{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:35:09Z","timestamp":1762421709477,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018001","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de lutte contre les Cancers et les leuc\u00e9mies de l&apos;Enfant et de l&apos;Adolescent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011599","name":"Direction R\u00e9gionale de l&apos;Alimentation, de l&apos;Agriculture et de la For\u00eat de la r\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011658","name":"French Infrastructure for Integrated Structural Biology","doi-asserted-by":"publisher","award":["ANR-10-INSB-05-02"],"award-info":[{"award-number":["ANR-10-INSB-05-02"]}],"id":[{"id":"10.13039\/501100011658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014808","name":"Groupement des Entreprises Fran\u00e7aises dans la lutte contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.omtm.2020.11.009","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T21:12:32Z","timestamp":1605561152000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7170-9194","authenticated-orcid":false,"given":"Benjamin","family":"Caulier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Stofleth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalil","family":"Hannani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Guidetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Josserand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Laurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Chroboczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Mossuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Plantaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2020.11.009_bib1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/s41375-018-0071-7","article-title":"Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012","volume":"32","author":"Rasche","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.omtm.2020.11.009_bib2","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1182\/blood-2012-03-362608","article-title":"Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel","volume":"120","author":"Creutzig","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2020.11.009_bib3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2009-07-235358","article-title":"Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet","volume":"115","author":"D\u00f6hner","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2020.11.009_bib4","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2020.11.009_bib5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute Myeloid Leukemia","volume":"373","author":"D\u00f6hner","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2020.11.009_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline Chemotherapy and Cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.omtm.2020.11.009_bib7","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1200\/JCO.2000.18.18.3273","article-title":"Late effects of treatment in survivors of childhood acute myeloid leukemia","volume":"18","author":"Leung","year":"2000","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.omtm.2020.11.009_bib8","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.drudis.2018.05.040","article-title":"Advances in treatment formulations for acute myeloid leukemia","volume":"23","author":"Briot","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.omtm.2020.11.009_bib9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrd4333","article-title":"Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery","volume":"13","author":"Torchilin","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtm.2020.11.009_bib10","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1158\/1078-0432.CCR-18-2990","article-title":"FDA Approval Summary: (Daunorubicin and Cytarabine) Liposome for Injection for the Treatment of Adults with High-Risk Acute Myeloid Leukemia","volume":"25","author":"Krauss","year":"2019","journal-title":"Clin. Cancer Res."},{"journal-title":"European Medicines Agency","article-title":"Vyxeos liposomal (previously known as Vyxeos)","year":"2018","key":"10.1016\/j.omtm.2020.11.009_bib11"},{"key":"10.1016\/j.omtm.2020.11.009_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrd3499","article-title":"Bio-inspired, bioengineered and biomimetic drug delivery carriers","volume":"10","author":"Yoo","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtm.2020.11.009_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-virology-100114-055141","article-title":"Virus-Based Nanoparticles as Versatile Nanomachines","volume":"2","author":"Koudelka","year":"2015","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.omtm.2020.11.009_bib14","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.4049\/jimmunol.174.11.7179","article-title":"Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein","volume":"174","author":"Sumida","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2020.11.009_bib15","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.4161\/hv.29594","article-title":"Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what\u2019s important?","volume":"10","author":"Fausther-Bovendo","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.omtm.2020.11.009_bib16","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nm952","article-title":"CD46 is a cellular receptor for group B adenoviruses","volume":"9","author":"Gaggar","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2020.11.009_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2020.11.009_bib18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.virol.2004.02.016","article-title":"Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors","volume":"322","author":"Short","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.omtm.2020.11.009_bib19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-E","article-title":"Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment","volume":"73","author":"Wickham","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2020.11.009_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0378-1119(94)90302-6","article-title":"The penton base of human adenovirus type 3 has the RGD motif","volume":"146","author":"Cuzange","year":"1994","journal-title":"Gene"},{"key":"10.1016\/j.omtm.2020.11.009_bib21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1126\/science.1069040","article-title":"Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand","volume":"296","author":"Xiong","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.omtm.2020.11.009_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.virol.2005.06.030","article-title":"Synthesis, cellular localization, and quantification of penton-dodecahedron in serotype 3 adenovirus-infected cells","volume":"340","author":"Fender","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.omtm.2020.11.009_bib23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nbt0197-52","article-title":"Adenovirus dodecahedron, a new vector for human gene transfer","volume":"15","author":"Fender","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtm.2020.11.009_bib24","doi-asserted-by":"crossref","first-page":"e46075","DOI":"10.1371\/journal.pone.0046075","article-title":"The structural basis for the integrity of adenovirus Ad3 dodecahedron","volume":"7","author":"Szolajska","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2020.11.009_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.virol.2007.09.026","article-title":"Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and integrins and vary along the cell cycle","volume":"371","author":"Fender","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.omtm.2020.11.009_bib26","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jgm.862","article-title":"Protein transduction into human cells by adenovirus dodecahedron using WW domains as universal adaptors","volume":"8","author":"Garcel","year":"2006","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omtm.2020.11.009_bib27","doi-asserted-by":"crossref","first-page":"5030589","DOI":"10.1155\/2016\/5030589","article-title":"The Use of Adenovirus Dodecahedron in the Delivery of an Enzymatic Activity in the Cell","volume":"2016","author":"Sumarheni","year":"2016","journal-title":"Biotechnol. Res. Int."