{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:40:30Z","timestamp":1790206830192,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["oarsiopenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage Open"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ocarto.2024.100467","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T15:58:31Z","timestamp":1712591911000},"page":"100467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-9867","authenticated-orcid":false,"given":"Carlos J.","family":"Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-3066","authenticated-orcid":false,"given":"Taylor D.","family":"Yeater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-6902","authenticated-orcid":false,"given":"Jacob L.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-9148","authenticated-orcid":false,"given":"Kyle D.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ocarto.2024.100467_bib1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2024.100467_bib2","doi-asserted-by":"crossref","unstructured":"Courties A, Sellam J, Berenbaum F. Role of the autonomic nervous system in osteoarthritis. Best Pract. Res. Clin. Rheumatol. Published online 2017. https:\/\/doi.org\/10.1016\/j.berh.2018.04.001.","DOI":"10.1016\/j.berh.2018.04.001"},{"key":"10.1016\/j.ocarto.2024.100467_bib3","doi-asserted-by":"crossref","unstructured":"Berenbaum F, Meng QJ. The brain-joint axis in osteoarthritis: Nerves, circadian clocks and beyond. Nat. Rev. Rheumatol. Published online 2016. 10.1038\/nrrheum.2016.93.","DOI":"10.1038\/nrrheum.2016.93"},{"key":"10.1016\/j.ocarto.2024.100467_bib4","doi-asserted-by":"crossref","unstructured":"Schaible HG. Nociceptive neurons detect cytokines in arthritis. Arthritis Res. Ther. Published online 2014. https:\/\/doi.org\/10.1186\/s13075-014-0470-8.","DOI":"10.1186\/s13075-014-0470-8"},{"key":"10.1016\/j.ocarto.2024.100467_bib5","doi-asserted-by":"crossref","unstructured":"Miller RJ, Malfait AM, Miller RE. The innate immune response as a mediator of osteoarthritis pain. Osteoarthritis Cartilage. Published online 2020. https:\/\/doi.org\/10.1016\/j.joca.2019.11.006.","DOI":"10.1016\/j.joca.2019.11.006"},{"key":"10.1016\/j.ocarto.2024.100467_bib6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2008.05.004","article-title":"A\u00a0comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain","volume":"1219","author":"Romero-Sandoval","year":"2008","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.ocarto.2024.100467_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11926-018-0716-6","article-title":"Peripheral mechanisms contributing to osteoarthritis pain","volume":"20","author":"Syx","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.ocarto.2024.100467_bib8","doi-asserted-by":"crossref","unstructured":"Kwok CHT, Kohro Y, Mousseau M, et\u00a0al. Role of primary afferents in arthritis induced spinal Microglial reactivity. Front. Immunol. Published online 2021. https:\/\/doi.org\/10.3389\/fimmu.2021.626884.","DOI":"10.3389\/fimmu.2021.626884"},{"key":"10.1016\/j.ocarto.2024.100467_bib9","doi-asserted-by":"crossref","unstructured":"Yeater TD, Cruz CJ, Cruz-Almeida Y, Allen KD. Autonomic nervous system dysregulation and osteoarthritis pain: mechanisms, measurement, and future outlook. Curr. Rheumatol. Rep. Published online April 2022. https:\/\/doi.org\/10.1007\/s11926-022-01071-9.","DOI":"10.1007\/s11926-022-01071-9"},{"key":"10.1016\/j.ocarto.2024.100467_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/24705470211030273","article-title":"Chronic pain is associated with reduced sympathetic nervous system reactivity during simple and complex walking tasks: potential cerebral mechanisms","volume":"5","author":"Yeater","year":"2021","journal-title":"Chronic Stress"},{"issue":"4","key":"10.1016\/j.ocarto.2024.100467_bib11","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.joca.2021.12.008","article-title":"Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat","volume":"30","author":"Yeater","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-immunol-042718-041812","article-title":"Neuro\u2013immune cell units: a new paradigm in physiology","volume":"37","author":"Godinho-Silva","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ocarto.2024.100467_bib13","doi-asserted-by":"crossref","unstructured":"Tracey KJ. The inflammatory reflex. Nature. Published online 2002. https:\/\/doi.org\/10.1038\/nature01321.","DOI":"10.1038\/nature01321"},{"key":"10.1016\/j.ocarto.2024.100467_bib14","doi-asserted-by":"crossref","unstructured":"Komegae EN, Farmer DGS, Brooks VL, McKinley MJ, McAllen RM, Martelli D. Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway. Brain Behav. Immun. Published online 2018. https:\/\/doi.org\/10.1016\/j.bbi.2018.06.005.","DOI":"10.1016\/j.bbi.2018.06.005"},{"key":"10.1016\/j.ocarto.2024.100467_bib15","doi-asserted-by":"crossref","unstructured":"De Herdt V, Puimege L, De Waele J, et\u00a0al. Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve. J. Neuroimmunol. Published online 2009. https:\/\/doi.org\/10.1016\/j.jneuroim.2009.04.013.","DOI":"10.1016\/j.jneuroim.2009.04.013"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.immunol.20.082401.104914","article-title":"Neuroendocrine regulation of immunity","volume":"20","author":"Webster","year":"2002","journal-title":"Annu. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.ocarto.2024.100467_bib17","doi-asserted-by":"crossref","first-page":"3035 LP","DOI":"10.2337\/diacare.26.11.3035","article-title":"Influence of autonomic nervous system dysfunction on the development of type 2 diabetes","volume":"26","author":"Carnethon","year":"2003","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.semarthrit.2019.01.005","article-title":"Type 2 diabetes mellitus and osteoarthritis","volume":"49","author":"Veronese","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.ocarto.2024.100467_bib19","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1161\/CIRCRESAHA.114.302524","article-title":"The autonomic nervous system and hypertension","volume":"114","author":"Mancia","year":"2014","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.ocarto.2024.100467_bib20","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/HYPERTENSIONAHA.118.11550","article-title":"Aging alters the relative contributions of the sympathetic and parasympathetic nervous system to blood pressure control in women","volume":"72","author":"Baker","year":"2018","journal-title":"Hypertension"},{"issue":"32","key":"10.1016\/j.ocarto.2024.100467_bib21","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007584","article-title":"Association between hypertension and risk of knee osteoarthritis: a meta-analysis of observational studies","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine"},{"issue":"7","key":"10.1016\/j.ocarto.2024.100467_bib22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/obr.12173","article-title":"Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons \u2013 a scoping review","volume":"15","author":"Bliddal","year":"2014","journal-title":"Obes. Rev."},{"key":"10.1016\/j.ocarto.2024.100467_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.autneu.2015.07.424","article-title":"Impact of obesity on autonomic modulation, heart rate and blood pressure in obese young people","volume":"193","author":"Rossi","year":"2015","journal-title":"Auton. Neurosci."},{"issue":"2","key":"10.1016\/j.ocarto.2024.100467_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10787-011-0118-0","article-title":"Obesity and knee osteoarthritis","volume":"20","author":"Lee","year":"2012","journal-title":"Inflammopharmacology"},{"issue":"11","key":"10.1016\/j.ocarto.2024.100467_bib25","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.joca.2019.07.005","article-title":"Physical inactivity and knee osteoarthritis in Guinea pigs","volume":"27","author":"Wallace","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.ocarto.2024.100467_bib26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2519\/jospt.2018.0507","article-title":"Exercise is essential for osteoarthritis: the many benefits of physical activity","volume":"48","year":"2018","journal-title":"Journal of Orthopaedic & Sports Physical Therapy"},{"key":"10.1016\/j.ocarto.2024.100467_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.autneu.2014.10.012","article-title":"Autonomic responses to exercise: deconditioning\/inactivity","volume":"188","author":"Hughson","year":"2015","journal-title":"Autonomic Neuroscience"},{"issue":"2","key":"10.1016\/j.ocarto.2024.100467_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00019501-200003000-00007","article-title":"Exercise and autonomic function","volume":"11","author":"Goldsmith","year":"2000","journal-title":"Coron Artery Dis."