{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:36:08Z","timestamp":1747168568735,"version":"3.40.5"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.omtm.2022.05.007","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T13:38:03Z","timestamp":1653831483000},"page":"38-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses"],"prefix":"10.1016","volume":"26","author":[{"given":"Jeeva","family":"Subbbiah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Hye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Hyun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Ryoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noopur","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youri","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baik-Lin","family":"Seong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-331X","authenticated-orcid":false,"given":"Sang-Moo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2022.05.007_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-065X.2010.00974.x","article-title":"Influenza vaccine immunology","volume":"239","author":"Dormitzer","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.omtm.2022.05.007_bib3","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1093\/infdis\/jiy711","article-title":"Universal influenza virus vaccines that target the conserved hemagglutinin stalk and conserved sites in the head domain","volume":"219","author":"Krammer","year":"2019","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.omtm.2022.05.007_bib4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/vaccines8030382","article-title":"Neutralizing antibodies targeting the conserved stem region of influenza hemagglutinin","volume":"8","author":"Nath Neerukonda","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.omtm.2022.05.007_bib5","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1205669","article-title":"A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins","volume":"333","author":"Corti","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.omtm.2022.05.007_bib6","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/biot.201400393","article-title":"Emerging influenza viruses and the prospect of a universal influenza virus vaccine","volume":"10","author":"Krammer","year":"2015","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.omtm.2022.05.007_bib7","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1126\/science.aac7263","article-title":"A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen","volume":"349","author":"Impagliazzo","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.omtm.2022.05.007_bib8","doi-asserted-by":"crossref","first-page":"E2514","DOI":"10.1073\/pnas.1402766111","article-title":"Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection","volume":"111","author":"Mallajosyula","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omtm.2022.05.007_bib9","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm.3927","article-title":"Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection","volume":"21","author":"Yassine","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2022.05.007_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00018-10","article-title":"Influenza virus vaccine based on the conserved hemagglutinin stalk domain","volume":"1","author":"Steel","year":"2010","journal-title":"mBio"},{"key":"10.1016\/j.omtm.2022.05.007_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12929-019-0572-3","article-title":"M2e-based universal influenza vaccines: a historical overview and new approaches to development","volume":"26","author":"Mezhenskaya","year":"2019","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.omtm.2022.05.007_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/vaccines3010105","article-title":"M2e-Based universal influenza A vaccines","volume":"3","author":"Deng","year":"2015","journal-title":"Vaccines"},{"key":"10.1016\/j.omtm.2022.05.007_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/14760584.2017.1240041","article-title":"M2-based influenza vaccines: recent advances and clinical potential","volume":"16","author":"Kolpe","year":"2017","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.omtm.2022.05.007_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/mt.2012.246","article-title":"Virus-like particles containing multiple M2 extracellular domains confer improved cross-protection against various subtypes of influenza virus","volume":"21","author":"Kim","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2022.05.007_bib15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/13484","article-title":"A universal influenza A vaccine based on the extracellular domain of the M2 protein","volume":"5","author":"Neirynck","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2022.05.007_bib16","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1016\/j.vaccine.2011.05.041","article-title":"Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults","volume":"29","author":"Turley","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.omtm.2022.05.007_bib17","doi-asserted-by":"crossref","first-page":"e14442","DOI":"10.1371\/journal.pone.0014442","article-title":"Immunopotentiation of trivalent influenza vaccine when given with VAX102, a recombinant influenza M2e vaccine fused to the TLR5 ligand flagellin","volume":"5","author":"Talbot","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2022.05.007_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4110\/in.2015.15.5.213","article-title":"Mechanisms of cross-protection by influenza virus M2-based vaccines","volume":"15","author":"Lee","year":"2015","journal-title":"Immune Netw."},{"key":"10.1016\/j.omtm.2022.05.007_bib19","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.4049\/jimmunol.1501637","article-title":"A novel vaccination strategy mediating the induction of lung-resident memory CD8 T\u00a0cells confers heterosubtypic immunity against future pandemic influenza virus","volume":"196","author":"Lee","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2022.05.007_bib20","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.4049\/jimmunol.172.9.5598","article-title":"Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity","volume":"172","author":"Jegerlehner","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2022.05.007_bib21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41467-017-02725-4","article-title":"Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2022.05.007_bib22","doi-asserted-by":"crossref","first-page":"e0201429","DOI":"10.1371\/journal.pone.0201429","article-title":"Combination of M2e peptide with stalk HA epitopes of influenza A virus enhances protective properties of recombinant vaccine","volume":"13","author":"Tsybalova","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2022.05.007_bib23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jmb.2004.02.020","article-title":"Very fast folding and association of a trimerization domain from bacteriophage T4 fibritin","volume":"337","author":"G\u00fcthe","year":"2004","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.omtm.2022.05.007_bib24","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1056\/NEJMoa1501184","article-title":"Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults","volume":"372","author":"Lal","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.omtm.2022.05.007_bib25","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/1060028018758431","article-title":"Shingrix: the new adjuvanted recombinant herpes zoster vaccine","volume":"52","author":"James","year":"2018","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.omtm.2022.05.007_bib26","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1073\/pnas.1012199108","article-title":"Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus","volume":"108","author":"Song","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omtm.2022.05.007_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02810-18","article-title":"Design of nanoparticulate group 2 influenza virus hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages","volume":"10","author":"Corbett","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.omtm.2022.05.007_bib28","doi-asserted-by":"crossref","first-page":"eabe5449","DOI":"10.1126\/scitranslmed.abe5449","article-title":"Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates","volume":"13","author":"Darricarr\u00e8re","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtm.2022.05.007_bib29","doi-asserted-by":"crossref","first-page":"22666","DOI":"10.1038\/srep22666","article-title":"Stalking influenza by vaccination with pre-fusion headless HA mini-stem","volume":"6","author":"Valkenburg","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2022.05.007_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1073\/pnas.1308701110","article-title":"Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omtm.2022.05.007_bib31","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1073\/pnas.1007465107","article-title":"Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge","volume":"107","author":"Bommakanti","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.omtm.2022.05.007_bib32","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1016\/j.vaccine.2008.09.015","article-title":"Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins","volume":"26","author":"Chun","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.omtm.2022.05.007_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2010.11.030","article-title":"Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus","volume":"403","author":"Hashem","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtm.2022.05.007_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41541-017-0036-2","article-title":"Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines","volume":"2","author":"Sutton","year":"2017","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.omtm.2022.05.007_bib35","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1128\/JVI.00641-13","article-title":"Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies","volume":"87","author":"Krammer","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtm.2022.05.007_bib36","doi-asserted-by":"crossref","first-page":"10435","DOI":"10.1128\/JVI.01715-13","article-title":"Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses","volume":"87","author":"Margine","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtm.2022.05.007_bib37","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1128\/JVI.03004-13","article-title":"Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets","volume":"88","author":"Krammer","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtm.2022.05.007_bib38","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"Ekiert","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.omtm.2022.05.007_bib39","doi-asserted-by":"crossref","first-page":"e80034","DOI":"10.1371\/journal.pone.0080034","article-title":"Mechanisms of hemagglutinin targeted influenza virus neutralization","volume":"8","author":"Brandenburg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2022.05.007_bib40","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1128\/JVI.02289-14","article-title":"Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin","volume":"88","author":"Tan","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtm.2022.05.007_bib41","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.antiviral.2013.06.010","article-title":"Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection","volume":"99","author":"Kim","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.omtm.2022.05.007_bib42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/imm.12310","article-title":"Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination","volume":"143","author":"Lee","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.omtm.2022.05.007_bib43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm.3443","article-title":"Broadly neutralizing hemagglutinin stalk\u2013specific antibodies require Fc\u03b3R interactions for protection against influenza virus in\u00a0vivo","volume":"20","author":"DiLillo","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2022.05.007_bib44","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.0902147","article-title":"Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection","volume":"186","author":"El Bakkouri","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2022.05.007_bib45","doi-asserted-by":"crossref","first-page":"e0154461","DOI":"10.1371\/journal.pone.0154461","article-title":"Influenza-specific antibody-dependent phagocytosis","volume":"11","author":"Ana-Sosa-Batiz","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2022.05.007_bib46","doi-asserted-by":"crossref","first-page":"e0137822","DOI":"10.1371\/journal.pone.0137822","article-title":"Cross protection against influenza A virus by yeast-expressed heterologous tandem repeat M2 extracellular proteins","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2022.05.007_bib47","doi-asserted-by":"crossref","first-page":"200ra114","DOI":"10.1126\/scitranslmed.3006366","article-title":"Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease","volume":"5","author":"Khurana","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtm.2022.05.007_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jps.22267","article-title":"Acceptable levels of endotoxin in vaccine formulations during preclinical research","volume":"100","author":"Brito","year":"2011","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.omtm.2022.05.007_bib49","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.vaccine.2019.01.068","article-title":"Universal monoclonal antibody-based influenza hemagglutinin quantitative enzyme-linked immunosorbent assay","volume":"37","author":"Chae","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.omtm.2022.05.007_bib50","first-page":"1","article-title":"Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2022.05.007_bib51","doi-asserted-by":"crossref","first-page":"5824","DOI":"10.1016\/j.vaccine.2014.08.030","article-title":"Influenza M2 virus-like particles confer a broader range of cross protection to the strain-specific pre-existing immunity","volume":"32","author":"Kim","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.omtm.2022.05.007_bib52","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1128\/JVI.02018-15","article-title":"Virus-like particle vaccine containing the F protein of respiratory syncytial virus confers protection without pulmonary disease by modulating specific subsets of dendritic cells and effector T\u00a0cells","volume":"89","author":"Kim","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.omtm.2022.05.007_bib53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4049\/jimmunol.1600173","article-title":"Roles of aluminum Hydroxide and monophosphoryl lipid A adjuvants in overcoming CD4+ T\u00a0cell deficiency to induce isotype-switched IgG antibody responses and protection by T-dependent influenza vaccine","volume":"198","author":"Ko","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtm.2022.05.007_bib54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jim.2016.12.002","article-title":"Characterization of Fc\u03b3RIIIA effector cells used in in\u00a0vitro ADCC bioassay: comparison of primary NK cells with engineered NK-92 and Jurkat T\u00a0cells","volume":"441","author":"Hsieh","year":"2017","journal-title":"J.\u00a0Immunol. Methods"}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050122000729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050122000729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:12:23Z","timestamp":1714695143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050122000729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":53,"alternative-id":["S2329050122000729"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2022.05.007","relation":{},"ISSN":["2329-0501"],"issn-type":[{"type":"print","value":"2329-0501"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2022.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}