{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:16:10Z","timestamp":1790252170770,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006315","name":"Reumafonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009709","name":"Stichting De Weijerhorst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.omtm.2021.03.009","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T19:05:56Z","timestamp":1616094356000},"page":"247-261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-9211","authenticated-orcid":false,"given":"Marjolein M.J.","family":"Caron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen G.J.","family":"Ripmeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus","family":"van den Akker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina K.A. P.","family":"Wijnands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Steijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don A.M.","family":"Surtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Cremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"Emans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodewijk W.","family":"van Rhijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.M.","family":"Welting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2021.03.009_bib1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.omtm.2021.03.009_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2613.2009.00676.x","article-title":"Analysing the role of endogenous matrix molecules in the development of osteoarthritis","volume":"90","author":"Sofat","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.omtm.2021.03.009_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","article-title":"Osteoarthritis: new insights. Part 1: the disease and its risk factors","volume":"133","author":"Felson","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.omtm.2021.03.009_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar3117","article-title":"Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders","volume":"12","author":"Dreier","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.omtm.2021.03.009_bib5","first-page":"683970","article-title":"Developmental mechanisms in articular cartilage degradation in osteoarthritis","volume":"2011","author":"Tchetina","year":"2011","journal-title":"Arthritis (Egypt)"},{"key":"10.1016\/j.omtm.2021.03.009_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joca.2011.12.003","article-title":"Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?","volume":"20","author":"van der Kraan","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib7","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.joca.2015.09.012","article-title":"Inflammation in osteoarthritis: changing views","volume":"23","author":"Berenbaum","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/annrheumdis-2017-212863","article-title":"Single-cell RNA-seq analysis reveals the progression of human osteoarthritis","volume":"78","author":"Ji","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.omtm.2021.03.009_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrrheum.2010.178","article-title":"Pharmacologic therapy for osteoarthritis--the era of disease modification","volume":"7","author":"Hunter","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.omtm.2021.03.009_bib10","doi-asserted-by":"crossref","first-page":"25386","DOI":"10.1074\/jbc.M302048200","article-title":"Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes","volume":"278","author":"Im","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2021.03.009_bib11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.biopha.2006.09.001","article-title":"Bone morphogenetic protein 7 (bmp-7) stimulates proteoglycan synthesis in human osteoarthritic chondrocytes in\u00a0vitro","volume":"60","author":"St\u00f6ve","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.omtm.2021.03.009_bib12","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/ar3300","article-title":"Regulation of chondrocyte gene expression by osteogenic protein-1","volume":"13","author":"Chubinskaya","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.omtm.2021.03.009_bib13","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00264-007-0423-9","article-title":"OP-1\/BMP-7 in cartilage repair","volume":"31","author":"Chubinskaya","year":"2007","journal-title":"Int. Orthop."},{"key":"10.1016\/j.omtm.2021.03.009_bib14","doi-asserted-by":"crossref","first-page":"R118","DOI":"10.1186\/ar2521","article-title":"Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression","volume":"10","author":"Hayashi","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.omtm.2021.03.009_bib15","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/jor.20840","article-title":"Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats","volume":"27","author":"Sekiya","year":"2009","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.omtm.2021.03.009_bib16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2474-11-232","article-title":"Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis","volume":"11","author":"Hunter","year":"2010","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.omtm.2021.03.009_bib17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.joca.2013.01.009","article-title":"Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7","volume":"21","author":"Caron","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/art.1780360207","article-title":"Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis","volume":"36","author":"Lohmander","year":"1993","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.omtm.2021.03.009_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0009-8981(99)00055-8","article-title":"Quantification of protease activities in synovial fluid from rheumatoid and osteoarthritis cases: comparison with antioxidant and free radical