{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:44:24Z","timestamp":1793051064253,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.nutres.2025.10.001","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:19:22Z","timestamp":1759537162000},"page":"89-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ellagic acid as a potential therapeutic agent in metabolic syndrome: A systematic review and meta-analysis of glycemic control markers and kidney function tests in animal and clinical studies"],"prefix":"10.1016","volume":"143","author":[{"given":"Kornvipa","family":"Settakorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratchanon","family":"Inpan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkwan","family":"Na Takuathung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-597X","authenticated-orcid":false,"given":"Nut","family":"Koonrungsesomboon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2025.10.001_bib0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.trsl.2017.01.001","article-title":"Cardiovascular consequences of metabolic syndrome","volume":"183","author":"Tune","year":"2017","journal-title":"Transl Res"},{"key":"10.1016\/j.nutres.2025.10.001_bib0002","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2025.10.001_bib0003","first-page":"1","article-title":"Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006","volume":"5","author":"Ervin","year":"2009","journal-title":"Natl Health Stat Report"},{"key":"10.1016\/j.nutres.2025.10.001_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109924","article-title":"Geographic distribution of metabolic syndrome and its components in the general adult population: a meta-analysis of global data from 28 million individuals","volume":"188","author":"Noubiap","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.nutres.2025.10.001_bib0005","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/jdi.12313","article-title":"Clinical characteristics of metabolic syndrome in Korea, and its comparison with other Asian countries","volume":"6","author":"Hong","year":"2015","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.nutres.2025.10.001_bib0006","author":"Mouri"},{"key":"10.1016\/j.nutres.2025.10.001_bib0007","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11906-009-0027-4","article-title":"The metabolic syndrome: insulin resistance","volume":"11","author":"Mikhail","year":"2009","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.nutres.2025.10.001_bib0008","first-page":"1961","article-title":"Impaired glucose tolerance and impaired fasting glucose","volume":"69","author":"Rao","year":"2004","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.nutres.2025.10.001_bib0009","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4137\/BMI.S38440","article-title":"Significance of HbA1c test in diagnosis and prognosis of diabetic patients","volume":"11","author":"Sherwani","year":"2016","journal-title":"Biomark Insights"},{"key":"10.1016\/j.nutres.2025.10.001_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4093\/dmj.2021.0280","article-title":"Insulin resistance: from mechanisms to therapeutic strategies","volume":"46","author":"Lee","year":"2022","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.nutres.2025.10.001_bib0011","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biopha.2018.07.157","article-title":"Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: an update on glucose toxicity","volume":"107","author":"Giri","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nutres.2025.10.001_bib0012","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000035285","article-title":"Vascular complications of diabetes: a narrative review","volume":"102","author":"Lu","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.nutres.2025.10.001_bib0013","first-page":"539","article-title":"The mechanism of hyperglycemia-induced renal cell injury in diabetic nephropathy disease: an update","volume":"13","author":"Wu","year":"2023","journal-title":"Life (Basel)"},{"key":"10.1016\/j.nutres.2025.10.001_bib0014","article-title":"Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes","volume":"2012","author":"Funk","year":"2012","journal-title":"Int J Vasc Med"},{"key":"10.1016\/j.nutres.2025.10.001_bib0015","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000093632","article-title":"Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications","volume":"26","author":"Sarafidis","year":"2006","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2021.0440","article-title":"Hypertension and the kidneys","volume":"83","author":"De Bhailis","year":"2022","journal-title":"Br J Hosp Med (Lond)"},{"key":"10.1016\/j.nutres.2025.10.001_bib0017","article-title":"Chronic kidney disease: its relationship with obesity","volume":"14","author":"Prasad","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.nutres.2025.10.001_bib0018","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5527\/wjn.v3.i4.210","article-title":"Metabolic syndrome and chronic kidney disease: current status and future directions","volume":"3","author":"Prasad","year":"2014","journal-title":"World J Nephrol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0019","author":"Vaidya"},{"key":"10.1016\/j.nutres.2025.10.001_bib0020","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1152\/advan.00080.2014","article-title":"Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle","volume":"38","author":"Stanford","year":"2014","journal-title":"Adv Physiol Educ"},{"key":"10.1016\/j.nutres.2025.10.001_bib0021","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s12020-016-0911-z","article-title":"Leisure-time exercise, physical activity during work and commuting, and risk of metabolic syndrome","volume":"53","author":"Kuwahara","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.nutres.2025.10.001_bib0022","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.jacc.2010.09.073","article-title":"The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals","volume":"57","author":"Kastorini","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0023","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11154-013-9253-9","article-title":"Mediterranean diet and metabolic