{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:20:19Z","timestamp":1792718419001,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F30 5F30AI164574-02"],"award-info":[{"award-number":["F30 5F30AI164574-02"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5R01CA201135"],"award-info":[{"award-number":["5R01CA201135"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009992","name":"Seattle Children's Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Advances"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.omta.2026.201666","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:53:30Z","timestamp":1767977610000},"page":"201666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function"],"prefix":"10.1016","volume":"34","author":[{"given":"Tyler F.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Helmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Yu-Hong Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah J.","family":"Homad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnal","family":"Narvekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Asher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma R.","family":"Suchland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andee R.","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris D.","family":"Thouvenel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Stoffers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lachkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Rawlings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-7367","authenticated-orcid":false,"given":"Richard G.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omta.2026.201666_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/2040620719899897","article-title":"Management of toxicities associated with novel immunotherapy agents in acute lymphoblastic leukemia","volume":"11","author":"Jain","year":"2020","journal-title":"Ther. Adv. Hematol."},{"key":"10.1016\/j.omta.2026.201666_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41573-023-00670-0","article-title":"Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems","volume":"22","author":"Baryakova","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omta.2026.201666_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2217\/ijr.15.39","article-title":"Improving treatment adherence in patients with rheumatoid arthritis: what are the options?","volume":"10","author":"Marengo","year":"2015","journal-title":"Int. J. Clin. Rheumtol."},{"key":"10.1016\/j.omta.2026.201666_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature10660","article-title":"Antibody-based protection against HIV infection by vectored immunoprophylaxis","volume":"481","author":"Balazs","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.omta.2026.201666_bib5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.omtm.2017.09.003","article-title":"In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections","volume":"7","author":"Andrews","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omta.2026.201666_bib6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/nm.1967","article-title":"Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys","volume":"15","author":"Johnson","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.omta.2026.201666_bib7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJMoa2410597","article-title":"Lentiviral gene therapy with CD34+ hematopoietic cells for hemophilia A","volume":"392","author":"Srivastava","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omta.2026.201666_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42995","article-title":"Reprogramming the antigen specificity of B cells using genome-editing technologies","volume":"8","author":"Voss","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.omta.2026.201666_bib9","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1038\/s41467-020-19649-1","article-title":"Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion","volume":"11","author":"Nahmad","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omta.2026.201666_bib10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1084\/jem.20190287","article-title":"HIV-specific humoral immune responses by CRISPR\/Cas9-edited B cells","volume":"216","author":"Hartweger","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omta.2026.201666_bib11","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1038\/s41467-020-19650-8","article-title":"Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells","volume":"11","author":"Huang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omta.2026.201666_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aax0644","article-title":"B cells engineered to express pathogen-specific antibodies protect against infection","volume":"4","author":"Moffett","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/s41419-020-03187-1","article-title":"Engineering of \u03b1-PD-1 antibody-expressing long-lived plasma cells by CRISPR\/Cas9-mediated targeted gene integration","volume":"11","author":"Luo","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omta.2026.201666_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/40540","article-title":"Lifetime of plasma cells in the bone marrow","volume":"388","author":"Manz","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.omta.2026.201666_bib15","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1056\/NEJMoa066092","article-title":"Duration of humoral immunity to common viral and vaccine antigens","volume":"357","author":"Amanna","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omta.2026.201666_bib16","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nbt.3964","article-title":"Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring","volume":"35","author":"Eyer","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omta.2026.201666_bib17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nri1886","article-title":"Competence and competition: the challenge of becoming a long-lived plasma cell","volume":"6","author":"Radbruch","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/eji.1830160206","article-title":"Limiting dilution analysis of the B cell compartment in human bone marrow","volume":"16","author":"Hibi","year":"1986","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib19","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1038\/s41467-022-33787-8","article-title":"Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo","volume":"13","author":"Cheng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omta.2026.201666_bib20","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.ymthe.2024.06.004","article-title":"Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing","volume":"32","author":"Hill","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omta.2026.201666_bib21","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41587-024-02283-3","article-title":"B