","article-title":"Effects of banana powder (Musa acuminata Colla) on the composition of human fecal microbiota and metabolic output using in vitro fermentation","volume":"85","author":"Tian","year":"2020","journal-title":"J Food Sci"},{"issue":"8","key":"10.1016\/j.nutres.2021.08.007_bib0193","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3390\/nu11081853","article-title":"Cooked red lentils dose-dependently modulate the colonic microenvironment in healthy C57Bl\/6 male mice","volume":"11","author":"Graf","year":"2019","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.nutres.2021.08.007_bib0194","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1039\/C9FO00475K","article-title":"Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats","volume":"10","author":"Hu","year":"2019","journal-title":"Food Funct"},{"issue":"5","key":"10.1016\/j.nutres.2021.08.007_bib0195","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/metabo11050262","article-title":"Impact of High-Pressure Processed onion on colonic metabolism using a dynamic gastrointestinal digestion simulator","volume":"11","author":"Fern\u00e1ndez-Jalao","year":"2021","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.nutres.2021.08.007_bib0196","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/microorganisms5020024","article-title":"Dairy Propionibacteria: versatile probiotics","volume":"5","author":"Rabah","year":"2017","journal-title":"Microorganisms"},{"issue":"7","key":"10.1016\/j.nutres.2021.08.007_bib0197","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3390\/foods9070861","article-title":"In vitro modulation of gut microbiota and metabolism by cooked cowpea and black bean","volume":"9","author":"Teixeira-Guedes","year":"2020","journal-title":"Foods"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531721000579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531721000579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:51:11Z","timestamp":1759449071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531721000579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":196,"alternative-id":["S0271531721000579"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2021.08.007","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2021.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}