{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:17:58Z","timestamp":1766179078291,"version":"3.48.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031905","name":"Caucasus International University","doi-asserted-by":"publisher","award":["12,13"],"award-info":[{"award-number":["12,13"]}],"id":[{"id":"10.13039\/100031905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obesity Pillars"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.obpill.2025.100221","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:57:06Z","timestamp":1762322226000},"page":"100221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Resolution of chronic idiopathic urticaria with setmelanotide in a patient with Bardet-Biedl Syndrome: A case report"],"prefix":"10.1016","volume":"16","author":[{"given":"Kate","family":"Haggerty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7596-4813","authenticated-orcid":false,"given":"Ruth","family":"Abeles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.obpill.2025.100221_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ejhg.2012.115","article-title":"Bardet-biedl syndrome","volume":"21","author":"Forsythe","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.obpill.2025.100221_bib2","series-title":"GeneReviews\u00ae [Internet]","first-page":"1993","article-title":"Bardet-biedl syndrome overview","author":"Forsyth","year":"2003"},{"issue":"4","key":"10.1016\/j.obpill.2025.100221_bib3","first-page":"489","article-title":"Mutations in BBS9 and BBS10 contribute to Bardet-Biedl syndrome in the Canadian population","volume":"86","author":"Billingsley","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1016\/j.obpill.2025.100221_bib4","first-page":"1041","article-title":"A BBSome subunit links ciliogenesis, microtubule stability, and acetylated tubulin levels","volume":"182","author":"Loktev","year":"2008","journal-title":"J Cell Biol"},{"issue":"19","key":"10.1016\/j.obpill.2025.100221_bib5","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1073\/pnas.1210192110","article-title":"Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice","volume":"110","author":"Berbari","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.obpill.2025.100221_bib7","first-page":"351","article-title":"Setmelanotide for treatment of obesity in Bardet-Biedl syndrome: phase 3 trial results","volume":"10","author":"Hagan","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"10.1016\/j.obpill.2025.100221_bib8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa1512693","article-title":"Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist","volume":"375","author":"K\u00fchnen","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.obpill.2025.100221_bib9","first-page":"413","article-title":"Activation of melanocortin type 4 receptor as a therapeutic strategy in chronic inflammation","volume":"61","author":"Getting","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.obpill.2025.100221_bib10","first-page":"102","article-title":"Melanocortin receptors in inflammation and sepsis","volume":"994","author":"Schi\u00f6th","year":"2003","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.obpill.2025.100221_bib11","first-page":"389","article-title":"Functions for proopiomelanocortin-derived peptides in obesity and diabetes","volume":"471","author":"Mountjoy","year":"2015","journal-title":"Biochem J"},{"issue":"5","key":"10.1016\/j.obpill.2025.100221_bib12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2007-0027","article-title":"\u03b1-MSH and related peptides: anti-inflammatory and immunomodulatory properties","volume":"29","author":"Brzoska","year":"2008","journal-title":"Endocr Rev"},{"issue":"8","key":"10.1016\/j.obpill.2025.100221_bib13","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bbi.2008.06.001","article-title":"Anti-inflammatory neuropeptides: a new class of endogenous immunoregulatory agents","volume":"22","author":"Delgado","year":"2008","journal-title":"Brain Behav Immun"},{"issue":"7","key":"10.1016\/j.obpill.2025.100221_bib14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.13397","article-title":"The EAACI\/GA2LEN\/EDF\/WAO guideline for the definition, classification, diagnosis and management of urticaria","volume":"73","author":"Zuberbier","year":"2018","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.obpill.2025.100221_bib15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4168\/aair.2017.9.6.477","article-title":"Chronic spontaneous urticaria: pathogenesis and treatment considerations","volume":"9","author":"Kaplan","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"issue":"1","key":"10.1016\/j.obpill.2025.100221_bib16","first-page":"1","article-title":"The orphan nuclear receptor NR4A2 induces Foxp3 and regulates differentiation of CD4+ T cells","volume":"10","author":"Ichiyama","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.obpill.2025.100221_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3892\/br.2021.1479","article-title":"A case of Bardet\u2013Biedl syndrome caused by a recurrent variant in BBS12: a case report","volume":"15","author":"Foc\u015fa","year":"2021","journal-title":"Biomed Rep"},{"issue":"4","key":"10.1016\/j.obpill.2025.100221_bib18","first-page":"23","article-title":"A diagnostic