cells as drug factories","volume":"42","author":"Sheridan","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omta.2026.201666_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ymthe.2017.11.012","article-title":"Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells","volume":"26","author":"Hung","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omta.2026.201666_bib23","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.humimm.2009.06.005","article-title":"Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid\/gammac-\/-Balb\/c-Rag1-\/-gammac-\/-and C.B-17-scid\/bg immunodeficient mice","volume":"70","author":"Lepus","year":"2009","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061508","article-title":"The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology","volume":"10","author":"Slamanig","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.omta.2026.201666_bib25","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.20112142","article-title":"Macrophages induce differentiation of plasma cells through CXCL10\/IP-10","volume":"209","author":"Xu","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omta.2026.201666_bib26","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1093\/infdis\/jit448","article-title":"Humoral immunity in humanized mice: a work in progress","volume":"208","author":"Seung","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.omta.2026.201666_bib27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1172\/JCI18025","article-title":"BAFF selectively enhances the survival of plasmablasts generated from human memory B cells","volume":"112","author":"Avery","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.omta.2026.201666_bib28","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1182\/blood-2018-02-832089","article-title":"BAFF bestows longevity on splenic plasma cells","volume":"131","author":"Tellier","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.omta.2026.201666_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O\u2019Connor","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omta.2026.201666_bib30","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/leu.2014.61","article-title":"IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors","volume":"28","author":"Jourdan","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.omta.2026.201666_bib31","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.4049\/jimmunol.175.12.7867","article-title":"IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells","volume":"175","author":"Ettinger","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fimmu.2014.00065","article-title":"Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage","volume":"5","author":"Moens","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib33","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.174.10.6477","article-title":"Human lymphoid and myeloid cell development in NOD\/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells","volume":"174","author":"Shultz","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209034","article-title":"Improved multilineage human hematopoietic reconstitution and function in NSGS mice","volume":"13","author":"Wunderlich","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.omta.2026.201666_bib35","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.immuni.2018.03.026","article-title":"An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus","volume":"48","author":"Snijder","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.omta.2026.201666_bib36","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1182\/blood.V69.5.1307.1307","article-title":"The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor","volume":"69","author":"Tweeddale","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.omta.2026.201666_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adh8846","article-title":"BCR signaling is required for posttransplant lymphoproliferative disease in immunodeficient mice receiving human B cells","volume":"16","author":"Zhang","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omta.2026.201666_bib38","article-title":"IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2","volume":"219","author":"Hale","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omta.2026.201666_bib39","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1002\/eji.201444729","article-title":"Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD\/LtSzscid\/IL-2R\u03b3(-\/-) mice","volume":"44","author":"Ishikawa","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2023.101111","article-title":"Production of therapeutic levels of human FIX-R338L by engineered B cells using GMP-compatible medium","volume":"31","author":"David","year":"2023","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omta.2026.201666_bib41","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/imr.12011","article-title":"The establishment of the plasma cell survival niche in the bone marrow","volume":"251","author":"Chu","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.omta.2026.201666_bib42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral immunity due to long-lived plasma cells","volume":"8","author":"Slifka","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.omta.2026.201666_bib43","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.immuni.2023.04.015","article-title":"Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan","volume":"56","author":"Robinson","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.omta.2026.201666_bib44","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221717","article-title":"Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow","volume":"220","author":"Koike","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.omta.2026.201666_bib45","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.humimm.2012.01.006","article-title":"Monocytes derived from humanized neonatal NOD\/SCID\/IL2R\u03b3(null) mice are phenotypically immature and exhibit functional impairments","volume":"73","author":"Gille","year":"2012","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib46","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev-immunol-032712-095921","article-title":"Human hemato-lymphoid system mice: current use and future potential for medicine","volume":"31","author":"Rongvaux","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib47","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ymthe.2024.12.042","article-title":"In vivo tracking of ex-vivo-generated 89Zr-oxine-labeled plasma