{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:32:35Z","timestamp":1778650355103,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda (English Edition)"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.oftale.2022.06.001","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T08:18:00Z","timestamp":1655885880000},"page":"464-472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Review of the literature on the currently available evidence for the management of infectious keratitis with PACK-CXL"],"prefix":"10.1016","volume":"97","author":[{"given":"S.M.","family":"Hamida Abdelkader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rodr\u00edguez Calvo-de-Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Geg\u00fandez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.L.","family":"Soler-Ferr\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rocha-de-Lossada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.oftale.2022.06.001_bib0005","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jtos.2019.08.006","article-title":"Photoactivated chromophore for infectious keratitis\u2013Corneal cross-linking (PACK-CXL): a systematic review and meta-analysis","volume":"17","author":"Ting","year":"2019","journal-title":"Ocul Surf."},{"key":"10.1016\/j.oftale.2022.06.001_bib0010","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/ICO.0000000000002335","article-title":"High fluence increases the antibacterial efficacy of PACK cross-linking","volume":"39","author":"Kling","year":"2020","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ajo.2016.02.030","article-title":"Photoactivated chromophore for moderate to severe infectious keratitis as an adjunct therapy: a randomized controlled trial","volume":"165","author":"Kasetsuwan","year":"2016","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jtos.2021.03.002","article-title":"Safety and efficacy of UV application for superficial infections in humans: a systematic review and meta-analysis","volume":"21","author":"Marasini","year":"2021","journal-title":"Ocul Surf."},{"key":"10.1016\/j.oftale.2022.06.001_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2021-000811","article-title":"Double-masked, sham and placebo- controlled trial of corneal cross-linking and topical difluprednate in the treatment of bacterial keratitis: Steroids and Cross-linking for Ulcer Treatment Trial (SCUT II) study protocol","volume":"6","author":"Radhakrishnan","year":"2021","journal-title":"BMJ Open Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0030","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/ICO.0000000000002349","article-title":"Endophthalmitis in advanced microbial keratitis: risk factors and examination findings","volume":"39","author":"Christopher","year":"2020","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0035","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.oret.2020.01.006","article-title":"Quantitative ocular ultrasound findings in microbial keratitis-associated endophthalmitis","volume":"4","author":"Viruni","year":"2020","journal-title":"Ophthalmol Retina."},{"key":"10.1016\/j.oftale.2022.06.001_bib0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ophtha.2014.07.052","article-title":"Therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis: risk factors, outcomes, and summary of the literature","volume":"122","author":"Robaei","year":"2015","journal-title":"Ophthalmology."},{"key":"10.1016\/j.oftale.2022.06.001_bib0045","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ajo.2018.03.011","article-title":"Long-term functional and anatomic outcomes of repeat graft after optically failed therapeutic keratoplasty","volume":"189","author":"Srujana","year":"2018","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0050","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9041837","article-title":"Repeat keratoplasty for failed therapeutic keratoplasty for microbial keratitis: an analysis of characteristics and risk factors","volume":"2020","author":"Wan","year":"2020","journal-title":"J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0055","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.2147\/OPTH.S284306","article-title":"Photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) improves outcomes of treatment-resistant infectious keratitis","volume":"14","author":"Ca\u00f1izo","year":"2020","journal-title":"Clin Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0060","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/ICO.0000000000002510","article-title":"Cross-Linking Assisted Infection Reduction (CLAIR): a randomized clinical trial evaluating the effect of adjuvant cross-linking on bacterial keratitis","volume":"40","author":"Prajna","year":"2021","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0065","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3928\/1081597X-20200226-02","article-title":"Accelerated corneal cross-linking as an adjunct therapy in the management of presumed bacterial keratitis: a cohort study","volume":"36","author":"Knyazer","year":"2020","journal-title":"J Refract Surg."},{"key":"10.1016\/j.oftale.2022.06.001_bib0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40662-016-0042-x","article-title":"PACK-CXL: corneal cross-linking in infectious keratitis","volume":"3","author":"Tabibian","year":"2016","journal-title":"Eye Vis (Lond)."},{"key":"10.1016\/j.oftale.2022.06.001_bib0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jtos.2015.04.007","article-title":"In vivo confocal microscopy after corneal collagen cross-linking","volume":"13","author":"Mazzotta","year":"2015","journal-title":"Ocul Surf."},{"key":"10.1016\/j.oftale.2022.06.001_bib0080","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10792-015-0054-x","article-title":"Collagen cross-linking in keratoconus in Asian eyes: visual, refractive and confocal microscopy outcomes in a prospective randomized controlled trial","volume":"35","author":"Sharma","year":"2015","journal-title":"Int Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0085","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/aos.12301","article-title":"The efficiency of cross-linking methods in eradication of bacteria is influenced by the riboflavin concentration and the irradiation time of ultraviolet light","volume":"92","author":"B\u00e4ckman","year":"2014","journal-title":"Acta Ophthalmol (Copenh)."