{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:02:09Z","timestamp":1759881729772,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.oftal.2019.01.013","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T22:03:01Z","timestamp":1553032981000},"page":"263-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Desarrollo y optimizaci\u00f3n de un modelo animal para el estudio de las c\u00e9lulas ganglionares en enfermedad degenerativa de la retina y nervio \u00f3ptico"],"prefix":"10.1016","volume":"94","author":[{"given":"A.","family":"Feliciano-Sanchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Garc\u00eda-Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cubas-Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Castillo-Villalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fuentes-Maestre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gil-Perotin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Garc\u00eda-Verdugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oftal.2019.01.013_bib0180","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/377150a0","article-title":"A genetic basis for familial aggregation in multiple sclerosis","volume":"337","author":"Ebers","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.oftal.2019.01.013_bib0185","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0165-5728(02)00215-1","article-title":"The HLA locus and multiple sclerosis in Spain Role in disease susceptibility, clinical course and response to interferon","volume":"130","author":"Villoslada","year":"2002","journal-title":"B J Neuroimmunol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0190","first-page":"1066","article-title":"HLA and multiple sclerosis. Studies of a spanish population [Article in Spanish]","volume":"31","author":"Ur\u00eda","year":"2000","journal-title":"Rev Neurol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0195","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0025-7753(15)30003-8","article-title":"Multiple sclerosis? socioeconomic effects and impact on quality of life","volume":"143","author":"Ayuso","year":"2014","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.oftal.2019.01.013_bib0200","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(98)03334-0","article-title":"Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing\/remitting multiple sclerosis","volume":"352","author":"Ebers","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.oftal.2019.01.013_bib0205","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.410390304","article-title":"Intramuscular Interferon Beta-la for Disease Progression in Relapsing Multiple Sclerosis","volume":"39","author":"Jacobs","year":"1996","journal-title":"Am Neurol Assoc"},{"key":"10.1016\/j.oftal.2019.01.013_bib0210","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jns.2006.08.019","article-title":"Combination therapy in multiple sclerosis","volume":"259","author":"Fern\u00e1ndez","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.oftal.2019.01.013_bib0215","first-page":"423","article-title":"Experimental allergic encephalomyelitis (EAE) in mice I. Induction of EAE with mouse spinal cord homogenate and myelin basic protein","volume":"45","author":"Yasuda","year":"1975","journal-title":"Jpn J Exp Med"},{"key":"10.1016\/j.oftal.2019.01.013_bib0220","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.4049\/jimmunol.114.5.1537","article-title":"Experimental autoimmune encephalomyelitis in mice: Immunologic response to mouse spinal cord and myelin basic proteins","volume":"114","author":"Bernard","year":"1975","journal-title":"J Immunol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0225","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1084\/jem.90.3.213","article-title":"Experimental disseminated encephalomyelitisin white mice","volume":"90","author":"Olitsky","year":"1949","journal-title":"J Exp Med"},{"key":"10.1016\/j.oftal.2019.01.013_bib0230","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2015.03.042","article-title":"Animals models of multiple sclerosis","volume":"759","author":"Procaccini","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-10-120","article-title":"Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model","volume":"10","author":"Horstmann","year":"2013","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.oftal.2019.01.013_bib0240","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12974-018-1208-3","article-title":"Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model","volume":"15","author":"Wilmes","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.oftal.2019.01.013_bib0245","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/978-1-60761-720-4_19","article-title":"Mouse Models of Multiple Sclerosis: Experimental autoinmune Encephalomyelitis and Theiler's virus-Induced Demyelinating Disease","volume":"900","author":"McCarthy","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0250","doi-asserted-by":"crossref","first-page":"e7754","DOI":"10.1371\/journal.pone.0007754","article-title":"What is the optimal value of the g-ratio for myelinated fibers in the rat CNS? A theoretical approach","volume":"4","author":"Chomiak","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.oftal.2019.01.013_bib0255","doi-asserted-by":"crossref","first-page":"E9685","DOI":"10.1073\/pnas.1714183114","article-title":"Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function","volume":"114","author":"Duncan","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.oftal.2019.01.013_bib0260","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/08916939809003872","article-title":"Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein","volume":"28","author":"Slavin","year":"1998","journal-title":"Autoimmunity"},{"key":"10.1016\/j.oftal.2019.01.013_bib0265","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2005.03.022","article-title":"Differential expression of protease M \/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis","volume":"382","author":"Terayama","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.oftal.2019.01.013_bib0270","first-page":"339","article-title":"Mouse