{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:47:03Z","timestamp":1793029623736,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001840","name":"Icelandic Centre for Research","doi-asserted-by":"publisher","award":["206806-051"],"award-info":[{"award-number":["206806-051"]}],"id":[{"id":"10.13039\/501100001840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001840","name":"Icelandic Centre for Research","doi-asserted-by":"publisher","award":["195835-051"],"award-info":[{"award-number":["195835-051"]}],"id":[{"id":"10.13039\/501100001840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP5OD017877"],"award-info":[{"award-number":["DP5OD017877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017114","name":"Louma Private G. Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.omtm.2021.02.011","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T13:34:46Z","timestamp":1613914486000},"page":"779-791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome"],"prefix":"10.1016","volume":"20","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genay","family":"Pilarowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio Merlo","family":"Pich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Daini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemitsu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhide","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6635-6753","authenticated-orcid":false,"given":"Hans Tomas","family":"Bjornsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2021.02.011_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1399-0004.2004.00348.x","article-title":"Kabuki syndrome: a review","volume":"67","author":"Adam","year":"2005","journal-title":"Clin. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/jmedgenet-2018-105625","article-title":"Kabuki syndrome: international consensus diagnostic criteria","volume":"56","author":"Adam","year":"2019","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/ng.646","article-title":"Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome","volume":"42","author":"Ng","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ajhg.2011.11.021","article-title":"Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome","volume":"90","author":"Lederer","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib5","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.18632\/oncotarget.1555","article-title":"KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation","volume":"4","author":"Guo","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtm.2021.02.011_bib6","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1158\/0008-5472.CAN-13-1896","article-title":"UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells","volume":"74","author":"Kim","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nature06145","article-title":"UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development","volume":"449","author":"Agger","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2021.02.011_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-genom-090613-094245","article-title":"Mendelian disorders of the epigenetic machinery: tipping the balance of chromatin states","volume":"15","author":"Fahrner","year":"2014","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib9","doi-asserted-by":"crossref","first-page":"256ra135","DOI":"10.1126\/scitranslmed.3009278","article-title":"Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome","volume":"6","author":"Bjornsson","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtm.2021.02.011_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1073\/pnas.1611431114","article-title":"A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome","volume":"114","author":"Benjamin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2021.02.011_bib11","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jaci.2019.11.034","article-title":"Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome","volume":"145","author":"Pilarowski","year":"2020","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.omtm.2021.02.011_bib12","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3390\/ph3092751","article-title":"Clinical toxicities of histone deacetylase inhibitors","volume":"3","author":"Subramanian","year":"2010","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.omtm.2021.02.011_bib13","doi-asserted-by":"crossref","first-page":"eaap8747","DOI":"10.1126\/sciadv.aap8747","article-title":"An Mll4\/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells","volume":"4","author":"Cao","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omtm.2021.02.011_bib14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2018.04.028","article-title":"MLL4 is required to maintain broad H3K4me3 peaks and super-enhancers at tumor suppressor genes","volume":"70","author":"Dhar","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtm.2021.02.011_bib15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2021.02.011_bib16","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2005.08.027","article-title":"Regulation of LSD1 histone demethylase activity by its associated factors","volume":"19","author":"Shi","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtm.2021.02.011_bib17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.sbi.2010.09.006","article-title":"Structural insights into histone lysine demethylation","volume":"20","author":"Hou","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3327","article-title":"Molecular mechanisms and potential functions of histone demethylases","volume":"13","author":"Kooistra","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"van Praag","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2021.02.011_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2021.02.011_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"Couillard-Despres","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.omtm.2021.02.011_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00441-007-0432-4","article-title":"Immunohistological markers for staging neurogenesis in adult hippocampus","volume":"329","author":"von Bohlen Und Halbach","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0896-6273(00)80777-1","article-title":"Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons","volume":"23","author":"Francis","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.omtm.2021.02.011_bib24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80778-3","article-title":"Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons","volume":"23","author":"Gleeson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.omtm.2021.02.011_bib25","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1128\/MCB.25.16.7278-7288.2005","article-title":"Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination","volume":"25","author":"Beglopoulos","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrm3890","article-title":"Histone