},{"key":"10.1016\/j.oftale.2022.06.001_bib0090","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/ICO.0000000000000375","article-title":"Ultraviolet A\/riboflavin collagen cross- linking for treatment of moderate bacterial corneal ulcers","volume":"34","author":"Bamdad","year":"2015","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000363371","article-title":"Toric topographically customized transepithelial, pulsed, very high-fluence, higher energy and higher riboflavin concentration collagen cross-linking in keratoconus","volume":"5","author":"Kanellopoulos","year":"2014","journal-title":"Case Rep Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ajo.2016.02.029","article-title":"Customized corneal cross-linking: one-year results","volume":"166","author":"Seiler","year":"2016","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0105","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1167\/iovs.19-26686","article-title":"Riboflavin concentrations at the endothelium during corneal cross-linking in humans","volume":"60","author":"Seiler","year":"2019","journal-title":"Invest Ophth Vis Sci."},{"key":"10.1016\/j.oftale.2022.06.001_bib0110","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/APO.0000000000000379","article-title":"Microbial keratitis after corneal collagen cross-linking for corneal ectasia","volume":"10","author":"Khoo","year":"2021","journal-title":"Asia Pac J Ophhtalmol (Phila)."},{"key":"10.1016\/j.oftale.2022.06.001_bib0115","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3928\/1081597X-20141118-01","article-title":"Antibacterial efficacy of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL)","volume":"30","author":"Richoz","year":"2014","journal-title":"J Refract Surg."},{"key":"10.1016\/j.oftale.2022.06.001_bib0120","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3928\/1081597X-20120921-06","article-title":"Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology","volume":"28","author":"Price","year":"2012","journal-title":"J Refract Surg."},{"key":"10.1016\/j.oftale.2022.06.001_bib0125","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3928\/1081597X-20141113-06","article-title":"Accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking as a first-line and sole treatment in early fungal keratitis","volume":"30","author":"Tabibian","year":"2014","journal-title":"J Refract Surg."},{"key":"10.1016\/j.oftale.2022.06.001_bib0130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/vop.12112","article-title":"Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in ten cats","volume":"18","author":"Famose","year":"2015","journal-title":"Vet Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0135","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/vop.12085","article-title":"Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in eight dogs","volume":"17","author":"Famose","year":"2014","journal-title":"Vet Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0140","article-title":"Corneal collagen cross-linking for bacterial infectious keratitis","volume":"6","author":"Davis","year":"2020","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.oftale.2022.06.001_bib0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1869-5760-3-47","article-title":"Corneal cross linking and infectious keratitis: a systematic review with a meta- analysis of reported cases","volume":"3","author":"Alio","year":"2013","journal-title":"J Ophthalmic Inflamm Infect."},{"key":"10.1016\/j.oftale.2022.06.001_bib0150","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/ICO.0000000000000644","article-title":"Corneal collagen cross-linking for infectious keratitis: a systematic review and meta-analysis","volume":"35","author":"Papaioannou","year":"2016","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0155","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ajo.2016.02.030","article-title":"Photoactivated chromophore for moderate to severe infectious keratitis as an adjunct therapy: a randomized controlled trial","volume":"165","author":"Kasetsuwan","year":"2016","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0160","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ophtha.2014.01.011","article-title":"Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal disoluci\u00f3n","volume":"121","author":"Said","year":"2014","journal-title":"Ophthalmology."},{"key":"10.1016\/j.oftale.2022.06.001_bib0165","unstructured":"Corneal collagen cross-linking (CXL) as an adjunct in the treatment of microbial keratitis. Available from: Anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=336545."},{"key":"10.1016\/j.oftale.2022.06.001_bib0170","unstructured":"Steroids and cross-linking for ulcer treatment (SCUT II). ClinicalTrials.gov. Available from: Ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trialid=30685&username=017136."},{"key":"10.1016\/j.oftale.2022.06.001_bib0175","unstructured":"Collagen cross-linking as adjunctive treatment for corneal ulcer. ClinicalTrials.gov. Available from: Ctri.nic.in\/Clinicaltrials\/pmaindet2.php?trial=22937&EncHid=&username=17601."},{"key":"10.1016\/j.oftale.2022.06.001_bib0180","unstructured":"Cross-linking for corneal ulcers treatment trial (CLAIR). ClinicalTrials.gov. Available from: Clinicaltrials.gov\/ct2\/show\/record\/NCT02570321."},{"key":"10.1016\/j.oftale.2022.06.001_bib0185","unstructured":"Swiss PACK-CXL multicenter trial for the treatment of infectious keratitis. ClinicalTrials.gov. Available from: clinicaltrials.gov\/ct2\/show\/record\/NCT02717871."