{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:34:47Z","timestamp":1792427687661,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P30-NS072030"],"award-info":[{"award-number":["P30-NS072030"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DC017117"],"award-info":[{"award-number":["R01-DC017117"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DC016932"],"award-info":[{"award-number":["R01-DC016932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-EY12196"],"award-info":[{"award-number":["P30-EY12196"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.omtm.2021.03.019","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T20:51:35Z","timestamp":1617051095000},"page":"382-398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-1427","authenticated-orcid":false,"given":"Maryna V.","family":"Ivanchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-6061","authenticated-orcid":false,"given":"Killian S.","family":"Hanlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6186-0798","authenticated-orcid":false,"given":"Daniel M.","family":"Hathaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-1996","authenticated-orcid":false,"given":"Alex J.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole W.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos I.","family":"Tamvakologos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Nammour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-5179","authenticated-orcid":false,"given":"Casey A.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-6016","authenticated-orcid":false,"given":"David P.","family":"Corey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2021.03.019_bib1","author":"Van Camp"},{"key":"10.1016\/j.omtm.2021.03.019_bib2","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.3390\/jcm9072309","article-title":"Inner ear gene therapies take off: current promises and future challenges","volume":"9","author":"Delmaghani","year":"2020","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.omtm.2021.03.019_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/gt.2013.59","article-title":"Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice","volume":"21","author":"Yu","year":"2014","journal-title":"Gene Ther."},{"key":"10.1016\/j.omtm.2021.03.019_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ymthe.2016.12.010","article-title":"Rescue of hearing by gene delivery to inner-ear hair cells using exosome-associated AAV","volume":"25","author":"Gy\u00f6rgy","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2021.03.019_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtm.2018.11.003","article-title":"Gene transfer with AAV9-PHP.B rescues hearing in a mouse model of usher syndrome 3A and transduces hair cells in a non-human primate","volume":"13","author":"Gy\u00f6rgy","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2021.03.019_bib6","doi-asserted-by":"crossref","first-page":"107930","DOI":"10.1016\/j.heares.2020.107930","article-title":"Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea","volume":"394","author":"Ivanchenko","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.omtm.2021.03.019_bib7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41467-018-08243-1","article-title":"AAV2.7m8 is a powerful viral vector for inner ear gene therapy","volume":"10","author":"Isgrig","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2021.03.019_bib8","doi-asserted-by":"crossref","first-page":"107882","DOI":"10.1016\/j.heares.2020.107882","article-title":"Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B","volume":"394","author":"Lee","year":"2020","journal-title":"Hear. Res."},{"key":"10.1016\/j.omtm.2021.03.019_bib9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nbt.3781","article-title":"A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear","volume":"35","author":"Landegger","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.omtm.2021.03.019_bib10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.omtm.2019.10.007","article-title":"Selection of an efficient AAV vector for robust CNS transgene expression","volume":"15","author":"Hanlon","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2021.03.019_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1089\/hum.2017.120","article-title":"Delivery of adeno-associated virus vectors in adult mammalian inner-ear cell subtypes without auditory dysfunction","volume":"29","author":"Tao","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2021.03.019_bib12","doi-asserted-by":"crossref","first-page":"45524","DOI":"10.1038\/srep45524","article-title":"Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction","volume":"7","author":"Suzuki","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.03.019_bib13","doi-asserted-by":"crossref","first-page":"13480","DOI":"10.1038\/s41598-017-13620-9","article-title":"Modeling and preventing progressive hearing loss in usher syndrome III","volume":"7","author":"Geng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.03.019_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10162-017-0628-6","article-title":"Rhesus cochlear and vestibular functions are preserved after inner ear injection of saline volume sufficient for gene therapy delivery","volume":"18","author":"Dai","year":"2017","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.omtm.2021.03.019_bib15","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41591-019-0500-9","article-title":"Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss","volume":"25","author":"Gy\u00f6rgy","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2021.03.019_bib16","doi-asserted-by":"crossref","first-page":"e99649","DOI":"10.15252\/embj.201899649","article-title":"Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos","volume":"37","author":"Keppeler","year":"2018","journal-title":"EMBO J."}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121000590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121000590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:52:31Z","timestamp":1778867551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050121000590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":16,"alternative-id":["S2329050121000590"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2021.03.019","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2021.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}]}}