{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:54:40Z","timestamp":1792695280486,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602852"],"award-info":[{"award-number":["81602852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.nutres.2022.10.004","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T13:22:35Z","timestamp":1665753755000},"page":"218-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["One-carbon metabolism-related nutrients intake is associated with lower risk of preeclampsia in pregnant women: a matched case-control study"],"prefix":"10.1016","volume":"107","author":[{"given":"Shunping","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacong","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanjun","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2022.10.004_bib0001","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ."},{"key":"10.1016\/j.nutres.2022.10.004_bib0002","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension."},{"key":"10.1016\/j.nutres.2022.10.004_bib0003","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ Res."},{"key":"10.1016\/j.nutres.2022.10.004_bib0004","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mam.2016.11.007","article-title":"One-carbon metabolism and epigenetics","volume":"54","author":"Friso","year":"2017","journal-title":"Mol Aspects Med."},{"key":"10.1016\/j.nutres.2022.10.004_bib0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1262\/jrd.2011-002","article-title":"Roles of one-carbon metabolism in preimplantation period\u2013effects on short-term development and long-term programming","volume":"58","author":"Ikeda","year":"2012","journal-title":"J Reprod Dev."},{"key":"10.1016\/j.nutres.2022.10.004_bib0006","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/ahg.12136","article-title":"Preeclampsia is associated with decreased methylation of the GNA12 promoter","volume":"80","author":"Ye","year":"2016","journal-title":"Ann Hum Genet."},{"key":"10.1016\/j.nutres.2022.10.004_bib0007","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/nrdp.2016.12","article-title":"Diabetic retinopathy","volume":"2","author":"Wong","year":"2016","journal-title":"Nat Rev Dis Primers."},{"key":"10.1016\/j.nutres.2022.10.004_bib0008","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/1933719113492206","article-title":"Global methylation in the placenta and umbilical cord blood from pregnancies with maternal gestational diabetes, preeclampsia, and obesity","volume":"21","author":"Nomura","year":"2014","journal-title":"Reprod Sci."},{"key":"10.1016\/j.nutres.2022.10.004_bib0009","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1080\/07420528.2017.1326125","article-title":"Early- and late-onset preeclampsia and the DNA methylation of circadian clock and clock-controlled genes in placental and newborn tissues","volume":"34","author":"van den Berg","year":"2017","journal-title":"Chronobiol Int."},{"key":"10.1016\/j.nutres.2022.10.004_bib0010","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/humupd\/dmt041","article-title":"The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism","volume":"19","author":"Steegers-Theunissen","year":"2013","journal-title":"Hum Reprod Update."},{"key":"10.1016\/j.nutres.2022.10.004_bib0011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208137","article-title":"Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: a case-control study","volume":"13","author":"Serrano","year":"2018","journal-title":"PLoS One."},{"key":"10.1016\/j.nutres.2022.10.004_bib0012","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1067\/S0002-9378(03)00669-0","article-title":"Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia","volume":"189","author":"Cotter","year":"2003","journal-title":"Am J Obstet Gynecol."},{"key":"10.1016\/j.nutres.2022.10.004_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111902","article-title":"A combined supplementation of omega-3 fatty acids and micronutrients (folic acid, vitamin B12) reduces oxidative stress markers in a rat model of pregnancy induced hypertension","volume":"9","author":"Kemse","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.nutres.2022.10.004_bib0014","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.19082\/3057","article-title":"The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia","volume":"8","author":"Shahbazian","year":"2016","journal-title":"Electron Physician."},{"key":"10.1016\/j.nutres.2022.10.004_bib0015","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ejcn.2014.295","article-title":"Folic acid supplementation and dietary folate intake, and risk of preeclampsia","volume":"69","author":"Wang","year":"2015","journal-title":"Eur J Clin Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1515321","article-title":"Early pregnancy serum metabolite profiles associated with hypertensive disorders of pregnancy in african american women: a pilot study","volume":"2020","author":"Ferranti","year":"2020","journal-title":"J Pregnancy."