},{"key":"10.1016\/j.oftale.2022.06.001_bib0190","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00417-011-1754-1","article-title":"UVA-riboflavin photochemical therapy of bacterial keratitis: a pilot study","volume":"250","author":"Makdoumi","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2015.03.024","article-title":"Corneal cross-linking as an adjuvant therapy in the management of recalcitrant deep stromal fungal keratitis: a randomized trial","volume":"160","author":"Uddaraju","year":"2015","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0200","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3928\/1081597X-20140609-01","article-title":"PACK-CXL: defining CXL for infectious keratitis","volume":"30","author":"Hafezi","year":"2014","journal-title":"J Refract Surg."},{"key":"10.1016\/j.oftale.2022.06.001_bib0205","article-title":"PACK cross-linking as adjuvant therapy improves clinical outcomes in culture-confirmed bacterial keratitis","author":"Achiron","year":"2021","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0210","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1167\/iovs.11-8382","article-title":"Assessing efficacy of combined riboflavin and UV-A light (365 nm) treatment of Acanthamoeba trophozoites","volume":"52","author":"Kashiwabuchi","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"10.1016\/j.oftale.2022.06.001_bib0215","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1167\/iovs.12-9828","article-title":"Effect of photodynamic therapy with methylene blue on Acanthamoeba in vitro","volume":"53","author":"Mito","year":"2012","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"10.1016\/j.oftale.2022.06.001_bib0220","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ajo.2011.07.025","article-title":"Evaluation of in vitro efficacy of combined riboflavin and ultraviolet a for Acanthamoeba isolates","volume":"153","author":"Del Buey","year":"2012","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0225","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1080\/02713683.2018.1501074","article-title":"Effect of riboflavin\/rose bengal-mediated PACK-CXL on acanthamoeba Trophozoites and Cysts in vitro","volume":"43","author":"Atalay","year":"2018","journal-title":"Curr Eye Res."},{"key":"10.1016\/j.oftale.2022.06.001_bib0230","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000331707","article-title":"Ultraviolet-a light and riboflavin therapy for Acanthamoeba keratitis: a case report","volume":"2","author":"Gardu\u00f1o-Vieyra","year":"2011","journal-title":"Case Rep Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0235","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1055\/s-0031-1299420","article-title":"Corneal cross-linking as supplementary treatment Option in melting keratitis: a case series","volume":"229","author":"Muller","year":"2012","journal-title":"Klin Monbl Augenheilkd."},{"key":"10.1016\/j.oftale.2022.06.001_bib0240","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/ICO.0b013e31823f8f48","article-title":"Photo-activated riboflavin therapy of refractory corneal ulcers","volume":"31","author":"Panda","year":"2012","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0245","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.ophtha.2018.04.005","article-title":"Collagen cross-linked therapeutic grafts in fungal keratitis","volume":"125","author":"Titiyal","year":"2018","journal-title":"Ophhtalmology."},{"key":"10.1016\/j.oftale.2022.06.001_bib0250","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ophtha.2019.08.029","article-title":"Cross-linking-assisted infection reduction: a randomized clinical trial evaluating the effect of adjuvant cross-linking on outcomes in fungal keratitis","volume":"127","author":"Prajna","year":"2020","journal-title":"Ophthalmology."},{"key":"10.1016\/j.oftale.2022.06.001_bib0255","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.ophtha.2020.09.042","article-title":"Cross-linking assisted infection reduction: one-year follow-up of a randomized clinical trial evaluating cross-linking for fungal keratitis","volume":"128","author":"Prajna","year":"2021","journal-title":"Ophthalmology."},{"key":"10.1016\/j.oftale.2022.06.001_bib0260","first-page":"204","article-title":"Corneal cross-linking as an adjunct for the management of refractory fungal keratitis","volume":"27","author":"Bamdad","year":"2021","journal-title":"Middle East Afr J Ophthalmol."},{"key":"10.1016\/j.oftale.2022.06.001_bib0265","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40662-021-00272-0","article-title":"PACK-CXL vs. antimicrobial therapy for bacterial, fungal, and mixed infectious keratitis: a prospective randomized phase 3 trial","volume":"9","author":"Hafezi","year":"2022","journal-title":"Eye Vis (Lond)."},{"key":"10.1016\/j.oftale.2022.06.001_bib0270","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/ICO.0000000000002210","article-title":"Corneal collagen cross-linking with photoactivated chromophore for infectious keratitis after penetrating keratoplasty","volume":"39","author":"Uzman","year":"2020","journal-title":"Cornea."},{"key":"10.1016\/j.oftale.2022.06.001_bib0275","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jcrs.2007.06.036","article-title":"Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus","volume":"33","author":"Kymionis","year":"2007","journal-title":"J Cataract Refract Surg."}],"container-title":["Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173579422000858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2173579422000858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:27:58Z","timestamp":1761881278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2173579422000858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2173579422000858"],"URL":"https:\/\/doi.org\/10.1016\/j.oftale.2022.06.001","relation":{},"ISSN":["2173-5794"],"issn-type":[{"value":"2173-5794","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review of the literature on the currently available evidence for the management of infectious keratitis with PACK-CXL","name":"articletitle","label":"Article Title"},{"value":"Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.oftale.2022.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.oftal.2022.02.003","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Sociedad Espa\u00f1ola de Oftalmolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}