{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:07:21Z","timestamp":1791518841674,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006380","name":"Rehabilitation Research and Development Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["oarsiopenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage Open"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ocarto.2020.100066","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T23:37:17Z","timestamp":1587166637000},"page":"100066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of OA development between sexes in the rat medial meniscal transection model"],"prefix":"10.1016","volume":"2","author":[{"given":"Krishna A.","family":"Pucha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"McKinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Willett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ocarto.2020.100066_bib1","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull. World Health Organ."},{"issue":"6","key":"10.1016\/j.ocarto.2020.100066_bib2","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2020.100066_bib3","series-title":"WHO | Chronic Rheumatic Conditions [Internet]","author":"Anonymous","year":"2016"},{"issue":"9","key":"10.1016\/j.ocarto.2020.100066_bib4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2005.04.014","article-title":"A\u00a0meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis","volume":"13","author":"Srikanth","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.ocarto.2020.100066_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis. Part III: changes in evidence following systematic cumulative update of research published through January 2009","volume":"18","author":"Zhang","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s002560000320","article-title":"Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging","volume":"30","author":"Faber","year":"2001","journal-title":"Skeletal Radiol."},{"issue":"6","key":"10.1016\/j.ocarto.2020.100066_bib7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/art.37926","article-title":"Relationship of bone mineral density to progression of knee osteoarthritis","volume":"65","author":"Lee","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2020.100066_bib8","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1016\/j.joca.2016.01.240","article-title":"Gender difference in knee joint loading: cross-sectional study in normal geriatric population","volume":"24","author":"Ro","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.ocarto.2020.100066_bib9","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.jbiomech.2015.05.016","article-title":"Sex differences in knee loading in recreational runners","volume":"48","author":"Sinclair","year":"2015","journal-title":"J.\u00a0Biomech."},{"issue":"4","key":"10.1016\/j.ocarto.2020.100066_bib10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.joca.2004.12.003","article-title":"Human articular chondrocytes exhibit sexual dimorphism in their responses to 17\u03b2-estradiol","volume":"13","author":"Kinney","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.ocarto.2020.100066_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1297-319X(03)00067-8","article-title":"Estrogens, cartilage, and osteoarthritis","volume":"70","author":"Richette","year":"2003","journal-title":"Jt. Bone Spine"},{"issue":"8","key":"10.1016\/j.ocarto.2020.100066_bib12","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.joca.2016.04.008","article-title":"Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men","volume":"24","author":"Hussain","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.ocarto.2020.100066_bib13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.mehy.2005.02.026","article-title":"Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects","volume":"65","author":"Teichtahl","year":"2005","journal-title":"Med. Hypotheses"},{"issue":"8","key":"10.1016\/j.ocarto.2020.100066_bib14","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/art.1780380817","article-title":"Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization","volume":"38","author":"Oliveria","year":"1995","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.ocarto.2020.100066_bib15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/BF03346664","article-title":"Serum concentrations of selected endogenous estrogen and estrogen metabolites in pre- and postmenopausal Chinese women with osteoarthritis","volume":"33","author":"Gao","year":"2010","journal-title":"J.\u00a0Endocrinol. Invest."},{"issue":"10","key":"10.1016\/j.ocarto.2020.100066_bib16","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1002\/art.22138","article-title":"Effect of hormone therapy on risk of hip and knee joint replacement in the women's health initiative","volume":"54","author":"Cirillo","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-5122(00)00118-3","article-title":"Menopause, oestrogens and arthritis","volume":"35","author":"Wluka","year":"2000","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.ocarto.2020.100066_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13075-015-0747-6","article-title":"On the predictive utility of animal models of osteoarthritis","volume":"17","author":"Malfait","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"9","key":"10.1016\/j.ocarto.2020.100066_bib19","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/jbmr.5650110904","article-title":"Osteoarthritis in cynomolgus macaques III: effects of age, gender, and subchondral bone thickness on the severity of disease","volume":"11","author":"Carlson","year":"2009","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.ocarto.2020.100066_bib20","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J.\u00a0Musculoskelet. Neuronal Interact."