{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:06:58Z","timestamp":1789056418797,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Advances"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.omta.2026.201822","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:29:55Z","timestamp":1785338995000},"page":"201822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutralization of pathogenic PC-OxPL by AAV-delivered scFv as a therapeutic strategy for amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-1906","authenticated-orcid":false,"given":"Andreia","family":"Gomes-Duarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Pasteuning-Vuhman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Pos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Haselberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Sogorb-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Pascoal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Borst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurima","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Giera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Tsimikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud A.","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"van Deventer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omta.2026.201822_bib1","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/nrdp.2017.71","article-title":"Amyotrophic lateral sclerosis","volume":"3","author":"Hardiman","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.omta.2026.201822_bib2","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"van Es","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.omta.2026.201822_bib3","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","article-title":"AMYOTROPHIC LATERAL SCLEROSIS","volume":"344","author":"Rowland","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omta.2026.201822_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s13311-015-0338-x","article-title":"TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets","volume":"12","author":"Scotter","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.omta.2026.201822_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00025","article-title":"Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis","volume":"12","author":"Prasad","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.103396","article-title":"TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration","volume":"100","author":"Gao","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-020-00397-1","article-title":"The role of TDP-43 mislocalization in amyotrophic lateral sclerosis","volume":"15","author":"Suk","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.omta.2026.201822_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nri.2016.63","article-title":"Innate sensing of oxidation-specific epitopes in health and disease","volume":"16","author":"Binder","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omta.2026.201822_bib9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and Biological Activities of Oxidized Phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.omta.2026.201822_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fddsv.2022.1043708","article-title":"Oxidized phospholipids are biomarkers, drug targets, and drug leads","volume":"2","author":"Oskolkova","year":"2022","journal-title":"Frontiers in Drug Discovery"},{"key":"10.1016\/j.omta.2026.201822_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.tins.2022.03.002","article-title":"Oxidized phospholipids as novel mediators of neurodegeneration","volume":"45","author":"Dong","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib12","doi-asserted-by":"crossref","first-page":"13577","DOI":"10.1021\/jacs.5c00594","article-title":"Membrane Charge Drives the Aggregation of TDP-43 Pathological Fragments","volume":"147","author":"Corucci","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.omta.2026.201822_bib13","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/s41418-020-0542-z","article-title":"Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation","volume":"27","author":"Angelova","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omta.2026.201822_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130200","article-title":"Molecular basis of the anchoring and stabilization of human islet amyloid polypeptide in lipid hydroperoxidized bilayers","volume":"1866","author":"Espinosa","year":"2022","journal-title":"Biochim. Biophys. Acta. Gen. Subj."},{"key":"10.1016\/j.omta.2026.201822_bib15","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1021\/bi200195s","article-title":"1-palmitoyl-2-(9\u2032-oxononanoyl)- sn -glycero-3-phosphocholine, an oxidized phospholipid, accelerates finnish type familial gelsolin amyloidosis in vitro","volume":"50","author":"Mahalka","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.omta.2026.201822_bib16","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1039\/B925228B","article-title":"Formation of lipid\/peptide tubules by IAPP and temporin B on supported lipid membranes","volume":"11","author":"Kinnunen","year":"2015","journal-title":"Soft Matter"},{"key":"10.1016\/j.omta.2026.201822_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.freeradbiomed.2017.03.008","article-title":"Phospholipid oxidation and carotenoid supplementation in Alzheimer\u2019s disease patients","volume":"108","author":"Ademowo","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.omta.2026.201822_bib18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neuron.2025.10.040","article-title":"Protective ApoE variants support neuronal function by effluxing oxidized phospholipids","volume":"114","author":"Ralhan","year":"2026","journal-title":"Neuron"},{"key":"10.1016\/j.omta.2026.201822_bib19","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuron.2023.10.023","article-title":"Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist","volume":"112","author":"Litvinchuk","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.omta.2026.201822_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41593-021-00801-z","article-title":"Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia","volume":"24","author":"Dong","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41593-025-02113-y","article-title":"Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1\u03b2 signaling","volume":"29","author":"Yu","year":"2026","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib22","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1007\/s10571-021-01059-6","article-title":"Main Role of Antibodies in Demyelination and Axonal Damage in Multiple Sclerosis","volume":"42","author":"Mu\u00f1oz","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.omta.2026.201822_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17389-9","article-title":"Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS","volume":"7","author":"Blasco","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omta.2026.201822_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ana.26375","article-title":"Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS","volume":"92","author":"Beers","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.omta.2026.201822_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cmet.2019.10.014","article-title":"Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis","volume":"31","author":"Sun","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.omta.2026.201822_bib26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41586-018-0198-8","article-title":"Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice","volume":"558","author":"Que","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.omta.2026.201822_bib27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41569-023-00937-4","article-title":"Oxidized