{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:35Z","timestamp":1791499235020,"version":"4.3.4"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K08981"],"award-info":[{"award-number":["JP18K08981"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H03788"],"award-info":[{"award-number":["JP20H03788"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ae0201005"],"award-info":[{"award-number":["JP22ae0201005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006264","name":"RIKEN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.omtm.2023.07.005","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T01:34:32Z","timestamp":1689384872000},"page":"333-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-8501","authenticated-orcid":false,"given":"Masafumi","family":"Arakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-7503","authenticated-orcid":false,"given":"Yoshitaka","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nitahara-Kasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashito","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2023.07.005_bib1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.omtm.2023.07.005_bib2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3174\/ajnr.A5586","article-title":"Randomized assessment of the safety and efficacy of intra-arterial infusion of autologous stem cells in subacute ischemic stroke","volume":"39","author":"Bhatia","year":"2018","journal-title":"AJNR. Am. J. Neuroradiol."},{"key":"10.1016\/j.omtm.2023.07.005_bib3","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/00004647-199611000-00006","article-title":"E-selectin in focal cerebral ischemia and reperfusion in the rat","volume":"16","author":"Zhang","year":"1996","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.omtm.2023.07.005_bib4","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1111\/j.1582-4934.2010.01135.x","article-title":"Neuroprotection in acute ischemic stroke--current status","volume":"14","author":"Auriel","year":"2010","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib5","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1161\/STROKEAHA.118.024351","article-title":"Effect of edaravone on neurological symptoms in real-world patients with acute ischemic stroke","volume":"50","author":"Kobayashi","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2023.07.005_bib6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3727\/096368916X694391","article-title":"Human dental pulp stem cells are more effective than human bone marrow-derived mesenchymal stem cells in cerebral ischemic injury","volume":"26","author":"Song","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.omtm.2023.07.005_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1440-1789.2012.01335.x","article-title":"Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct","volume":"33","author":"Kawabori","year":"2013","journal-title":"Neuropathology"},{"key":"10.1016\/j.omtm.2023.07.005_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/cns.12216","article-title":"Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke","volume":"20","author":"Wang","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib9","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.2174\/1381612824666180604111806","article-title":"Current Perspectives regarding stem cell-based therapy for ischemic stroke","volume":"24","author":"Kwak","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.omtm.2023.07.005_bib10","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/jnr.21056","article-title":"Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat","volume":"84","author":"Horita","year":"2006","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0041-1","article-title":"Interleukin-1 receptor antagonist-mediated neuroprotection by umbilical cord-derived mesenchymal stromal cells following transplantation into a rodent stroke model","volume":"50","author":"Oh","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib12","first-page":"240","article-title":"[Effects of interleukin 10 gene modified bone marrow mesenchymal stem cells on expression of inflammatory cytokines and neuronal apoptosis in rats after cerebral ischemia reperfusion injury]","volume":"31","author":"L\u00fc","year":"2017","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"10.1016\/j.omtm.2023.07.005_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.jcbfm.9600527","article-title":"Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia","volume":"28","author":"Onda","year":"2008","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.omtm.2023.07.005_bib14","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1089\/neu.2006.0161","article-title":"Mesenchymal stem cells derived from peripheral blood protects against ischemia","volume":"24","author":"Ukai","year":"2007","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.omtm.2023.07.005_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brainres.2008.07.116","article-title":"Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats","volume":"1236","author":"Omori","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1460-9568.2011.07733.x","article-title":"Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats","volume":"34","author":"Bao","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.omtm.2023.07.005_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/468748","article-title":"Stem cell-based therapies for ischemic stroke","volume":"2014","author":"Hao","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.omtm.2023.07.005_bib18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.omtm.2017.06.005","article-title":"Mesenchymal stem cells overexpressing interleukin-10 promote neuroprotection in experimental acute ischemic stroke","volume":"6","author":"Nakajima","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2023.07.005_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.omtm.2018.07.009","article-title":"Impact of dental pulp stem cells overexpressing hepatocyte growth factor after cerebral ischemia\/reperfusion in rats","volume":"10","author":"Sowa","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2023.07.005_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12883-017-0955-6","article-title":"Research on advanced intervention using novel bone marrow stem cell (RAINBOW): a study protocol for a phase I, open-label, uncontrolled, dose-response trial of autologous bone marrow stromal cell transplantation in patients with acute ischemic stroke","volume":"17","author":"Shichinohe","year":"2017","journal-title":"BMC Neurol."