{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:31:31Z","timestamp":1768033891964,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.nutres.2025.09.008","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:42:09Z","timestamp":1758577329000},"page":"44-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Systemic inflammation mediates the association between docosahexaenoic acid\/docosapentaenoic acid ratio and the risk of periodontitis"],"prefix":"10.1016","volume":"143","author":[{"given":"Yunqiang","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuncheng","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2025.09.008_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontology. 2000"},{"key":"10.1016\/j.nutres.2025.09.008_bib0002","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int Dent J."},{"key":"10.1016\/j.nutres.2025.09.008_bib0003","doi-asserted-by":"crossref","DOI":"10.1111\/odi.15297","article-title":"Periodontitis: grade modifiers revisited","author":"Saleh","year":"2025","journal-title":"Oral Dis."},{"key":"10.1016\/j.nutres.2025.09.008_bib0004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12447","article-title":"Risk factors for periodontitis & peri-implantitis","volume":"90","author":"Darby","year":"2022","journal-title":"Periodontol 2000."},{"key":"10.1016\/j.nutres.2025.09.008_bib0005","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10266-023-00831-y","article-title":"A diet rich in omega-3 fatty acid improves periodontitis and tissue destruction by MMP2- and MMP9-linked inflammation in a murine model","volume":"112","author":"Gonzalez-Alva","year":"2024","journal-title":"Odontology."},{"key":"10.1016\/j.nutres.2025.09.008_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092614","article-title":"Omega-3 polyunsaturated fatty acids EPA and DHA as an adjunct to non-surgical treatment of periodontitis: a randomized clinical trial","volume":"12","author":"Stando","year":"2020","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2025.09.008_bib0007","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12944-024-02159-0","article-title":"The association between polyunsaturated fatty acids and periodontitis: NHANES 2011-2014 and mendelian randomisation analysis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.nutres.2025.09.008_bib0008","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0029665107005472","article-title":"Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease","volume":"66","author":"Sijben","year":"2007","journal-title":"Proc Nutr Soc."},{"key":"10.1016\/j.nutres.2025.09.008_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111996","article-title":"Omega3-PUFA alleviates neuroinflammation by upregulating Mir-107 targeting PIEZO1\/NF\u03baB P65","volume":"132","author":"Liu","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0010","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1080\/09637486.2016.1201790","article-title":"PUFA and oxidative stress. Differential modulation of the cell response by DHA","volume":"67","author":"Di Nunzio","year":"2016","journal-title":"Int J Food Sci Nutr."},{"key":"10.1016\/j.nutres.2025.09.008_bib0011","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1902\/jop.2012.120171","article-title":"Serum levels of long-chain polyunsaturated fatty acids in patients with periodontal disease","volume":"84","author":"Figueredo","year":"2013","journal-title":"J Periodontol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0012","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/jcpe.13736","article-title":"Association between circulating 25-hydroxyvitamin D metabolites and periodontitis: results from the NHANES 2009-2012 and mendelian randomization study","volume":"50","author":"Li","year":"2023","journal-title":"J Clin Periodontol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0013","unstructured":"NHANES, Fatty acids \u2013 serum (FAS_H) https:\/\/wwwn.cdc.gov\/Nchs\/Data\/Nhanes\/Public\/2013\/DataFiles\/FAS_H.htm; (accessed 14 September 2025)."},{"key":"10.1016\/j.nutres.2025.09.008_bib0014","doi-asserted-by":"crossref","first-page":"S498","DOI":"10.1097\/00005768-200009001-00009","article-title":"Compendium of physical activities: an update of activity codes and MET intensities","volume":"32","author":"Ainsworth","year":"2000","journal-title":"Med Sci Sports Exerc."},{"key":"10.1016\/j.nutres.2025.09.008_bib0015","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1210\/clinem\/dgab415","article-title":"Relationship between insulin sensitivity and menstrual cycle is modified by BMI, fitness, and physical activity in NHANES","volume":"106","author":"MacGregor","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.nutres.2025.09.008_bib0016","doi-asserted-by":"crossref","first-page":"k2575","DOI":"10.1136\/bmj.k2575","article-title":"Predicted lean body mass, fat mass, and all cause and cause specific mortality in men: prospective US cohort study","volume":"362","author":"Lee","year":"2018","journal-title":"BMJ."