{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T22:14:54Z","timestamp":1771971294040,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obstetrics and Gynecology Clinics of North America"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ogc.2013.03.004","type":"journal-article","created":{"date-parts":[[2013,6,2]],"date-time":"2013-06-02T00:31:06Z","timestamp":1370133066000},"page":"291-316","source":"Crossref","is-referenced-by-count":8,"title":["Treatment Options for High-Grade Squamous Intraepithelial Lesions"],"prefix":"10.1016","volume":"40","author":[{"given":"Stephanie","family":"Long","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Leeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/LGT.0b013e31825c31dd","article-title":"The lower anogenital squamous terminology standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology","volume":"16","author":"Darragh","year":"2012","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"8","key":"10.1016\/j.ogc.2013.03.004_bib2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.297.8.813","article-title":"Prevalence of HPV infection among females in the United States","volume":"297","author":"Dunne","year":"2007","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.ogc.2013.03.004_bib3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/infdis\/jir341","article-title":"Prevalence of genital human papillomavirus among females in the United States, the National Health and Nutrition Examination Survey, 2003-2006","volume":"204","author":"Hariri","year":"2011","journal-title":"J\u00a0Infect Dis"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 2","key":"10.1016\/j.ogc.2013.03.004_bib5","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.ygyno.2010.01.024","article-title":"Pathology and epidemiology of HPV infection in females","volume":"117","author":"Stanley","year":"2010","journal-title":"Gynecol Oncol"},{"issue":"7","key":"10.1016\/j.ogc.2013.03.004_bib6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7326\/0003-4819-148-7-200804010-00004","article-title":"Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003-2005","volume":"148","author":"Datta","year":"2008","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00128360-200404000-00010","article-title":"Evidence supporting the current management guidelines for high-grade squamous intraepithelial lesion cytology","volume":"8","author":"Padilla-Paz","year":"2004","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib8","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/AOG.0b013e31827001d5","article-title":"Revised terminology for cervical histopathology and its implications for management of high-grade squamous intraepithelial lesions of the cervix","volume":"120","author":"Waxman","year":"2012","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib9","first-page":"S1","article-title":"2012 Consensus guidelines for the management of cervical intraepithelial neoplasia","volume":"17","author":"Wright","year":"2013","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.ogc.2013.03.004_bib10","unstructured":"American Society for Colposcopy and Cervical Pathology. Histology of the normal cervix. 2012. Available at: http:\/\/www.asccp.org\/practicemanagement\/cervix\/histologyofthenormalcervix\/tabid\/5842\/default.aspx. Accessed November 26, 2012."},{"issue":"4","key":"10.1016\/j.ogc.2013.03.004_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/LGT.0b013e318159408b","article-title":"2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ","volume":"11","author":"Wright","year":"2007","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/LGT.0b013e31822e83cf","article-title":"Risk factors for progression or persistence of squamous intraepithelial lesions diagnosed during pregnancy","volume":"16","author":"Cubo-Abert","year":"2012","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib13","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/AOG.0b013e3181fe777f","article-title":"Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women","volume":"116","author":"Moscicki","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00126334-200108150-00003","article-title":"Evolution of cervical abnormalities among women with HIV-1: evidence from surveillance cytology in the women's interagency HIV study","volume":"27","author":"Massad","year":"2001","journal-title":"J\u00a0Acquir Immune Defic Syndr"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/LGT.0b013e318160b9a5","article-title":"High-grade cervical disease in adolescents with HIV","volume":"12","author":"Massad","year":"2008","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001421.pub2","article-title":"Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia","author":"Martin-Hirsch","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"10.1016\/j.ogc.2013.03.004_bib17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/jnci\/djp089","article-title":"Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort Study","volume":"101","author":"Melnikow","year":"2009","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijgo.2012.01.029","article-title":"World Health Organization Guidelines: use of cryotherapy for cervical intraepithelial neoplasia","volume":"118","author":"Santesso","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib19","first-page":"149","article-title":"Efficacy, safety, acceptability and affordability of cryotherapy: a review of current