phospholipids in cardiovascular disease","volume":"21","author":"Tsimikas","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.omta.2026.201822_bib28","doi-asserted-by":"crossref","first-page":"eabn0050","DOI":"10.1126\/sciadv.abn0050","article-title":"Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis","volume":"8","author":"Upchurch","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omta.2026.201822_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13442","article-title":"Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice","volume":"20","author":"Palmieri","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.omta.2026.201822_bib30","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1111\/bph.14340","article-title":"Antinociception by the anti-oxidized phospholipid antibody E06","volume":"175","author":"Mohammadi","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.omta.2026.201822_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/cvr\/cvy136","article-title":"Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids","volume":"115","author":"Yeang","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.omta.2026.201822_bib32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00401-019-02077-x","article-title":"The basis of clinicopathological heterogeneity in TDP-43 proteinopathy","volume":"138","author":"Kawakami","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.omta.2026.201822_bib33","series-title":"Clinical Metabolomics Methods and Protocols","author":"Giera","year":"2025"},{"key":"10.1016\/j.omta.2026.201822_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exger.2015.08.011","article-title":"Of mice, pigs and humans: An analysis of mitochondrial phospholipids from mammals with very different maximal lifespans","volume":"70","author":"Cortie","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.omta.2026.201822_bib35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-017-3203-x","article-title":"Comprehensive analysis of phospholipids in the brain, heart, kidney, and liver: brain phospholipids are least enriched with polyunsaturated fatty acids","volume":"442","author":"Choi","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.omta.2026.201822_bib36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11357-017-9961-2","article-title":"The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging","volume":"39","author":"Hancock","year":"2017","journal-title":"GeroScience"},{"key":"10.1016\/j.omta.2026.201822_bib37","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/humu.22157","article-title":"ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics","volume":"33","author":"Abel","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.omta.2026.201822_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10488-7","article-title":"Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS","volume":"7","author":"D\u2019Erchia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omta.2026.201822_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-022-04436-3","article-title":"TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A","volume":"603","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.omta.2026.201822_bib68","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.mad.2010.05.003","article-title":"Mitochondrial dysfunction and intracellular calcium dysregulation in ALS","volume":"131","author":"Kawamata","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.omta.2026.201822_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24786","article-title":"Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment","volume":"10","author":"Mohan","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.omta.2026.201822_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114088","article-title":"RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson\u2019s disease by suppressing NLRP3 inflammasome activation","volume":"439","author":"Hu","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.omta.2026.201822_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/2264799","article-title":"RND3 Potentiates Proinflammatory Activation through NOTCH Signaling in Activated Macrophages","volume":"2024","author":"de \u00c1vila","year":"2024","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.omta.2026.201822_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/379817","article-title":"Implication of Caspase-3 as a Common Therapeutic Target for Multineurodegenerative Disorders and Its Inhibition Using Nonpeptidyl Natural Compounds","volume":"2015","author":"Khan","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.omta.2026.201822_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.expneurol.2017.03.014","article-title":"Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS","volume":"292","author":"Rosenblum","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.omta.2026.201822_bib46","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2353\/ajpath.2008.080434","article-title":"Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer\u2019s disease","volume":"173","author":"Louneva","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.omta.2026.201822_bib47","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.celrep.2015.04.030","article-title":"Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins","volume":"11","author":"Hosp","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.omta.2026.201822_bib48","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0092-8674(00)80748-5","article-title":"Involvement of Caspases in Proteolytic Cleavage of Alzheimer\u2019s Amyloid-\u03b2 Precursor Protein and Amyloidogenic A\u03b2 Peptide Formation","volume":"97","author":"Gervais","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.omta.2026.201822_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1368200","article-title":"Enhancing of cerebral Abeta clearance by modulation of ABC transporter expression: a review of experimental approaches","volume":"16","author":"Loeffler","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75057-x","article-title":"CELF2 regulates the species-specific alternative splicing of TREM2","volume":"10","author":"Yanaizu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omta.2026.201822_bib51","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1242\/jcs.002063","article-title":"Hrk\/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis","volume":"120","author":"Coultas","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.omta.2026.201822_bib52","doi-asserted-by":"crossref","first-page":"17004","DOI":"10.1073\/pnas.1109356108","article-title":"Ubiquitin ligase Nedd4 promotes \u03b1-synuclein degradation by the endosomal-lysosomal pathway","volume":"108","author":"Tofaris","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omta.2026.201822_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac207","article-title":"Apolipoprotein B-100-mediated motor neuron degeneration in sporadic amyotrophic lateral sclerosis","volume":"4","author":"Wong","year":"2022","journal-title":"Brain Commun."