{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:14:46Z","timestamp":1790014486244,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["DOAC14\/19\/092"],"award-info":[{"award-number":["DOAC14\/19\/092"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["DOA\/2023\/02"],"award-info":[{"award-number":["DOA\/2023\/02"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/20\/117"],"award-info":[{"award-number":["C14\/20\/117"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","oarsiopenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage Open"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ocarto.2026.100866","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:33:49Z","timestamp":1787985229000},"page":"100866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["SHIP2 deletion in cartilage does not modulate osteoarthritis in male mice"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-3208","authenticated-orcid":false,"given":"Ana Victoria","family":"Rojo-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4144-5861","authenticated-orcid":false,"given":"Frederique M.F.","family":"Cornelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-6578","authenticated-orcid":false,"given":"Leire","family":"Casas-Fraile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Schurmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-6270","authenticated-orcid":false,"given":"Silvia","family":"Monteagudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-3092","authenticated-orcid":false,"given":"Rik J.","family":"Lories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ocarto.2026.100866_bib1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.ocarto.2026.100866_bib2","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.joca.2024.07.014","article-title":"Osteoarthritis year in review 2024: epidemiology and therapy","volume":"32","author":"Courties","year":"2024","journal-title":"Osteoarthr. Cartil."},{"issue":"9991","key":"10.1016\/j.ocarto.2026.100866_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ocarto.2026.100866_bib4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/annrheumdis-2013-204111","article-title":"The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?","volume":"73","author":"Karsdal","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.ocarto.2026.100866_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/jhg.2016.119","article-title":"INPPL1 gene mutations in opsismodysplasia","volume":"62","author":"Fradet","year":"2017","journal-title":"J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ajhg.2012.11.015","article-title":"Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia","volume":"92","author":"Huber","year":"2013","journal-title":"Am. J. Hum. Genet."},{"issue":"11","key":"10.1016\/j.ocarto.2026.100866_bib7","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.cellsig.2012.06.012","article-title":"Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse","volume":"24","author":"Dubois","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ocarto.2026.100866_bib8","article-title":"Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1\/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia","volume":"76","author":"Vande Catsyne","year":"2020","journal-title":"Adv. Bio. Regul."},{"issue":"9","key":"10.1016\/j.ocarto.2026.100866_bib9","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ocarto.2026.100866_bib10","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"10","key":"10.1016\/j.ocarto.2026.100866_bib11","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.joca.2024.05.006","article-title":"A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis","volume":"32","author":"Obeidat","year":"2024","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/ard.2010.134619","article-title":"GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes","volume":"70","author":"Daans","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.ocarto.2026.100866_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.joca.2018.11.008","article-title":"Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice","volume":"27","author":"Cornelis","year":"2019","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.ocarto.2026.100866_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.joca.2014.10.010","article-title":"Loss of frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis","volume":"23","author":"Thysen","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.ocarto.2026.100866_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/ar4405","article-title":"Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes","volume":"15","author":"Li","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/nyas.13930","article-title":"Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy","volume":"1442","author":"Singh","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nyas.12091","article-title":"Role of SHIP1 in bone biology","volume":"1280","author":"Iyer","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.ocarto.2026.100866_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/cbic.201600541","article-title":"SHIP2: structure, function and inhibition","volume":"18","author":"Thomas","year":"2017","journal-title":"Chembiochem"},{"issue":"9","key":"10.1016\/j.ocarto.2026.100866_bib20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1089\/scd.2014.0501","article-title":"SHIP1-Expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging","volume":"24","author":"Iyer","year":"2015","journal-title":"Stem Cell. Dev."},{"issue":"19","key":"10.1016\/j.ocarto.2026.100866_bib21","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1089\/scd.2014.0122","article-title":"SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K\/Akt\/\u03b2-Catenin\/Id2 axis","volume":"23","author":"Iyer","year":"2014","journal-title":"Stem Cell. Dev."},{"issue":"2","key":"10.1016\/j.ocarto.2026.100866_bib22","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/jcp.29063","article-title":"Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development","volume":"235","author":"So","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.ocarto.2026.100866_bib23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MCD.0000000000000136","article-title":"Novel compound heterozygous mutations in inositol polyphosphate phosphatase-like 1 in a family with severe opsismodysplasia","volume":"25","author":"Feist","year":"2016","journal-title":"Clin. Dysmorphol."},{"issue":"9","key":"10.1016\/j.ocarto.2026.100866_bib24","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/ajmg.a.36640","article-title":"Opsismodysplasia resulting from an insertion mutation in the SH2 domain, which destabilizes INPPL1","volume":"164","author":"Li","year":"2014","journal-title":"American J of Med Genetics Pt A"},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-021-00147-z","article-title":"Subchondral bone microenvironment in osteoarthritis and pain","volume":"9","author":"Hu","year":"2021","journal-title":"Bone Res."},{"issue":"14","key":"10.1016\/j.ocarto.2026.100866_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo7868","article-title":"Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis pro","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci Adv"},{"issue":"8","key":"10.1016\/j.ocarto.2026.100866_bib27","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/art.39174","article-title":"Down-regulation of rac GTPase-Activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development","volume":"67","author":"Zhu","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ocarto.2026.100866_bib28","first-page":"285","article-title":"Role of sex hormone in the pathogenesis of osteoarthrosis of mice","volume":"12","author":"Silberberg","year":"1963","journal-title":"Lab. Invest."},{"issue":"6","key":"10.1016\/j.ocarto.2026.100866_bib29","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.ocarto.2026.100866_bib30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.joca.2012.05.006","article-title":"Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and Discord between hip and knee OA","volume":"20","author":"Xu","year":"2012","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41413-020-00109-x","article-title":"Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas","volume":"8","author":"Yuan","year":"2020","journal-title":"Bone Res."},{"issue":"6","key":"10.1016\/j.ocarto.2026.100866_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199734","article-title":"A whole-genome transcriptome analysis of articular chondrocytes in secondary osteoarthritis of the hip","volume":"13","author":"Aki","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ocarto.2026.100866_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/dvg.22734","article-title":"Generation of a mouse line harboring a bi-transgene expressing luciferase and tamoxifen-activatable creERT2 recombinase in cartilage","volume":"52","author":"Cascio","year":"2014","journal-title":"Genesis"},{"issue":"2","key":"10.1016\/j.ocarto.2026.100866_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/joca.2002.0873","article-title":"Osteophyte development--molecular characterization of differentiation stages","volume":"11","author":"Gelse","year":"2003","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.ocarto.2026.100866_bib35","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)42806-2","article-title":"Aggrecan core protein is expressed in membranous bone of the chick embryo. Molecular and biomechanical studies of normal and nanomelia embryos","volume":"267","author":"Wong","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ocarto.2026.100866_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.30802\/AALAS-CM-21-000043","article-title":"Mouse models of osteoarthritis: a summary of models and outcomes assessment","volume":"72","author":"Drevet","year":"2022","journal-title":"Comp. Med."}],"container-title":["Osteoarthritis and Cartilage Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266591312600124X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266591312600124X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:40:39Z","timestamp":1790012439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266591312600124X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S266591312600124X"],"URL":"https:\/\/doi.org\/10.1016\/j.ocarto.2026.100866","relation":{},"ISSN":["2665-9131"],"issn-type":[{"value":"2665-9131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SHIP2 deletion in cartilage does not modulate osteoarthritis in male mice","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ocarto.2026.100866","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI).","name":"copyright","label":"Copyright"}],"article-number":"100866"}}