syndrome: an updated systematic review","volume":"14","author":"Esposito","year":"2013","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.nutres.2025.10.001_bib0024","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1753944717711379","article-title":"Metabolic syndrome: pathophysiology, management, and modulation by natural compounds","volume":"11","author":"Rochlani","year":"2017","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"10.1016\/j.nutres.2025.10.001_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21844","article-title":"The effect of ellagic acid on the metabolic syndrome: a review article","volume":"9","author":"Naraki","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.nutres.2025.10.001_bib0026","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1021\/jf0001684","article-title":"Ellagic acid, vitamin C, and total phenolic contents and radical scavenging capacity affected by freezing and frozen storage in raspberry fruit","volume":"48","author":"de Ancos","year":"2000","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nutres.2025.10.001_bib0027","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/jf0403484","article-title":"Identification and quantification of polyphenolic compounds in longan (Euphoria longana Lam.) fruit","volume":"53","author":"Rangkadilok","year":"2005","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.nutres.2025.10.001_bib0028","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jnutbio.2005.09.004","article-title":"The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma caco-2 cells by using the mitochondrial pathway","volume":"17","author":"Larrosa","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nutres.2025.10.001_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.106887","article-title":"Effects of the Longan pulp and seed extract beverage product on bone turnover markers, lipid profiles, glycemic markers, and safety profiles in the elderly: a randomized, double-blind, placebo-controlled trial","volume":"129","author":"Na Takuathung","year":"2025","journal-title":"J Funct Foods"},{"key":"10.1016\/j.nutres.2025.10.001_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/5558665","article-title":"Effects of ellagic acid on glucose and lipid metabolism: a systematic review and meta-analysis","volume":"2024","author":"Wang","year":"2024","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.nutres.2025.10.001_bib0031","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cbi.2014.05.011","article-title":"Ellagic acid, an NF-\u03bab inhibitor, ameliorates renal function in experimental diabetic nephropathy","volume":"219","author":"Ahad","year":"2014","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.nutres.2025.10.001_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacme.2015.02.003","article-title":"Cardioprotective effect of ellagic acid on doxorubicin induced cardiotoxicity in Wistar rats","volume":"5","author":"Warpe","year":"2015","journal-title":"J Acute Med"},{"key":"10.1016\/j.nutres.2025.10.001_bib0033","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/advances\/nmab007","article-title":"Neuroprotective potential of ellagic acid: a critical review","volume":"12","author":"Gupta","year":"2021","journal-title":"Adv Nutr"},{"key":"10.1016\/j.nutres.2025.10.001_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131307","article-title":"Complexation of ellagic acid with \u03b1-lactalbumin and its antioxidant property","volume":"372","author":"Diao","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.nutres.2025.10.001_bib0035","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/s41598-018-19732-0","article-title":"Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose","volume":"8","author":"Chen","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.nutres.2025.10.001_bib0036","doi-asserted-by":"crossref","first-page":"104951","DOI":"10.1016\/j.jff.2022.104951","article-title":"Indian gooseberry and barley sprout mixture prevents obesity by regulating adipogenesis, lipogenesis, and lipolysis in C57BL\/6J mice with high-fat diet-induced obesity","volume":"90","author":"Park","year":"2022","journal-title":"J Funct Foods"},{"key":"10.1016\/j.nutres.2025.10.001_bib0037","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jnutbio.2016.02.006","article-title":"Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation","volume":"32","author":"Kang","year":"2016","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nutres.2025.10.001_bib0038","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13753","article-title":"Subclinical hypothyroidism contributes to poor glycemic control in patients with type 2 diabetes mellitus, and ellagic acid attenuates methimazole-induced abnormal glucose metabolism in mice model","volume":"45","author":"Liu","year":"2021","journal-title":"J Food Biochem"},{"key":"10.1016\/j.nutres.2025.10.001_bib0039","first-page":"105","article-title":"Renal protection by ellagic acid in a rat model of glycerol-induced acute kidney injury","volume":"15","author":"Khombi Shooshtari","year":"2024","journal-title":"Vet Res Forum"},{"key":"10.1016\/j.nutres.2025.10.001_bib0040","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s13197-017-2683-8","article-title":"Attenuation of diabetic retinopathy in rats by ellagic acid through inhibition of AGE formation","volume":"54","author":"Raghu","year":"2017","journal-title":"J Food Sci Technol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0041","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Br Med J"},{"key":"10.1016\/j.nutres.2025.10.001_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.nutres.2025.10.001_bib0043","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jclinepi.2020.01.008","article-title":"A full systematic review was completed in 2 weeks using automation tools: a case study","volume":"121","author":"Clark","year":"2020","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0044","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.nutres.2025.10.001_bib0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/0145445516673998","article-title":"Intercoder reliability and validity of WebPlotDigitizer in extracting graphed