{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:23:28Z","timestamp":1792650208293,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.omtm.2022.08.006","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T01:43:36Z","timestamp":1661305416000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["AAV2\/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modification"],"prefix":"10.1016","volume":"27","author":[{"given":"Benoit","family":"Gautier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9na","family":"Meneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Feret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Audrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Hudecek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Kuony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Bourdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Le Guiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Blouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Delettre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4305-305X","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Michon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2022.08.006_bib1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/stem.2767","article-title":"Bmi1+ progenitor cell dynamics in murine cornea during homeostasis and wound healing","volume":"36","author":"Kalha","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.omtm.2022.08.006_bib2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1387\/ijdb.041860jz","article-title":"Corneal development associated with eyelid opening","volume":"48","author":"Zieske","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.omtm.2022.08.006_bib3","doi-asserted-by":"crossref","DOI":"10.1242\/dev.176693","article-title":"Ectodysplasin-A signaling is a key integrator in the lacrimal gland\u2013cornea feedback loop","volume":"146","author":"Kuony","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.omtm.2022.08.006_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2147\/OPTH.S45921","article-title":"Diagnosis and management of neurotrophic keratitis","volume":"8","author":"Lambiase","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.omtm.2022.08.006_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"M\u00fcller","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.omtm.2022.08.006_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jcp.25623","article-title":"Understanding the pathogenesis of neurotrophic keratitis: the role of corneal nerves: the role of corneal nerves in neurotrophic keratitis","volume":"232","author":"Mastropasqua","year":"2017","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.omtm.2022.08.006_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jtos.2017.10.006","article-title":"The impact of diabetes on corneal nerve morphology and ocular surface integrity","volume":"16","author":"Markoulli","year":"2018","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.omtm.2022.08.006_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2147\/CIA.S190713","article-title":"Influence of diabetes mellitus on anterior segment of the eye","volume":"14","author":"Han","year":"2019","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.omtm.2022.08.006_bib9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/ICO.0000000000002264","article-title":"The use of autologous serum to reverse severe contact lens-induced limbal stem cell deficiency","volume":"39","author":"Yeh","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.omtm.2022.08.006_bib10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/08820538.2021.1890793","article-title":"Nerve growth factor as an ocular therapy: applications, challenges, and future directions","volume":"36","author":"Kanu","year":"2021","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.omtm.2022.08.006_bib11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/eye.2015.155","article-title":"A novel eye drop application monitor to assess patient compliance with a prescribed regimen: a pilot study","volume":"29","author":"Eaton","year":"2015","journal-title":"Eye"},{"key":"10.1016\/j.omtm.2022.08.006_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtm.2022.08.006_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ymthe.2020.12.007","article-title":"Current clinical applications of in\u00a0vivo gene therapy with AAVs","volume":"29","author":"Mendell","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/d41573-021-00017-7","article-title":"The clinical landscape for AAV gene therapies","volume":"20","author":"Kuzmin","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.omtm.2022.08.006_bib15","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.ophtha.2021.03.031","article-title":"Durability of voretigene neparvovec for biallelic RPE65-mediated inherited retinal disease: phase 3 results at 3 and 4 years","volume":"128","author":"Maguire","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.omtm.2022.08.006_bib16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S1474-4422(21)00001-6","article-title":"Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial","volume":"20","author":"Day","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.omtm.2022.08.006_bib17","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1089\/hum.2017.164","article-title":"The future looks brighter after 25 Years of retinal gene therapy","volume":"28","author":"Auricchio","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108361","article-title":"Novel insights into gene therapy in the cornea","volume":"202","author":"Mohan","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.omtm.2022.08.006_bib19","doi-asserted-by":"crossref","first-page":"9567","DOI":"10.1167\/iovs.11-8171","article-title":"Transduction, tropism, and biodistribution of AAV vectors in the lacrimal