{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:24:05Z","timestamp":1770755045736,"version":"3.50.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UG3HL140131"],"award-info":[{"award-number":["UG3HL140131"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UG1HD027915"],"award-info":[{"award-number":["UG1HD027915"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Obstetrics and Gynecology Clinics of North America"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ogc.2022.10.005","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T22:04:35Z","timestamp":1677017075000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy"],"prefix":"10.1016","volume":"50","author":[{"given":"Joe","family":"Eid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara M.","family":"Rood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged M.","family":"Costantine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ogc.2022.10.005_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ogc.2022.10.005_bib2","first-page":"e1","article-title":"ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia","volume":"133","author":"Espinoza","year":"2019","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib3","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0140-6736(06)69380-X","article-title":"Maternal mortality: who, when, where, and why","volume":"368","author":"Ronsmans","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2022.10.005_bib4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: a systematic review","volume":"367","author":"Khan","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ogc.2022.10.005_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The Global Impact of Pre-eclampsia and Eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ogc.2022.10.005_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-3016.2005.00653.x","article-title":"An assessment of pregnancy-related mortality in the United States","volume":"19","author":"MacKay","year":"2005","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.ogc.2022.10.005_bib7","first-page":"147","article-title":"Preeclampsia: the role of angiogenic factors in its pathogenesis","volume":"24","author":"Wang","year":"2009","journal-title":"Physiology (Bethesda)"},{"issue":"3","key":"10.1016\/j.ogc.2022.10.005_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ajog.2017.04.032","article-title":"Short-term costs of preeclampsia to the United States health care system","volume":"217","author":"Stevens","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ogc.2022.10.005_bib10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/GRF.0000000000000349","article-title":"Reducing disparities in severe maternal morbidity and mortality","volume":"61","author":"Howell","year":"2018","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib11","series-title":"Williams obstetrics","author":"Cunningham","year":"2014"},{"issue":"Suppl A","key":"10.1016\/j.ogc.2022.10.005_bib12","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.ogc.2022.10.005_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0378(03)00044-5","article-title":"Trophoblast deportation and the maternal inflammatory response in pre-eclampsia","volume":"59","author":"Sargent","year":"2003","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ogc.2022.10.005_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.plefa.2003.04.010","article-title":"Eicosanoids in preeclampsia","volume":"70","author":"Walsh","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"3","key":"10.1016\/j.ogc.2022.10.005_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0002-9378(85)80223-4","article-title":"Preeclampsia: an imbalance in placental prostacyclin and thromboxane production","volume":"152","author":"Walsh","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib16","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1056\/NEJM197905173002006","article-title":"Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls","volume":"300","author":"Moncada","year":"1979","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.ogc.2022.10.005_bib17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.282.4.356","article-title":"Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: A multicenter prospective study","volume":"282","author":"Mills","year":"1999","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.ogc.2022.10.005_bib18","doi-asserted-by":"crossref","unstructured":"Bdolah Y, Sukhatme VP, Karumanchi SA. Angiogenic imbalance in the pathophysiology of preeclampsia: Newer insights. In: Seminars in Nephrology. ; 2004.","DOI":"10.1016\/S0270-9295(04)00125-1"},{"issue":"1","key":"10.1016\/j.ogc.2022.10.005_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.ogc.2022.10.005_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000477903","article-title":"Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1\/PlGF Ratio in Singleton Pregnancies","volume":"43","author":"Herraiz","year":"2018","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.ogc.2022.10.005_bib21","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.ogc.2022.10.005_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/j.semperi.2014.03.005","article-title":"Pathophysiology of ischemic placental disease","volume":"38","author":"Roberts","year":"2014","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ogc.2022.10.005_bib23","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s40265-017-0823-0","article-title":"Aspirin for prevention of preeclampsia","volume":"77","author":"Atallah","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.ogc.2022.10.005_bib24","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat New Biol"},{"issue":"3","key":"10.1016\/j.ogc.2022.10.005_bib25","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1124\/pr.111.004770","article-title":"Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn","volume":"64","author":"Majed","year":"2012","journal-title":"Pharmacol Rev"},{"issue":"41","key":"10.1016\/j.ogc.2022.10.005_bib26","doi-asserted-by":"crossref","first-page":"29108","DOI":"10.1074\/jbc.274.41.29108","article-title":"Molecular mechanism of thromboxane A2-induced platelet aggregation","volume":"274","author":"Paul","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ogc.2022.10.005_bib27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/00325481.2015.1050341","article-title":"A\u00a0randomized trial to assess the pharmacodynamics and pharmacokinetics of a single dose of an extended-release aspirin formulation","volume":"127","author":"Patrick","year":"2015","journal-title":"Postgrad