{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:28:02Z","timestamp":1773494882732,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX106-10605PI"],"award-info":[{"award-number":["NHRI-EX106-10605PI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["103-2314-B-037-027-MY2"],"award-info":[{"award-number":["103-2314-B-037-027-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2314-B-039-050"],"award-info":[{"award-number":["105-2314-B-039-050"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2314-B-039-021"],"award-info":[{"award-number":["MOST 106-2314-B-039-021"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST103-2314-B-037-026-MY3"],"award-info":[{"award-number":["MOST103-2314-B-037-026-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","award":["100TM014"],"award-info":[{"award-number":["100TM014"]}],"id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.omtm.2018.11.011","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T23:36:30Z","timestamp":1546990590000},"page":"121-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["miR-195 Has a Potential to Treat Ischemic and Hemorrhagic Stroke through Neurovascular Protection and Neurogenesis"],"prefix":"10.1016","volume":"13","author":[{"given":"Hsin-Yun","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suh-Hang H.","family":"Juo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2018.11.011_bib1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(09)70025-0","article-title":"Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review","volume":"8","author":"Feigin","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.omtm.2018.11.011_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1941874415583116","article-title":"Intravenous thrombolysis for acute ischemic stroke within 3 hours versus between 3 and 4.5 hours of symptom onset","volume":"5","author":"Cheng","year":"2015","journal-title":"Neurohospitalist"},{"key":"10.1016\/j.omtm.2018.11.011_bib3","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.STR.0000165902.18021.5b","article-title":"Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry","volume":"36","author":"Reeves","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.11.011_bib4","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1161\/STR.0b013e3181ec611b","article-title":"Guidelines for the management of spontaneous intracerebral hemorrhage:\u00a0a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"41","author":"Morgenstern","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.11.011_bib5","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/ijs.12309","article-title":"European Stroke Organisation (ESO) guidelines for the management of spontaneous\u00a0intracerebral hemorrhage","volume":"9","author":"Steiner","year":"2014","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.omtm.2018.11.011_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/cvr\/cvs223","article-title":"MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation","volume":"95","author":"Wang","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.omtm.2018.11.011_bib7","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1523\/JNEUROSCI.1997-12.2013","article-title":"MicroRNA-195 protects against dementia induced by chronic\u00a0brain hypoperfusion via its anti-amyloidogenic effect in rats","volume":"33","author":"Ai","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2018.11.011_bib8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.brainresbull.2012.05.018","article-title":"MicroRNA-195 downregulates Alzheimer\u2019s disease amyloid-\u03b2 production by targeting BACE1","volume":"88","author":"Zhu","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.omtm.2018.11.011_bib9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jocn.2014.08.018","article-title":"Aberrant microRNA expression in peripheral plasma and mononuclear cells as specific blood-based biomarkers in schizophrenia patients","volume":"22","author":"Sun","year":"2015","journal-title":"J.\u00a0Clin. Neurosci."},{"key":"10.1016\/j.omtm.2018.11.011_bib10","doi-asserted-by":"crossref","first-page":"e50926","DOI":"10.1371\/journal.pone.0050926","article-title":"Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction","volume":"7","author":"Long","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2018.11.011_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4615-0119-0_10","article-title":"Neuropilin and class 3 semaphorins\u00a0in nervous system regeneration","volume":"515","author":"De Winter","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.omtm.2018.11.011_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/mcne.1999.0787","article-title":"Semaphorin III can induce death in sensory\u00a0neurons","volume":"14","author":"Gagliardini","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.omtm.2018.11.011_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/bgh220","article-title":"Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1\/JNK-dependent signaling pathway in human leukemia HL-60 cells","volume":"26","author":"Su","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.omtm.2018.11.011_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2014.04.046","article-title":"Protective effect of\u00a0coconut water concentrate and its active component shikimic acid against hydroperoxide\u00a0mediated oxidative stress through suppression of NF-\u03baB and activation\u00a0of Nrf2 pathway","volume":"155","author":"Manna","year":"2014","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.omtm.2018.11.011_bib15","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1038\/sj.onc.1203895","article-title":"p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42\/JNK1 pathway","volume":"19","author":"Thomas","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.omtm.2018.11.011_bib16","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1523\/JNEUROSCI.4485-05.2006","article-title":"Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia","volume":"26","author":"Hou","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2018.11.011_bib17","doi-asserted-by":"crossref","first-page":"25358","DOI":"10.1074\/jbc.M001725200","article-title":"Induction and modulation of cerebellar granule neuron death by