literature","volume":"64","author":"McClung","year":"2012","journal-title":"Minerva Ginecol"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib20","first-page":"263","article-title":"Evaluation of removing devitalized cervical tissue in the reduction of vaginal discharge after cervical cryotherapy: a prospective study","volume":"26","author":"Nahhas","year":"1981","journal-title":"J\u00a0Reprod Med"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib21","first-page":"75","article-title":"Cryotherapy and carbon dioxide laser management of cervical intraepithelial neoplasia: a controlled comparison","volume":"61","author":"Townsend","year":"1983","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib22","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00404-011-2148-7","article-title":"Inpatient and outpatient loop electrosurgery excision procedure for cervical intraepithelial neoplasia: a retrospective analysis","volume":"285","author":"Leimbacher","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ygyno.2005.09.015","article-title":"Preoperative predictors of positive margins after loop electrosurgical excisional procedure\u2014Cone","volume":"100","author":"Tillmanns","year":"2006","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1471-0528.2006.01107.x","article-title":"Precancerous changes in the cervix and risk of subsequent preterm birth","volume":"114","author":"Bruinsma","year":"2007","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/01.lgt.0000265776.29173.e1","article-title":"A\u00a0LEEP cervical conization is rarely indicated for a two-step discrepancy","volume":"11","author":"Lanneau","year":"2007","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"4","key":"10.1016\/j.ogc.2013.03.004_bib26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0029-7844(00)01194-7","article-title":"Effects of ball cauterization following loop excision and follow-up colposcopy","volume":"97","author":"Paraskevaidis","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib27","doi-asserted-by":"crossref","first-page":"291.e1","DOI":"10.1016\/j.ajog.2010.07.035","article-title":"Loop electrosurgical excision procedure with an intrauterine device in place","volume":"203","author":"Bailey","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib28","first-page":"731","article-title":"The use of large-loop excision of the transformation zone in an inner-city population","volume":"82","author":"Spitzer","year":"1993","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib29","first-page":"49","article-title":"Bowel injury occurring during an outpatient LLETZ procedure. A case report","volume":"48","author":"Dunn","year":"2003","journal-title":"J\u00a0Reprod Med"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib30","first-page":"583","article-title":"Complications of loop electrosurgical excision procedure for cervical neoplasia: a prospective study","volume":"89","author":"Kietpeerakool","year":"2006","journal-title":"J\u00a0Med Assoc Thai"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000329324","article-title":"Loop electrosurgical excision procedures in Israel","volume":"72","author":"Siegler","year":"2011","journal-title":"Gynecol Obstet Invest"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib32","first-page":"351","article-title":"Perioperative complications of an outpatient loop electrosurgical excision procedure: a review of 857 consecutive cases","volume":"10","author":"Sutthichon","year":"2009","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib33","first-page":"64","article-title":"Consequences and treatment of cervical stenoses after laser conization or loop electrosurgical excision","volume":"26","author":"Baldauf","year":"1997","journal-title":"J\u00a0Gynecol Obstet Biol Reprod (Paris)"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib34","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0301-2115(02)00245-2","article-title":"Long-term outcome of a randomized study comparing three techniques of conization: cold knife, laser, and LEEP","volume":"106","author":"Mathevet","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/LGT.0b013e3181b0f73f","article-title":"Depot medroxyprogesterone acetate: a risk factor for cervical stenosis after loop electrosurgical excisional procedure management of cervical intraepithelial neoplasia?","volume":"14","author":"Martirosian","year":"2010","journal-title":"J\u00a0Low Genit Tract Dis"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib36","first-page":"75","article-title":"Cone biopsy: perfecting the procedure","volume":"14","author":"Toglia","year":"2002","journal-title":"J\u00a0Fam Pract"},{"issue":"4","key":"10.1016\/j.ogc.2013.03.004_bib37","first-page":"640","article-title":"Hemostasis and cold knife cone biopsy: a prospective randomized trial comparing a suture versus non-suture technique","volume":"74","author":"Gilbert","year":"1989","journal-title":"Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ogc.2013.03.004_bib38","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0029-7844(03)00622-7","article-title":"Superiority of electrocautery over the suture method for achieving cervical cone bed hemostasis","volume":"102","author":"Kamat","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0950-3552(05)80367-0","article-title":"Cone biopsy and hysterectomy in the management of cervical intraepithelial neoplasia","volume":"9","author":"Jones","year":"1995","journal-title":"Baillieres