{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:55:22Z","timestamp":1791197722927,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","oarsiopenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage Open"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ocarto.2022.100331","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T12:42:13Z","timestamp":1671712933000},"page":"100331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-6334","authenticated-orcid":false,"given":"Michelle S.","family":"Yau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helgi","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-2741","authenticated-orcid":false,"given":"John A.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-5796","authenticated-orcid":false,"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Torner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Felson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ocarto.2022.100331_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/NOR.0b013e31824fcd42","article-title":"The impact of osteoarthritis in the United States: a population-health perspective: a population-based review of the fourth most common cause of hospitalization in U.S. adults","volume":"31","author":"Murphy","year":"2012","journal-title":"Orthop. Nurs."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/art.23177","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I","volume":"58","author":"Helmick","year":"2008","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.23176","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II","volume":"58","author":"Lawrence","year":"2008","journal-title":"Arthritis Rheumatol."},{"issue":"9","key":"10.1016\/j.ocarto.2022.100331_bib4","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P","article-title":"Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines","volume":"43","year":"2000","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ocarto.2022.100331_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1478-7954-4-11","article-title":"The burden of disease and injury in the United States 1996","volume":"4","author":"Michaud","year":"2006","journal-title":"Popul. Health Metrics"},{"issue":"4751","key":"10.1016\/j.ocarto.2022.100331_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/bmj.1.4751.181","article-title":"Generalized osteoarthritis and Heberden's nodes","volume":"1","author":"Kellgren","year":"1952","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/ard.55.1.25","article-title":"Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset","volume":"55","author":"Hirsch","year":"1996","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E","article-title":"Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study","volume":"42","author":"Hart","year":"1999","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.ocarto.2022.100331_bib9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/art.20035","article-title":"Association of radiographic hand osteoarthritis with radiographic knee osteoarthritis after meniscectomy","volume":"50","author":"Englund","year":"2004","journal-title":"Arthritis Rheumatol."},{"issue":"11","key":"10.1016\/j.ocarto.2022.100331_bib10","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1002\/art.21375","article-title":"Does hand osteoarthritis predict future hip or knee osteoarthritis?","volume":"52","author":"Dahaghin","year":"2005","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"10.1016\/j.ocarto.2022.100331_bib11","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3899\/jrheum.091154","article-title":"Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips: the Johnston County Osteoarthritis Project","volume":"37","author":"Sayre","year":"2010","journal-title":"J.\u00a0Rheumatol."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3899\/jrheum.110603","article-title":"Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative","volume":"39","author":"Haugen","year":"2012","journal-title":"J.\u00a0Rheumatol."},{"issue":"8","key":"10.1016\/j.ocarto.2022.100331_bib13","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/1529-0131(199908)42:8<1729::AID-ANR23>3.0.CO;2-H","article-title":"Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine","volume":"42","author":"Bijkerk","year":"1999","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.ocarto.2022.100331_bib14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/annrheumdis-2012-202461","article-title":"Clustering of hand osteoarthritis progression and its relationship to progression of osteoarthritis at the knee","volume":"73","author":"Bijsterbosch","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.ocarto.2022.100331_bib15","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/1529-0131(199806)41:6<1064::AID-ART13>3.0.CO;2-K","article-title":"Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study","volume":"41","author":"Felson","year":"1998","journal-title":"Arthritis Rheumatol."},{"issue":"7","key":"10.1016\/j.ocarto.2022.100331_bib16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/sj.ejhg.5201829","article-title":"Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis","volume":"15","author":"Min","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib17","first-page":"13","article-title":"Prognostic factors of progression of osteoarthritis of the knee: a systematic review of observational studies","volume":"57","author":"Belo","year":"2007","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.joca.2012.09.012","article-title":"Osteoarthritis as a disease of mechanics","volume":"21","author":"Felson","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib19","first-page":"1","article-title":"Etiopathogenesis of osteoarthritis","volume":"93","author":"Brandt","year":"2009","journal-title":"Med. Clin."