{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:15:32Z","timestamp":1783160132138,"version":"3.54.6"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["2024NSCQ-MSX0460"],"award-info":[{"award-number":["2024NSCQ-MSX0460"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.nutres.2026.04.012","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:14:10Z","timestamp":1777515250000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Higher dietary isoflavone intake is associated with lower risk of new-onset hypertension: An 18-year national cohort study"],"prefix":"10.1016","volume":"151","author":[{"given":"Lifu","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-6783","authenticated-orcid":false,"family":"Shiwen Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nutres.2026.04.012_bib0001","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.2016.19043","article-title":"Global burden of hypertension and systolic blood pressure of at least 110 to 115 mmHg, 1990-2015","volume":"317","author":"Forouzanfar","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2026.04.012_bib0002","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.nutres.2026.04.012_bib0003","first-page":"1515","article-title":"Majority of people live with uncontrolled hypertension worldwide","volume":"330","author":"Harris","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.nutres.2026.04.012_bib0004","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","article-title":"Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension","volume":"18","author":"Zhou","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0005","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biochi.2020.03.016","article-title":"Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?","volume":"173","author":"Psara","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.nutres.2026.04.012_bib0006","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/HCO.0000000000000532","article-title":"The role of diet for prevention and management of hypertension","volume":"33","author":"Ozemek","year":"2018","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0007","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/HYPERTENSIONAHA.116.08290","article-title":"Gaps in hypertension guidelines in low- and middle-income versus high-income countries: a systematic review","volume":"68","author":"Owolabi","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.nutres.2026.04.012_bib0008","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1093\/eurheartj\/ehad436","article-title":"Vegetarian and vegan diets: benefits and drawbacks","volume":"44","author":"Wang","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.nutres.2026.04.012_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2021.100902","article-title":"Effect of genistein intake on some cardiovascular risk factors: an updated systematic review and meta-analysis","volume":"47","author":"Amerizadeh","year":"2022","journal-title":"Curr Probl Cardiol"},{"issue":"6","key":"10.1016\/j.nutres.2026.04.012_bib0010","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.3390\/ijms22063212","article-title":"Utilization of isoflavones in soybeans for women with menopausal syndrome: an overview","volume":"22","author":"Chen","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nutres.2026.04.012_bib0011","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1210\/en.2007-0245","article-title":"Genistein attenuates the hypertensive effects of dietary NaCl in hypertensive male rats","volume":"148","author":"Cho","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.nutres.2026.04.012_bib0012","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/09637486.2021.1910630","article-title":"Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension","volume":"73","author":"Wang","year":"2022","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.nutres.2026.04.012_bib0013","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/molecules23020368","article-title":"Dietary phytoestrogen intake is inversely associated with hypertension in a cohort of adults living in the mediterranean area","volume":"23","author":"Godos","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.nutres.2026.04.012_bib0014","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/01.hjh.0000125435.28861.d2","article-title":"Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study","volume":"22","author":"Kreijkamp-Kaspers","year":"2004","journal-title":"J Hypertens"},{"key":"10.1016\/j.nutres.2026.04.012_bib0015","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00394-020-02424-9","article-title":"Association between flavonoid intake and risk of hypertension in two cohorts of Australian women: a longitudinal study","volume":"60","author":"Do Rosario","year":"2021","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.nutres.2026.04.012_bib0016","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00394-017-1438-7","article-title":"Dietary polyphenol intake and risk of hypertension in the polish arm of the HAPIEE study","volume":"57","author":"Grosso","year":"2018","journal-title":"Eur J Nutr"},{"issue":"Suppl 1","key":"10.1016\/j.nutres.2026.04.012_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/obr.12119","article-title":"The China health and nutrition survey, 1989-2011","volume":"15","author":"Zhang","year":"2014","journal-title":"Obes Rev"},{"issue":"22","key":"10.1016\/j.nutres.2026.04.012_bib0018","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12933-023-01795-7","article-title":"Positive association of triglyceride-glucose index with new-onset hypertension among adults: a national cohort study in China","volume":"16","author":"Gao","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0019","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.clnu.2021.12.037","article-title":"U-shaped association between dietary copper intake and new-onset hypertension","volume":"41","author":"He","year":"2022","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nutres.2026.04.012_bib0020","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1016\/j.clnu.2021.04.004","article-title":"Inverse association between dietary vitamin A intake and new-onset hypertension","volume":"40","author":"Zhang","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.nutres.2026.04.012_bib0021","doi-asserted-by":"crossref","first-page":"bap024.22","DOI":"10.1093\/database\/bap024","article-title":"Phenol-Explorer: an online comprehensive database on polyphenol contents in foods","volume":"2010","author":"Neveu","year":"2010","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.nutres.2026.04.012_bib0022","unstructured":"United States Department of Agriculture. USDA database for the isoflavone content of selected foods, Release 2.1, http:\/\/www.ars.usda.gov\/nutrientdata\/isoflav; 2023 [accessed 20 September 2023]."