{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:58:56Z","timestamp":1770433136924,"version":"3.49.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obstetrics and Gynecology Clinics of North America"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.ogc.2006.05.011","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T15:08:25Z","timestamp":1168441705000},"page":"357-374","source":"Crossref","is-referenced-by-count":12,"title":["Inherited Thrombophilias"],"prefix":"10.1016","volume":"33","author":[{"given":"Michiel","family":"Coppens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stef P.","family":"Kaandorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ogc.2006.05.011_bib1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1055\/s-0038-1656297","article-title":"Inherited antithrombin deficiency causing thrombophilia","volume":"13","author":"Egeberg","year":"1965","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1016\/j.ogc.2006.05.011_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1055\/s-0037-1615887","article-title":"Risk factors for venous thrombotic disease","volume":"82","author":"Rosendaal","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(98)10266-0","article-title":"Venous thrombosis: a multicausal disease","volume":"353","author":"Rosendaal","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/01.AOG.0000146250.85561.e9","article-title":"Genetic thrombophilias and preeclampsia: a meta-analysis","volume":"105","author":"Lin","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ogc.2006.05.011_bib5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(03)12771-7","article-title":"Thrombophilic disorders and fetal loss: a meta-analysis","volume":"361","author":"Rey","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1182\/blood.V70.2.343.343","article-title":"The pathophysiology of the prethrombotic state in humans: insights gained from studies using markers of hemostatic system activation","volume":"70","author":"Bauer","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.ogc.2006.05.011_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0268-960X(90)90014-J","article-title":"Assessment of hypercoagulable states by measurement of activation fragments and peptides","volume":"4","author":"Boisclair","year":"1990","journal-title":"Blood Rev"},{"key":"10.1016\/j.ogc.2006.05.011_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-0038-1655930","article-title":"Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis","volume":"77","author":"Lane","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib9","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1055\/s-0038-1653885","article-title":"Protein C deficiency: a database of mutations, 1995 update. On behalf of the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH","volume":"73","author":"Reitsma","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib10","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1055\/s-0037-1614137","article-title":"Protein S deficiency: a database of mutations\u2014summary of the first update","volume":"84","author":"Gandrille","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/369064a0","article-title":"Mutation in blood coagulation factor V associated with resistance to activated protein C","volume":"369","author":"Bertina","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ogc.2006.05.011_bib12","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(94)92939-4","article-title":"Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V","volume":"343","author":"Voorberg","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib13","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A common genetic variation in the 3\u2032-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.ogc.2006.05.011_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0140-6736(95)90166-3","article-title":"Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis","volume":"345","author":"Koster","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1538-7836.2004.01033.x","article-title":"Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis","volume":"3","author":"Bank","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-0037-1614985","article-title":"Familial clustering of factor VIII and von Willebrand factor levels","volume":"79","author":"Kamphuisen","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0037-1613747","article-title":"High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism","volume":"83","author":"Kraaijenhagen","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0037-1613748","article-title":"Elevation of FVIII: C in venous thromboembolism is persistent and independent of the acute phase response","volume":"83","author":"O'Donnell","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib19","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1055\/s-0037-1615380","article-title":"Hyperhomocysteinemia and venous thrombosis: a meta-analysis","volume":"80","author":"den Heijer","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ogc.2006.05.011_bib21","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/01.CIR.98.23.2520","article-title":"Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis","volume":"98","author":"Brattstrom","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ogc.2006.05.011_bib22","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1056\/NEJM199011293232202","article-title":"Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis","volume":"323","author":"Heijboer","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7326\/0003-4819-128-1-199801010-00003","article-title":"The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis","volume":"128","author":"Middeldorp","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1055\/s-0037-1614442","article-title":"Incidence of venous thromboembolism in families with inherited thrombophilia","volume":"81","author":"Simioni","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib25","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1001\/archinte.164.17.1932","article-title":"Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study","volume":"164","author":"Bank","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2141.1990.tb02635.x","article-title":"Antithrombin III activity in healthy blood donors: age and sex related changes and prevalence of asymptomatic