},{"issue":"3","key":"10.1016\/j.ocarto.2024.100467_bib29","first-page":"CC11","article-title":"Age related changes in autonomic functions","volume":"10","author":"Parashar","year":"2016","journal-title":"J\u00a0Clin Diagn Res"},{"issue":"7","key":"10.1016\/j.ocarto.2024.100467_bib30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.ocarto.2024.100467_bib31","article-title":"Effect of transcutaneous vagus nerve stimulation in erosive hand osteoarthritis: results from a pilot trial","volume":"11","author":"Courties","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.ocarto.2024.100467_bib32","doi-asserted-by":"crossref","unstructured":"Cruz CJ, Dewberry LS, Otto KJ, Allen KD. Neuromodulation as a potential disease-modifying therapy for osteoarthritis. Curr Rheumatol Rep. Published online November 2022. https:\/\/doi.org\/10.1007\/s11926-022-01094-2.","DOI":"10.1007\/s11926-022-01094-2"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20010311","article-title":"Transcutaneous vagal stimulation in knee osteoarthritis (TRAVKO): protocol of a superiority, outcome assessor- and participant-blind, randomised controlled trial","volume":"20","author":"Bascour-Sandoval","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-45908-4","article-title":"Exploring the impact of integrated polyvagal exercises and knee reinforcement in females with grade II knee osteoarthritis: a randomized controlled trial","volume":"13","author":"Rizvi","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000531626","article-title":"Role of vagus nerve stimulation in the treatment of chronic pain","volume":"30","author":"Shao","year":"2023","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.ocarto.2024.100467_bib36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fnins.2019.00877","article-title":"An effective method for acute vagus nerve stimulation in experimental inflammation","volume":"13","author":"Caravaca","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.ocarto.2024.100467_bib37","doi-asserted-by":"crossref","unstructured":"Van Maanen MA, Lebre MC, Van Der Poll T, et\u00a0al. Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum. Published online 2009. https:\/\/doi.org\/10.1002\/art.24177.","DOI":"10.1002\/art.24177"},{"key":"10.1016\/j.ocarto.2024.100467_bib38","doi-asserted-by":"crossref","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. Published online 1994. https:\/\/doi.org\/10.1016\/0165-0270(94)90144-9.","DOI":"10.1016\/0165-0270(94)90144-9"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib39","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1038\/s41598-018-28134-1","article-title":"The open source GAITOR suite for rodent gait analysis","volume":"8","author":"Jacobs","year":"2018","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ocarto.2024.100467_bib40","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10439-016-1717-0","article-title":"Automated gait analysis through hues and areas (AGATHA): a method to characterize the spatiotemporal pattern of rat gait","volume":"45","author":"Kloefkorn","year":"2017","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.ocarto.2024.100467_bib41","doi-asserted-by":"crossref","unstructured":"Jacobs BY, Kloefkorn HE, Allen KD. Gait analysis methods for rodent models of osteoarthritis. Curr Pain Headache Rep. Published online 2014. https:\/\/doi.org\/10.1007\/s11916-014-0456-x.","DOI":"10.1007\/s11916-014-0456-x"},{"issue":"12","key":"10.1016\/j.ocarto.2024.100467_bib42","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1002\/jor.25306","article-title":"Age alters gait compensations following meniscal injury in male rats","volume":"40","author":"Chan","year":"2022","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1016\/j.ocarto.2024.100467_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gaitpost.2018.04.023","article-title":"Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis","volume":"63","author":"Lakes","year":"2018","journal-title":"Gait Posture"},{"issue":"11","key":"10.1016\/j.ocarto.2024.100467_bib44","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.joca.2016.03.008","article-title":"Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations","volume":"24","author":"Lakes","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.joca.2018.09.005","article-title":"A\u00a0graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open-source tool for histological grading","volume":"27","author":"Kloefkorn","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.ocarto.2024.100467_bib47","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology."},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jneumeth.2009.12.002","article-title":"Technique for collection of cerebrospinal fluid from the cisterna magna in rat","volume":"187","author":"Pegg","year":"2010","journal-title":"J\u00a0Neurosci Methods"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13075-015-0791-2","article-title":"Spatiotemporal gait compensations following medial collateral ligament and medial meniscus injury in the rat: correlating gait patterns to joint damage","volume":"17","author":"Kloefkorn","year":"2015","journal-title":"Arthritis Res Ther."},{"issue":"5","key":"10.1016\/j.ocarto.2024.100467_bib50","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.joca.2016.12.012","article-title":"Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis","volume":"25","author":"Jacobs","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib51","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-019-1544-y","article-title":"Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation","volume":"16","author":"Kobrzycka","year":"2019","journal-title":"J\u00a0Neuroinflammation"},{"issue":"2","key":"10.1016\/j.ocarto.2024.100467_bib52","doi-asserted-by":"crossref","first-page":"F155","DOI":"10.1152\/ajprenal.00201.2020","article-title":"Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus","volume":"319","author":"Pham","year":"2020","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"10.1016\/j.ocarto.2024.100467_bib53","doi-asserted-by":"crossref","unstructured":"Provan SA, Olstad DS, Solberg EE, Smedslund G, Dagfinrud H. Evidence of reduced parasympathetic autonomic regulation in inflammatory joint disease: a meta-analyses study. Semin Arthritis Rheum. Published online 2018. https:\/\/doi.org\/10.1016\/j.semarthrit.2017.11.010.","DOI":"10.1016\/j.semarthrit.2017.11.010"},{"issue":"17","key":"10.1016\/j.ocarto.2024.100467_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23179851","article-title":"Unilateral cervical vagotomy modulates immune cell profiles and the response to a traumatic brain injury","volume":"23","author":"Newell-Rogers","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ocarto.2024.100467_bib57","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbi.2017.04.003","article-title":"Modulation of experimental arthritis by vagal sensory and central brain stimulation","volume":"64","author":"Bassi","year":"2017","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-013-9752-4","article-title":"Control of bone remodeling by the peripheral sympathetic nervous system","volume":"94","author":"Elefteriou","year":"2014","journal-title":"Calcif Tissue Int"},{"issue":"Pt A","key":"10.1016\/j.ocarto.2024.100467_bib56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2018.02.013","article-title":"Cortical stimulation in conscious rats controls joint inflammation","volume":"84","author":"Bassi","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.ocarto.2024.100467_bib58","doi-asserted-by":"crossref","unstructured":"Lorenz J, Sch\u00e4fer N, Bauer R, Jenei-Lanzl Z, Springorum RH, Gr\u00e4ssel S. Norepinephrine modulates osteoarthritic chondrocyte metabolism and inflammatory responses. Osteoarthritis Cartilage. Published online 2016. https:\/\/doi.org\/10.1016\/j.joca.2015.08.007.","DOI":"10.1016\/j.joca.2015.08.007"},{"issue":"1","key":"10.1016\/j.ocarto.2024.100467_bib59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13075-022-02966-9","article-title":"Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner","volume":"25","author":"Yeater","year":"2023","journal-title":"Arthritis Res Ther"}],"container-title":["Osteoarthritis and Cartilage Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913124000347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913124000347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T10:39:27Z","timestamp":1715855967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665913124000347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2665913124000347"],"URL":"https:\/\/doi.org\/10.1016\/j.ocarto.2024.100467","relation":{},"ISSN":["2665-9131"],"issn-type":[{"value":"2665-9131","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ocarto.2024.100467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI).","name":"copyright","label":"Copyright"}],"article-number":"100467"}}