},{"key":"10.1016\/j.nutres.2026.04.012_bib0023","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12874-016-0159-6","article-title":"Identification of confounder in epidemiologic data contaminated by measurement error in covariates","volume":"16","author":"Lee","year":"2016","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0024","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyw040","article-title":"Outcome modelling strategies in epidemiology: traditional methods and basic alternatives","volume":"45","author":"Greenland","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"1","key":"10.1016\/j.nutres.2026.04.012_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26599\/1671-5411.2025.01.008","article-title":"Chinese guidelines for the prevention and treatment of hypertension (2024 revision)","volume":"22","author":"Wang","year":"2025","journal-title":"J Geriatr Cardiol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0026","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/nu10010043","article-title":"Soy, soy foods and their role in vegetarian diets","volume":"10","author":"Rizzo","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.nutres.2026.04.012_bib0027","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/jch.12760","article-title":"Dietary total isoflavone intake is associated with lower systolic blood pressure: the coronary artery risk development in young adults (CARDIA) study","volume":"18","author":"Richardson","year":"2016","journal-title":"J Clin Hypertens"},{"key":"10.1016\/j.nutres.2026.04.012_bib0028","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/01.CIR.103.2.258","article-title":"The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17 beta-estradiol","volume":"103","author":"Walker","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.nutres.2026.04.012_bib0029","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejphar.2009.02.015","article-title":"Isoflavone genistein inhibits the angiotensin-converting enzyme and alters the vascular responses to angiotensin I and bradykinin","volume":"607","author":"Montenegro","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112601","article-title":"Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats","volume":"146","author":"Poasakate","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nutres.2026.04.012_bib0031","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1681\/ASN.2016080927","article-title":"Novel paradigms of salt and hypertension","volume":"28","author":"Feng","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0032","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/5584_2016_147","article-title":"Impact of salt intake on the pathogenesis and treatment of hypertension","volume":"956","author":"Rust","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0033","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s12012-022-09765-3","article-title":"Genistein alleviates oxidative stress and inflammation in the hypothalamic paraventricular nucleus by activating the Sirt1\/Nrf2 pathway in high salt-induced hypertension","volume":"22","author":"Niu","year":"2022","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.nutres.2026.04.012_bib0034","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/ijms17040480","article-title":"High salt diet affects renal sodium excretion and err\u03b1 expression","volume":"17","author":"Wang","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nutres.2026.04.012_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4162\/nrp.2021.15.1.1","article-title":"Validation of soy isoflavone intake and its health effects: a review of the development of exposure biomarkers","volume":"1","author":"Jang","year":"2021","journal-title":"Nutr Res Pract"},{"key":"10.1016\/j.nutres.2026.04.012_bib0036","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/GME.0000000000001018","article-title":"The history and basic science development of soy isoflavones","volume":"24","author":"Setchell","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.nutres.2026.04.012_bib0037","article-title":"Significance of soy-based fermented food and their bioactive compounds against obesity, diabetes, and cardiovascular diseases","volume":"20","author":"Dwivedi","year":"2023","journal-title":"Plant Foods Hum Nutr"}],"container-title":["Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531726000539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0271531726000539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T09:18:38Z","timestamp":1783156718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0271531726000539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":37,"alternative-id":["S0271531726000539"],"URL":"https:\/\/doi.org\/10.1016\/j.nutres.2026.04.012","relation":{},"ISSN":["0271-5317"],"issn-type":[{"value":"0271-5317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher dietary isoflavone intake is associated with lower risk of new-onset hypertension: An 18-year national cohort study","name":"articletitle","label":"Article Title"},{"value":"Nutrition Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nutres.2026.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}