{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:55:08Z","timestamp":1791230108056,"version":"4.1.0"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.omtm.2021.05.016","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T20:16:59Z","timestamp":1622837819000},"page":"133-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Exosomes and organ-specific metastasis"],"prefix":"10.1016","volume":"22","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-9761","authenticated-orcid":false,"given":"Xiaoting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2021.05.016_bib1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bbcan.2019.04.004","article-title":"Exosomes in cancer development, metastasis, and immunity","volume":"1871","author":"Zhang","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib2","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3892\/or.2012.1967","article-title":"Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines","volume":"28","author":"Chiba","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.omtm.2021.05.016_bib3","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2021.05.016_bib4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12943-019-1049-4","article-title":"Exosomes promote pre-metastatic niche formation in ovarian cancer","volume":"18","author":"Feng","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12974-017-1038-8","article-title":"In\u00a0vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation","volume":"15","author":"Li","year":"2018","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.omtm.2021.05.016_bib6","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.7150\/thno.22958","article-title":"Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis","volume":"8","author":"Chen","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.omtm.2021.05.016_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/prca.201400114","article-title":"Exosomes in bodily fluids are a highly stable resource of disease biomarkers","volume":"9","author":"Boukouris","year":"2015","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.omtm.2021.05.016_bib8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3390\/cancers11101449","article-title":"Increased Plasmatic Levels of PSA-Expressing Exosomes Distinguish Prostate Cancer Patients from Benign Prostatic Hyperplasia: A Prospective Study","volume":"11","author":"Logozzi","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtm.2021.05.016_bib9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/14756366.2018.1538980","article-title":"Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity","volume":"34","author":"Logozzi","year":"2019","journal-title":"J.\u00a0Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.omtm.2021.05.016_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/10717544.2018.1425777","article-title":"Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide","volume":"25","author":"Lin","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.omtm.2021.05.016_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2021.05.016_bib12","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ccell.2016.09.011","article-title":"Characteristics and Significance of the Pre-metastatic Niche","volume":"30","author":"Liu","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omtm.2021.05.016_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ncb3015","article-title":"The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis","volume":"16","author":"McAllister","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00109-015-1376-x","article-title":"Immunosuppressive cells in tumor immune escape and metastasis","volume":"94","author":"Liu","year":"2016","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.omtm.2021.05.016_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjc.6602316","article-title":"Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects","volume":"92","author":"Taylor","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/BST20120265","article-title":"Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)","volume":"41","author":"Whiteside","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.omtm.2021.05.016_bib17","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.4049\/jimmunol.0900970","article-title":"Tumor-derived microvesicles promote regulatory T\u00a0cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes","volume":"183","author":"Wieckowski","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2021.05.016_bib18","doi-asserted-by":"crossref","first-page":"e11469","DOI":"10.1371\/journal.pone.0011469","article-title":"Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T\u00a0cells (Treg)","volume":"5","author":"Szajnik","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.05.016_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2021.05.016_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","article-title":"Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory","volume":"177","author":"Poggio","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2021.05.016_bib21","doi-asserted-by":"crossref","first-page":"e1062968","DOI":"10.1080\/2162402X.2015.1062968","article-title":"Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-\u03b2 and miR23a transfer","volume":"5","author":"Berchem","year":"2015","journal-title":"OncoImmunology"},{"key":"10.1016\/j.omtm.2021.05.016_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fonc.2015.00044","article-title":"Supportive and rejective functions of tumor stroma on tumor cell growth, survival, and invasivity: the cancer evolution","volume":"5","author":"Dudas","year":"2015","journal-title":"Front. Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mehy.2016.07.009","article-title":"Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes","volume":"94","author":"Hood","year":"2016","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.omtm.2021.05.016_bib25","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1038\/oncsis.2015.21","article-title":"Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes","volume":"4","author":"Franzen","year":"2015","journal-title":"Oncogenesis"},{"key":"10.1016\/j.omtm.2021.05.016_bib26","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1038\/onc.2014.66","article-title":"Exosomal HIF1\u03b1 supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes","volume":"33","author":"Aga","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.omtm.2021.05.016_bib27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.canlet.2016.03.050","article-title":"Melanoma cell-derived exosomes promote epithelial-mesenchymal transition in primary melanocytes through paracrine\/autocrine signaling in the tumor