Med"},{"issue":"10","key":"10.1016\/j.ogc.2022.10.005_bib28","doi-asserted-by":"crossref","first-page":"18928","DOI":"10.1002\/jcp.28533","article-title":"Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK\/AP-1 pathway in human trophoblast and endothelial cells","volume":"234","author":"Lin","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"issue":"4","key":"10.1016\/j.ogc.2022.10.005_bib29","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.placenta.2015.01.004","article-title":"Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1","volume":"36","author":"Li","year":"2015","journal-title":"Placenta"},{"issue":"3\u20134","key":"10.1016\/j.ogc.2022.10.005_bib30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0049-3848(80)90066-3","article-title":"Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects","volume":"17","author":"Patrono","year":"1980","journal-title":"Thromb Res"},{"key":"10.1016\/j.ogc.2022.10.005_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.preghy.2021.09.003","article-title":"Low-dose aspirin increases 15-epi-lipoxins A4 in pregnancies at high-risk for developing preeclampsia","volume":"26","author":"Gonzalez-Brown","year":"2021","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ogc.2022.10.005_bib32","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0140-6736(79)91996-2","article-title":"Effect of aspirin on incidence of preeclampsia","volume":"1","author":"Crandon","year":"1979","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.ogc.2022.10.005_bib33","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199803123381101","article-title":"Low-dose aspirin to prevent preeclampsia in women at high risk","volume":"338","author":"Caritis","year":"1998","journal-title":"N\u00a0Engl J Med"},{"issue":"8898","key":"10.1016\/j.ogc.2022.10.005_bib34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(94)92633-6","article-title":"CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women","volume":"343","year":"1994","journal-title":"Lancet"},{"issue":"17","key":"10.1016\/j.ogc.2022.10.005_bib35","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1056\/NEJM199310213291701","article-title":"Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women","volume":"329","author":"Sibai","year":"1993","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.ogc.2022.10.005_bib36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajog.2017.11.561","article-title":"Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis","volume":"218","author":"Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ogc.2022.10.005_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajog.2016.10.016","article-title":"Antiplatelet therapy before or after 16\u00a0weeks\u2019 gestation for preventing preeclampsia: an individual participant data meta-analysis","volume":"216","author":"Meher","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ogc.2022.10.005_bib38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajog.2016.09.076","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"Roberge","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib39","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/uog.18816","article-title":"ASPRE trial: performance of screening for preterm pre-eclampsia","volume":"50","author":"Rolnik","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib40","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/uog.18899","article-title":"Early screening and prevention of preterm pre-eclampsia with aspirin: time for clinical implementation","volume":"50","author":"Rolnik","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ogc.2022.10.005_bib41","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/HYPERTENSIONAHA.108.127977","article-title":"First-trimester prediction of hypertensive disorders in pregnancy","volume":"53","author":"Poon","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.ogc.2022.10.005_bib42","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1097\/AOG.0000000000001049","article-title":"American college of obstetricians and gynecologists. first-trimester risk assessment for early-onset preeclampsia","volume":"126","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.ogc.2022.10.005_bib43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm pre-eclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.ogc.2022.10.005_bib44","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/M14-1884","article-title":"Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement","volume":"161","author":"LeFevre","year":"2014","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.ogc.2022.10.005_bib45","first-page":"1","article-title":"Gestational hypertension and preeclampsia","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"12","key":"10.1016\/j.ogc.2022.10.005_bib46","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1001\/jama.2021.8551","article-title":"Aspirin use to prevent preeclampsia and related morbidity and mortality: updated evidence report and systematic review for the us preventive services task force","volume":"326","author":"Henderson","year":"2021","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.ogc.2022.10.005_bib47","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/AOG.0000000000003167","article-title":"A\u00a0nudge toward universal aspirin for preeclampsia prevention","volume":"133","author":"Ayala","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.ogc.2022.10.005_bib48","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/AOG.0000000000001115","article-title":"A\u00a0cost-benefit analysis of low-dose aspirin prophylaxis for the prevention of preeclampsia in the United States","volume":"126","author":"Werner","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib49","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1046\/j.1471-0528.2003.t01-1-02097.x","article-title":"Aspirin (100\u00a0mg) used for prevention of pre-eclampsia in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 1)","volume":"110","author":"Subtil","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.ogc.2022.10.005_bib50","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1471-0528.1998.tb10088.x","article-title":"Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications","volume":"105","author":"Rotchell","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib51","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7326\/M13-2844","article-title":"Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. preventive services task