{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:46:33Z","timestamp":1760647593956,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["115045-03"],"award-info":[{"award-number":["115045-03"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.nutres.2022.03.012","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T17:54:33Z","timestamp":1648403673000},"page":"10-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Quamoclit angulata extract supplementation attenuates hepatic damage via regulation of AMPK\/SIRT associated hepatic lipid metabolism in streptozotocin and high fat diet\u2013induced T2DM mice"],"prefix":"10.1016","volume":"104","author":[{"given":"Heaji","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younmi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Yeou","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-8595","authenticated-orcid":false,"given":"Yunsook","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2022.03.012_bib0001","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","article-title":"Non-alcoholic fatty liver disease and diabetes","volume":"65","author":"Hazlehurst","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.nutres.2022.03.012_bib0002","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/CS20030285","article-title":"Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients","volume":"106","author":"Rodrigo","year":"2004","journal-title":"Clin Sci"},{"issue":"2","key":"10.1016\/j.nutres.2022.03.012_bib0003","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00004836-200308000-00017","article-title":"Serum lipids, lipoproteins and apolipoproteins levels in patients with nonalcoholic steatohepatitis","volume":"37","author":"Koruk","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.nutres.2022.03.012_bib0004","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J Clin Inves"},{"key":"10.1016\/j.nutres.2022.03.012_bib0005","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1038\/sj.emboj.7601784","article-title":"Foxo1 links insulin signaling to C\/EBPalpha and regulates gluconeogenesis during liver development","volume":"26","author":"Sekine","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.nutres.2022.03.012_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes","volume":"389","author":"Chatterjee","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.nutres.2022.03.012_bib0007","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.dsx.2019.01.040","article-title":"The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)","volume":"13","author":"Halim","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.nutres.2022.03.012_bib0008","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","article-title":"Sampling variability of liver fibrosis in chronic hepatitis C","volume":"38","author":"Bedossa","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.nutres.2022.03.012_bib0009","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nature reviews. Mol Cell Biol."},{"key":"10.1016\/j.nutres.2022.03.012_bib0010","doi-asserted-by":"crossref","first-page":"20015","DOI":"10.1074\/jbc.M802187200","article-title":"SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase","volume":"283","author":"Hou","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nutres.2022.03.012_bib0011","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.dsx.2016.01.028","article-title":"Lipid peroxidation is associated with poor control of type-2 diabetes mellitus","volume":"10","author":"Fatani","year":"2016","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.nutres.2022.03.012_bib0012","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejphar.2017.12.038","article-title":"Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway","volume":"820","author":"Kang","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nutres.2022.03.012_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9060459","article-title":"Effect of Quamoclit angulata extract supplementation on oxidative stress and inflammation on hyperglycemia-induced renal damage in type 2 diabetic mice","volume":"9","author":"Park","year":"2020","journal-title":"Antioxidants"},{"issue":"5 Suppl","key":"10.1016\/j.nutres.2022.03.012_bib0014","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J Nutr"},{"issue":"10","key":"10.1016\/j.nutres.2022.03.012_bib0016","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3390\/antiox10101546","article-title":"Ameliorative effect of Annona muricata (Graviola) extract on hyperglycemia induced hepatic damage in type 2 diabetic mice","volume":"10","author":"Son","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.nutres.2022.03.012_bib0017","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10787-011-0086-4","article-title":"Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice","volume":"19","author":"Lend","year":"2011","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.nutres.2022.03.012_bib0018","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.2337\/db10-1461","article-title":"Cyanidin-3-O-\u03b2-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPAR\u03b3 activity in human omental adipocytes","volume":"60","author":"Scazzocchio","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.nutres.2022.03.012_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/593902","article-title":"Pharmacological properties of protocatechuic Acid and its potential roles as complementary medicine","author":"Semaming","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.nutres.2022.03.012_bib0020","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.3390\/ijms22157783","article-title":"Glucose variability: how does it work?","volume":"22","author":"Klimontov","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nutres.2022.03.012_bib0021","article-title":"Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c","volume":"295","author":"Han","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.nutres.2022.03.012_bib0022","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1080\/09168451.2017.1282805","article-title":"Quercetin inhibits advanced glycation end product formation via chelating metal ions, trapping methylglyoxal, and trapping reactive oxygen species","volume":"81","author":"Bhuiyan","year":"2017","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.nutres.2022.03.012_bib0023","doi-asserted-by":"crossref","DOI":"10.1007\/s12272-011-0319-5","article-title":"Chlorogenic acid inhibits the formation of advanced glycation end products and associated protein cross-linking","volume":"34","author":"Kim","year":"2011","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.nutres.2022.03.012_bib0024","doi-asserted-by":"crossref","first-page":"e13172","DOI":"10.1111\/jfbc.13172","article-title":"Chlorogenic acid improves lipid membrane peroxidation and morphological changes in nitrite-induced erythrocyte model of methemoglobinemia","volume":"44","author":"Cheng","year":"2020","journal-title":"J Food Biochem"},{"key":"10.1016\/j.nutres.2022.03.012_bib0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.febslet.2007.11.034","article-title":"Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways","volume":"582","author":"Rodgers","year":"2008","journal-title":"FEBS letters"},{"key":"10.1016\/j.nutres.2022.03.012_bib0026","doi-asserted-by":"crossref","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.nutres.2022.03.012_bib0027","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2018.05.003","article-title":"Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats","volume":"103","author":"Qiu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nutres.2022.03.012_bib0028","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12906-016-1258-y","article-title":"Biomechanism of chlorogenic acid complex mediated plasma free fatty acid metabolism in rat liver","volume":"16","author":"HV","year":"2016","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.nutres.2022.03.012_bib0029","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-019-2671-9","article-title":"Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK\/ACC\/CPT-1A and SREBP-1c\/FAS signaling pathways in LO2 cells","volume":"19","author":"Fang","year":"2019","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.nutres.2022.03.012_bib0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.18295\/squmj.2016.16.02.002","article-title":"Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation","volume":"16","author":"Mohamed","year":"2016","journal-title":"Sultan Qaboos Univ Med J"},{"key":"10.1016\/j.nutres.2022.03.012_bib0031","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/s41366-018-0075-4","article-title":"Effect of protocatechuic acid on insulin responsiveness and inflammation in visceral adipose tissue from obese individuals: possible role for PTP1B","volume":"42","author":"Ormazabal","year":"2018","journal-title":"Int J Obes"},{"key":"10.1016\/j.nutres.2022.03.012_bib0032","doi-asserted-by":"crossref","DOI":"10.1039\/C7FO00265C","article-title":"Cyanidin-3-O-\u03b2-glucoside combined with its metabolite protocatechuic acid attenuated the activation of mice hepatic stellate cells","volume":"8","author":"Jiang","year":"2017","journal-title":"Food & function"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531722000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531722000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:52:16Z","timestamp":1759449136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531722000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":31,"alternative-id":["S0271531722000288"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2022.03.012","relation":{},"ISSN":["0271-5317"],"issn-type":[{"type":"print","value":"0271-5317"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quamoclit angulata extract supplementation attenuates hepatic damage via regulation of AMPK\/SIRT associated hepatic lipid metabolism in streptozotocin and high fat diet\u2013induced T2DM mice","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2022.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}