damage markers","volume":"284","author":"Mantle","year":"1999","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.omtm.2021.03.009_bib20","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.omtm.2021.03.009_bib21","doi-asserted-by":"crossref","first-page":"e0231240","DOI":"10.1371\/journal.pone.0231240","article-title":"REG-O3 chimeric peptide combining growth hormone and somatostatin sequences improves joint function and prevents cartilage degradation in rat model of traumatic knee osteoarthritis","volume":"15","author":"Montjean","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.03.009_bib22","first-page":"501","article-title":"Functional peptides for cartilage repair and regeneration","volume":"10","author":"Liu","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.omtm.2021.03.009_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1563\/1548-1336(2003)029<0057:IVMSWS>2.3.CO;2","article-title":"In\u00a0vitro mineralization studies with substrate-immobilized bone morphogenetic protein peptides","volume":"29","author":"Kirkwood","year":"2003","journal-title":"J.\u00a0Oral Implantol."},{"key":"10.1016\/j.omtm.2021.03.009_bib24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jbm.a.32246","article-title":"Increased osteoblast functions in the presence of BMP-7 short peptides for nanostructured biomaterial applications","volume":"91","author":"Chen","year":"2009","journal-title":"J.\u00a0Biomed. Mater. Res. A"},{"key":"10.1016\/j.omtm.2021.03.009_bib25","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1038\/emm.2017.40","article-title":"Bone-forming peptide-2 derived from BMP-7 enhances osteoblast differentiation from multipotent bone marrow stromal cells and bone formation","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.omtm.2021.03.009_bib26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nm.2629","article-title":"Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis","volume":"18","author":"Sugimoto","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2021.03.009_bib27","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1002\/art.39293","article-title":"BAPX-1\/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis","volume":"67","author":"Caron","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.omtm.2021.03.009_bib28","doi-asserted-by":"crossref","first-page":"13446","DOI":"10.1038\/s41598-019-49758-x","article-title":"A Bone Morphogenetic Protein (BMP)-derived Peptide Based on the Type I Receptor-binding Site Modifies Cell-type Dependent BMP Signalling","volume":"9","author":"Tong","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.03.009_bib29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1242\/dev.02258","article-title":"Nkx3.2\/Bapx1 acts as a negative regulator of chondrocyte maturation","volume":"133","author":"Provot","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.omtm.2021.03.009_bib30","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.yexcr.2009.03.008","article-title":"Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes","volume":"315","author":"Yamashita","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.omtm.2021.03.009_bib31","doi-asserted-by":"crossref","first-page":"8704","DOI":"10.1128\/MCB.23.23.8704-8717.2003","article-title":"Smad-dependent recruitment of a histone deacetylase\/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2","volume":"23","author":"Kim","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.omtm.2021.03.009_bib32","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.M111023200","article-title":"Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter","volume":"277","author":"Korchynskyi","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2021.03.009_bib33","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/emboj\/17.11.3091","article-title":"Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene","volume":"17","author":"Dennler","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.omtm.2021.03.009_bib34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1053\/joca.2002.0823","article-title":"Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor","volume":"10","author":"Janusz","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 3","key":"10.1016\/j.omtm.2021.03.009_bib35","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1570-9639(03)00235-8","article-title":"Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope","volume":"1651","author":"Saito","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.omtm.2021.03.009_bib37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fbioe.2018.00018","article-title":"Recent Insights into the Contribution of the Changing Hypertrophic Chondrocyte Phenotype in the Development and Progression of Osteoarthritis","volume":"6","author":"Ripmeester","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.omtm.2021.03.009_bib38","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1089\/ten.tea.2009.0189","article-title":"Murine preosteoblast differentiation induced by a peptide derived from bone morphogenetic proteins-9","volume":"15","author":"Bergeron","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.omtm.2021.03.009_bib39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-4636(20000605)50:3<405::AID-JBM15>3.0.CO;2-Z","article-title":"Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in\u00a0vivo","volume":"50","author":"Suzuki","year":"2000","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.omtm.2021.03.009_bib40","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1089\/ten.tea.2011.0400","article-title":"Bone morphogenetic protein-derived peptide promotes chondrogenic differentiation of human mesenchymal stem cells","volume":"18","author":"Renner","year":"2012","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.omtm.2021.03.009_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/jb\/mvp148","article-title":"Bone morphogenetic protein receptors and signal transduction","volume":"147","author":"Miyazono","year":"2010","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.omtm.2021.03.009_bib42","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nature01245","article-title":"Structural basis of BMP signalling inhibition by the cystine knot protein Noggin","volume":"420","author":"Groppe","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2021.03.009_bib43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1507\/endocrj.53.51","article-title":"Analysis of the three dimensional structure of the CXGXC motif in the CMGCC and CAGYC regions of alpha-and beta-subunits of human chorionic gonadotropin: importance of glycine residue (G) in the motif","volume":"53","author":"Kinoshita","year":"2006","journal-title":"Endocr. J."