},{"key":"10.1016\/j.nutres.2022.10.004_bib0017","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1039\/C8FO00467F","article-title":"Increased intake of vitamin B(12), folate, and omega-3 fatty acids to improve cognitive performance in offspring born to rats with induced hypertension during pregnancy","volume":"9","author":"Kemse","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.nutres.2022.10.004_bib0018","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejogrb.2012.06.020","article-title":"Influence of mineral and vitamin supplements on pregnancy outcome","volume":"164","author":"Hovdenak","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"10.1016\/j.nutres.2022.10.004_bib0019","doi-asserted-by":"crossref","first-page":"e894","DOI":"10.6061\/clinics\/2019\/e894","article-title":"Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential","volume":"74","author":"Souza","year":"2019","journal-title":"Clinics (Sao Paulo)."},{"key":"10.1016\/j.nutres.2022.10.004_bib0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fgene.2019.00200","article-title":"A conceptual framework for studying and investing in precision nutrition","volume":"10","author":"Zeisel","year":"2019","journal-title":"Front Genet."},{"key":"10.1016\/j.nutres.2022.10.004_bib0021","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.3390\/nu11122995","article-title":"Neuroprotective effects of choline and other methyl donors","volume":"11","author":"Bekdash","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2022.10.004_bib0022","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2174\/1573402112666161010151632","article-title":"Evaluation of homocysteine, vitamin B12 and folic acid levels during all the trimesters in pregnant and preeclamptic women","volume":"12","author":"Kharb","year":"2016","journal-title":"Curr Hypertens Rev."},{"key":"10.1016\/j.nutres.2022.10.004_bib0023","doi-asserted-by":"crossref","first-page":"1206s","DOI":"10.1093\/ajcn\/81.5.1206","article-title":"Multiple micronutrients in pregnancy and lactation: an overview","volume":"81","author":"Allen","year":"2005","journal-title":"Am J Clin Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0024","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/nu14051019","article-title":"Maternal amino acid status in severe preeclampsia: a cross-sectional study","volume":"14","author":"Prameswari","year":"2022","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2022.10.004_bib0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1203\/PDR.0b013e318123fba2","article-title":"Homocysteine, cysteine, and related metabolites in maternal and fetal plasma in preeclampsia","volume":"62","author":"Braekke","year":"2007","journal-title":"Pediatr Res."},{"key":"10.1016\/j.nutres.2022.10.004_bib0026","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/plac.1999.0417","article-title":"Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review","volume":"20","author":"Ray","year":"1999","journal-title":"Placenta."},{"key":"10.1016\/j.nutres.2022.10.004_bib0027","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.numecd.2009.07.002","article-title":"Folic acid is positively associated with uteroplacental vascular resistance: the Generation R study","volume":"21","author":"Timmermans","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis."},{"key":"10.1016\/j.nutres.2022.10.004_bib0028","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3390\/foods9091267","article-title":"Comparative analysis of physicochemical characteristics, nutritional and functional components and antioxidant capacity of fifteen kiwifruit (actinidia) cultivars-comparative analysis of fifteen kiwifruit (actinidia) cultivars","volume":"9","author":"Zhang","year":"2020","journal-title":"Foods."},{"key":"10.1016\/j.nutres.2022.10.004_bib0029","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/10641963.2021.1916942","article-title":"A narrative review on the role of folate-mediated one-carbon metabolism and its associated gene polymorphisms in posing risk to preeclampsia","volume":"43","author":"Mahmood","year":"2021","journal-title":"Clin Exp Hypertens."},{"key":"10.1016\/j.nutres.2022.10.004_bib0030","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1038\/s41598-020-65912-2","article-title":"Adherence to a Dietary Approaches to Stop Hypertension (DASH)-style diet in relation to preeclampsia: a case-control study","volume":"10","author":"Cao","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.nutres.2022.10.004_bib0031","first-page":"721","article-title":"Diagnosis and treatment guideline of hypertensive disorders in pregnancy","volume":"50","year":"2015","journal-title":"Chin J Obstet Gynecol."},{"key":"10.1016\/j.nutres.2022.10.004_bib0032","first-page":"240","article-title":"Validity and reproducibility of a food frequency questionnaire among Chinese women in Guangdong province","volume":"18","author":"Zhang","year":"2009","journal-title":"Asia Pac J Clin Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0033","series-title":"Chinese food composition tables","author":"Yang","year":"2004"},{"key":"10.1016\/j.nutres.2022.10.004_bib0034","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/cas.12064","article-title":"Choline and betaine intake is inversely associated with breast cancer risk: a two-stage case-control study in China","volume":"104","author":"Zhang","year":"2013","journal-title":"Cancer Sci."