conundrum in Bardet\u2013Biedl syndrome: when genetic diagnosis precedes clinical diagnosis","volume":"2023","author":"Van Roy","year":"2023","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"2","key":"10.1016\/j.obpill.2025.100221_bib19","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050785","article-title":"Bardet\u2013biedl syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance","volume":"22","author":"Tsyklauri","year":"2021","journal-title":"EMBO Rep"},{"key":"10.1016\/j.obpill.2025.100221_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/TCRM.S338653","article-title":"Bardet-biedl syndrome: current perspectives and clinical outlook","volume":"19","author":"Melluso","year":"2023","journal-title":"Therapeut Clin Risk Manag"},{"issue":"12","key":"10.1016\/j.obpill.2025.100221_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.13183","article-title":"Variant reclassification over time decreases the level of diagnostic uncertainty in monogenic obesity: experience from two centres","volume":"19","author":"Morandi","year":"2024","journal-title":"Pediatr Obes"},{"issue":"1","key":"10.1016\/j.obpill.2025.100221_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s13679-024-00601-z","article-title":"Defining hyperphagia for improved diagnosis and management of MC4R pathway\u2013associated disease: a roundtable summary","volume":"14","author":"Heymsfield","year":"2025","journal-title":"Curr Obes Rep"},{"year":"2022","series-title":"Substantial burden associated with hyperphagia and obesity in children with Bardet-Biedl syndrome: analysis of CRIBBS registry data","author":"Haws","key":"10.1016\/j.obpill.2025.100221_bib23"},{"key":"10.1016\/j.obpill.2025.100221_bib24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3389\/fimmu.2019.00627","article-title":"Autoimmune chronic spontaneous urticaria","volume":"10","author":"Kolkhir","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.obpill.2025.100221_bib25","article-title":"Combined therapy of severe obesity in patients with Bardet-Biedl syndrome","author":"Mouw","year":"2025","journal-title":"ASMBS Annual Meeting Abstracts"},{"issue":"3","key":"10.1016\/j.obpill.2025.100221_bib26","doi-asserted-by":"crossref","first-page":"E528","DOI":"10.1210\/jc.2010-2290","article-title":"Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance","volume":"96","author":"Feuillan","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.obpill.2025.100221_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cmet.2006.01.006","article-title":"A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance","volume":"3","author":"Lee","year":"2006","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.obpill.2025.100221_bib28","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/jmedgenet-2018-105315","article-title":"Genetic obesity: next-generation sequencing results of 123 patients with obesity","volume":"55","author":"Kleinendorst","year":"2018","journal-title":"J Med Genet"},{"issue":"11","key":"10.1016\/j.obpill.2025.100221_bib29","first-page":"4421","article-title":"Mutational analysis of the pro-opiomelanocortin gene in a large cohort of severely Obese children: identification and functional analysis of novel variants","volume":"93","author":"Dubern","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.obpill.2025.100221_bib30","first-page":"e229","article-title":"Genetic characterization of childhood obesity and severe insulin resistance in a consanguineous Indian cohort","volume":"108","author":"Shah","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.obpill.2025.100221_bib31","first-page":"1094","article-title":"Rare variants in the melanocortin 4 receptor gene (MC4R) contribute to severe early-onset obesity in a Norwegian population","volume":"25","author":"Nordang","year":"2017","journal-title":"Obesity"},{"key":"10.1016\/j.obpill.2025.100221_bib32","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/ijd.14412","article-title":"Cutaneous findings in Bardet-Biedl syndrome","volume":"58","author":"Haws","year":"2019","journal-title":"Int J Dermatol"},{"year":"2023","series-title":"Setmelanotide (Imcivree): CADTH Reimbursement review: therapeutic area: bardet-biedl syndrome","key":"10.1016\/j.obpill.2025.100221_bib33"}],"container-title":["Obesity Pillars"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667368125000658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667368125000658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:14:04Z","timestamp":1766178844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667368125000658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"alternative-id":["S2667368125000658"],"URL":"https:\/\/doi.org\/10.1016\/j.obpill.2025.100221","relation":{},"ISSN":["2667-3681"],"issn-type":[{"type":"print","value":"2667-3681"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolution of chronic idiopathic urticaria with setmelanotide in a patient with Bardet-Biedl Syndrome: A case report","name":"articletitle","label":"Article Title"},{"value":"Obesity Pillars","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.obpill.2025.100221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Obesity Medicine Association.","name":"copyright","label":"Copyright"}],"article-number":"100221"}}