},{"key":"10.1016\/j.omtm.2021.03.009_bib44","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.joca.2009.06.008","article-title":"TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads","volume":"17","author":"van der Kraan","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib45","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.1210\/jc.2012-3851","article-title":"Theca-derived BMP4 and BMP7 down-regulate connexin43 expression and decrease gap junction intercellular communication activity in immortalized human granulosa cells","volume":"98","author":"Chang","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.omtm.2021.03.009_bib46","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.1038\/s41598-018-27602-y","article-title":"Co-treatment of TGF-\u03b23 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments","volume":"8","author":"Huang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.03.009_bib47","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2353\/ajpath.2010.090459","article-title":"Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression","volume":"176","author":"Luo","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.omtm.2021.03.009_bib48","first-page":"103","article-title":"Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1","volume":"22","author":"Fan","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.omtm.2021.03.009_bib49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/CS20140401","article-title":"BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy","volume":"128","author":"Li","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.omtm.2021.03.009_bib50","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/cells9020280","article-title":"The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases","volume":"9","author":"Aluganti Narasimhulu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.omtm.2021.03.009_bib51","doi-asserted-by":"crossref","first-page":"e0147897","DOI":"10.1371\/journal.pone.0147897","article-title":"BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo E-\/- Mice","volume":"11","author":"Singla","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.03.009_bib52","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.joca.2005.03.003","article-title":"Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis","volume":"13","author":"Moore","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib53","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/art.24629","article-title":"A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models","volume":"60","author":"Baragi","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.omtm.2021.03.009_bib54","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.joca.2005.04.004","article-title":"Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1\u03b2","volume":"13","author":"Gebauer","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib55","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1128\/MCB.00206-14","article-title":"Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins","volume":"34","author":"Groot","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.omtm.2021.03.009_bib56","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.joca.2018.01.025","article-title":"Celecoxib-mediated reduction of prostanoid release in Hoffa\u2019s fat pad from donors with cartilage pathology results in an attenuated inflammatory phenotype","volume":"26","author":"Timur","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.omtm.2021.03.009_bib57","doi-asserted-by":"crossref","first-page":"e33467","DOI":"10.1371\/journal.pone.0033467","article-title":"Activation of NF-\u03baB\/p65 facilitates early chondrogenic differentiation during endochondral ossification","volume":"7","author":"Caron","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.03.009_bib58","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03008208209160269","article-title":"A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures","volume":"9","author":"Farndale","year":"1982","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.omtm.2021.03.009_bib59","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J.\u00a0Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.omtm.2021.03.009_bib60","first-page":"501","article-title":"Animal models of osteoarthritis in an era of molecular biology","volume":"2","author":"Bendele","year":"2002","journal-title":"J.\u00a0Musculoskelet. Neuronal Interact."}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121000498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121000498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:30:41Z","timestamp":1762421441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050121000498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":60,"alternative-id":["S2329050121000498"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2021.03.009","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2021.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}