data","volume":"41","author":"Drevon","year":"2017","journal-title":"Behav Modif"},{"key":"10.1016\/j.nutres.2025.10.001_bib0046","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE\u2019s risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0047","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"Br Med J"},{"key":"10.1016\/j.nutres.2025.10.001_bib0048","author":"Sch\u00fcnemann"},{"key":"10.1016\/j.nutres.2025.10.001_bib0049","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0050","doi-asserted-by":"crossref","unstructured":"Deeks JJ, Higgins JPT, Altman DG, On Behalf of the Cochrane Statistical Methods Group. Analysing data and undertaking meta-analyses. In: Higgins J.P.T., Thomas J., Chandler J., Cumpston M., Li T., Page M.J., et al., editors. Cochrane handbook for systematic reviews of interventions. Wiley Online Library, New York. 2019.","DOI":"10.1002\/9781119536604.ch10"},{"key":"10.1016\/j.nutres.2025.10.001_bib0051","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Br Med J"},{"key":"10.1016\/j.nutres.2025.10.001_bib0052","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1016\/j.sjbs.2020.09.060","article-title":"Antidiabetic effects of novel ellagic acid nanoformulation: insulin-secreting and anti-apoptosis effects","volume":"27","author":"Harakeh","year":"2020","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.nutres.2025.10.001_bib0053","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.phymed.2017.10.014","article-title":"Hybrid drug combination: anti-diabetic treatment of type 2 diabetic Wistar rats with combination of ellagic acid and pioglitazone","volume":"37","author":"Nankar","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.nutres.2025.10.001_bib0054","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2147\/TCRM.S169748","article-title":"Effect of pharmaceutical care interventions on glycemic control in patients with diabetes: a systematic review and meta-analysis","volume":"14","author":"Jeong","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.nutres.2025.10.001_bib0055","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3390\/nu13030804","article-title":"Ellagic acid affects metabolic and transcriptomic profiles and attenuates features of metabolic syndrome in adult male rats","volume":"13","author":"K\u00e1belov\u00e1","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2025.10.001_bib0056","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1507\/endocrj.EJ18-0467","article-title":"Ellagic acid promotes browning of white adipose tissues in high-fat diet-induced obesity in rats through suppressing white adipocyte maintaining genes","volume":"66","author":"Wang","year":"2019","journal-title":"Endocr J"},{"key":"10.1016\/j.nutres.2025.10.001_bib0057","first-page":"251","article-title":"Hypoglycemic and antidiabetic activity of flavonoids: boswellic acid, ellagic acid, quercetin, rutin on streptozotocin-nicotinamide induced type 2 diabetic rats","volume":"4","author":"Jadhav","year":"2012","journal-title":"Int J Pharm Pharm Sci"},{"key":"10.1016\/j.nutres.2025.10.001_bib0058","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1476-5381.2009.00267.x","article-title":"To scale or not to scale: the principles of dose extrapolation","volume":"157","author":"Sharma","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0059","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/ptr.6867","article-title":"Randomized double-blind clinical trial examining the ellagic acid effects on glycemic status, insulin resistance, antioxidant, and inflammatory factors in patients with type 2 diabetes","volume":"35","author":"Ghadimi","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.nutres.2025.10.001_bib0060","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.3390\/jcm11195741","article-title":"Ellagic acid effect on the components of metabolic syndrome, insulin sensitivity and insulin secretion: a randomized, double-blind, placebo-controlled clinical trial","volume":"11","author":"Hidalgo-Lozada","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.nutres.2025.10.001_bib0061","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/13880209.2021.1990969","article-title":"Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK","volume":"60","author":"Altamimi","year":"2022","journal-title":"Pharm Biol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0062","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/FPC.0b013e3283559b22","article-title":"Metformin pathways: pharmacokinetics and pharmacodynamics","volume":"22","author":"Gong","year":"2012","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.nutres.2025.10.001_bib0063","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3892\/etm.2021.10449","article-title":"Ellagic acid inhibits high glucose-induced injury in rat mesangial cells via the PI3K\/Akt\/FOXO3a signaling pathway","volume":"22","author":"Lin","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.nutres.2025.10.001_bib0064","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1111\/jcmm.13259","article-title":"Liraglutide, a human glucagon-like peptide-1 analogue, stimulates AKT-dependent survival signalling and inhibits pancreatic \u03b2-cell apoptosis","volume":"22","author":"Kapodistria","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.nutres.2025.10.001_bib0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/ph15030341","article-title":"Pioglitazone synthetic analogue ameliorates streptozotocin-induced diabetes mellitus through modulation of ACE 2\/angiotensin 1-7 via PI3K\/AKT\/mTOR signaling pathway","volume":"15","author":"Ahmed","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.nutres.2025.10.001_bib0066","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopha.2018.11.018","article-title":"Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223\/keap1-Nrf2 pathway","volume":"110","author":"Ding","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nutres.2025.10.001_bib0067","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12902-023-01291-9","article-title":"Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes?","volume":"23","author":"Khalili","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.nutres.2025.10.001_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104397","article-title":"Ellagic