force","volume":"160","author":"Henderson","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ogc.2022.10.005_bib52","first-page":"CD004659","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","volume":"2","author":"Duley","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ogc.2022.10.005_bib53","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ajog.2017.12.238","article-title":"Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage","volume":"218","author":"Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/AAP.0000000000000763","article-title":"Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: american society of regional anesthesia and pain medicine evidence-based guidelines (4th edition)","volume":"43","author":"Horlocker","year":"2018","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.ogc.2022.10.005_bib55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/1874467209666160112123457","article-title":"Statins, Mevalonate Pathway and its Intermediate Products in Placental Development and Preeclampsia","volume":"10","author":"Caniggia","year":"2016","journal-title":"Curr Mol Pharmacol"},{"issue":"5519","key":"10.1016\/j.ogc.2022.10.005_bib56","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1059344","article-title":"Structural mechanism for statin inhibition of HMG-CoA reductase","volume":"292","author":"Istvan","year":"2001","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ogc.2022.10.005_bib57","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/OGX.0000000000000522","article-title":"Pravastatin for preventing and treating preeclampsia: a systematic review","volume":"73","author":"Esteve-Valverde","year":"2018","journal-title":"Obstet Gynecol Surv"},{"issue":"373","key":"10.1016\/j.ogc.2022.10.005_bib58","first-page":"e1","article-title":"Transplacental transfer and distribution of pravastatin","volume":"209","author":"Nanovskaya","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ogc.2022.10.005_bib59","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1073\/pnas.1011293108","article-title":"Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model","volume":"108","author":"Kumasawa","year":"2010","journal-title":"Proc Natl Acad Sci"},{"issue":"116","key":"10.1016\/j.ogc.2022.10.005_bib60","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/AOG.0b013e3181e10ebd","article-title":"Using pravastatin to improve the vascular reactivity in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia","volume":"116","author":"Costantine","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib61","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jri.2017.09.009","article-title":"Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies","volume":"124","author":"Girardi","year":"2017","journal-title":"J\u00a0Reprod Immunol"},{"key":"10.1016\/j.ogc.2022.10.005_bib62","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/HYPERTENSIONAHA.111.00226","article-title":"Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension","volume":"61","author":"Bauer","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.ogc.2022.10.005_bib63","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1161\/HYPERTENSIONAHA.114.03115","article-title":"Clinical Improvement and Successful Pregnancy in a Preeclamptic Patient With Antiphospholipid Syndrome Treated With Pravastatin","volume":"63","author":"Lefkou","year":"2014","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.ogc.2022.10.005_bib64","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1172\/JCI86957","article-title":"Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy","volume":"126","author":"Lefkou","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ogc.2022.10.005_bib65","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/HYPERTENSIONAHA.115.05445","article-title":"Effects of Pravastatin on Human Placenta, Endothelium, and Women with Severe Preeclampsia","volume":"66","author":"Brownfoot","year":"2015","journal-title":"Hypertension"},{"issue":"720","key":"10.1016\/j.ogc.2022.10.005_bib66","first-page":"e1","article-title":"Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: A pilot randomized controlled trial","volume":"214","author":"Costantine","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ogc.2022.10.005_bib67","first-page":"1","article-title":"Pravastatin is useful for prevention of recurrent severe placenta-mediated complications - a pilot study","author":"Kupferminc","year":"2021","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ogc.2022.10.005_bib68","article-title":"INOVASIA study: a multicenter randomized clinical trial of pravastatin to prevent preeclampsia in high-risk patients","author":"Akbar","year":"2022","journal-title":"Am J Perinatol"},{"issue":"9","key":"10.1016\/j.ogc.2022.10.005_bib69","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCULATIONAHA.121.053963","article-title":"Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia","volume":"144","author":"D\u00f6bert","year":"2021","journal-title":"Circulation"},{"issue":"27","key":"10.1016\/j.ogc.2022.10.005_bib70","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/eurheartj\/ehy182","article-title":"Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract","volume":"39","author":"Mach","year":"2018","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.ogc.2022.10.005_bib71","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10557-005-5686-z","article-title":"Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study","volume":"19","author":"Bruckert","year":"2005","journal-title":"Cardiovasc Drugs Ther"},{"issue":"5","key":"10.1016\/j.ogc.2022.10.005_bib72","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jacl.2016.07.002","article-title":"The risks of statin use in pregnancy: A systematic review","volume":"10","author":"Karalis","year":"2016","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.ogc.2022.10.005_bib73","doi-asserted-by":"crossref","first-page":"h1035","DOI":"10.1136\/bmj.h1035","article-title":"Statins and congenital malformations: cohort study","volume":"350","author":"Bateman","year":"2015","journal-title":"BMJ"}],"container-title":["Obstetrics and Gynecology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889854522000961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889854522000961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:26:41Z","timestamp":1760178401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889854522000961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0889854522000961"],"URL":"https:\/\/doi.org\/10.1016\/j.ogc.2022.10.005","relation":{},"ISSN":["0889-8545"],"issn-type":[{"value":"0889-8545","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy","name":"articletitle","label":"Article Title"},{"value":"Obstetrics and Gynecology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ogc.2022.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}