microenvironment","volume":"376","author":"Xiao","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtm.2021.05.016_bib29","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3892\/ijo.2012.1535","article-title":"MiR-23a regulates TGF-\u03b2-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells","volume":"41","author":"Cao","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/carcin\/bgt274","article-title":"miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer","volume":"35","author":"Zheng","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.omtm.2021.05.016_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12943-019-0959-5","article-title":"Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1158\/1541-7786.MCR-16-0163","article-title":"Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis","volume":"15","author":"Maji","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncb1725","article-title":"Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells","volume":"10","author":"Al-Nedawi","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1593\/neo.07133","article-title":"Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells","volume":"9","author":"Millimaggi","year":"2007","journal-title":"Neoplasia"},{"key":"10.1016\/j.omtm.2021.05.016_bib35","doi-asserted-by":"crossref","first-page":"14450","DOI":"10.1038\/ncomms14450","article-title":"A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis","volume":"8","author":"Feng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2021.05.016_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jcb.25611","article-title":"c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes","volume":"118","author":"DeRita","year":"2017","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.omtm.2021.05.016_bib37","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1182\/blood-2009-08-239228","article-title":"New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes","volume":"116","author":"Sheldon","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2021.05.016_bib38","first-page":"959","article-title":"Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3","volume":"21","author":"Lang","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.omtm.2021.05.016_bib39","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","article-title":"Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis","volume":"9","author":"Zeng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2021.05.016_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-019-0995-1","article-title":"Effects of exosomes on pre-metastatic niche formation in tumors","volume":"18","author":"Guo","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib41","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2021.05.016_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","article-title":"Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis","volume":"25","author":"Zhou","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.omtm.2021.05.016_bib43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.canlet.2016.09.013","article-title":"Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers","volume":"384","author":"Di Modica","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtm.2021.05.016_bib44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nature05760","article-title":"Mediators of vascular remodelling co-opted for sequential steps in lung metastasis","volume":"446","author":"Gupta","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2021.05.016_bib45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.addr.2015.07.007","article-title":"Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment","volume":"99","author":"Ishii","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.omtm.2021.05.016_bib46","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1158\/1541-7786.MCR-17-0784","article-title":"Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGF\u03b2 Signaling","volume":"16","author":"Ringuette Goulet","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ygyno.2011.08.005","article-title":"Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts","volume":"123","author":"Cho","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib48","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00589-20","article-title":"Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration","volume":"11","author":"Nkosi","year":"2020","journal-title":"MBio"},{"key":"10.1016\/j.omtm.2021.05.016_bib49","doi-asserted-by":"crossref","first-page":"e1009023","DOI":"10.1371\/journal.ppat.1009023","article-title":"Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells","volume":"16","author":"Nkosi","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.omtm.2021.05.016_bib50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2020.03.004","article-title":"Extracellular vesicle packaged LMP1-activated fibroblasts promote tumor progression via autophagy and stroma-tumor metabolism coupling","volume":"478","author":"Wu","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtm.2021.05.016_bib51","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1159\/000493218","article-title":"Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts","volume":"49","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.omtm.2021.05.016_bib52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41467-017-02583-0","article-title":"Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer","volume":"9","author":"Fang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2021.05.016_bib53","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ncb3169","article-title":"Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver","volume":"17","author":"Costa-Silva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib54","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.18632\/oncotarget.6540","article-title":"Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche","volume":"7","author":"S\u00e1nchez","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtm.2021.05.016_bib55","doi-asserted-by":"crossref","first-page":"e6472","DOI":"10.1590\/1414-431x20176472","article-title":"Exosomes promote cetuximab resistance via the PTEN\/Akt pathway in colon cancer cells","volume":"51","author":"Zhang","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib56","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.2174\/09298673113209990003","article-title":"Role of microRNA deregulation in breast cancer cell chemoresistance and