acid protects against diabetic nephropathy in rats by regulating the transcription and activity of Nrf2","volume":"79","author":"Altamimi","year":"2021","journal-title":"J Funct Foods"},{"key":"10.1016\/j.nutres.2025.10.001_bib0069","first-page":"442","article-title":"Type 2 diabetes and its impact on the immune system","volume":"16","author":"Berbudi","year":"2020","journal-title":"Curr Diabetes Rev"},{"key":"10.1016\/j.nutres.2025.10.001_bib0070","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1172\/JCI129188","article-title":"\u03b2 cell dysfunction during progression of metabolic syndrome to type 2 diabetes","volume":"129","author":"Hudish","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nutres.2025.10.001_bib0071","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ctcp.2015.12.003","article-title":"Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: a randomized controlled clinical trial","volume":"22","author":"Hosseini","year":"2016","journal-title":"Complement Ther Clin Pract"},{"key":"10.1016\/j.nutres.2025.10.001_bib0072","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jff.2014.03.028","article-title":"Pomegranate vinegar beverage reduces visceral fat accumulation in association with AMPK activation in overweight women: a double-blind, randomized, and placebo-controlled trial","volume":"8","author":"Park","year":"2014","journal-title":"J Funct Foods"},{"key":"10.1016\/j.nutres.2025.10.001_bib0073","doi-asserted-by":"crossref","first-page":"582","DOI":"10.52547\/koomesh.23.5.582","article-title":"Effects of ellagic acid supplementation on glycemic index and insulin resistance in type 2 diabetics: a double blind randomized clinical trial","volume":"23","author":"Iran","year":"2021","journal-title":"Koomesh"},{"key":"10.1016\/j.nutres.2025.10.001_bib0074","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/nu10050531","article-title":"Ellagic acid alleviates hepatic oxidative stress and insulin resistance in diabetic female rats","volume":"10","author":"Polce","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2025.10.001_bib0075","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.ATV.0000122852.22604.78","article-title":"Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited","volume":"24","author":"Ceriello","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0076","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/978-1-4419-5913-3_55","article-title":"Modeling of ATP-sensitive inward rectifier potassium channel 11 and inhibition mechanism of the natural ligand, ellagic acid, using molecular docking","volume":"680","author":"Mathew","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0077","unstructured":"Hosten A. BUN and creatinine. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK305\/, 1990 (Accessed September 30, 2025)."},{"key":"10.1016\/j.nutres.2025.10.001_bib0078","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fct.2018.10.036","article-title":"Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling","volume":"123","author":"Zhou","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0079","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molimm.2021.08.007","article-title":"Ellagic acid protects rats from chronic renal failure via MiR-182\/FOXO3a axis","volume":"138","author":"Chen","year":"2021","journal-title":"Mol Immunol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12906-023-03907-y","article-title":"Ellagic acid ameliorates aging-induced renal oxidative damage through upregulating SIRT1 and NRF2","volume":"23","author":"Naghibi","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.nutres.2025.10.001_bib0081","doi-asserted-by":"crossref","first-page":"118684","DOI":"10.1016\/j.jep.2024.118684","article-title":"Syzygium cumini (L.) skeels mitigate diabetic nephropathy by regulating Nrf2 pathway and mitocyhondrial dysfunction: in vitro and in vivo studies","volume":"336","author":"Bangar","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0082","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fct.2018.10.036","article-title":"Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling","volume":"123","author":"Zhou","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.nutres.2025.10.001_bib0083","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1039\/C5FO01372K","article-title":"Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats","volume":"7","author":"Raghu","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.nutres.2025.10.001_bib0084","doi-asserted-by":"crossref","first-page":"55","DOI":"10.7897\/2230-8407.080111","article-title":"Ellagic acid ameliorates the progression of nephropathy in streptozotocin induced diabetic rats","volume":"8","author":"Vishwanath","year":"2017","journal-title":"Int Res J Pharm"},{"key":"10.1016\/j.nutres.2025.10.001_bib0085","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/09637486.2020.1830263","article-title":"Metabolites of the ellagitannin, geraniin inhibit human ACE; in vitro and in silico evidence","volume":"72","author":"Looi","year":"2021","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.nutres.2025.10.001_bib0086","article-title":"Therapeutic approaches to slowing the progression of diabetic nephropathy\u2014is less best?","volume":"2013","author":"Vivian","year":"2013","journal-title":"Drugs Context"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531725001253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531725001253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:00:22Z","timestamp":1762444822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531725001253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":86,"alternative-id":["S0271531725001253"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2025.10.001","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ellagic acid as a potential therapeutic agent in metabolic syndrome: A systematic review and meta-analysis of glycemic control markers and kidney function tests in animal and clinical studies","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2025.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}