core modifications regulating nucleosome structure and dynamics","volume":"15","author":"Tessarz","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib27","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1101\/gr.190629.115","article-title":"The Mendelian disorders of the epigenetic machinery","volume":"25","author":"Bjornsson","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ajhg.2017.11.013","article-title":"Histone lysine methylases and demethylases in the landscape of human developmental disorders","volume":"102","author":"Faundes","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib29","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.neuron.2004.05.021","article-title":"Chromatin acetylation, memory, and LTP are impaired in CBP+\/\u2212 mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration","volume":"42","author":"Alarc\u00f3n","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.omtm.2021.02.011_bib30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/jir.12596","article-title":"Molecularly confirmed Kabuki (Niikawa-Kuroki) syndrome patients demonstrate a specific cognitive profile with extensive visuospatial abnormalities","volume":"63","author":"Harris","year":"2019","journal-title":"J.\u00a0Intellect. Disabil. Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/jir.12597","article-title":"Exploring the cognitive phenotype of Kabuki (Niikawa-Kuroki) syndrome","volume":"63","author":"van Dongen","year":"2019","journal-title":"J.\u00a0Intellect. Disabil. Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib32","doi-asserted-by":"crossref","first-page":"101610","DOI":"10.1016\/j.nicl.2018.11.020","article-title":"Anatomical and functional abnormalities on MRI in Kabuki syndrome","volume":"21","author":"Boisgontier","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.omtm.2021.02.011_bib33","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1128\/MCB.00723-06","article-title":"Functional interplay between histone demethylase and deacetylase enzymes","volume":"26","author":"Lee","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib34","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.tins.2013.05.001","article-title":"Epigenetic layers and players underlying neurodevelopment","volume":"36","author":"LaSalle","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.omtm.2021.02.011_bib35","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ncb1312","article-title":"Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation","volume":"7","author":"Wynder","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib36","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/ajmg.a.36450","article-title":"De novo ANKRD11 and KDM1A gene mutations in a male with features of KBG syndrome and Kabuki syndrome","volume":"164A","author":"Tunovic","year":"2014","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.omtm.2021.02.011_bib37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/gim.2015.161","article-title":"Gene discovery for Mendelian conditions via social networking: de novo variants in KDM1A cause developmental delay and distinctive facial features","volume":"18","author":"Chong","year":"2016","journal-title":"Genet. Med."},{"key":"10.1016\/j.omtm.2021.02.011_bib38","first-page":"2578","article-title":"LSD1\/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors","volume":"25","author":"Pilotto","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2021.02.011_bib39","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1073\/pnas.1511974113","article-title":"LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior","volume":"113","author":"Rusconi","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2021.02.011_bib40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tins.2016.11.002","article-title":"NeuroLSD1: splicing-generated epigenetic enhancer of neuroplasticity","volume":"40","author":"Rusconi","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.omtm.2021.02.011_bib41","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1172\/JCI80102","article-title":"RAP1-mediated MEK\/ERK pathway defects in Kabuki syndrome","volume":"125","author":"B\u00f6gershausen","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtm.2021.02.011_bib42","doi-asserted-by":"crossref","first-page":"10779","DOI":"10.1038\/s41598-018-28709-y","article-title":"Small molecule inhibition of RAS\/MAPK signaling ameliorates developmental pathologies of Kabuki Syndrome","volume":"8","author":"Tsai","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.02.011_bib43","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nprot.2007.202","article-title":"Extraction, purification and analysis of histones","volume":"2","author":"Shechter","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.omtm.2021.02.011_bib44","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib45","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1093\/nar\/gkw158","article-title":"CLASS2: accurate and efficient splice variant annotation from RNA-seq reads","volume":"44","author":"Song","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.omtm.2021.02.011_bib46","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nbt.2450","article-title":"Differential analysis of gene regulation at transcript resolution with RNA-seq","volume":"31","author":"Trapnell","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtm.2021.02.011_bib48","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtm.2021.02.011_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.omtm.2021.02.011_bib50","first-page":"e153","article-title":"Differential peak calling of ChIP-seq signals with replicates with THOR","volume":"44","author":"Allhoff","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtm.2021.02.011_bib51","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:53:25Z","timestamp":1778867605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050121000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":51,"alternative-id":["S2329050121000267"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2021.02.011","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.11.986976","asserted-by":"object"}]},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2021.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}]}}