},{"key":"10.1016\/j.nutres.2025.09.008_bib0017","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13075-023-03018-6","article-title":"The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999-2018","volume":"25","author":"Liu","year":"2023","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.nutres.2025.09.008_bib0018","article-title":"Predictive role of neutrophil-percentage-to-albumin ratio (NPAR) in nonalcoholic fatty liver disease and advanced liver fibrosis in nondiabetic US adults: evidence from NHANES 2017-2018","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2025.09.008_bib0019","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12933-025-02698-5","article-title":"Oxidative stress and inflammation mediate the adverse effects of cadmium exposure on all-cause and cause-specific mortality in patients with diabetes and prediabetes","volume":"24","author":"Liu","year":"2025","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0020","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jad.2025.01.108","article-title":"Associations between metabolic syndrome and depression, and the mediating role of inflammation: based on the NHANES database","volume":"375","author":"Meng","year":"2025","journal-title":"J Affect Disord."},{"key":"10.1016\/j.nutres.2025.09.008_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1466807","article-title":"Association between composite dietary antioxidant index and fatty liver index among US adults","volume":"11","author":"Zheng","year":"2024","journal-title":"Front Nutr."},{"key":"10.1016\/j.nutres.2025.09.008_bib0022","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12944-024-02081-5","article-title":"Association between obstructive sleep apnea and visceral adiposity index and lipid accumulation product: NHANES 2015-2018","volume":"23","author":"Zhou","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.nutres.2025.09.008_bib0023","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12944-024-02314-7","article-title":"Association between cardiometabolic index (CMI) and endometriosis: a cross-sectional study on NHANES","volume":"23","author":"Wang","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.nutres.2025.09.008_bib0024","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.archoralbio.2014.04.009","article-title":"Plasma polyunsaturated fatty acids and periodontal recovery in Taiwanese with periodontitis: a significant relationship","volume":"59","author":"Wang","year":"2014","journal-title":"Arch Oral Biol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0025","article-title":"Ratio of pro-resolving and pro-inflammatory lipid mediator precursors as potential markers for aggressive periodontitis","volume":"8","author":"Elabdeen","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.nutres.2025.09.008_bib0026","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0765.2008.01108.x","article-title":"Effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse","volume":"44","author":"Bendyk","year":"2009","journal-title":"J Periodontal Res."},{"key":"10.1016\/j.nutres.2025.09.008_bib0027","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.joen.2017.01.006","article-title":"Omega 3 fatty acids reduce bone resorption while promoting bone generation in rat apical periodontitis","volume":"43","author":"Azuma","year":"2017","journal-title":"J Endod."},{"key":"10.1016\/j.nutres.2025.09.008_bib0028","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/0022034514541125","article-title":"Docosahexaenoic acid and periodontitis in adults: a randomized controlled trial","volume":"93","author":"Naqvi","year":"2014","journal-title":"J Dent Res."},{"key":"10.1016\/j.nutres.2025.09.008_bib0029","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00784-024-05835-8","article-title":"Clinical effects of omega-3 fatty acids supplementation in the periodontal treatment of smokers and non-smokers with periodontitis: a retrospective study","volume":"28","author":"Savran","year":"2024","journal-title":"Clin Oral Investig."},{"key":"10.1016\/j.nutres.2025.09.008_bib0030","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/ijdr.IJDR_647_18","article-title":"Efficacy of omega 3 fatty acid as an adjunct in the management of chronic periodontitis: a randomized controlled trial","volume":"31","author":"Kujur","year":"2020","journal-title":"Indian J Dent Res."