},{"key":"10.1016\/j.nutres.2022.10.004_bib0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1017\/S0007114515004146","article-title":"Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case-control study","volume":"115","author":"Zeng","year":"2016","journal-title":"Br J Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0036","doi-asserted-by":"crossref","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for total energy intake in epidemiologic studies","volume":"65","author":"Willett","year":"1997","journal-title":"Am J Clin Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0037","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3945\/jn.111.157222","article-title":"Alternative dietary indices both strongly predict risk of chronic disease","volume":"142","author":"Chiuve","year":"2012","journal-title":"J Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0038","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jada.2009.03.001","article-title":"Dietary quality during pregnancy varies by maternal characteristics in Project Viva: a US cohort","volume":"109","author":"Rifas-Shiman","year":"2009","journal-title":"J Am Diet Assoc."},{"key":"10.1016\/j.nutres.2022.10.004_bib0039","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000069992","article-title":"Hyperhomocysteinemia and vitamin score: correlations with silent brain ischemic lesions and brain atrophy","volume":"16","author":"Polyak","year":"2003","journal-title":"Dement Geriatr Cogn Disord."},{"key":"10.1016\/j.nutres.2022.10.004_bib0040","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/ijc.33007","article-title":"One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: a prospective cohort study","volume":"147","author":"Antwi","year":"2020","journal-title":"Int J Cancer."},{"key":"10.1016\/j.nutres.2022.10.004_bib0041","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/14767058.2011.564242","article-title":"The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women","volume":"25","author":"La Merrill","year":"2012","journal-title":"J Matern Fetal Neonatal Med."},{"key":"10.1016\/j.nutres.2022.10.004_bib0042","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/aje\/kwf129","article-title":"Risk of gestational hypertension in relation to folic acid supplementation during pregnancy","volume":"156","author":"Hern\u00e1ndez-D\u00edaz","year":"2002","journal-title":"Am J Epidemiol."},{"key":"10.1016\/j.nutres.2022.10.004_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.06.067","article-title":"Folic acid supplementation in early second trimester and the risk of preeclampsia","volume":"198","author":"Wen","year":"2008","journal-title":"Am J Obstet Gynecol."},{"key":"10.1016\/j.nutres.2022.10.004_bib0044","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1503\/cmaj.080859","article-title":"Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes","volume":"179","author":"Wen","year":"2008","journal-title":"CMAJ."},{"key":"10.1016\/j.nutres.2022.10.004_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226969","article-title":"Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies","volume":"14","author":"Heil","year":"2019","journal-title":"PLoS One."},{"key":"10.1016\/j.nutres.2022.10.004_bib0046","first-page":"416","article-title":"Magnetic resonance spectroscopy in pre-eclampsia: evidence of cerebral ischaemia","volume":"110","author":"Rutherford","year":"2003","journal-title":"BJOG."},{"key":"10.1016\/j.nutres.2022.10.004_bib0047","first-page":"147","article-title":"Preeclampsia: the role of angiogenic factors in its pathogenesis","volume":"24","author":"Wang","year":"2009","journal-title":"Physiology (Bethesda)."},{"key":"10.1016\/j.nutres.2022.10.004_bib0048","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med."},{"key":"10.1016\/j.nutres.2022.10.004_bib0049","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1096\/fj.12-221648","article-title":"A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1)","volume":"27","author":"Jiang","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.nutres.2022.10.004_bib0050","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3945\/ajcn.111.030783","article-title":"Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice","volume":"95","author":"Beaudin","year":"2012","journal-title":"Am J Clin Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0051","doi-asserted-by":"crossref","DOI":"10.1242\/dev.172205","article-title":"Periconceptional alcohol exposure causes female-specific perturbations to trophoblast differentiation and placental formation in the rat","volume":"146","author":"Kalisch-Smith","year":"2019","journal-title":"Development."},{"key":"10.1016\/j.nutres.2022.10.004_bib0052","doi-asserted-by":"crossref","first-page":"14616","DOI":"10.1038\/s41598-018-32804-5","article-title":"A non-targeted LC-MS profiling reveals elevated levels of carnitine precursors and trimethylated compounds in the cord plasma of pre-eclamptic infants","volume":"8","author":"J\u00e4\u00e4skel\u00e4inen","year":"2018","journal-title":"Sci Rep."