{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:45:04Z","timestamp":1761709504969,"version":"3.37.3"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China-Japan Union Hospital of Jilin University","award":["201510382781.X"],"award-info":[{"award-number":["201510382781.X"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100702","81601445"],"award-info":[{"award-number":["81100702","81601445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Family Planning Foundation of Jilin Province","award":["20152046"],"award-info":[{"award-number":["20152046"]}]},{"name":"Science and Technology Development Plan Foundation of Jilin Province","award":["20160101070JC"],"award-info":[{"award-number":["20160101070JC"]}]},{"name":"Norman Bethune Program of Jilin University","award":["2015305"],"award-info":[{"award-number":["2015305"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.omtm.2018.09.004","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T23:19:46Z","timestamp":1538608786000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["P-FN12, an H4R-Based Epitope Vaccine Screened by Phage Display, Regulates the Th1\/Th2 Balance in Rat Allergic Rhinitis"],"prefix":"10.1016","volume":"11","author":[{"given":"Yuqian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jichao","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2018.09.004_bib1","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00405-017-4606-8","article-title":"Concentration-dependent effects of PM2.5 mass on expressions of adhesion molecules and inflammatory cytokines in nasal mucosa of rats with allergic rhinitis","volume":"274","author":"Wang","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.omtm.2018.09.004_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0091-6749(92)90155-U","article-title":"Mediators of allergic rhinitis","volume":"90","author":"White","year":"1992","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2222.1998.0280s6015.x","article-title":"Histamine\u2013a major role in allergy?","volume":"28","author":"Bachert","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.omtm.2018.09.004_bib4","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.4049\/jimmunol.176.11.7062","article-title":"The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T\u00a0cells","volume":"176","author":"Dunford","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2465","article-title":"The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines","volume":"7","author":"Thurmond","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtm.2018.09.004_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/all.12779","article-title":"Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis","volume":"71","author":"Rossbach","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.omtm.2018.09.004_bib7","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/all.12875","article-title":"Human basophil chemotaxis and activation are regulated via the histamine H4 receptor","volume":"71","author":"Mommert","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.omtm.2018.09.004_bib8","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/all.12904","article-title":"Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function","volume":"71","author":"Wang","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.omtm.2018.09.004_bib9","first-page":"967","article-title":"Azines as histamine H4 receptor antagonists","volume":"4","author":"Lazewska","year":"2012","journal-title":"Front. Biosci. (Schol. Ed.)"},{"key":"10.1016\/j.omtm.2018.09.004_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1465-9921-11-86","article-title":"Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines","volume":"11","author":"Cowden","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.omtm.2018.09.004_bib11","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.intimp.2009.02.011","article-title":"Effect of histamine H4 receptor antagonist on allergic rhinitis in mice","volume":"9","author":"Takahashi","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.omtm.2018.09.004_bib12","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/all.12904","article-title":"Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced intestinal anaphylaxis by regulating dendritic cell function","volume":"71","author":"Wang","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.omtm.2018.09.004_bib13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/eji.201445179","article-title":"The histamine H4 -receptor (H4 R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice","volume":"45","author":"Hartwig","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib14","first-page":"628","article-title":"A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic","volume":"12","author":"Engelhardt","year":"2009","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1016\/j.omtm.2018.09.004_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2007.03.034","article-title":"Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study","volume":"120","author":"Walker","year":"2007","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.omtm.2018.09.004_bib16","first-page":"32","article-title":"Allergic rhinitis and school performance","volume":"19","author":"J\u00e1uregui","year":"2009","journal-title":"J.\u00a0Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2332\/allergolint.09-RAI-0151","article-title":"Antigen-specific immunotherapy against allergic rhinitis: the state of the art","volume":"59","author":"Fujimura","year":"2010","journal-title":"Allergol. Int."},{"key":"10.1016\/j.omtm.2018.09.004_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2500\/aap.2011.32.3428","article-title":"Novel cytokines and cytokine-producing T\u00a0cells in allergic disorders","volume":"32","author":"Wisniewski","year":"2011","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.omtm.2018.09.004_bib19","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/cea.12378","article-title":"Th17 response and its regulation in inflammatory upper airway diseases","volume":"45","author":"Liu","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.omtm.2018.09.004_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2500\/aap.2012.33.3588","article-title":"Innate and lymphocytic response of birch-allergic patients before and after sublingual immunotherapy","volume":"33","author":"Guida","year":"2012","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.omtm.2018.09.004_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/dna.2015.3037","article-title":"Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In\u00a0Vivo","volume":"35","author":"Wang","year":"2016","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.omtm.2018.09.004_bib22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/imm.12257","article-title":"Role of a histamine 4 receptor as an anti-inflammatory target in carrageenan-induced pleurisy in mice","volume":"142","author":"Ahmad","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.omtm.2018.09.004_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1517\/14656566.2014.860445","article-title":"Pharmacotherapy of allergic rhinitis: current options and future perspectives","volume":"15","author":"Ridolo","year":"2014","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.omtm.2018.09.004_bib24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4049\/jimmunol.1202049","article-title":"Sequential engagement of Fc\u03b5RI on Mast Cells and Basophil Histamine H(4) Receptor and Fc\u03b5RI in Allergic Rhinitis","volume":"190","author":"Shiraishi","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib25","doi-asserted-by":"crossref","first-page":"e0150463","DOI":"10.1371\/journal.pone.0150463","article-title":"Mouse Model of Cat Allergic Rhinitis and Intranasal Liposome-Adjuvanted Refined Fel d 1 Vaccine","volume":"11","author":"Tasaniyananda","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2018.09.004_bib26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000486313","article-title":"Therapeutic Role for TSP-2 Antibody in a Murine Asthma Model","volume":"175","author":"Li","year":"2018","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.molimm.2017.07.015","article-title":"Derp1-modified dendritic cells attenuate allergic inflammation by regulating the development of T helper type1(Th1)\/Th2 cells and regulatory T\u00a0cells in a murine model of allergic rhinitis","volume":"90","author":"Yu","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.omtm.2018.09.004_bib28","doi-asserted-by":"crossref","first-page":"e69106","DOI":"10.1371\/journal.pone.0069106","article-title":"Protection of radiation-induced damage to the hematopoietic system, small intestine and salivary glands in rats by JNJ7777120 compound, a histamine H4 ligand","volume":"8","author":"Martinel Lamas","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050118300950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050118300950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T13:45:14Z","timestamp":1565271914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050118300950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":28,"alternative-id":["S2329050118300950"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2018.09.004","relation":{},"ISSN":["2329-0501"],"issn-type":[{"type":"print","value":"2329-0501"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P-FN12, an H4R-Based Epitope Vaccine Screened by Phage Display, Regulates the Th1\/Th2 Balance in Rat Allergic Rhinitis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2018.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}