Clin Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib40","first-page":"257","article-title":"Comparison of the efficacy and complications of different surgical methods for cervical intraepithelial neoplasia","volume":"33","author":"Zeng","year":"2012","journal-title":"Eur J Gynaecol Oncol"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib41","first-page":"1291","article-title":"Sexual function after loop electrosurgical excision procedure for cervical dysplasia","volume":"7","author":"Inna","year":"2010","journal-title":"J\u00a0Sex Med"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib42","first-page":"2267","article-title":"The impact of the loop electrosurgical excisional procedure for cervical intraepithelial lesions on female sexual function","volume":"7","author":"Serati","year":"2010","journal-title":"J\u00a0Sex Med"},{"issue":"9","key":"10.1016\/j.ogc.2013.03.004_bib43","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1471-0528.2011.02944.x","article-title":"The risk of preterm birth following treatment for precancerous changes in the cervix: a systematic review and meta-analysis","volume":"118","author":"Bruinsma","year":"2011","journal-title":"BJOG"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib44","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/AOG.0b013e3181bf1ef2","article-title":"Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery","volume":"114","author":"Noehr","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.ogc.2013.03.004_bib45","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1471-0528.2011.03252.x","article-title":"The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity","volume":"119","author":"Khalid","year":"2012","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/AOG.0b013e3181b052de","article-title":"Loop electrosurgical excision procedure and the risk for preterm birth","volume":"114","author":"Jakobsson","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"17","key":"10.1016\/j.ogc.2013.03.004_bib47","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1001\/jama.291.17.2100","article-title":"Treatment for cervical intraepithelial neoplasia and risk of preterm delivery","volume":"291","author":"Sadler","year":"2004","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.ogc.2013.03.004_bib48","first-page":"909","article-title":"Cervical length screening in patients who have undergone loop electrosurgical excision procedure","volume":"53","author":"Parikh","year":"2008","journal-title":"J\u00a0Reprod Med"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/01.AOG.0000192169.44775.76","article-title":"Transvaginal ultrasonography in the prediction of preterm birth after treatment for cervical intraepithelial neoplasia","volume":"107","author":"Crane","year":"2006","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2011.12.003","article-title":"Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data","volume":"206","author":"Romero","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ogc.2013.03.004_bib51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/AOG.0b013e318278f904","article-title":"Risk of cesarean delivery after loop electrosurgical excision procedure","volume":"121","author":"Frey","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ogc.2013.03.004_bib52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jcp.53.3.191","article-title":"Completeness of excision and follow up cytology in patients treated with loop excision biopsy","volume":"53","author":"Zaitoun","year":"2000","journal-title":"J\u00a0Clin Pathol"},{"issue":"11","key":"10.1016\/j.ogc.2013.03.004_bib53","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1470-2045(07)70283-8","article-title":"Incomplete excision of cervical intraepithelial neoplasia and risk of treatment failure: a meta-analysis","volume":"8","author":"Ghaem-Maghami","year":"2007","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib54","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ygyno.2012.01.015","article-title":"High-risk human papillomavirus testing versus cytology in predicting post-treatment disease in women treated for high-grade cervical disease: a systematic review and meta-analysis","volume":"125","author":"Kocken","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10.1016\/j.ogc.2013.03.004_bib55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ctrv.2003.07.008","article-title":"The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature","volume":"30","author":"Paraskevaidis","year":"2004","journal-title":"Cancer Treat Rev"},{"issue":"5","key":"10.1016\/j.ogc.2013.03.004_bib56","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1097\/LGT.0b013e318285423c","article-title":"Benchmarking CIN3+ Risk as the Basis for Incorporating HPV and Pap Cotesting into Cervical Screening and Management Guidelines","volume":"17","author":"Katki","year":"2013","journal-title":"J Low Genit Tract Dis"}],"container-title":["Obstetrics and Gynecology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889854513000296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889854513000296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T11:26:57Z","timestamp":1539602817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889854513000296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0889854513000296"],"URL":"https:\/\/doi.org\/10.1016\/j.ogc.2013.03.004","relation":{},"ISSN":["0889-8545"],"issn-type":[{"value":"0889-8545","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}