{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:57:45Z","timestamp":1759798665440,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.oftal.2020.09.018","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T18:05:34Z","timestamp":1608228334000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Col\u00e1geno polivinilpirrolidona versus mitomicina C en trabeculectom\u00eda en pacientes con glaucoma primario de \u00e1ngulo abierto. Seguimiento a 36 meses"],"prefix":"10.1016","volume":"96","author":[{"given":"F.","family":"Gil-Carrasco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Alvarez-Ascencio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tolosa-Tort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alvarez-Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jimenez-Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Castillejos-Chevez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oftal.2020.09.018_bib0215","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9394(68)91288-9","article-title":"Preliminary report of a new method","volume":"66","author":"Cairns","year":"1968","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0220","first-page":"231","article-title":"Trabeculectomy. Subtitle: \u201cA surgical method of reducing intra-ocular pressure in chronic simple glaucoma without sub-conjunctival drainage of aqueous humour\u201d","volume":"88","author":"Cairns","year":"1969","journal-title":"Trans Ophthalmol Soc U K"},{"key":"10.1016\/j.oftal.2020.09.018_bib0225","first-page":"481","article-title":"Trabeculectomy for chronic simple open-angle glaucoma","volume":"89","author":"Cairns","year":"1970","journal-title":"Trans Ophthalmol Soc U K"},{"key":"10.1016\/j.oftal.2020.09.018_bib0230","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0161-6420(84)34291-9","article-title":"5-\ufb02uorouracil and glaucoma \ufb01ltering surgery II. A pilot study","volume":"91","author":"Heuer","year":"1984","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oftal.2020.09.018_bib0235","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1001\/archopht.1991.01080120077030","article-title":"Trabeculectomy with mitomycin. A comparative study with \ufb02uorouracil","volume":"109","author":"Kitazawa","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0240","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/IJG.0000000000001438","article-title":"Historical Considerations and Innovations in the Perioperative Use of Mitomycin C for Glaucoma Filtration Surgery and Bleb Revisions","volume":"29","author":"Grover","year":"2020","journal-title":"J Glaucoma"},{"key":"10.1016\/j.oftal.2020.09.018_bib0245","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/archopht.1992.01080200052023","article-title":"A randomized study of trabeculectomy and subconjunctival administration of \ufb02uorouracil in primary glaucomas","volume":"110","author":"Ophir","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0250","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0161-6420(92)31951-7","article-title":"Intraoperative mitomycin vs postoperative 5-\ufb02uorouracil in high-risk glaucoma \ufb01ltering surgery","volume":"99","author":"Skuta","year":"1992","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oftal.2020.09.018_bib0255","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0161-6420(94)31223-1","article-title":"5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study","volume":"101","author":"Goldenfeld","year":"1994","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oftal.2020.09.018_bib0260","first-page":"449","article-title":"Antimetabolite-induced apoptosis in Tenon's capsule \ufb01broblasts","volume":"39","author":"Crowston","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oftal.2020.09.018_bib0265","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0161-6420(02)01439-2","article-title":"Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence-based review","volume":"109","author":"Jampel","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.oftal.2020.09.018_bib0270","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/jop.1990.6.175","article-title":"Trabeculectomy with simultaneous topical application of mitomycin-C in refractory glaucoma","volume":"6","author":"Chen","year":"1990","journal-title":"J Ocul Pharmacol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0275","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/bjo.2005.077800","article-title":"Mitomycin C augmented glaucoma surgery: Evolution of \ufb01ltering bleb avascularity, transconjunctival oozing, and leaks","volume":"90","author":"Anand","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0280","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10792-018-0851-0","article-title":"Bleb-related infections and long-term follow-up after trabeculectomy","volume":"39","author":"Luebke","year":"2019","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0285","doi-asserted-by":"crossref","DOI":"10.1007\/s10792-020-01454-w","article-title":"Overview of cicatricial modulators in glaucoma fistulizing surgery","author":"de Oliveira","year":"2020","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0290","doi-asserted-by":"crossref","first-page":"e16094","DOI":"10.1097\/MD.0000000000016094","article-title":"Ologen implant versus mitomycin-C for trabeculectomy: A meta-analysis","volume":"98","author":"Song","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.oftal.2020.09.018_bib0295","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/IJG.0000000000000818","article-title":"Outcomes of Trabeculectomy and Phacotrabeculectomy With Collagen Matrix Implant (Ologen) and Low-dose Mitomycin C: 2-Year Follow-up","volume":"27","author":"Castej\u00f3n","year":"2018","journal-title":"J Glaucoma"},{"key":"10.1016\/j.oftal.2020.09.018_bib0300","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0022-4804(02)00099-9","article-title":"Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions","volume":"110","author":"Cervantes-Sanchez","year":"2003","journal-title":"J Surg Res"},{"key":"10.1016\/j.oftal.2020.09.018_bib0305","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-4632.2007.03181.x","article-title":"Pressure ulcers: A pilot study for treatment with collagen polyvinylpyrrolidone","volume":"46","author":"Zeron","year":"2007","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0310","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0974-2077.79180","article-title":"Collagen dressing versus conventional dressings in burn and chronic wounds: A retrospective study","volume":"4","author":"Singh","year":"2011","journal-title":"J Cutan Aesthet Surg"},{"key":"10.1016\/j.oftal.2020.09.018_bib0315","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1021\/jp502476x","article-title":"Physicochemical and functional characterization of the collagen-polyvinylpyrrolidone copolymer","volume":"118","author":"Leyva-Gomez","year":"2014","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.oftal.2020.09.018_bib0320","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1089\/ten.tec.2013.0733","article-title":"Novel