Models of Multiple Sclerosis","volume":"102","author":"Fuller","year":"2004","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.oftal.2019.01.013_bib0275","first-page":"162","article-title":"Generaci\u00f3n de un modelo murino de encefalomielitis autoinmune experimental cr\u00f3nico progresivo para estudios de farmacolog\u00eda molecular en esclerosis m\u00faltiple","volume":"29","author":"Mac\u00edas-Cosme","year":"2012","journal-title":"Biotecnol Apl"},{"key":"10.1016\/j.oftal.2019.01.013_bib0280","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/1352458506070629","article-title":"Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis","volume":"12","author":"Shindler","year":"2006","journal-title":"Mult Scler"},{"key":"10.1016\/j.oftal.2019.01.013_bib0285","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.exer.2008.05.017","article-title":"Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis","volume":"87","author":"Shindler","year":"2008","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.oftal.2019.01.013_bib0355","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2202-8-19","article-title":"Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice","volume":"8","author":"Li","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.oftal.2019.01.013_bib0360","first-page":"2002","article-title":"Retinal Ganglion Cell Death After Different Transient Periods of Pressure-Induced Ischemia and Survival Intervals A Quantitative In Vivo Study","volume":"37","author":"Selles-Navarro","year":"1996","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"10.1016\/j.oftal.2019.01.013_bib0290","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/cne.10411","article-title":"Ultrastructure of retinal ganglion cell death after axotomy in chick embryos","volume":"453","author":"Borsello","year":"2002","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0295","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.exer.2011.02.008","article-title":"Axotomy-induced retinal ganglion cell death in adult mice: Quantitative and topographic time course analyses","volume":"92","author":"Galindo-Romero","year":"2011","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.oftal.2019.01.013_bib0300","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2006.05.019","article-title":"Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice","volume":"178","author":"Guan","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0305","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.nbd.2011.09.008","article-title":"Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?","volume":"45","author":"Vo\u00df","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.oftal.2019.01.013_bib0310","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1750-3639.1998.tb00170.x","article-title":"Microvascular and cellular responses in the retina of rats with acute experimental allergic encephalomyelitis (EAE)","volume":"8","author":"Hu","year":"1998","journal-title":"Brain Pathol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0315","first-page":"256","article-title":"Experimental allergic encephalomyelitis I. Optic nerve and central nervous system manifestations","volume":"21","author":"Hayreh","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oftal.2019.01.013_bib0320","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1742-2094-10-120","article-title":"Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model","volume":"10","author":"Horstmann","year":"2013","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.oftal.2019.01.013_bib0325","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/09273948.2011.628432","article-title":"C. Genetics of immunological and inflammatory components in age-related macular degeneration","volume":"20","author":"Tuo","year":"2012","journal-title":"Ocul Immunol Inflamm"},{"issue":"Suppl 1","key":"10.1016\/j.oftal.2019.01.013_bib0330","first-page":"S9","article-title":"The interplay between the immune and central nervous systems in neuronal injury","volume":"74","author":"Yong","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.oftal.2019.01.013_bib0335","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1189\/jlb.0207114","article-title":"Microglia activation in retinal degeneration","volume":"81","author":"Langmann","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.oftal.2019.01.013_bib0340","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/brain\/113.5.1477","article-title":"Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications","volume":"113","author":"Kermode","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.oftal.2019.01.013_bib0345","first-page":"602","article-title":"Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis","volume":"16","author":"Motulsky","year":"2010","journal-title":"Mol Vis"},{"key":"10.1016\/j.oftal.2019.01.013_bib0350","doi-asserted-by":"crossref","first-page":"e7507","DOI":"10.1371\/journal.pone.0007507","article-title":"Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography","volume":"4","author":"Fischer","year":"2009","journal-title":"PLoS One"}],"container-title":["Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365669119300450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365669119300450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:43:24Z","timestamp":1759794204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365669119300450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0365669119300450"],"URL":"https:\/\/doi.org\/10.1016\/j.oftal.2019.01.013","relation":{},"ISSN":["0365-6691"],"issn-type":[{"type":"print","value":"0365-6691"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Desarrollo y optimizaci\u00f3n de un modelo animal para el estudio de las c\u00e9lulas ganglionares en enfermedad degenerativa de la retina y nervio \u00f3ptico","name":"articletitle","label":"Article Title"},{"value":"Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oftal.2019.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Sociedad Espa\u00f1ola de Oftalmolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}