},{"key":"10.1016\/j.nutres.2025.09.008_bib0031","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/jcpe.13603","article-title":"Supplemental or dietary intake of omega-3 fatty acids for the treatment of periodontitis: a meta-analysis","volume":"49","author":"Heo","year":"2022","journal-title":"J Clin Periodontol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101165","article-title":"Polyunsaturated fatty acids and fatty acid-derived lipid mediators: recent advances in the understanding of their biosynthesis, structures, and functions","volume":"86","author":"Dyall","year":"2022","journal-title":"Prog Lipid Res."},{"key":"10.1016\/j.nutres.2025.09.008_bib0033","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1007\/s00394-022-02922-y","article-title":"The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism","volume":"61","author":"Vaittinen","year":"2022","journal-title":"Eur J Nutr."},{"key":"10.1016\/j.nutres.2025.09.008_bib0034","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2021.12.007","article-title":"Sting orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses","volume":"34","author":"Vila","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.nutres.2025.09.008_bib0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1194\/jlr.M059113","article-title":"FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue","volume":"57","author":"Vaittinen","year":"2016","journal-title":"J Lipid Res."},{"key":"10.1016\/j.nutres.2025.09.008_bib0036","first-page":"10","article-title":"[association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis]","volume":"48","author":"Song","year":"2016","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"10.1016\/j.nutres.2025.09.008_bib0037","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/jre.12116","article-title":"Periodontal disease: modulation of the inflammatory cascade by dietary n - 3 polyunsaturated fatty acids","volume":"49","author":"Sculley","year":"2014","journal-title":"J Periodontal Res."},{"key":"10.1016\/j.nutres.2025.09.008_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310717","article-title":"DHA\/EPA (omega-3) and LA\/GLA (omega-6) as bioactive molecules in neurodegenerative diseases","volume":"24","author":"Kousparou","year":"2023","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.nutres.2025.09.008_bib0039","doi-asserted-by":"crossref","DOI":"10.3390\/nu15040821","article-title":"Polyunsaturated fatty acids and their immunomodulatory actions in periodontal disease","volume":"15","author":"Panezai","year":"2023","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2025.09.008_bib0040","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.clinbiochem.2014.09.006","article-title":"Enhanced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsaturated fatty acid load in familial hypercholesterolemia","volume":"47","author":"Cortes","year":"2014","journal-title":"Clin Biochem."},{"key":"10.1016\/j.nutres.2025.09.008_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040872","article-title":"Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation","volume":"11","author":"Yang","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.nutres.2025.09.008_bib0042","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29235502","article-title":"The role of unsaturated fatty acid-rich dairy products in adipocyte metabolism","volume":"29","author":"Machado","year":"2024","journal-title":"Molecules."},{"key":"10.1016\/j.nutres.2025.09.008_bib0043","doi-asserted-by":"crossref","first-page":"C738","DOI":"10.1152\/ajpcell.00196.2014","article-title":"Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids","volume":"307","author":"Lager","year":"2014","journal-title":"Am J Physiol Cell Physiol."},{"key":"10.1016\/j.nutres.2025.09.008_bib0044","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.joen.2020.11.015","article-title":"Omega-3 fatty acids alter systemic inflammatory mediators caused by apical periodontitis","volume":"47","author":"Azuma","year":"2021","journal-title":"J Endod."},{"key":"10.1016\/j.nutres.2025.09.008_bib0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.joen.2017.12.008","article-title":"Omega-3 fatty acids reduce inflammation in rat apical periodontitis","volume":"44","author":"Azuma","year":"2018","journal-title":"J Endod."}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531725001198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531725001198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:00:12Z","timestamp":1762444812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531725001198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":45,"alternative-id":["S0271531725001198"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2025.09.008","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic inflammation mediates the association between docosahexaenoic acid\/docosapentaenoic acid ratio and the risk of periodontitis","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2025.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}