{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:26:17Z","timestamp":1792664777169,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","orthopedic.theclinics.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Orthopedic Clinics of North America"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ocl.2015.09.002","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T19:15:32Z","timestamp":1452107732000},"page":"335-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Thromboembolic Disease After Orthopedic Trauma"],"prefix":"10.1016","volume":"47","author":[{"given":"Paul S.","family":"Whiting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Alex","family":"Jahangir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/TA.0b013e3182984a9b","article-title":"Uncontrolled hemorrhagic shock results in a hypercoagulable state modulated by initial fluid resuscitation regimens","volume":"75","author":"Riha","year":"2013","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.surg.2011.12.022","article-title":"Quantification of hypercoagulable state after blunt trauma: microparticle and thrombin generation are increased relative to injury severity, while standard markers are not","volume":"151","author":"Park","year":"2012","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.thromres.2010.10.018","article-title":"Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism","volume":"127","author":"Owen","year":"2011","journal-title":"Thromb Res"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib4","first-page":"578","article-title":"The 'procoagulopathy' of trauma: too much, too late?","volume":"19","author":"Holley","year":"2013","journal-title":"Curr Opin Crit Care"},{"issue":"24","key":"10.1016\/j.ocl.2015.09.002_bib5","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1056\/NEJM199412153312401","article-title":"A\u00a0prospective study of venous thromboembolism after major trauma","volume":"331","author":"Geerts","year":"1994","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.ocl.2015.09.002_bib6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archsurg.1993.01420170107016","article-title":"The epidemiology of traumatic death. A population-based analysis","volume":"128","author":"Shackford","year":"1993","journal-title":"Arch Surg"},{"issue":"2","key":"10.1016\/j.ocl.2015.09.002_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2106\/JBJS.D.02932","article-title":"Prophylaxis against deep-vein thrombosis following trauma: a prospective, randomized comparison of mechanical and pharmacologic prophylaxis","volume":"88","author":"Stannard","year":"2006","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"3","key":"10.1016\/j.ocl.2015.09.002_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008303.pub2","article-title":"Thromboprophylaxis for trauma patients","author":"Barrera","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.ocl.2015.09.002_bib9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.amjsurg.2013.12.010","article-title":"A\u00a0retrospective analysis of the effectiveness of low molecular weight heparin for venous thromboembolism prophylaxis in trauma patients","volume":"207","author":"Gritsiouk","year":"2014","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005131-199502000-00001","article-title":"Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomized study of compression alone versus no prophylaxis","volume":"9","author":"Fisher","year":"1995","journal-title":"J\u00a0Orthop Trauma"},{"issue":"2 suppl","key":"10.1016\/j.ocl.2015.09.002_bib11","doi-asserted-by":"crossref","first-page":"e278S","DOI":"10.1378\/chest.11-2404","article-title":"American College of Chest Physicians: prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Falck-Ytter","year":"2012","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib12","first-page":"142","article-title":"Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group","volume":"53","author":"Rogers","year":"2002","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.ocl.2015.09.002_bib13","unstructured":"Sagi HC, Ciesla D, Collinge C, et\u00a0al. Orthopedic Trauma Association Evidence Based Quality Value and Safety Committee: synopsis of current practice patterns and a suggested evidence-based therapeutic algorithm for venous thromboembolism prophylaxis in orthopaedic trauma patients. Presented at Orthopaedic Trauma Association Annual Meeting. Minneapolis, October 3\u20136, 2012."