use for polyvinylpyrrolidone as a macromolecular crowder for enhanced extracellular matrix deposition and cell proliferation","volume":"20","author":"Rashid","year":"2014","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.oftal.2020.09.018_bib0325","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1046\/j.1523-1747.1998.00329.x","article-title":"Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hypertrophic scars","volume":"111","author":"Kr\u00f6tzsch-G\u00f3mez","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0330","first-page":"1029","article-title":"Cellular and humoral responses to collagen-polyvinylpyrrolidone administered during short and long periods in humans","volume":"81","author":"Furuzawa-Carballeda","year":"2003"},{"key":"10.1016\/j.oftal.2020.09.018_bib0335","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2230.2004.01691.x","article-title":"Subcutaneous administration of collagen-polyvinylpyrrolidone down regulates IL-1beta, TNF-alpha, TGF-beta1 ELAM-1 and VCAM-1 expression in scleroderma skin lesions","volume":"30","author":"Furuzawa-Carballeda","year":"2005","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0340","article-title":"Medical versus surgical interventions for open angle glaucoma","volume":"2","author":"Burr","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.oftal.2020.09.018_bib0345","doi-asserted-by":"crossref","DOI":"10.1007\/s10792-020-01454-w","article-title":"Overview of cicatricial modulators in glaucoma fistulizing surgery","author":"de Oliveira","year":"2020","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0350","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00004397-200404420-00007","article-title":"Wound healing modulation in glaucoma \ufb01ltering surgery","volume":"44","author":"Atreides","year":"2004","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.oftal.2020.09.018_bib0355","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1167\/iovs.12-9483l","article-title":"Advances in glaucoma treatment and management: Surgery","volume":"53","author":"Coleman","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.oftal.2020.09.018_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.survophthal.2011.07.005","article-title":"The changing conceptual basis of trabeculectomy: A review of past and current surgical techniques","volume":"57","author":"Razeghinejad","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0365","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.survophthal.2012.01.008","article-title":"Wound modulation after \ufb01ltration surgery","volume":"57","author":"Seibold","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0370","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2147\/OPTH.S48745","article-title":"Improving patient outcomes following glaucoma surgery: State of the art and future perspectives","volume":"8","author":"Van Bergen","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0375","article-title":"The role of mitomycin C and porcine extracellular matrix in phacotrabeculectomy","author":"Hamdi","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0380","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1874364101610010068","article-title":"Current and Future Techniques in Wound Healing Modulation after Glaucoma Filtering Surgeries","volume":"10","author":"Masoumpour","year":"2016","journal-title":"Open Ophthalmol J"},{"key":"10.1016\/j.oftal.2020.09.018_bib0385","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1755-3768.2009.01753.x","article-title":"Trabeculectomy with OloGen vs trabeculectomy for the treatment of glaucoma: A pilot study","volume":"88","author":"Papaconstantinou","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0390","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/IJG.0b013e3182594f5b","article-title":"Trabeculectomy with combined use of subconjunctival collagen implant and low-dose mitomycin C","volume":"22","author":"Dada","year":"2013","journal-title":"J Glaucoma"},{"key":"10.1016\/j.oftal.2020.09.018_bib0395","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/ceo.12058","article-title":"Ef\ufb01cacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year","volume":"41","author":"Narayanaswamy","year":"2013","journal-title":"Clin Experiment Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0400","doi-asserted-by":"crossref","first-page":"e85782","DOI":"10.1371\/journal.pone.0085782","article-title":"Ologen implant versus mitomycin C for trabeculectomy: A systematic review and meta-analysis","volume":"9","author":"He","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.oftal.2020.09.018_bib0405","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12886-016-0198-0","article-title":"Biodegradable collagen matrix implant versus mitomycin-C intrabeculectomy: Five-year follow-up","volume":"16","author":"Cillino","year":"2016","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0410","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/eye.2016.114","article-title":"Trabeculectomy with ologen in secondary glaucomas following failed trabeculectomy with MMC: Comparative study","volume":"30","author":"El-Saied","year":"2016","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.oftal.2020.09.018_bib0415","doi-asserted-by":"crossref","first-page":"e817","DOI":"10.1111\/aos.14102","article-title":"Phacotrabeculectomy using collagen matrix implant (Ologen\u00ae) versus mitomycin C: A prospective randomized controlled trial","volume":"97","author":"Wla\u017a","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.oftal.2020.09.018_bib0420","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10792-019-01145-1","article-title":"Effect of filtering bleb dimensions on postoperative intraocular pressure in deep sclerectomy with collagen implant: A comparative study","volume":"40","author":"Elmekawey","year":"2020","journal-title":"Int Ophthalmol"}],"container-title":["Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365669120304202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0365669120304202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:44:51Z","timestamp":1759794291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0365669120304202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0365669120304202"],"URL":"https:\/\/doi.org\/10.1016\/j.oftal.2020.09.018","relation":{},"ISSN":["0365-6691"],"issn-type":[{"type":"print","value":"0365-6691"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Col\u00e1geno polivinilpirrolidona versus mitomicina C en trabeculectom\u00eda en pacientes con glaucoma primario de \u00e1ngulo abierto. Seguimiento a 36 meses","name":"articletitle","label":"Article Title"},{"value":"Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oftal.2020.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sociedad Espa\u00f1ola de Oftalmolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}