stemness","volume":"20","author":"Tekiner","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.omtm.2021.05.016_bib57","doi-asserted-by":"crossref","first-page":"e88193","DOI":"10.1371\/journal.pone.0088193","article-title":"Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin","volume":"9","author":"Federici","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.05.016_bib58","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1007\/s13277-015-4161-0","article-title":"Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222","volume":"37","author":"Yu","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib59","doi-asserted-by":"crossref","first-page":"e89534","DOI":"10.1371\/journal.pone.0089534","article-title":"Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.05.016_bib60","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.2147\/IJN.S131516","article-title":"Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner","volume":"12","author":"Qin","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.omtm.2021.05.016_bib61","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.devcel.2019.03.011","article-title":"Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity","volume":"49","author":"Latifkar","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omtm.2021.05.016_bib62","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1002\/jcb.27850","article-title":"Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells","volume":"120","author":"Kia","year":"2019","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.omtm.2021.05.016_bib63","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.2217\/nnm-2018-0094","article-title":"Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines","volume":"13","author":"Campos","year":"2018","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.omtm.2021.05.016_bib64","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.18632\/oncotarget.23238","article-title":"Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis","volume":"9","author":"Piao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtm.2021.05.016_bib65","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1073\/pnas.1717363115","article-title":"Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A","volume":"115","author":"Hashimoto","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2021.05.016_bib66","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/cancers9080095","article-title":"Integrins and Exosomes, a Dangerous Liaison in Cancer Progression","volume":"9","author":"Paolillo","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.omtm.2021.05.016_bib67","doi-asserted-by":"crossref","first-page":"4649705","DOI":"10.1155\/2019\/4649705","article-title":"Potential Role of Exosomes in Cancer Metastasis","volume":"2019","author":"Tian","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.omtm.2021.05.016_bib68","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.matbio.2018.05.002","article-title":"Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling","volume":"78-79","author":"McAtee","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib69","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/jcm8010026","article-title":"Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression","volume":"8","author":"Conigliaro","year":"2018","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.omtm.2021.05.016_bib70","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/pros.23653","article-title":"Thrombotic characteristics of extracellular vesicles derived from prostate cancer cells","volume":"78","author":"Al Saleh","year":"2018","journal-title":"Prostate"},{"key":"10.1016\/j.omtm.2021.05.016_bib71","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.18632\/oncotarget.6540","article-title":"Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche","volume":"7","author":"S\u00e1nchez","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtm.2021.05.016_bib72","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/onc.2013.560","article-title":"Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes","volume":"34","author":"Webber","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.omtm.2021.05.016_bib73","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","article-title":"Exosome-Mediated Metastasis: Communication from a Distance","volume":"49","author":"Wortzel","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.omtm.2021.05.016_bib74","doi-asserted-by":"crossref","first-page":"12905","DOI":"10.1038\/s41598-018-31323-7","article-title":"Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment","volume":"8","author":"Shu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.05.016_bib75","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1016\/j.bmcl.2015.10.067","article-title":"Sanguiin H6 suppresses TGF-\u03b2 induction of the epithelial-mesenchymal transition and inhibits migration and invasion in A549 lung cancer","volume":"25","author":"Ko","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.omtm.2021.05.016_bib76","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.3892\/ol.2015.4044","article-title":"The regulation of cancer cell migration by lung cancer cell-derived exosomes through TGF-\u03b2 and IL-10","volume":"11","author":"Wang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.omtm.2021.05.016_bib77","doi-asserted-by":"crossref","first-page":"E2110","DOI":"10.1073\/pnas.1209414109","article-title":"MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response","volume":"109","author":"Fabbri","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2021.05.016_bib78","first-page":"1007","article-title":"Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer, pulmonary tuberculosis, or pneumonia","volume":"42","author":"Lin","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib79","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/07357907.2013.789905","article-title":"Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T\u00a0cells","volume":"31","author":"Huang","year":"2013","journal-title":"Cancer Invest."},{"key":"10.1016\/j.omtm.2021.05.016_bib80","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"Kosaka","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2021.05.016_bib81","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1038\/onc.2014.300","article-title":"Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes","volume":"34","author":"Cui","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.omtm.2021.05.016_bib82","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1007\/s00018-018-2877-x","article-title":"Overview upon miR-21 in lung cancer: focus on NSCLC","volume":"75","author":"Bica-Pop","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.omtm.2021.05.016_bib83","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1038\/s41598-020-65207-6","article-title":"Exosomal miR-21 promotes proliferation, invasion and therapy resistance of colon adenocarcinoma cells through its target PDCD4","volume":"10","author":"Sun","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2021.05.016_bib84","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","article-title":"MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer","volume":"27","author":"Asangani","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.omtm.2021.05.016_bib85","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.lfs.2019.02.049","article-title":"Curcumol