{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:01:26Z","timestamp":1784001686308,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["328657"],"award-info":[{"award-number":["328657"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006133","name":"Anders Jahres Fond til Vitenskapens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008570","name":"Dr Trygve Gythfeldt og Frues Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["oarsiopenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage Open"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ocarto.2024.100558","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T23:19:54Z","timestamp":1734218394000},"page":"100558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis"],"prefix":"10.1016","volume":"7","author":[{"given":"Alexander","family":"Mathiessen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Gaundal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Sj\u00f8lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-4255","authenticated-orcid":false,"given":"Pernille","family":"Steen Pettersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Slatkowsky-Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-2216","authenticated-orcid":false,"given":"Ida Kristin","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ocarto.2024.100558_bib1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.joca.2015.11.014","article-title":"Synovitis and radiographic progression in non-erosive and erosive hand osteoarthritis: is erosive hand osteoarthritis a separate inflammatory phenotype?","volume":"24","author":"Haugen","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ocarto.2024.100558_bib2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1136\/ard.2011.150078","article-title":"Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study","volume":"70","author":"Haugen","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/annrheumdis-2011-200341","article-title":"Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis","volume":"71","author":"Haugen","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/annrheumdis-2014-206829","article-title":"Increasing synovitis and bone marrow lesions are associated with incident joint tenderness in hand osteoarthritis","volume":"75","author":"Haugen","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/annrheumdis-2015-207241","article-title":"Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5 years","volume":"75","author":"Mathiessen","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/annrheumdis-2014-205949","article-title":"MRI findings predict radiographic progression and development of erosions in hand osteoarthritis","volume":"75","author":"Haugen","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/annrheumdis-2018-213826","article-title":"2018 update of the EULAR recommendations for the management of hand osteoarthritis","volume":"78","author":"Kloppenburg","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib8","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ocarto.2024.100558_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/acr.24131","article-title":"2019 American College of Rheumatology\/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.ocarto.2024.100558_bib10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/rheumatology\/kes386","article-title":"Ash ZR, Conaghan PG. Methotrexate for pain relief in knee osteoarthritis: an open-label study","volume":"52","author":"Wenham","year":"2013","journal-title":"Rheumatology"},{"issue":"Suppl II","key":"10.1016\/j.ocarto.2024.100558_bib11","first-page":"402","article-title":"Methotrexate in the treatment of erosive OA of the hands [abstract]","volume":"65","author":"Pavelka","year":"2006","journal-title":"Ann. Rheum. Dis."},{"issue":"Suppl 10","key":"10.1016\/j.ocarto.2024.100558_bib12","article-title":"Significant pain reduction with oral methotrexate in knee osteoarthritis; results from a randomised controlled phase III trial of treatment effectiveness [abstract]","volume":"70","author":"Kingsbury","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ocarto.2024.100558_bib13","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/S0140-6736(23)01572-6","article-title":"Methotrexate to treat hand osteoarthritis with synovitis (METHODS): an Australian, multisite, parallel-group, double-blind, randomised, placebo-controlled trial","volume":"402","author":"Wang","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ocarto.2024.100558_bib14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.semarthrit.2021.04.016","article-title":"Methotrexate treatment in hand osteoarthritis refractory to usual treatments: a randomised, double-blind, placebo-controlled trial","volume":"51","author":"Ferrero","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2024.100558_bib15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3899\/jrheum.130738","article-title":"Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis","volume":"41","author":"Shea","year":"2014","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.ocarto.2024.100558_bib16","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.1780331101","article-title":"The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand","volume":"33","author":"Altman","year":"1990","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2024.100558_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/art.1780340502","article-title":"The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip","volume":"34","author":"Altman","year":"1991","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2024.100558_bib18","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2024.100558_bib19","series-title":"Eular Handbook of Clinical Assessments in Rheumatoid Arthritis: on Behalf of the EULAR Standing Committee for International Clinical Studies Including Therapeutic Trials - ESCISIT","author":"van Riel","year":"2000"},{"key":"10.1016\/j.ocarto.2024.100558_bib20","first-page":"321","article-title":"Grip strength as measured by the Jamar dynamometer","volume":"51","author":"Schmidt","year":"1970","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.ocarto.2024.100558_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2021.100198","article-title":"Study protocol for the follow-up examination of the Nor-Hand study: a hospital-based observational cohort study exploring pain and biomarkers in people with hand osteoarthritis","volume":"3","author":"Gl\u00f8ersen","year":"2021","journal-title":"Osteoarthr. Cartil. Open"},{"key":"10.1016\/j.ocarto.2024.100558_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016938","article-title":"A\u00a0hospital-based observational cohort study exploring pain and biomarkers in patients with hand osteoarthritis in Norway: the Nor-Hand protocol","volume":"7","author":"Gl\u00f8ersen","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.ocarto.2024.100558_bib23","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.joca.2007.06.004","article-title":"A\u00a0systematic search and narrative review of radiographic definitions of hand osteoarthritis in population-based studies","volume":"16","author":"Marshall","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl A","key":"10.1016\/j.ocarto.2024.100558_bib25","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.joca.2006.11.009","article-title":"Atlas of individual radiographic features in osteoarthritis, revised","volume":"15","author":"Altman","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ocarto.2024.100558_bib26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/art.1780390221","article-title":"Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints","volume":"39","author":"Verbruggen","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ocarto.2024.100558_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/ard.2007.077081","article-title":"The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis","volume":"67","author":"Keen","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib28","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/annrheumdis-2014-206774","article-title":"An OMERACT reliability exercise of inflammatory and structural abnormalities in patients with knee osteoarthritis using ultrasound assessment","volume":"75","author":"Bruyn","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3899\/jrheum.131086","article-title":"Iterative development and reliability of the OMERACT hand osteoarthritis MRI scoring system","volume":"41","author":"Haugen","year":"2014","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.ocarto.2024.100558_bib30","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3899\/jrheum.161099","article-title":"Development and reliability of the OMERACT thumb base osteoarthritis magnetic resonance imaging scoring system","volume":"44","author":"Kroon","year":"2017","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.ocarto.2024.100558_bib31","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1136\/annrheumdis-2018-213202","article-title":"Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"77","author":"Kloppenburg","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ocarto.2024.100558_bib32","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(19)32489-4","article-title":"Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial","volume":"394","author":"Kroon","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ocarto.2024.100558_bib33","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3899\/jrheum.081316","article-title":"Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Altman","year":"2009","journal-title":"J.\u00a0Rheumatol."},{"key":"10.1016\/j.ocarto.2024.100558_bib34","first-page":"589","article-title":"Efficacy and tolerability of lumiracoxib versus placebo in patients with osteoarthritis of the hand","volume":"22","author":"Grifka","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.ocarto.2024.100558_bib35","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1002\/art.30574","article-title":"Symptomatic effect of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled trial at single center","volume":"63","author":"Gabay","year":"2011","journal-title":"Arthritis Rheum."}],"container-title":["Osteoarthritis and Cartilage Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913124001250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665913124001250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:10:15Z","timestamp":1762636215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665913124001250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2665913124001250"],"URL":"https:\/\/doi.org\/10.1016\/j.ocarto.2024.100558","relation":{},"ISSN":["2665-9131"],"issn-type":[{"value":"2665-9131","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ocarto.2024.100558","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI).","name":"copyright","label":"Copyright"}],"article-number":"100558"}}