},{"key":"10.1016\/j.nutres.2022.10.004_bib0053","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.abb.2007.04.005","article-title":"Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells","volume":"462","author":"Perry","year":"2007","journal-title":"Arch Biochem Biophys."},{"key":"10.1016\/j.nutres.2022.10.004_bib0054","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jnutbio.2012.03.003","article-title":"Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation","volume":"23","author":"Anderson","year":"2012","journal-title":"J Nutr Biochem."},{"key":"10.1016\/j.nutres.2022.10.004_bib0055","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1515\/CCLM.2004.228","article-title":"Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency","volume":"42","author":"Herrmann","year":"2004","journal-title":"Clin Chem Lab Med."},{"key":"10.1016\/j.nutres.2022.10.004_bib0056","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1515\/CCLM.2005.198","article-title":"Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status","volume":"43","author":"Herrmann","year":"2005","journal-title":"Clin Chem Lab Med."},{"key":"10.1016\/j.nutres.2022.10.004_bib0057","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6652231","article-title":"A novel review of homocysteine and pregnancy complications","volume":"2021","author":"Dai","year":"2021","journal-title":"Biomed Res Int."},{"key":"10.1016\/j.nutres.2022.10.004_bib0058","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0083-6729(08)60982-6","article-title":"The interactions between vitamin B6 and hormones","volume":"36","author":"Rose","year":"1978","journal-title":"Vitam Horm."},{"key":"10.1016\/j.nutres.2022.10.004_bib0059","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.nutres.2022.10.004_bib0060","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.drudis.2020.12.006","article-title":"Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy","volume":"26","author":"Yang","year":"2021","journal-title":"Drug Discov Today."},{"key":"10.1016\/j.nutres.2022.10.004_bib0061","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ajcn\/72.4.998","article-title":"Genomic DNA methylation decreases in response to moderate folate depletion in elderly women","volume":"72","author":"Rampersaud","year":"2000","journal-title":"Am J Clin Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0062","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/jn\/137.7.1713","article-title":"Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon","volume":"137","author":"Keyes","year":"2007","journal-title":"J Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0063","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1096\/fj.05-4707com","article-title":"Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains","volume":"20","author":"Niculescu","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.nutres.2022.10.004_bib0064","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.biopha.2016.12.072","article-title":"Epigenetic modifications and epigenetic based medication implementations of autoimmune diseases","volume":"87","author":"Ahmadi","year":"2017","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.nutres.2022.10.004_bib0065","doi-asserted-by":"crossref","first-page":"H1295","DOI":"10.1152\/ajpheart.00958.2015","article-title":"DNA methylation profiles in preeclampsia and healthy control placentas","volume":"310","author":"Yeung","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.1016\/j.nutres.2022.10.004_bib0066","doi-asserted-by":"crossref","first-page":"16873","DOI":"10.1038\/s41598-018-35111-1","article-title":"Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood","volume":"8","author":"Knight","year":"2018","journal-title":"Sci Rep."},{"key":"10.1016\/j.nutres.2022.10.004_bib0067","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/07315724.2017.1333929","article-title":"Association between serum unmetabolized folic acid concentrations and folic acid from fortified foods","volume":"36","author":"Palchetti","year":"2017","journal-title":"J Am Coll Nutr."},{"key":"10.1016\/j.nutres.2022.10.004_bib0068","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3945\/ajcn.112.048462","article-title":"DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women","volume":"97","author":"Dominguez-Salas","year":"2013","journal-title":"Am J Clin Nutr."}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531722000963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531722000963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:54:48Z","timestamp":1759449288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531722000963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":68,"alternative-id":["S0271531722000963"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2022.10.004","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"One-carbon metabolism-related nutrients intake is associated with lower risk of preeclampsia in pregnant women: a matched case-control study","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2022.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}