inhibits colorectal cancer proliferation by targeting miR-21 and modulated PTEN\/PI3K\/Akt pathways","volume":"221","author":"Liu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.omtm.2021.05.016_bib86","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3892\/ijo.2015.3255","article-title":"Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway","volume":"48","author":"Chiba","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib87","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1053\/j.gastro.2005.03.045","article-title":"Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape","volume":"128","author":"Huber","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.omtm.2021.05.016_bib88","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood-2007-03-081133","article-title":"Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer","volume":"110","author":"L\u00f6ffler","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2021.05.016_bib89","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/carcin\/bgy115","article-title":"Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis","volume":"39","author":"Shao","year":"2018","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.omtm.2021.05.016_bib90","doi-asserted-by":"crossref","first-page":"e1027472","DOI":"10.1080\/2162402X.2015.1027472","article-title":"The exosomes in tumor immunity","volume":"4","author":"Liu","year":"2015","journal-title":"OncoImmunology"},{"key":"10.1016\/j.omtm.2021.05.016_bib91","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13045-018-0625-1","article-title":"Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties","volume":"11","author":"Wang","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib92","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/jamaoncol.2016.5116","article-title":"Validation of a Risk Estimation of Tumor Recurrence After Transplant (RETREAT) Score for Hepatocellular Carcinoma Recurrence After Liver Transplant","volume":"3","author":"Mehta","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib93","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41419-018-0534-9","article-title":"HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK\/ERK signalling pathway","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtm.2021.05.016_bib94","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bbrc.2018.05.208","article-title":"Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2\/TP53INP1\/CDKN1A","volume":"502","author":"Xue","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtm.2021.05.016_bib95","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lfs.2018.02.006","article-title":"LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells","volume":"197","author":"Li","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.omtm.2021.05.016_bib96","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/bfgp\/elv058","article-title":"Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer","volume":"15","author":"Mohankumar","year":"2016","journal-title":"Brief. Funct. Genomics"},{"key":"10.1016\/j.omtm.2021.05.016_bib97","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41419-017-0180-7","article-title":"14-3-3\u03b6 delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtm.2021.05.016_bib98","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.omtn.2018.02.014","article-title":"Hepatocellular Carcinoma Cell-Secreted Exosomal MicroRNA-210 Promotes Angiogenesis In\u00a0Vitro and In\u00a0Vivo","volume":"11","author":"Lin","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtm.2021.05.016_bib99","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/hep.29920","article-title":"Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins","volume":"68","author":"Fang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.omtm.2021.05.016_bib100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/mc.22340","article-title":"Regulation of NANOG in cancer cells","volume":"54","author":"Gong","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.omtm.2021.05.016_bib101","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13048-018-0391-2","article-title":"Comparison of benign peritoneal fluid- and ovarian cancer ascites-derived extracellular vesicle RNA biomarkers","volume":"11","author":"Yamamoto","year":"2018","journal-title":"J.\u00a0Ovarian Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib102","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ygyno.2019.03.099","article-title":"SOX2 and SOX9 are markers of clinically aggressive disease in metastatic high-grade serous carcinoma","volume":"153","author":"Sherman-Samis","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.omtm.2021.05.016_bib103","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1186\/s12885-018-4974-5","article-title":"Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells","volume":"18","author":"Yoshimura","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib104","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1172\/JCI87252","article-title":"Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer","volume":"126","author":"Yin","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtm.2021.05.016_bib105","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.4049\/jimmunol.1801041","article-title":"Sialic Acid-Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments","volume":"201","author":"Shenoy","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2021.05.016_bib106","doi-asserted-by":"crossref","first-page":"36691","DOI":"10.1074\/jbc.M113.512806","article-title":"Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling","volume":"288","author":"Bretz","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2021.05.016_bib107","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1007\/s13277-015-4313-2","article-title":"Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity","volume":"37","author":"Labani-Motlagh","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib108","first-page":"5062","article-title":"High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis","volume":"8","author":"Yi","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.omtm.2021.05.016_bib109","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/proteomes7020014","article-title":"Extracellular Vesicle Integrins Distinguish Unique Cancers","volume":"7","author":"Hurwitz","year":"2019","journal-title":"Proteomes"},{"key":"10.1016\/j.omtm.2021.05.016_bib110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13046-018-0763-x","article-title":"Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma","volume":"37","author":"Huang","year":"2018","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib111","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ar.23338","article-title":"Integrin \u03b14 Induces Lymphangiogenesis and Metastasis via Upregulation of VEGF-C in Human Colon Cancer","volume":"299","author":"Lv","year":"2016","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.omtm.2021.05.016_bib112","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1593\/neo.91604","article-title":"Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma","volume":"12","author":"Rebhun","year":"2010","journal-title":"Neoplasia"},{"key":"10.1016\/j.omtm.2021.05.016_bib113","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1158\/0008-5472.CAN-09-3761","article-title":"Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis","volume":"70","author":"Garmy-Susini","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib114","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/jcp.21029","article-title":"High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers","volume":"212","author":"Klemke","year":"2007","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.omtm.2021.05.016_bib115","doi-asserted-by":"crossref","first-page":"9042","DOI":"10.1073\/pnas.1219603110","article-title":"PI3K\u03b1 activates integrin \u03b14\u03b21 to establish a metastatic niche in lymph nodes","volume":"110","author":"Garmy-Susini","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2021.05.016_bib116","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/bcr1398","article-title":"Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone","volume":"8","author":"Sloan","year":"2006","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib117","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.3892\/or.2015.3910","article-title":"Orally active \u03b1v\u03b23 integrin inhibitor MK-0429 reduces melanoma metastasis","volume":"33","author":"Pickarski","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.omtm.2021.05.016_bib118","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/cr.2015.153","article-title":"Organotropic metastasis: role of tumor exosomes","volume":"26","author":"Liu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib119","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1165\/rcmb.2006-0238OC","article-title":"Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function","volume":"36","author":"Su","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib120","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/ncomms12502","article-title":"PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis","volume":"7","author":"Martin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2021.05.016_bib121","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathol-052016-100322","article-title":"The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer","volume":"12","author":"Affo","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.omtm.2021.05.016_bib122","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1158\/0008-5472.CAN-09-0315","article-title":"Integrin alpha2 mediates selective metastasis to the liver","volume":"69","author":"Yoshimura","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib123","doi-asserted-by":"crossref","first-page":"215","DOI":"10.18632\/oncotarget.13832","article-title":"VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers","volume":"8","author":"Bartolom\u00e9","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.omtm.2021.05.016_bib124","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/onc.2010.532","article-title":"Ligand-independent activation of c-Met by fibronectin and \u03b1(5)\u03b2(1)-integrin regulates ovarian cancer invasion and metastasis","volume":"30","author":"Mitra","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.omtm.2021.05.016_bib125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/ijc.10958","article-title":"Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice","volume":"104","author":"Stoeltzing","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib126","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1002\/ijc.28267","article-title":"\u03b1v-Integrin isoform expression in primary human tumors and brain metastases","volume":"133","author":"Vogetseder","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib127","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10585-014-9675-0","article-title":"\u03b1v\u03b23, \u03b1v\u03b25 and \u03b1v\u03b26 integrins in brain metastases of lung cancer","volume":"31","author":"Berghoff","year":"2014","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.omtm.2021.05.016_bib128","first-page":"4029","article-title":"High \u03b1v Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats","volume":"37","author":"Wu","year":"2017","journal-title":"Anticancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib129","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1173>3.0.CO;2-L","article-title":"The pattern of metastasis of human melanoma to the central nervous system is not influenced by integrin alpha(v)beta(3) expression","volume":"92","author":"K\u00fcsters","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib130","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1158\/0008-5472.CAN-13-1796","article-title":"Integrin \u03b1v\u03b26 promotes an osteolytic program in cancer cells by upregulating MMP2","volume":"74","author":"Dutta","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtm.2021.05.016_bib131","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1074\/jbc.C114.617662","article-title":"The \u03b1v\u03b26 integrin is transferred intercellularly via exosomes","volume":"290","author":"Fedele","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2021.05.016_bib132","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.matbio.2018.03.009","article-title":"Exosomal \u03b1v\u03b26 integrin is required for monocyte M2 polarization in prostate cancer","volume":"70","author":"Lu","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib133","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/jcb.21298","article-title":"Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration","volume":"101","author":"Hayashi","year":"2007","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.omtm.2021.05.016_bib134","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/0092-8674(94)90007-8","article-title":"Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels","volume":"79","author":"Brooks","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2021.05.016_bib135","first-page":"55","article-title":"Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells","volume":"148","author":"Matsuura","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.omtm.2021.05.016_bib136","doi-asserted-by":"crossref","first-page":"298732","DOI":"10.1155\/2012\/298732","article-title":"Emerging putative biomarkers: the role of alpha 2 and 6 integrins in susceptibility, treatment, and prognosis","volume":"2012","author":"Marthick","year":"2012","journal-title":"Prostate Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib137","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4939-9769-5_4","article-title":"Exosomes Extraction and Identification","volume":"2054","author":"Wu","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib138","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1039\/C6MB00082G","article-title":"Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation","volume":"12","author":"Abramowicz","year":"2016","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.omtm.2021.05.016_bib139","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.nano.2017.03.011","article-title":"Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation","volume":"13","author":"Mol","year":"2017","journal-title":"Nanomedicine (Lond.)"