gland","volume":"52","author":"Rocha","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.omtm.2022.08.006_bib20","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1167\/iovs.10-5423","article-title":"Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis","volume":"51","author":"Thomas","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.omtm.2022.08.006_bib21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1542-0124(12)70613-4","article-title":"Growth factors in the tear film: role in tissue maintenance, wound healing, and ocular pathology","volume":"5","author":"Klenkler","year":"2007","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.omtm.2022.08.006_bib22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s40265-020-01289-w","article-title":"Cenegermin: a review in neurotrophic keratitis","volume":"80","author":"Deeks","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.omtm.2022.08.006_bib23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3389\/fphys.2017.00739","article-title":"Epithelial markers aSMA, Krt14, and Krt19 unveil elements of murine lacrimal gland morphogenesis and maturation","volume":"8","author":"Kuony","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.omtm.2022.08.006_bib24","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0969-2126(97)00280-3","article-title":"Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins","volume":"5","author":"Bax","year":"1997","journal-title":"Structure"},{"key":"10.1016\/j.omtm.2022.08.006_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.str.2018.09.013","article-title":"The structure of the pro-domain of mouse proNGF in contact with the NGF domain","volume":"27","author":"Yan","year":"2019","journal-title":"Structure"},{"key":"10.1016\/j.omtm.2022.08.006_bib26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/978-1-4615-0717-8_75","article-title":"Nerve growth factor (NGF): an important molecule for trophism and healing of the ocular surface","volume":"506","author":"Bonini","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.omtm.2022.08.006_bib27","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.4110\/in.2019.19.e3","article-title":"Age-related autoimmune changes in lacrimal glands","volume":"19","author":"de Souza","year":"2019","journal-title":"Immune Netw."},{"key":"10.1016\/j.omtm.2022.08.006_bib28","series-title":"StatPearls","article-title":"Cornea foreign body removal","author":"Guier","year":"2022"},{"key":"10.1016\/j.omtm.2022.08.006_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107709","article-title":"Corneal injury: clinical and molecular aspects","volume":"186","author":"Barrientez","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.omtm.2022.08.006_bib30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.omtm.2022.08.006_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111820","article-title":"Autoimmune epithelitis and chronic inflammation in sj\u00f6gren\u2019s syndrome-related dry eye disease","volume":"22","author":"Ogawa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtm.2022.08.006_bib32","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1097\/ICO.0000000000002500","article-title":"Using medical big data to develop personalized medicine for dry eye disease","volume":"39","author":"Inomata","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.omtm.2022.08.006_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/bioengineering8080108","article-title":"Stem cell niche microenvironment: review","volume":"8","author":"Abdul-Al","year":"2021","journal-title":"Bioengineering"},{"key":"10.1016\/j.omtm.2022.08.006_bib34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuron.2019.02.017","article-title":"Therapeutic AAV gene transfer to the nervous system: a clinical reality","volume":"101","author":"Hudry","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.omtm.2022.08.006_bib35","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.drudis.2019.05.038","article-title":"Ocular gene therapies in clinical practice: viral vectors and nonviral alternatives","volume":"24","author":"Bordet","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.omtm.2022.08.006_bib36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnins.2017.00174","article-title":"Retinal gene therapy: surgical vector delivery in the translation to clinical trials","volume":"11","author":"Ochakovski","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.omtm.2022.08.006_bib37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnana.2014.00042","article-title":"Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse","volume":"8","author":"Schuster","year":"2014","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.omtm.2022.08.006_bib38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/hmg\/ddp475","article-title":"Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate","volume":"19","author":"Colle","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2022.08.006_bib39","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1038\/s41467-021-22593-3","article-title":"AAV2\/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A","volume":"12","author":"Gautier","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2022.08.006_bib40","first-page":"49","article-title":"Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy","volume":"19","author":"Powell","year":"2015","journal-title":"Discov. Med."