{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:53:09Z","timestamp":1782301989869,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019522","name":"JCR Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019522","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["15K10317"],"award-info":[{"award-number":["15K10317"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26293328"],"award-info":[{"award-number":["26293328"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.omtm.2018.07.009","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T23:03:27Z","timestamp":1533337407000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia\/Reperfusion in Rats"],"prefix":"10.1016","volume":"10","author":[{"given":"Kota","family":"Sowa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nitahara-Kasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Nakamura-Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2018.07.009_bib1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1161\/STROKEAHA.115.009163","article-title":"Marked regional variation in acute stroke treatment among Medicare beneficiaries","volume":"46","author":"Skolarus","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.07.009_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2015.11.1.1","article-title":"Endovascular therapy for ischemic stroke","volume":"11","author":"Appireddy","year":"2015","journal-title":"J.\u00a0Clin. Neurol."},{"issue":"2, Suppl","key":"10.1016\/j.omtm.2018.07.009_bib3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.STR.0000247888.25985.62","article-title":"Cell transplantation therapy for stroke","volume":"38","author":"Bliss","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.07.009_bib4","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1161\/STROKEAHA.117.019216","article-title":"Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products","volume":"49","author":"Houkin","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.07.009_bib5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.07.009_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1479-5876-8-63","article-title":"Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats","volume":"8","author":"Leu","year":"2010","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.omtm.2018.07.009_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5607\/en.2017.26.1.55","article-title":"Effect of single and double administration of human umbilical cord blood-derived mesenchymal stem cells following focal cerebral ischemia in rats","volume":"26","author":"Park","year":"2017","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.omtm.2018.07.009_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(03)00174-5","article-title":"Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia","volume":"343","author":"Chu","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.omtm.2018.07.009_bib9","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.omtm.2018.07.009_bib10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/stem.1909","article-title":"Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells","volume":"33","author":"Liu","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.omtm.2018.07.009_bib11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/01.tp.0000173794.72151.88","article-title":"Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp","volume":"80","author":"Pierdomenico","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.omtm.2018.07.009_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/1305-7456.137631","article-title":"Comparison of phenotype and differentiation marker gene expression profiles in human dental pulp and bone marrow mesenchymal stem cells","volume":"8","author":"Ponnaiyan","year":"2014","journal-title":"Eur. J. Dent."},{"key":"10.1016\/j.omtm.2018.07.009_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/dbio.2001.0400","article-title":"Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in\u00a0vitro, and rescue motoneurons after spinal cord injury","volume":"238","author":"Nosrat","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.omtm.2018.07.009_bib14","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1111\/j.0953-816X.2004.03314.x","article-title":"Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in\u00a0vitro; implications for tissue engineering and repair in the nervous system","volume":"19","author":"Nosrat","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.omtm.2018.07.009_bib15","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1634\/stemcells.2008-0285","article-title":"Putative dental pulp-derived stem\/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice","volume":"26","author":"Huang","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.omtm.2018.07.009_bib16","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/stem.138","article-title":"Implanted adult human dental pulp stem cells induce endogenous axon guidance","volume":"27","author":"Arthur","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.omtm.2018.07.009_bib17","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1089\/ten.tea.2010.0306","article-title":"Dental pulp-derived CD31\u2212\/CD146\u2212 side population stem\/progenitor cells enhance recovery of focal cerebral ischemia in rats","volume":"17","author":"Sugiyama","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.omtm.2018.07.009_bib18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3727\/096368916X694391","article-title":"Human dental pulp stem cells are more effective than human bone marrow-derived mesenchymal stem cells in cerebral ischemic injury","volume":"26","author":"Song","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.omtm.2018.07.009_bib19","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(84)91253-1","article-title":"Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats","volume":"122","author":"Nakamura","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtm.2018.07.009_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0014-5793(87)80475-1","article-title":"Purification and subunit structure of hepatocyte growth factor from rat platelets","volume":"224","author":"Nakamura","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.omtm.2018.07.009_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/oxfordjournals.jbchem.a021283","article-title":"Emerging multipotent aspects of hepatocyte growth factor","volume":"119","author":"Matsumoto","year":"1996","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.omtm.2018.07.009_bib22","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/342440a0","article-title":"Molecular cloning and expression of human hepatocyte growth factor","volume":"342","author":"Nakamura","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2018.07.009_bib23","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/hep.1840160520","article-title":"Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in\u00a0vivo","volume":"16","author":"Ishiki","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.omtm.2018.07.009_bib24","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1002\/jnr.21372","article-title":"Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury","volume":"85","author":"Kitamura","year":"2007","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.omtm.2018.07.009_bib25","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1523\/JNEUROSCI.22-15-06537.2002","article-title":"Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS","volume":"22","author":"Sun","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2018.07.009_bib26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.HYP.0000136394.08900.ed","article-title":"Safety