deficiency","volume":"75","author":"Tait","year":"1990","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ogc.2006.05.011_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0038-1653730","article-title":"Prevalence of protein C deficiency in the healthy population","volume":"73","author":"Tait","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib28","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1055\/s-0037-1614519","article-title":"Activated protein C resistance (FV:Q506) and pregnancy","volume":"81","author":"Lindqvist","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib29","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(94)90286-0","article-title":"Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation","volume":"344","author":"Vandenbroucke","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib30","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1001\/archinte.163.11.1285","article-title":"The incidence of recurrent venous thromboembolism after treatment with vitamin K antagonists in relation to time since first event: a meta-analysis","volume":"163","author":"van Dongen","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib31","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/asheducation-2004.1.424","article-title":"Thrombophilia and new anticoagulant drugs","volume":"1","author":"Weitz","year":"2004","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"10.1016\/j.ogc.2006.05.011_bib32","doi-asserted-by":"crossref","first-page":"I10","DOI":"10.1161\/01.CIR.0000140902.46296.ae","article-title":"Long-term management of patients after venous thromboembolism","volume":"110","author":"Kearon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ogc.2006.05.011_bib33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-0038-1650282","article-title":"The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women","volume":"75","author":"Sanson","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib34","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(96)04125-6","article-title":"Increased fetal loss in women with heritable thrombophilia","volume":"348","author":"Preston","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib35","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7326\/0003-4819-130-9-199905040-00013","article-title":"Increased risk for fetal loss in carriers of the factor V Leiden mutation","volume":"130","author":"Meinardi","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1053\/beog.2000.0123","article-title":"Epidemiology and the medical causes of miscarriage","volume":"14","author":"Regan","year":"2000","journal-title":"Baillieres Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ogc.2006.05.011_bib37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejogrb.2004.07.019","article-title":"Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature","volume":"118","author":"Krabbendam","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ogc.2006.05.011_bib38","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1093\/humrep\/dei167","article-title":"Updated and revised nomenclature for description of early pregnancy events","volume":"20","author":"Farquharson","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ogc.2006.05.011_bib39","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0301-2115(01)00496-1","article-title":"How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review","volume":"101","author":"Alfirevic","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ogc.2006.05.011_bib40","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1160\/TH03-10-0637","article-title":"The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis","volume":"91","author":"Dudding","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archinte.164.5.558","article-title":"Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis","volume":"164","author":"Kovalevsky","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib42","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1111\/j.1538-7836.2003.00496.x","article-title":"Elevated plasma levels of factor VIII in women with early recurrent miscarriage","volume":"1","author":"Marietta","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib43","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1160\/TH04-03-0198","article-title":"Unselected women with elevated levels of factor VIII:C or homocysteine are not at increased risk for obstetric complications","volume":"92","author":"Middeldorp","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib44","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0015-0282(00)01595-8","article-title":"Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis","volume":"74","author":"Nelen","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ogc.2006.05.011_bib45","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0037-1613083","article-title":"Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review","volume":"87","author":"Morrison","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib46","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.thromres.2004.09.009","article-title":"Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation","volume":"115","author":"Witsenburg","year":"2005","journal-title":"Thromb Res"},{"key":"10.1016\/j.ogc.2006.05.011_bib47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7326\/0003-4819-128-1-199801010-00003","article-title":"The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis","volume":"128","author":"Middeldorp","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib48","series-title":"Hemostasis and thrombosis: basic principles and clinical practice","first-page":"1085","article-title":"Approach to the thrombophilic patient","author":"Middeldorp","year":"2001"},{"key":"10.1016\/j.ogc.2006.05.011_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001367","article-title":"Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism","author":"Hutten","year":"2000","journal-title":"Cochrane Database"},{"key":"10.1016\/j.ogc.2006.05.011_bib50","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1046\/j.1365-2141.1998.00632.x","article-title":"Risk of recurrent venous thromboembolism in patients with the factor V Leiden (FVR506Q) mutation: effect of warfarin and prediction by precipitating factors. East Anglian Thrombophilia Study