},{"key":"10.1016\/j.omta.2026.201822_bib54","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1212\/WNL.58.7.1112","article-title":"APOE: A potential marker of disease progression in ALS","volume":"58","author":"Lacomblez","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.omta.2026.201822_bib55","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","article-title":"Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism","volume":"36","author":"Mahley","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.omta.2026.201822_bib56","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.omta.2026.201822_bib57","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0014-4886(03)00185-7","article-title":"Differential metabolism of ApoE isoforms in plasma and CSF","volume":"183","author":"Wahrle","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.omta.2026.201822_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14010110","article-title":"Oxidative Stress and the Central Nervous System","volume":"14","author":"D\u2019Ascenzo","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.omta.2026.201822_bib59","doi-asserted-by":"crossref","first-page":"100990","DOI":"10.1016\/j.jlr.2026.100990","article-title":"From damage signals to immune modulators: oxidized lipids in immunometabolic inflammation","volume":"67","author":"Srivastava","year":"2026","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.omta.2026.201822_bib60","doi-asserted-by":"crossref","first-page":"14756","DOI":"10.1021\/acs.langmuir.7b03236","article-title":"Understanding how sterols regulate membrane remodeling in supported lipid bilayers","volume":"33","author":"Kawakami","year":"2017","journal-title":"Langmuir"},{"key":"10.1016\/j.omta.2026.201822_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-025-11553-6","article-title":"Assessing concordance between RNA-Seq and NanoString technologies in Ebola-infected nonhuman primates using machine learning","volume":"26","author":"Rezapour","year":"2025","journal-title":"BMC Genom."},{"key":"10.1016\/j.omta.2026.201822_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15145-7","article-title":"Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques","volume":"7","author":"Speranza","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omta.2026.201822_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105760","article-title":"Alternative normalization and analysis pipeline to address systematic bias in NanoString GeoMx Digital Spatial Profiling data","volume":"26","author":"van Hijfte","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.omta.2026.201822_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1620181","article-title":"Targeting oxidized phosphatidylcholines in SOD1-associated ALS: therapeutic potential of PC-OxPL-VecTab\u00ae","volume":"19","author":"Gomes-Duarte","year":"2025","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib65","doi-asserted-by":"crossref","first-page":"11694","DOI":"10.1021\/acs.jpcb.4c05451","article-title":"Atherosclerotic Oxidized Lipids Affect Formation and Biophysical Properties of Supported Lipid Bilayers and Simulated Membranes","volume":"128","author":"Santa","year":"2024","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.omta.2026.201822_bib66","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1021\/la100657a","article-title":"Oxidation changes physical properties of phospholipid bilayers: Fluorescence spectroscopy and molecular simulations","volume":"26","author":"Beranova","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.omta.2026.201822_bib67","article-title":"Mechanisms of TDP-43 proteinopathy onset and propagation","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omta.2026.201822_bib69","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00401-018-1835-x","article-title":"Energy metabolism in ALS: an underappreciated opportunity?","volume":"135","author":"Vandoorne","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.omta.2026.201822_bib70","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40035-022-00322-0","article-title":"Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine","volume":"11","author":"Agrawal","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.omta.2026.201822_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.01310","article-title":"ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?","volume":"13","author":"Mejzini","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.omta.2026.201822_bib72","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00401-012-1058-5","article-title":"Unravelling the enigma of selective vulnerability in neurodegeneration: Motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity","volume":"125","author":"Brockington","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.omta.2026.201822_bib73","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s11064-024-04194-w","article-title":"The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment","volume":"49","author":"Wang","year":"2024","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.omta.2026.201822_bib74","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41418-021-00910-z","article-title":"Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.omta.2026.201822_bib75","first-page":"19","article-title":"A Brief Overview on Oxylipins and their Analytical Techniques","volume":"12","author":"Suzuki","year":"2022","journal-title":"Int J Pharm"},{"key":"10.1016\/j.omta.2026.201822_bib76","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJMoa1905239","article-title":"Lipoprotein(a) Reduction in Persons with Cardiovascular Disease","volume":"382","author":"Tsimikas","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.omta.2026.201822_bib77","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1194\/jlr.P027235","article-title":"Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia","volume":"53","author":"Arai","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.omta.2026.201822_bib78","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/mt.2008.35","article-title":"Intron splicing-mediated expression of AAV rep and cap genes and production of AAV vectors in insect cells","volume":"16","author":"Chen","year":"2008","journal-title":"Mol. Ther."}],"container-title":["Molecular Therapy Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3117387X26001576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3117387X26001576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:17:24Z","timestamp":1789053444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3117387X26001576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S3117387X26001576"],"URL":"https:\/\/doi.org\/10.1016\/j.omta.2026.201822","relation":{},"ISSN":["3117-387X"],"issn-type":[{"value":"3117-387X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutralization of pathogenic PC-OxPL by AAV-delivered scFv as a therapeutic strategy for amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omta.2026.201822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"201822"}}