},{"issue":"4","key":"10.1016\/j.ocarto.2022.100331_bib20","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0950-3579(97)80003-9","article-title":"Understanding the relationship between body weight and osteoarthritis","volume":"11","author":"Felson","year":"1997","journal-title":"Bailliere\u2019s Clin. Rheumatol."},{"issue":"3","key":"10.1016\/j.ocarto.2022.100331_bib21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/art.41520","article-title":"Familial clustering of erosive hand osteoarthritis in a large statewide cohort","volume":"73","author":"Kazmers","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"8","key":"10.1016\/j.ocarto.2022.100331_bib22","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1002\/art.21218","article-title":"Pain elsewhere\" and the impact of knee pain in older people","volume":"52","author":"Croft","year":"2005","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.ocarto.2022.100331_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jbspin.2010.09.024","article-title":"Prevalence of generalized osteoarthritis in a population with knee osteoarthritis","volume":"78","author":"Forestier","year":"2011","journal-title":"Joint Bone Spine"},{"issue":"8","key":"10.1016\/j.ocarto.2022.100331_bib24","first-page":"647","article-title":"The Multicenter Osteoarthritis Study: opportunities for rehabilitation research","volume":"5","author":"Segal","year":"2013","journal-title":"Pharm. Manag. PM R"},{"issue":"3","key":"10.1016\/j.ocarto.2022.100331_bib25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.pain.2005.05.002","article-title":"Sex differences in musculoskeletal pain in older adults","volume":"116","author":"Leveille","year":"2005","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.ocarto.2022.100331_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3899\/jrheum.160853","article-title":"The effect of widespread pain on knee pain worsening, incident knee osteoarthritis (OA), and incident knee pain: the multicenter OA (MOST) study","volume":"44","author":"Carlesso","year":"2017","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.ocarto.2022.100331_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2474-13-20","article-title":"The use of digital photographs for the diagnosis of hand osteoarthritis: the AGES-Reykjavik study","volume":"13","author":"Jonsson","year":"2012","journal-title":"BMC Muscoskel. Disord."},{"issue":"10","key":"10.1016\/j.ocarto.2022.100331_bib28","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.joca.2017.05.019","article-title":"Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study","volume":"25","author":"Crema","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.ocarto.2022.100331_bib29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.semarthrit.2013.12.007","article-title":"Generalized osteoarthritis\": a systematic review","volume":"43","author":"Nelson","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"issue":"8340","key":"10.1016\/j.ocarto.2022.100331_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0140-6736(83)90003-X","article-title":"Influence of primary generalised osteoarthritis on development of secondary osteoarthritis","volume":"2","author":"Doherty","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.ocarto.2022.100331_bib31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13075-016-0939-8","article-title":"Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins","volume":"18","author":"Skousgaard","year":"2016","journal-title":"Arthritis Res. Ther."},{"issue":"4","key":"10.1016\/j.ocarto.2022.100331_bib32","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.joca.2018.12.018","article-title":"Nature vs nurture in knee osteoarthritis - the importance of age, sex and body mass index","volume":"27","author":"Magnusson","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"10.1016\/j.ocarto.2022.100331_bib33","first-page":"895","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J.\u00a0Pain"},{"issue":"6","key":"10.1016\/j.ocarto.2022.100331_bib34","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/acr.23086","article-title":"Knee pain and structural damage as risk factors for incident widespread pain: data from the multicenter osteoarthritis study","volume":"69","author":"Carlesso","year":"2017","journal-title":"Arthritis Care Res."},{"issue":"1","key":"10.1016\/j.ocarto.2022.100331_bib35","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/s12891-017-1870-0","article-title":"Age related prevalence of hand osteoarthritis diagnosed by photography (HOASCORE)","volume":"18","author":"Jonsson","year":"2017","journal-title":"BMC Muscoskel. Disord."}],"container-title":["Osteoarthritis and Cartilage Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913122000991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913122000991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:59:12Z","timestamp":1790888352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665913122000991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2665913122000991"],"URL":"https:\/\/doi.org\/10.1016\/j.ocarto.2022.100331","relation":{},"ISSN":["2665-9131"],"issn-type":[{"value":"2665-9131","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ocarto.2022.100331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI).","name":"copyright","label":"Copyright"}],"article-number":"100331"}}