Group","volume":"100","author":"Baglin","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ogc.2006.05.011_bib51","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/archinte.1993.00410130073007","article-title":"Bleeding complications in oral anticoagulant therapy. An analysis of risk factors","volume":"153","author":"van der Meer","year":"1993","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib52","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(96)01109-9","article-title":"Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy","volume":"348","author":"Palareti","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib53","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1056\/NEJM199609053351002","article-title":"Low-molecular-weight heparin (enoxaparin) as prophylaxis against venous thromboembolism after total hip replacement","volume":"335","author":"Bergqvist","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib54","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(96)01453-5","article-title":"Risk of deep-venous thrombosis after hospital discharge in patients having undergone total hip replacement: double-blind randomised comparison of enoxaparin versus placebo","volume":"348","author":"Planes","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib55","doi-asserted-by":"crossref","DOI":"10.1378\/chest.126.3_suppl.627S","article-title":"Use of antithrombotic agents during pregnancy. The seventh ACCP conference on antithrombotic and thrombolytic therapy","volume":"126","author":"Bates","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.ogc.2006.05.011_bib56","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1056\/NEJM200105173442007","article-title":"Oral contraceptives and the risk of venous thrombosis","volume":"344","author":"Vandenbroucke","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib57","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1136\/bmj.321.7270.1190","article-title":"Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995: cohort and case-control analysis","volume":"321","author":"Jick","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ogc.2006.05.011_bib58","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.312.7023.83","article-title":"Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case-control study. Transnational Research Group on Oral Contraceptives and the Health of Young Women","volume":"312","author":"Spitzer","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.ogc.2006.05.011_bib59","doi-asserted-by":"crossref","DOI":"10.1378\/chest.126.3_suppl.401S","article-title":"Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Buller","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.ogc.2006.05.011_bib60","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1001\/jama.293.19.2352","article-title":"Thrombophilia, clinical factors, and recurrent venous thrombotic events","volume":"293","author":"Christiansen","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ogc.2006.05.011_bib61","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1056\/NEJM200011163432002","article-title":"Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group","volume":"343","author":"Brill-Edwards","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib62","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1538-7836.2005.01307.x","article-title":"Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis","volume":"3","author":"Pabinger","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1542\/peds.107.1.123","article-title":"In utero exposure to coumarins and cognition at 8\u00a0to 14 years old","volume":"107","author":"Van Driel","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.ogc.2006.05.011_bib64","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-3782(00)00080-3","article-title":"Behavioural outcome of school-age children after prenatal exposure to coumarins","volume":"58","author":"Wesseling","year":"2000","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ogc.2006.05.011_bib65","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-3782(01)00140-2","article-title":"Neurological outcome in school-age children after in utero exposure to coumarins","volume":"63","author":"Wesseling","year":"2001","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ogc.2006.05.011_bib66","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1055\/s-0037-1614550","article-title":"Safety of low-molecular-weight heparin in pregnancy: a systematic review","volume":"81","author":"Sanson","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib67","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0002-9378(89)90095-1","article-title":"Recurrent thromboembolism in pregnancy and puerperium. Is there a need for thromboprophylaxis?","volume":"160","author":"Tengborn","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ogc.2006.05.011_bib68","article-title":"Homocysteine lowering by B vitamins and the secondary prevention of deep-vein thrombosis and pulmonary embolism. A randomised, placebo-controlled, double blind trial","volume":"3","author":"den Heijer","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib69","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1055\/s-0037-1614156","article-title":"Increased risk of recurrent venous thromboembolism during hormone replacement therapy. Results of the randomized, double-blind, placebo-controlled estrogen in venous thromboembolism trial (EVTET)","volume":"84","author":"Hoibraaten","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib70","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/bmj.314.7076.253","article-title":"Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)","volume":"314","author":"Rai","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.ogc.2006.05.011_bib71","doi-asserted-by":"crossref","unstructured":"Empson M, Lassere M, Craig JC, et\u00a0al. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. The Cochrane Database of Systematic Reviews. 