},{"key":"10.1016\/j.omtm.2022.08.006_bib41","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1089\/hum.2010.245","article-title":"Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors","volume":"22","author":"Gray","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib42","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature04791","article-title":"Fatality in mice due to oversaturation of cellular microRNA\/short hairpin RNA pathways","volume":"441","author":"Grimm","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2022.08.006_bib43","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/hmg\/10.26.3075","article-title":"Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model","volume":"10","author":"Auricchio","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2022.08.006_bib44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/hum.2018.015","article-title":"Severe toxicity in nonhuman primates and piglets following high-dose intravenous administration of an adeno-associated virus vector expressing human SMN","volume":"29","author":"Hinderer","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib45","doi-asserted-by":"crossref","first-page":"E9873","DOI":"10.1073\/pnas.1706365114","article-title":"Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells","volume":"114","author":"Haimovich","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2022.08.006_bib46","article-title":"miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas","volume":"9","author":"Flemming","year":"2020","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.omtm.2022.08.006_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67206-z","article-title":"Features of p53 protein distribution in the corneal epithelium and corneal tear film","volume":"10","author":"Tendler","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2022.08.006_bib48","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/mt.2008.76","article-title":"Analysis of AAV serotypes 1\u20139 mediated gene expression and tropism in mice after systemic injection","volume":"16","author":"Zincarelli","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib49","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.omtm.2018.02.005","article-title":"Development of intrathecal AAV9 gene therapy for giant axonal neuropathy","volume":"9","author":"Bailey","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.08.006_bib50","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nm1398","article-title":"Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer","volume":"12","author":"Brown","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtm.2022.08.006_bib51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/0891693031000141077","article-title":"Presence of B7-2+ dendritic cells and expression of Th1 cytokines in the early development of sialodacryoadenitis in the IqI\/Jic mouse model of primary Sj\u00f6rgren\u2019s syndrome","volume":"36","author":"Konno","year":"2003","journal-title":"Autoimmunity"},{"key":"10.1016\/j.omtm.2022.08.006_bib52","first-page":"587","article-title":"A new scenario for the evolutionary origin of hair, feather, and avian scales","volume":"214","author":"Dhouailly","year":"2009","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.omtm.2022.08.006_bib53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.omtm.2017.11.007","article-title":"Emerging issues in AAV-mediated in\u00a0vivo gene therapy","volume":"8","author":"Colella","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.08.006_bib54","first-page":"127","article-title":"Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study","volume":"104","author":"Sacchetti","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.omtm.2022.08.006_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1167\/tvst.9.7.7","article-title":"Microbial cross-contamination in multidose eyedrops: the impact of instillation angle and bottle geometry","volume":"9","author":"da Costa","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.omtm.2022.08.006_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/08977194.2013.804073","article-title":"Nerve growth factor: basic studies and possible therapeutic applications","volume":"31","author":"Manni","year":"2013","journal-title":"Growth Factors"},{"key":"10.1016\/j.omtm.2022.08.006_bib57","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2174\/156652310793797685","article-title":"Production, purification and characterization of adeno-associated vectors","volume":"10","author":"Ayuso","year":"2010","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib58","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1089\/hum.2014.057","article-title":"Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard","volume":"25","author":"Ayuso","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib59","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1089\/hum.2022.050","article-title":"Human and insect cell-produced recombinant adeno-associated viruses show differences in genome heterogeneity","volume":"33","author":"Tran","year":"2022","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.08.006_bib60","doi-asserted-by":"crossref","DOI":"10.3791\/58071","article-title":"Corneal epithelial abrasion with ocular burr as a model for cornea wound healing","author":"Kalha","year":"2018","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.omtm.2022.08.006_bib61","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-019-1656-4","article-title":"Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem","volume":"16","author":"Fakih","year":"2019","journal-title":"J.\u00a0Neuroinflammation"}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050122001164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050122001164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:30:13Z","timestamp":1762421413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050122001164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":61,"alternative-id":["S2329050122001164"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2022.08.006","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.02.16.480632","asserted-by":"object"}]},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AAV2\/9-mediated gene transfer into murine lacrimal gland leads to a long-term targeted tear film modification","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2022.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}