evaluation of clinical gene\u00a0therapy using hepatocyte growth factor to treat peripheral arterial disease","volume":"44","author":"Morishita","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.omtm.2018.07.009_bib27","first-page":"629","article-title":"Short-term safety and curative effect of recombinant adenovirus carrying hepatocyte growth factor gene on ischemic cardiac disease","volume":"22","author":"Yuan","year":"2008","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.omtm.2018.07.009_bib28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.CIR.0000109496.82683.49","article-title":"Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model","volume":"109","author":"Shimamura","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.omtm.2018.07.009_bib29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.omtm.2018.07.009_bib30","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/WCO.0b013e32832b4db3","article-title":"Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options","volume":"22","author":"Kleinig","year":"2009","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.omtm.2018.07.009_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/TP.0b013e318259d38e","article-title":"Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury","volume":"94","author":"Liu","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.omtm.2018.07.009_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1479-5876-7-97","article-title":"Inflammatory mechanisms in ischemic stroke: therapeutic approaches","volume":"7","author":"Lakhan","year":"2009","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.omtm.2018.07.009_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12868-014-0125-3","article-title":"Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia","volume":"15","author":"Yuan","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.omtm.2018.07.009_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neulet.2006.08.050","article-title":"Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels","volume":"407","author":"Date","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.omtm.2018.07.009_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mvr.2013.12.004","article-title":"Hepatocyte growth factor enhances the barrier function in primary cultures of rat brain microvascular endothelial cells","volume":"92","author":"Yamada","year":"2014","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.omtm.2018.07.009_bib36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.bbrc.2005.11.133","article-title":"Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries","volume":"339","author":"Kago","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtm.2018.07.009_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1474-4422(09)70061-4","article-title":"Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic","volume":"8","author":"Zhang","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.omtm.2018.07.009_bib38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yexcr.2005.11.026","article-title":"Discovery of vascular permeability factor (VPF)","volume":"312","author":"Dvorak","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.omtm.2018.07.009_bib39","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1177\/00220345000790081201","article-title":"The role of vascular endothelial growth factor in human dental pulp cells: induction of chemotaxis, proliferation, and differentiation and activation of the AP-1-dependent signaling pathway","volume":"79","author":"Matsushita","year":"2000","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.omtm.2018.07.009_bib40","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1440-1789.2010.01182.x","article-title":"Human embryonic neural stem cell transplantation increases subventricular zone cell proliferation and promotes peri-infarct angiogenesis after focal cerebral ischemia","volume":"31","author":"Zhang","year":"2011","journal-title":"Neuropathology"},{"key":"10.1016\/j.omtm.2018.07.009_bib41","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awl207","article-title":"Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia","volume":"129","author":"Liu","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.omtm.2018.07.009_bib42","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0002-9440(10)64058-8","article-title":"Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in\u00a0vitro and in\u00a0vivo","volume":"158","author":"Xin","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.omtm.2018.07.009_bib43","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1158\/1078-0432.CCR-08-3252","article-title":"HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer","volume":"15","author":"Knowles","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtm.2018.07.009_bib44","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/CMR.00008-08","article-title":"Gene therapy using adeno-associated virus vectors","volume":"21","author":"Daya","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.omtm.2018.07.009_bib45","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/mt.2008.103","article-title":"Recombinant adeno-associated virus transduction and integration","volume":"16","author":"Schultz","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2018.07.009_bib46","doi-asserted-by":"crossref","first-page":"15058","DOI":"10.1038\/mtm.2015.58","article-title":"Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1)","volume":"3","author":"Tomono","year":"2016","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2018.07.009_bib47","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1179\/1743132811Y.0000000019","article-title":"FK506 ameliorates oxidative damage and protects rat brain following transient focal cerebral ischemia","volume":"33","author":"Nito","year":"2011","journal-title":"Neurol. Res."},{"key":"10.1016\/j.omtm.2018.07.009_bib48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.omtm.2017.06.005","article-title":"Mesenchymal stem cells overexpressing interleukin-10 promote neuroprotection in experimental acute ischemic stroke","volume":"6","author":"Nakajima","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2018.07.009_bib49","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1523\/JNEUROSCI.23-25-08733.2003","article-title":"Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?","volume":"23","author":"Kim","year":"2003","journal-title":"J.\u00a0Neurosci."}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050118300731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050118300731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:22:27Z","timestamp":1762420947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050118300731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":49,"alternative-id":["S2329050118300731"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2018.07.009","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia\/Reperfusion in Rats","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2018.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}