{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:20:32Z","timestamp":1792120832103,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211292"],"award-info":[{"award-number":["BK20211292"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701031"],"award-info":[{"award-number":["31701031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072221"],"award-info":[{"award-number":["32072221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272318"],"award-info":[{"award-number":["32272318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.nutres.2024.01.008","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T04:19:45Z","timestamp":1705724385000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Chaenomeles sinensis (Thouin) Koehne fruit polyphenols alleviate high-fat diet\u2013induced obesity and liver steatosis by improving lipid metabolism in mice"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-3084","authenticated-orcid":false,"given":"Haizhao","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minfang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2024.01.008_bib0001","first-page":"269","article-title":"Natural anti-obesity agents","volume":"52","author":"Mohamed","year":"2014","journal-title":"Bull Faculty Pharmacy"},{"key":"10.1016\/j.nutres.2024.01.008_bib0002","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Despres","year":"2006","journal-title":"Nature."},{"key":"10.1016\/j.nutres.2024.01.008_bib0003","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopha.2018.11.076","article-title":"Natural anti-obesity agents and their therapeutic role in management of obesity: a future trend perspective","volume":"110","author":"Karri","year":"2019","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.nutres.2024.01.008_bib0004","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.phytochem.2010.07.011","article-title":"Possible anti-obesity therapeutics from nature\u2013a review","volume":"71","author":"Yun","year":"2010","journal-title":"Phytochemistry."},{"key":"10.1016\/j.nutres.2024.01.008_bib0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11936-010-0080-y","article-title":"Therapeutic approaches to obesity","volume":"12","author":"Powell","year":"2010","journal-title":"Curr Treat Options Cardiovasc Med."},{"key":"10.1016\/j.nutres.2024.01.008_bib0006","doi-asserted-by":"crossref","first-page":"e14264","DOI":"10.1111\/jfbc.14264","article-title":"Health benefits of polyphenols: a concise review","volume":"46","author":"Rana","year":"2022","journal-title":"J Food Biochem."},{"key":"10.1016\/j.nutres.2024.01.008_bib0007","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ifset.2009.05.010","article-title":"Effects of micronization on properties of Chaenomeles sinensis (Thouin) Koehne fruit powder","volume":"10","author":"Zhang","year":"2009","journal-title":"Innov Food Sci Emerg Technol."},{"key":"10.1016\/j.nutres.2024.01.008_bib0008","doi-asserted-by":"crossref","first-page":"40","DOI":"10.24304\/kjcp.2018.28.1.40","article-title":"Antioxidant activity of n-butanol fraction of Chaenomeles sinensis fruit in Caenorhabditis elegans","volume":"49","author":"Kim","year":"2018","journal-title":"Korean J Pharmacognosy."},{"key":"10.1016\/j.nutres.2024.01.008_bib0009","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.etp.2011.05.010","article-title":"Antidiabetic and antiacetylcholinesterase effects of ethyl acetate fraction of Chaenomeles sinensis (Thouin) Koehne fruits in streptozotocin-induced diabetic rats","volume":"65","author":"Sancheti","year":"2013","journal-title":"Exp Toxicol Pathol."},{"key":"10.1016\/j.nutres.2024.01.008_bib0010","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1039\/C8FO01480A","article-title":"Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice","volume":"9","author":"Zhang","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.nutres.2024.01.008_bib0011","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"10.1016\/j.nutres.2024.01.008_bib0012","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/mnfr.201200431","article-title":"Effects of dietary polyphenols on neuroregulatory factors and pathways that mediate food intake and energy regulation in obesity","volume":"57","author":"Panickar","year":"2013","journal-title":"Mol Nutr Food Res."},{"key":"10.1016\/j.nutres.2024.01.008_bib0013","first-page":"e13565","article-title":"Effect of the polyphenol-rich extract from Allium cepa on hyperlipidemic Sprague-Dawley rats","volume":"45","author":"Li","year":"2021","journal-title":"J Food Biochem."},{"key":"10.1016\/j.nutres.2024.01.008_bib0014","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apolipoproteins, and risk of vascular disease","volume":"302","author":"Di Angelantonio","year":"2009","journal-title":"JAMA."},{"key":"10.1016\/j.nutres.2024.01.008_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109609","article-title":"Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease","volume":"121","author":"Xi","year":"2020","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.nutres.2024.01.008_bib0016","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2016-312431","article-title":"Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease","volume":"66","author":"Rotman","year":"2017","journal-title":"Gut."},{"key":"10.1016\/j.nutres.2024.01.008_bib0017","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med."},{"key":"10.1016\/j.nutres.2024.01.008_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/nu11123067","article-title":"Nonalcoholic fatty liver disease induced by high-fat diet in c57bl\/6 models","volume":"11","author":"Recena Aydos","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2024.01.008_bib0019","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/j.1582-4934.2010.01128.x","article-title":"High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia","volume":"15","author":"Carabelli","year":"2011","journal-title":"J Cell Mol Med."},{"key":"10.1016\/j.nutres.2024.01.008_bib0020","article-title":"Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.nutres.2024.01.008_bib0021","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1194\/jlr.M088419","article-title":"Extrahepatic PPAR\u03b1 modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice","volume":"59","author":"Brocker","year":"2018","journal-title":"J Lipid Res."},{"key":"10.1016\/j.nutres.2024.01.008_bib0022","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2020.05.007","article-title":"Acetyl-coa derived from hepatic peroxisomal \u03b2-oxidation inhibits autophagy and promotes steatosis via mTORC1 activation","volume":"79","author":"He","year":"2020","journal-title":"Mol Cell."},{"key":"10.1016\/j.nutres.2024.01.008_bib0023","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1161\/CIRCULATIONAHA.111.075978","article-title":"Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity","volume":"126","author":"He","year":"2012","journal-title":"Circulation."},{"key":"10.1016\/j.nutres.2024.01.008_bib0024","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1128\/MCB.00077-06","article-title":"Stearoyl-coenzyme a desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver x receptor activation","volume":"26","author":"Chu","year":"2006","journal-title":"Mol Cell Biol."},{"key":"10.1016\/j.nutres.2024.01.008_bib0025","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bbalip.2011.09.017","article-title":"Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?","volume":"1821","author":"Jensen-Urstad","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"10.1016\/j.nutres.2024.01.008_bib0026","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-nutr-082018-124250","article-title":"FADS1 and FADS2 polymorphisms modulate fatty acid metabolism and dietary impact on health","volume":"39","author":"Koletzko","year":"2019","journal-title":"Annu Rev Nutr."},{"key":"10.1016\/j.nutres.2024.01.008_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4558867","article-title":"High-risk polymorphisms associated with the molecular function of human HMGCR gene infer the inhibition of cholesterol biosynthesis","volume":"2022","author":"Das","year":"2022","journal-title":"Biomed Res Int."},{"key":"10.1016\/j.nutres.2024.01.008_bib0028","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat Rev Mol Cell Biol."},{"key":"10.1016\/j.nutres.2024.01.008_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2019.153953","article-title":"The role of adiponectin in cholesterol efflux and HDL biogenesis and metabolism","volume":"100","author":"Hafiane","year":"2019","journal-title":"Metabolism."}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531724000101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531724000101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:55:37Z","timestamp":1759449337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531724000101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":29,"alternative-id":["S0271531724000101"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2024.01.008","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chaenomeles sinensis (Thouin) Koehne fruit polyphenols alleviate high-fat diet\u2013induced obesity and liver steatosis by improving lipid metabolism in mice","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2024.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}