cells by PET in a non-human primate model","volume":"33","author":"Young","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omta.2026.201666_bib48","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1074\/jbc.M109.081828","article-title":"Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding","volume":"285","author":"Andersen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.omta.2026.201666_bib49","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000619","article-title":"Fc\u03b3RII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion","volume":"8","author":"Oldham","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.omta.2026.201666_bib50","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1158\/1535-7163.MCT-18-0977","article-title":"Mouse strains influence clearance and efficacy of antibody and antibody-drug conjugate via Fc-Fc\u03b3R interaction","volume":"18","author":"Li","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omta.2026.201666_bib51","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.4049\/jimmunol.1200356","article-title":"Crosstalk between human IgG isotypes and murine effector cells","volume":"189","author":"Overdijk","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib52","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1158\/1535-7163.MCT-17-0998","article-title":"Antibody-dependent cellular phagocytosis by macrophages is a novel mechanism of action of elotuzumab","volume":"17","author":"Kurdi","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.omta.2026.201666_bib53","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200045R","article-title":"Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15","volume":"36","author":"Aryee","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.omta.2026.201666_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/v15020365","article-title":"Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection","volume":"15","author":"Abeynaike","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.omta.2026.201666_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8101667","article-title":"NK Cell-Fc Receptors Advance Tumor Immunotherapy","volume":"8","author":"Sanseviero","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.omta.2026.201666_bib56","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.2337\/diab.42.11.1574","article-title":"Complement lytic activity has no role in the pathogenesis of autoimmune diabetes in NOD mice","volume":"42","author":"Baxter","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.omta.2026.201666_bib57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jim.2017.03.021","article-title":"A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo","volume":"446","author":"Verma","year":"2017","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.omta.2026.201666_bib58","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.stem.2014.06.001","article-title":"Kit regulates HSC engraftment across the human-mouse species barrier","volume":"15","author":"Cosgun","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.omta.2026.201666_bib59","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41590-024-01880-3","article-title":"A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses","volume":"25","author":"Chupp","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.molcel.2009.05.019","article-title":"LysRS serves as a key signaling molecule in the immune response by regulating gene expression","volume":"34","author":"Yannay-Cohen","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omta.2026.201666_bib61","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.104.3.761","article-title":"Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein","volume":"104","author":"Hendershot","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.omta.2026.201666_bib62","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/mabs.23392","article-title":"Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression","volume":"5","author":"Buchanan","year":"2013","journal-title":"mAbs"},{"key":"10.1016\/j.omta.2026.201666_bib63","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/protein\/gzs042","article-title":"Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions","volume":"25","author":"Perchiacca","year":"2012","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.omta.2026.201666_bib64","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1126\/science.adi1763","article-title":"Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand","volume":"383","author":"Gigu\u00e8re","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.omta.2026.201666_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-39367-8","article-title":"SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells","volume":"14","author":"Cheng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omta.2026.201666_bib66","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.2000583","article-title":"A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection","volume":"205","author":"Alsoussi","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.omta.2026.201666_bib67","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cell.2020.11.029","article-title":"Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19","volume":"184","author":"Rodda","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.omta.2026.201666_bib68","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14041","article-title":"2FAST2Q: a general-purpose sequence search and counting program for FASTQ files","volume":"10","author":"Bravo","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.omta.2026.201666_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/v12050513","article-title":"Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays","volume":"12","author":"Crawford","year":"2020","journal-title":"Viruses"}],"container-title":["Molecular Therapy Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3117387X26000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3117387X26000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:44:38Z","timestamp":1788554678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3117387X26000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S3117387X26000017"],"URL":"https:\/\/doi.org\/10.1016\/j.omta.2026.201666","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.07.14.664835","asserted-by":"object"}]},"ISSN":["3117-387X"],"issn-type":[{"value":"3117-387X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Humanized mice enable in vivo evaluation of engineered plasma cell biology and therapeutic function","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omta.2026.201666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"201666"}}