},{"issue":"134","key":"10.1016\/j.omtm.2021.05.016_bib140","first-page":"e57467","article-title":"Protein Digestion, Ultrafiltration, and Size Exclusion Chromatography to Optimize the Isolation of Exosomes from Human Blood Plasma and Serum","author":"Diaz","year":"2018","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.omtm.2021.05.016_bib141","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ymeth.2015.05.028","article-title":"Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches","volume":"87","author":"Zarovni","year":"2015","journal-title":"Methods"},{"key":"10.1016\/j.omtm.2021.05.016_bib142","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/978-1-4939-1538-5_27","article-title":"Magnetic bead-based isolation of exosomes","volume":"1218","author":"Oksvold","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtm.2021.05.016_bib143","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1007\/s00216-018-1052-4","article-title":"Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling","volume":"410","author":"Ding","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"issue":"59","key":"10.1016\/j.omtm.2021.05.016_bib144","first-page":"e3037","article-title":"Isolation and characterization of RNA-containing exosomes","author":"L\u00e4sser","year":"2012","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.omtm.2021.05.016_bib145","doi-asserted-by":"crossref","first-page":"e0227949","DOI":"10.1371\/journal.pone.0227949","article-title":"Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid","volume":"15","author":"Emelyanov","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtm.2021.05.016_bib146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-018-0433-3","article-title":"Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires","volume":"17","author":"Lim","year":"2019","journal-title":"J.\u00a0Nanobiotechnology"},{"key":"10.1016\/j.omtm.2021.05.016_bib147","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.7150\/jca.18026","article-title":"Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients","volume":"8","author":"Zhao","year":"2017","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.omtm.2021.05.016_bib148","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jconrel.2014.07.042","article-title":"Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in\u00a0vitro tumor growth: a new approach for drug delivery","volume":"192","author":"Pascucci","year":"2014","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.omtm.2021.05.016_bib149","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.biomaterials.2013.11.083","article-title":"A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy","volume":"35","author":"Tian","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtm.2021.05.016_bib150","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejps.2018.05.001","article-title":"Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems","volume":"121","author":"Lu","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.omtm.2021.05.016_bib151","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1039\/C7NR06966A","article-title":"Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach","volume":"10","author":"Kooijmans","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.omtm.2021.05.016_bib152","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biomaterials.2017.01.004","article-title":"Exosome-SIRP\u03b1, a CD47 blockade increases cancer cell phagocytosis","volume":"121","author":"Koh","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.omtm.2021.05.016_bib153","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nano.2017.09.011","article-title":"Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in\u00a0vitro and in\u00a0vivo evaluations","volume":"14","author":"Kim","year":"2018","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.omtm.2021.05.016_bib154","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/85438","article-title":"Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming","volume":"7","author":"Wolfers","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2021.05.016_bib155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.canlet.2008.10.021","article-title":"MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models","volume":"275","author":"Cho","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.omtm.2021.05.016_bib156","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1074\/jbc.M112.340588","article-title":"Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in\u00a0vitro","volume":"287","author":"Lv","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2021.05.016_bib157","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1479-5876-10-134","article-title":"Exosome removal as a therapeutic adjuvant in cancer","volume":"10","author":"Marleau","year":"2012","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.omtm.2021.05.016_bib158","doi-asserted-by":"crossref","first-page":"e101629","DOI":"10.1371\/journal.pone.0101629","article-title":"Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes","volume":"9","author":"Cossetti","year":"2014","journal-title":"PLoS ONE"}],"container-title":["Molecular Therapy - Methods &amp; Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121001005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050121001005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:27:24Z","timestamp":1762421244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050121001005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":156,"alternative-id":["S2329050121001005"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2021.05.016","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes and organ-specific metastasis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2021.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}