},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.injury.2009.06.010","article-title":"Trauma registry of DGU. Venous thromboembolism after severe trauma: incidence, risk factors and outcome","volume":"41","author":"Paffrath","year":"2010","journal-title":"Injury"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib15","first-page":"748","article-title":"Pulmonary embolism in major trauma patients","volume":"30","author":"O'Malley","year":"1990","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib16","first-page":"90","article-title":"Statewide, population-based, time-series analysis of the frequency and outcome of pulmonary embolus in 318,554 trauma patients","volume":"42","author":"Tuttle-Newhall","year":"1997","journal-title":"J\u00a0Trauma"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib17","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.3928\/01477447-20140528-50","article-title":"Multiple lower-extremity and pelvic fractures increase pulmonary embolus risk","volume":"37","author":"Godzik","year":"2014","journal-title":"Orthopedics"},{"issue":"7","key":"10.1016\/j.ocl.2015.09.002_bib18","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1302\/0301-620X.87B7.15989","article-title":"Deep-vein thrombosis in high-energy skeletal trauma despite thromboprophylaxis","volume":"87","author":"Stannard","year":"2005","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"10","key":"10.1016\/j.ocl.2015.09.002_bib19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199609053351003","article-title":"A\u00a0comparison of\u00a0low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma","volume":"335","author":"Geerts","year":"1996","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.ocl.2015.09.002_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.7326\/0003-4819-159-4-201308200-00008","article-title":"Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review","volume":"159","author":"Adam","year":"2013","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.ocl.2015.09.002_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11239-013-1046-1","article-title":"Efficacy and safety of rivaroxaban versus low-molecular-weight heparin therapy in patients with lower limb fractures","volume":"38","author":"Long","year":"2014","journal-title":"J\u00a0Thromb Thrombolysis"},{"issue":"5","key":"10.1016\/j.ocl.2015.09.002_bib22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1538-7836.2012.04701.x","article-title":"Semuloparin for prevention of venous thromboembolism after major orthopedic surgery: results from three randomized clinical trials, SAVE-HIP1, SAVE-HIP2 and SAVEKNEE","volume":"10","author":"Lassen","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"issue":"suppl 1","key":"10.1016\/j.ocl.2015.09.002_bib23","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1097\/BOT.0000000000000061","article-title":"Treatment and complications in orthopaedic trauma patients with symptomatic pulmonary embolism","volume":"28","author":"Bogdan","year":"2014","journal-title":"J\u00a0Orthop Trauma"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5435\/JAAOS-23-01-1","article-title":"Venous thromboembolism in orthopaedic trauma","volume":"23","author":"Scolaro","year":"2015","journal-title":"J\u00a0Am Acad Orthop Surg"},{"issue":"3","key":"10.1016\/j.ocl.2015.09.002_bib25","first-page":"557","article-title":"The practice of venous thromboembolism prophylaxis in the major trauma patient","volume":"62","author":"Nathens","year":"2007","journal-title":"J\u00a0Trauma"},{"issue":"5","key":"10.1016\/j.ocl.2015.09.002_bib26","first-page":"E33","article-title":"Caring for the polytrauma patient: is your system surviving or thriving?","volume":"42","author":"Stinner","year":"2013","journal-title":"Am J Orthop (Belle Mead NJ)"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib27","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1097\/TA.0b013e31825ac49e","article-title":"A\u00a0randomized, double-blinded, placebo controlled pilot trial of anticoagulation in low-risk traumatic brain injury: the Delayed Versus Early Enoxaparin Prophylaxis I (DEEP I) study","volume":"73","author":"Phelan","year":"2012","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.ocl.2015.09.002_bib28","series-title":"Venous thromboembolism prophylaxis in orthopedic surgery","author":"Sobieraj","year":"2012"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004318.pub2","article-title":"Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery","author":"Rasmussen","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib30","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.clinthera.2009.06.002","article-title":"Extended thromboprophylaxis with low-molecular-weight heparins after hospital discharge in high-risk surgical and medical patients: a review","volume":"31","author":"Huo","year":"2009","journal-title":"Clin Ther"},{"issue":"2","key":"10.1016\/j.ocl.2015.09.002_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006212.pub4","article-title":"Vena caval filters for the prevention of pulmonary embolism","author":"Young","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.ocl.2015.09.002_bib32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/CIRCULATIONAHA.104.512834","article-title":"Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d'Embolie Pulmonaire par Interruption Cave) randomized study","volume":"112","author":"PREPIC Study