},{"key":"10.1016\/j.omtm.2023.07.005_bib21","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00277-012-1438-x","article-title":"Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells","volume":"91","author":"Zaim","year":"2012","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.omtm.2023.07.005_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrm.2016.10","article-title":"Pluripotent stem cells progressing to the clinic","volume":"17","author":"Trounson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.omtm.2023.07.005_bib23","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/jcmm.12062","article-title":"The tumourigenicity of iPS cells and their differentiated derivates","volume":"17","author":"Liu","year":"2013","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib24","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41551-021-00778-x","article-title":"Induction and expansion of human PRRX1(+) limb-bud-like mesenchymal cells from pluripotent stem cells","volume":"5","author":"Yamada","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.omtm.2023.07.005_bib25","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1038\/s41467-021-24921-z","article-title":"Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in\u00a0vitro","volume":"12","author":"Tan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2023.07.005_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.stem.2013.11.010","article-title":"Redefining the in\u00a0vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells","volume":"14","author":"Taguchi","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.omtm.2023.07.005_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112291","article-title":"Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media","volume":"9","author":"Fukuta","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2023.07.005_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.diff.2016.04.003","article-title":"LNGFR(+)THY-1(+) human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells","volume":"92","author":"Ouchi","year":"2016","journal-title":"Differentiation."},{"key":"10.1016\/j.omtm.2023.07.005_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1634\/stemcells.2006-0420","article-title":"Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs","volume":"25","author":"Lian","year":"2007","journal-title":"Stem Cell."},{"key":"10.1016\/j.omtm.2023.07.005_bib30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCULATIONAHA.109.898312","article-title":"Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice","volume":"121","author":"Lian","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.omtm.2023.07.005_bib31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/sctm.17-0305","article-title":"Mesenchymal stem cells (MSC) derived from induced pluripotent stem cells (iPSC) equivalent to adipose-derived MSC in promoting intestinal healing and microbiome normalization in mouse inflammatory bowel disease model","volume":"7","author":"Soontararak","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jcyt.2016.10.007","article-title":"Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury","volume":"19","author":"Yun","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.omtm.2023.07.005_bib33","first-page":"6232","article-title":"Human induced pluripotent stem cell-derived mesenchymal stem cell therapy effectively reduced brain infarct volume and preserved neurological function in rat after acute intracranial hemorrhage","volume":"11","author":"Chen","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s13287-020-01834-0","article-title":"Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke","volume":"11","author":"Xia","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib35","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.3390\/ijms20081922","article-title":"Production of Mesenchymal Stem Cells Through Stem Cell Reprogramming","volume":"20","author":"Abdal Dayem","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtm.2023.07.005_bib36","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.4103\/1673-5374.162759","article-title":"Bone marrow mesenchymal stem cells transplantation promotes the release of endogenous erythropoietin after ischemic stroke","volume":"10","author":"Lv","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib37","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.3727\/096368914X685023","article-title":"Intra-arterial delivery of human bone marrow mesenchymal stem cells is a safe and effective way to treat cerebral ischemia in rats","volume":"23","author":"Du","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.omtm.2023.07.005_bib38","first-page":"184","article-title":"[Treatment of stroke in rats with bone marrow mesenchymal stem cells]","volume":"87","author":"Wei","year":"2007","journal-title":"Zhonghua Yixue Zazhi"},{"key":"10.1016\/j.omtm.2023.07.005_bib39","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.3727\/096368916X692627","article-title":"The dose of intravenously transplanted bone marrow stromal cells determines the therapeutic effect on vascular remodeling in a rat model of ischemic stroke","volume":"25","author":"He","year":"2016","journal-title":"Cell Transplant."},{"key":"10.1016\/j.omtm.2023.07.005_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2010.10.063","article-title":"Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats","volume":"1367","author":"Bao","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.brainresbull.2019.10.001","article-title":"Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke","volume":"153","author":"Li","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.omtm.2023.07.005_bib42","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/stem.430","article-title":"A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cell."