2005;CD002859.","DOI":"10.1002\/14651858.CD002859.pub2"},{"key":"10.1016\/j.ogc.2006.05.011_bib72","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1055\/s-0038-1653781","article-title":"Use of a low-molecular weight heparin (enoxaparin) or of a phenformin-like substance (moroxydine chloride) in primary early recurrent aborters with an impaired fibrinolytic capacity","volume":"73","author":"Gris","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib73","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1055\/s-0037-1613894","article-title":"Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin","volume":"83","author":"Brenner","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib74","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1471-0528.2000.tb13240.x","article-title":"The effect of thromboprophylaxis on pregnancy outcome in patients with recurrent pregnancy loss associated with factor V Leiden mutation","volume":"107","author":"Younis","year":"2000","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ogc.2006.05.011_bib75","doi-asserted-by":"crossref","unstructured":"DiNisio M, Peters LW, Middeldorp S. Anticoagulants for the treatment of recurrent pregnancy loss in women without antiphospholipid syndrome. The Cochrane Database of Systematic Reviews 2005;CD004734.","DOI":"10.1002\/14651858.CD004734.pub2"},{"key":"10.1016\/j.ogc.2006.05.011_bib76","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1182\/blood-2003-12-4250","article-title":"Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder","volume":"103","author":"Gris","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ogc.2006.05.011_bib77","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1538-7836.2004.01090.x","article-title":"Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study","volume":"3","author":"Brenner","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib78","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1538-7836.2005.01288.x","article-title":"The use of LMWH in pregnancies at risk: new evidence or perception?","volume":"3","author":"Middeldorp","year":"2005","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib79","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(94)92633-6","article-title":"CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women","volume":"343","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib80","doi-asserted-by":"crossref","unstructured":"Duley L, Henderson-Smart DJ, Knight M, et\u00a0al. Antiplatelet agents for preventing and its complications pre-eclampsia (Cochrane Review). The Cochrane Library; 2003;CD004659.","DOI":"10.1002\/14651858.CD004659"},{"key":"10.1016\/j.ogc.2006.05.011_bib81","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJM198710153171604","article-title":"Absence of thrombosis in subjects with heterozygous protein C deficiency","volume":"317","author":"Miletich","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib82","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2141.1994.tb04878.x","article-title":"Prevalence of antithrombin deficiency in the healthy population","volume":"87","author":"Tait","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ogc.2006.05.011_bib83","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","article-title":"World distribution of factor V Leiden","volume":"346","author":"Rees","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2006.05.011_bib84","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1001\/jama.1997.03540400055031","article-title":"Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening","volume":"277","author":"Ridker","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.ogc.2006.05.011_bib85","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0022-2143(98)90121-4","article-title":"Prevalence of the prothrombin 20210 G-to-A variant in blacks: infants, patients with venous thrombosis, patients with myocardial infarction, and control subjects","volume":"132","author":"Dilley","year":"1998","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib86","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1055\/s-0037-1615049","article-title":"Geographic distribution of the 20210 G to A prothrombin variant","volume":"79","author":"Rosendaal","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ogc.2006.05.011_bib87","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1365-2141.1997.2353052.x","article-title":"The prothrombin gene G20210A variant: prevalence in a UK anticoagulant clinic population","volume":"98","author":"Cumming","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ogc.2006.05.011_bib88","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1056\/NEJM199603213341203","article-title":"Hyperhomocysteinemia as a risk factor for deep-vein thrombosis","volume":"334","author":"den Heijer","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ogc.2006.05.011_bib89","first-page":"3702","article-title":"The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study","volume":"94","author":"Sanson","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.ogc.2006.05.011_bib90","doi-asserted-by":"crossref","first-page":"322","DOI":"10.7326\/0003-4819-135-5-200109040-00008","article-title":"A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism","volume":"135","author":"Middeldorp","year":"2001","journal-title":"Ann Intern Med"},{"issue":"Suppl 1","key":"10.1016\/j.ogc.2006.05.011_bib91","article-title":"Incidence of venous and arterial thromboembolism in asymptomatic carriers of the prothrombin 20210A mutation\u2014a prospective cohort study","volume":"3","author":"Coppens","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"10.1016\/j.ogc.2006.05.011_bib92","first-page":"1056","article-title":"A prospective cohort study of asymptomatic individuals with elevated factor VIII:c to determine the absolute incidence of venous and arterial thromboembolism","volume":"3","author":"Bank","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"10.1016\/j.ogc.2006.05.011_bib93","article-title":"Absolute risk of venous and arterial thromboembolism associated with mild hyperhomocysteinemia. Results from a retrospective family cohort study","volume":"3","author":"Van de Poel","year":"2005","journal-title":"J Thromb Haemost"}],"container-title":["Obstetrics and Gynecology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889854506000556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889854506000556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T17:59:21Z","timestamp":1587319161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889854506000556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":93,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0889854506000556"],"URL":"https:\/\/doi.org\/10.1016\/j.ogc.2006.05.011","relation":{},"ISSN":["0889-8545"],"issn-type":[{"value":"0889-8545","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}