Group","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11239-010-0544-7","article-title":"Pulmonary embolism prophylaxis with inferior vena cava filters in trauma patients: a systematic review using the meta-analysis of observational studies in epidemiology (MOOSE) guidelines","volume":"32","author":"Rajasekhar","year":"2011","journal-title":"J\u00a0Thromb Thrombolysis"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000098","article-title":"An economic evaluation of venous thromboembolism prophylaxis strategies in critically ill trauma patients at risk of bleeding","volume":"6","author":"Chiasson","year":"2009","journal-title":"PLoS Med"},{"issue":"7","key":"10.1016\/j.ocl.2015.09.002_bib35","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2106\/00004623-200107000-00010","article-title":"Mechanical prophylaxis against deep-vein thrombosis after pelvic and acetabular fractures","volume":"83-A","author":"Stannard","year":"2001","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"5","key":"10.1016\/j.ocl.2015.09.002_bib36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/BOT.0b013e3181a5369c","article-title":"A\u00a0systematic review of thromboprophylaxis for pelvic and acetabular fractures","volume":"23","author":"Slobogean","year":"2009","journal-title":"J\u00a0Orthop Trauma"},{"issue":"4","key":"10.1016\/j.ocl.2015.09.002_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006681.pub3","article-title":"Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization","author":"Testroote","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.ocl.2015.09.002_bib38","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0049-3848(02)00059-2","article-title":"Low molecular weight heparin (Innohep) as thromboprophylaxis in outpatients with a plaster cast: a venographic controlled study","volume":"105","author":"J\u00f8rgensen","year":"2002","journal-title":"Thromb Res"},{"issue":"5","key":"10.1016\/j.ocl.2015.09.002_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/107110070202300507","article-title":"Incidence of DVT following surgery\u00a0of the foot and ankle","volume":"23","author":"Solis","year":"2002","journal-title":"Foot Ankle Int"},{"issue":"10","key":"10.1016\/j.ocl.2015.09.002_bib40","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1302\/0301-620X.89B10.19241","article-title":"Incidence of deep-vein thrombosis in patients with fractures of the ankle treated in a plaster cast","volume":"89","author":"Patil","year":"2007","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/j.jfas.2011.10.017","article-title":"Incidence of acute deep vein thrombosis and pulmonary embolism in foot and ankle trauma: analysis of the National Trauma Data Bank","volume":"51","author":"Shibuya","year":"2012","journal-title":"J\u00a0Foot Ankle Surg"},{"issue":"3","key":"10.1016\/j.ocl.2015.09.002_bib42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1302\/0301-620X.91B3.20820","article-title":"Prophylaxis of deep-vein thrombosis in fractures below the knee: a prospective randomised controlled trial","volume":"91","author":"Goel","year":"2009","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"10","key":"10.1016\/j.ocl.2015.09.002_bib43","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.2106\/JBJS.M.00236","article-title":"Symptomatic venous thromboembolism uncommon without thromboprophylaxis after isolated lower-limb fracture: the knee-to-ankle fracture (KAF) cohort study","volume":"96","author":"Selby","year":"2014","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.ocl.2015.09.002_bib44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00402-010-1094-3","article-title":"Is upper extremity trauma an independent risk factor for lower extremity venous thromboembolism? An 11-year experience at a level I trauma center","volume":"131","author":"Hsu","year":"2011","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"10.1016\/j.ocl.2015.09.002_bib45","first-page":"273","article-title":"Hazards of benchmarking complications with the National Trauma Data Bank: numerators in search of denominators","volume":"64","author":"Kardooni","year":"2008","journal-title":"J\u00a0Trauma"}],"container-title":["Orthopedic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030589815001601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030589815001601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T05:54:04Z","timestamp":1537077244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0030589815001601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0030589815001601"],"URL":"https:\/\/doi.org\/10.1016\/j.ocl.2015.09.002","relation":{},"ISSN":["0030-5898"],"issn-type":[{"value":"0030-5898","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thromboembolic Disease After Orthopedic Trauma","name":"articletitle","label":"Article Title"},{"value":"Orthopedic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ocl.2015.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}