},{"issue":"6","key":"10.1016\/j.ocarto.2020.100066_bib21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/ard.53.6.406","article-title":"Animal models for osteoarthritis: processes, problems and prospects","volume":"53","author":"Pritzker","year":"1994","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.ocarto.2020.100066_bib22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/0300985815588611","article-title":"Animal models of osteoarthritis: comparisons and key considerations","volume":"52","author":"McCoy","year":"2015","journal-title":"Vet. Pathol."},{"issue":"1","key":"10.1016\/j.ocarto.2020.100066_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13018-016-0346-5","article-title":"Animal models of osteoarthritis: classification, update, and measurement of outcomes","volume":"11","author":"Kuyinu","year":"2016","journal-title":"J.\u00a0Orthop. Surg. Res."},{"issue":"6","key":"10.1016\/j.ocarto.2020.100066_bib24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2020.100066_bib25","doi-asserted-by":"crossref","first-page":"42294","DOI":"10.1038\/srep42294","article-title":"Age-dependent changes in the articular cartilage and subchondral bone of C57BL\/6 mice after surgical destabilization of medial meniscus","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.ocarto.2020.100066_bib26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.joca.2019.11.003","article-title":"Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis","volume":"28","author":"Temp","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"51","key":"10.1016\/j.ocarto.2020.100066_bib27","doi-asserted-by":"crossref","first-page":"19255","DOI":"10.1073\/pnas.0606406103","article-title":"Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography","volume":"103","author":"Palmer","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.ocarto.2020.100066_bib28","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.joca.2013.05.018","article-title":"Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration","volume":"21","author":"Thote","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2020.100066_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.joca.2017.10.017","article-title":"Contrast enhanced \u03bcCT imaging of early articular changes in a pre-clinical model of osteoarthritis","volume":"26","author":"Reece","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2020.100066_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/ar4476","article-title":"Intra-articular injection of micronized dehydrated human amnion\/chorion membrane attenuates osteoarthritis development","volume":"16","author":"Willett","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","article-title":"Osteophytes: relevance and biology","volume":"15","author":"van der Kraan","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1053\/joca.1998.0200","article-title":"Gender differences in knee cartilage volume as measured by magnetic resonance imaging","volume":"7","author":"Cicuttini","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1063-4584(05)80088-3","article-title":"Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences","volume":"1","author":"van Osch","year":"1993","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/joca.1998.0186","article-title":"Osteophyte formation in osteoarthritis","volume":"7","author":"Van Den Berg","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.ocarto.2020.100066_bib35","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/BRS.0b013e3181df1a70","article-title":"Mechanical function of vertebral body osteophytes, as revealed by experiments on cadaveric spines","volume":"36","author":"Al-Rawahi","year":"2011","journal-title":"Spine"},{"key":"10.1016\/j.ocarto.2020.100066_bib36","doi-asserted-by":"crossref","first-page":"S305","DOI":"10.1016\/j.joca.2017.02.513","article-title":"Osteophyte Formation and the effect of mechanical loading: comparisons to fracture healing","volume":"25","author":"Hsia","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2020.100066_bib37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1359\/jbmr.2003.18.1.150","article-title":"The structural and hormonal basis of sex differences in peak appendicular bone strength in rats","volume":"18","author":"Kim","year":"2003","journal-title":"J.\u00a0Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.7547\/0940315","article-title":"Radiography of soft tissue of the foot and ankle with diffraction enhanced imaging","volume":"94","author":"Li","year":"2004","journal-title":"J.\u00a0Am. Podiatr. Med. Assoc."},{"issue":"3","key":"10.1016\/j.ocarto.2020.100066_bib39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bcp.2011.09.018","article-title":"Subchondral bone as a key target for osteoarthritis treatment","volume":"83","author":"Casta\u00f1eda","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"21","key":"10.1016\/j.ocarto.2020.100066_bib40","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.4103\/0366-6999.168045","article-title":"Dynamic alterations in microarchitecture, mineralization and mechanical property of subchondral bone in rat medial meniscal tear model of osteoarthritis","volume":"128","author":"Yu","year":"2015","journal-title":"Chin. Med. J."}],"container-title":["Osteoarthritis and Cartilage Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913120300558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913120300558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:19:53Z","timestamp":1762939193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665913120300558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S2665913120300558"],"URL":"https:\/\/doi.org\/10.1016\/j.ocarto.2020.100066","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/769521","asserted-by":"object"}]},"ISSN":["2665-9131"],"issn-type":[{"value":"2665-9131","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of OA development between sexes in the rat medial meniscal transection model","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ocarto.2020.100066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI).","name":"copyright","label":"Copyright"}],"article-number":"100066"}}