{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:10:25Z","timestamp":1787501425436,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Janssen Pharmaceutical Companies of Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.omtm.2022.09.017","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T19:38:51Z","timestamp":1664912331000},"page":"272-280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors"],"prefix":"10.1016","volume":"27","author":[{"given":"Makoto","family":"Horiuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Hinderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny A.","family":"Greig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Buza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Chichester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanying","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Goode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9630-3131","authenticated-orcid":false,"given":"James M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2022.09.017_bib1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/hum.2018.015","article-title":"Severe toxicity in nonhuman primates and Piglets following high-dose intravenous administration of an adeno-associated virus vector expressing human SMN","volume":"29","author":"Hinderer","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jhep.2020.11.001","article-title":"Hepatotoxicity following administration of onasemnogene abeparvovec (AVXS-101) for the treatment of spinal muscular atrophy","volume":"74","author":"Chand","year":"2021","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.omtm.2022.09.017_bib3","doi-asserted-by":"crossref","first-page":"14051","DOI":"10.1038\/mtm.2014.51","article-title":"Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna","volume":"1","author":"Hinderer","year":"2014","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.09.017_bib4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.omtm.2020.04.012","article-title":"Translational feasibility of lumbar puncture for intrathecal AAV administration","volume":"17","author":"Hinderer","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.09.017_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.omtm.2018.12.001","article-title":"Kinetics and MR-based monitoring of AAV9 vector delivery into cerebrospinal fluid of nonhuman primates","volume":"13","author":"Ohno","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.09.017_bib6","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1089\/hum.2020.116","article-title":"Quantitative whole-body imaging of I-124-Labeled adeno-associated viral vector biodistribution in nonhuman primates","volume":"31","author":"Ballon","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.omtm.2018.03.004","article-title":"A rationally engineered capsid variant of AAV9 for systemic CNS-directed and peripheral tissue-detargeted gene delivery in neonates","volume":"9","author":"Wang","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.09.017_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41593-021-00969-4","article-title":"AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset","volume":"25","author":"Goertsen","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.omtm.2022.09.017_bib9","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/gt.2012.101","article-title":"Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates","volume":"20","author":"Gray","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/hum.2017.026","article-title":"Evaluation of intrathecal routes of administration for adeno-associated viral vectors in large animals","volume":"29","author":"Hinderer","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib11","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1172\/JCI66778","article-title":"Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy","volume":"123","author":"Haurigot","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtm.2022.09.017_bib12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1086\/595830","article-title":"Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses","volume":"199","author":"Calcedo","year":"2009","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.omtm.2022.09.017_bib13","doi-asserted-by":"crossref","first-page":"102569","DOI":"10.1016\/j.autrev.2020.102569","article-title":"Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: a comprehensive review","volume":"19","author":"Alijotas-Reig","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.omtm.2022.09.017_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12987-018-0093-6","article-title":"Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration","volume":"15","author":"Wang","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.omtm.2022.09.017_bib15","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1089\/hum.2011.031","article-title":"Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors","volume":"22","author":"Wang","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1089\/hum.2020.167","article-title":"Adeno-associated virus-induced dorsal root ganglion pathology","volume":"31","author":"Hordeaux","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib17","doi-asserted-by":"crossref","first-page":"25658","DOI":"10.1038\/srep25658","article-title":"Trafficking of endogenous immunoglobulins by endothelial cells at the blood-brain barrier","volume":"6","author":"Villase\u00f1or","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2022.09.017_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.omtm.2018.09.003","article-title":"Adeno-associated virus neutralizing antibodies in large animals and their impact on brain intraparenchymal gene transfer","volume":"11","author":"Wang","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2022.09.017_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jneuroim.2007.11.009","article-title":"Inflammatory responses in the rat brain in response to different methods of intra-cerebral administration","volume":"194","author":"McCluskey","year":"2008","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.omtm.2022.09.017_bib20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.mt.6300090","article-title":"Pre-existing AAV capsid-specific CD8+ T\u00a0cells are unable to eliminate AAV-transduced hepatocytes","volume":"15","author":"Li","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib21","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1158\/0008-5472.CAN-18-0363","article-title":"Intrathecal viral vector delivery of trastuzumab prevents or inhibits tumor growth of human HER2-positive xenografts in mice","volume":"78","author":"Rothwell","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.omtm.2022.09.017_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccl.2019.07.005","article-title":"Trastuzumab-induced cardiomyopathy","volume":"37","author":"Barish","year":"2019","journal-title":"Cardiol. Clin."},{"key":"10.1016\/j.omtm.2022.09.017_bib23","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/mt.2011.22","article-title":"Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer","volume":"19","author":"Pulicherla","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib24","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1016\/j.vaccine.2016.10.053","article-title":"Intramuscular administration of AAV overcomes pre-existing neutralizing antibodies in rhesus macaques","volume":"34","author":"Greig","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.omtm.2022.09.017_bib25","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1212\/WNL.0000000000200676","article-title":"Child neurology: Pathologically confirmed thrombotic microangiopathy caused by onasemnogene abeparvovec treatment for SMA","volume":"98","author":"Yazaki","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.omtm.2022.09.017_bib26","first-page":"2568","article-title":"Immunotherapy of guillain-barre syndrome","volume":"14","author":"Liu","year":"2018","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.omtm.2022.09.017_bib27","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1089\/hum.2010.055","article-title":"Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale","volume":"21","author":"Lock","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1089\/hum.2018.206","article-title":"A single injection of an optimized adeno-associated viral vector into cerebrospinal fluid corrects neurological disease in a murine model of GM1 gangliosidosis","volume":"31","author":"Hinderer","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib29","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/hgtb.2018.041","article-title":"Standardized method for intra-cisterna magna delivery under fluoroscopic guidance in nonhuman primates","volume":"29","author":"Katz","year":"2018","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.omtm.2022.09.017_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ymthe.2006.03.008","article-title":"Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver","volume":"14","author":"Bell","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2022.09.017_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1089\/hgtb.2018.038","article-title":"Assessment of humoral, innate, and T-cell immune responses to adeno-associated virus vectors","volume":"29","author":"Calcedo","year":"2018","journal-title":"Hum. Gene Ther. Methods"}],"updated-by":[{"DOI":"10.1016\/j.omtm.2022.11.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000}}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050122001425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050122001425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T23:23:48Z","timestamp":1671146628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050122001425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":31,"alternative-id":["S2329050122001425"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2022.09.017","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2022.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}