},{"key":"10.1016\/j.omtm.2020.11.009_bib28","doi-asserted-by":"crossref","first-page":"e5569","DOI":"10.1371\/journal.pone.0005569","article-title":"Adenovirus dodecahedron, as a drug delivery vector","volume":"4","author":"Zochowska","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2020.11.009_bib29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.nano.2014.07.009","article-title":"Virus-like particle-mediated intracellular delivery of mRNA cap analog with in\u00a0vivo activity against hepatocellular carcinoma","volume":"11","author":"Zochowska","year":"2015","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.omtm.2020.11.009_bib30","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.nano.2018.05.001","article-title":"Leukocytes and drug-resistant cancer cells are targets for intracellular delivery by adenoviral dodecahedron","volume":"14","author":"Jedynak","year":"2018","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.omtm.2020.11.009_bib31","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1083\/jcb.135.5.1249","article-title":"A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages","volume":"135","author":"Araki","year":"1996","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtm.2020.11.009_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.200302028","article-title":"Caveolae\/raft-dependent endocytosis","volume":"161","author":"Nabi","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtm.2020.11.009_bib33","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.123.5.1107","article-title":"Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation","volume":"123","author":"Wang","year":"1993","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtm.2020.11.009_bib34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.virol.2004.01.015","article-title":"Heparan sulfate proteoglycan mediates the selective attachment and internalization of serotype 3 human adenovirus dodecahedron","volume":"321","author":"Viv\u00e8s","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.omtm.2020.11.009_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ccr.2010.12.012","article-title":"Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia","volume":"19","author":"Goardon","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omtm.2020.11.009_bib36","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1182\/blood-2016-10-696054","article-title":"Biology and relevance of human acute myeloid leukemia stem cells","volume":"129","author":"Thomas","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2020.11.009_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.virol.2009.10.049","article-title":"Ex\u00a0vivo detection of adenovirus specific CD4+ T-cell responses to HLA-DR-epitopes of the Hexon protein show a contracted specificity of T(HELPER) cells following stem cell transplantation","volume":"397","author":"Serangeli","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.omtm.2020.11.009_bib38","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/JVI.01689-07","article-title":"Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy","volume":"82","author":"Leen","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtm.2020.11.009_bib39","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/emboj.2008.38","article-title":"Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3","volume":"27","author":"Amstutz","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.omtm.2020.11.009_bib40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.142.2.595","article-title":"A role for the alphavbeta3 integrin in the transmigration of monocytes","volume":"142","author":"Weerasinghe","year":"1998","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtm.2020.11.009_bib41","first-page":"982","article-title":"Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin \u03b1V\u03b23 in Mycobacterium tuberculosis Infection","volume":"199","author":"Brilha","year":"2017","journal-title":"J.I."},{"key":"10.1016\/j.omtm.2020.11.009_bib42","doi-asserted-by":"crossref","first-page":"111405","DOI":"10.18632\/oncotarget.22808","article-title":"A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells","volume":"8","author":"Al-Asadi","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtm.2020.11.009_bib43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccr.2013.05.004","article-title":"In\u00a0Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling","volume":"24","author":"Miller","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omtm.2020.11.009_bib44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/ijms19010251","article-title":"The Possible Importance of \u03b23 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia","volume":"19","author":"Johansen","year":"2018","journal-title":"IJMS"},{"key":"10.1016\/j.omtm.2020.11.009_bib45","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.15252\/embj.201796771","article-title":"Integrin \u03b1v\u03b23 enhances the suppressive effect of interferon-\u03b3 on hematopoietic stem cells","volume":"36","author":"Umemoto","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.omtm.2020.11.009_bib46","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41598-017-02352-5","article-title":"Bone marrow niche-mimetics modulate HSPC function via integrin signaling","volume":"7","author":"Kr\u00e4ter","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2020.11.009_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exphem.2019.07.001","article-title":"Lineage marker expression on mouse hematopoietic stem cells","volume":"76","author":"Wang","year":"2019","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.omtm.2020.11.009_bib48","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.2147\/OTT.S191621","article-title":"Mechanisms of drug resistance in acute myeloid leukemia","volume":"12","author":"Zhang","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.omtm.2020.11.009_bib49","first-page":"e1631","article-title":"Immune Cell Isolation from Mouse Femur Bone Marrow","volume":"5","author":"Liu","year":"2015","journal-title":"Biol. Protoc"}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050120302369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050120302369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:30:31Z","timestamp":1762421431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050120302369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":49,"alternative-id":["S2329050120302369"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2020.11.009","relation":{},"ISSN":["2329-0501"],"issn-type":[{"type":"print","value":"2329-0501"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2020.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}]}}