E2F-1","volume":"275","author":"O\u2019Hare","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2018.11.011_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/01.CIR.0000133384.38551.A8","article-title":"Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"110","author":"Kouroedov","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.omtm.2018.11.011_bib19","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1093\/emboj\/cdf688","article-title":"Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression","volume":"21","author":"Tzima","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.omtm.2018.11.011_bib20","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1161\/STROKEAHA.107.509844","article-title":"In\u00a0vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody","volume":"39","author":"Klohs","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2018.11.011_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2018.11.011_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-2094-2-3","article-title":"Effects of the cyclooxygenase-2 inhibitor nimesulide\u00a0on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat","volume":"2","author":"Candelario-Jalil","year":"2005","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.omtm.2018.11.011_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"A randomized trial of intraarterial treatment for acute ischemic stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2018.11.011_bib24","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2018.11.011_bib25","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","article-title":"Endovascular therapy for ischemic stroke with perfusion-imaging selection","volume":"372","author":"Campbell","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2018.11.011_bib26","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","article-title":"Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke","volume":"372","author":"Saver","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2018.11.011_bib27","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMoa1503780","article-title":"Thrombectomy within 8 hours after symptom onset in ischemic stroke","volume":"372","author":"Jovin","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2018.11.011_bib28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.7150\/ijbs.15071","article-title":"BDNF-mediates down-regulation\u00a0of microRNA-195 inhibits ischemic cardiac apoptosis in rats","volume":"12","author":"Hang","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.omtm.2018.11.011_bib29","first-page":"1568","article-title":"Downregulation of BCL2 by miRNAs augments drug-induced apoptosis\u2014a combined computational and experimental approach","volume":"125","author":"Singh","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.omtm.2018.11.011_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/cvr\/cvr145","article-title":"MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1","volume":"92","author":"Zhu","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.omtm.2018.11.011_bib31","doi-asserted-by":"crossref","first-page":"e2850","DOI":"10.1038\/cddis.2017.243","article-title":"MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtm.2018.11.011_bib32","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/ng.905","article-title":"MicroRNAs can generate thresholds in target gene expression","volume":"43","author":"Mukherji","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2018.11.011_bib33","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.4161\/rna.21998","article-title":"Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs","volume":"9","author":"Shu","year":"2012","journal-title":"RNA Biol."},{"key":"10.1016\/j.omtm.2018.11.011_bib34","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1074\/jbc.M109.080689","article-title":"Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons","volume":"285","author":"Jiang","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2018.11.011_bib35","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.1038\/srep07890","article-title":"Semaphorin3A elevates vascular permeability and contributes to cerebral\u00a0ischemia-induced brain damage","volume":"5","author":"Hou","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2018.11.011_bib36","doi-asserted-by":"crossref","first-page":"9962","DOI":"10.1523\/JNEUROSCI.18-23-09962.1998","article-title":"Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons","volume":"18","author":"Pasterkamp","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2018.11.011_bib37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cellsig.2006.10.006","article-title":"Down-regulation Cdc42 attenuates\u00a0neuronal apoptosis through inhibiting MLK3\/JNK3 cascade during ischemic reperfusion in rat hippocampus","volume":"19","author":"Zhao","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.omtm.2018.11.011_bib38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.brainres.2015.04.029","article-title":"Classic and novel stem cell niches in brain homeostasis\u00a0and repair","volume":"1628","author":"Lin","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.omtm.2018.11.011_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2014.11.016","article-title":"Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability","volume":"74","author":"Lin","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.omtm.2018.11.011_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1523\/JNEUROSCI.22-01-00239.2002","article-title":"Growth-associated\u00a0protein-43 is required for commissural axon guidance in the developing vertebrate nervous system","volume":"22","author":"Shen","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2018.11.011_bib41","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","article-title":"Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity","volume":"149","author":"Frey","year":"2000","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtm.2018.11.011_bib42","first-page":"644","article-title":"Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics","volume":"10","author":"Candelario-Jalil","year":"2009","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.omtm.2018.11.011_bib43","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1002\/rcm.4620","article-title":"Direct profiling of phospholipids and lysophospholipids in rat brain sections after ischemic stroke","volume":"24","author":"Wang","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050119300026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050119300026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:22:43Z","timestamp":1762420963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050119300026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":43,"alternative-id":["S2329050119300026"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2018.11.011","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-195 Has a Potential to Treat Ischemic and Hemorrhagic Stroke through Neurovascular Protection and Neurogenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2018.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}