},{"issue":"Pt 6","key":"10.1016\/j.omtm.2023.07.005_bib43","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/brain\/awr063","article-title":"Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke","volume":"134","author":"Honmou","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.omtm.2023.07.005_bib44","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s12975-020-00787-z","article-title":"Autologous mesenchymal stem cells improve motor recovery in subacute ischemic stroke: a randomized clinical trial","volume":"11","author":"Jaillard","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","article-title":"Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses","volume":"78","author":"Costa","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.omtm.2023.07.005_bib46","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1741-7015-11-146","article-title":"Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells","volume":"11","author":"Siegel","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s13287-017-0716-x","article-title":"Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue","volume":"8","author":"Xu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib48","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2003.07.005","article-title":"Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells","volume":"33","author":"Stenderup","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.omtm.2023.07.005_bib49","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/biom10020340","article-title":"Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging","volume":"10","author":"Neri","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.omtm.2023.07.005_bib50","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fcell.2020.00258","article-title":"Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.omtm.2023.07.005_bib51","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.omtm.2023.07.005_bib52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13287-015-0137-7","article-title":"Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity","volume":"6","author":"Kang","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib53","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1038\/srep02243","article-title":"A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds","volume":"3","author":"Zou","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2023.07.005_bib54","article-title":"potent paracrine effects of human induced pluripotent stem cell-derived mesenchymal stem cells attenuate doxorubicin-induced cardiomyopathy","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2023.07.005_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9013089","article-title":"Differentiation and molecular properties of mesenchymal stem cells derived from murine induced pluripotent stem cells derived on gelatin or collagen","volume":"2016","author":"Obara","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.omtm.2023.07.005_bib56","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/stem.2993","article-title":"Induced pluripotent stem cell-derived mesenchymal stromal cells are functionally and genetically different from bone marrow-derived mesenchymal stromal cells","volume":"37","author":"Xu","year":"2019","journal-title":"Stem Cell."},{"key":"10.1016\/j.omtm.2023.07.005_bib57","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1089\/scd.2013.0477","article-title":"Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor","volume":"23","author":"Diederichs","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.omtm.2023.07.005_bib58","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1089\/scd.2013.0111","article-title":"Generation of functional mesenchymal stem cells from different induced pluripotent stem cell lines","volume":"23","author":"Hynes","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.omtm.2023.07.005_bib59","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.stemcr.2014.07.003","article-title":"Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells","volume":"3","author":"Frobel","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.omtm.2023.07.005_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ncb2411","article-title":"Programming human pluripotent stem cells into white and brown adipocytes","volume":"14","author":"Ahfeldt","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.omtm.2023.07.005_bib61","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13287-019-1209-x","article-title":"Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature","volume":"10","author":"Spitzhorn","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib62","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","article-title":"Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib63","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1089\/ten.tea.2013.0211","article-title":"Human induced pluripotent stem cell-derived mesenchymal stem cell seeding on calcium phosphate scaffold for bone regeneration","volume":"207-8","author":"Tang","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.omtm.2023.07.005_bib64","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1073\/pnas.1423008112","article-title":"MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs","volume":"112","author":"Zhao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.07.005_bib65","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2092315","article-title":"Inhibitory Effects of iPSC-MSCs and their extracellular vesicles on the onset of sialadenitis in a mouse model of Sj\u00f6gren's syndrome","volume":"2018","author":"Hai","year":"2018","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.omtm.2023.07.005_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.reth.2022.06.003","article-title":"Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis","volume":"17","author":"Mizuno","year":"2022","journal-title":"Regen. Ther. Jun"},{"key":"10.1016\/j.omtm.2023.07.005_bib68","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.7150\/thno.34008","article-title":"Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.omtm.2023.07.005_bib69","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/mt.2010.192","article-title":"Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model","volume":"19","author":"Katsha","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib70","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.expneurol.2012.09.018","article-title":"Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats","volume":"239","author":"Mitkari","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.omtm.2023.07.005_bib71","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2967\/jnumed.112.109280","article-title":"Monitoring bone marrow stem cells with a reporter gene system in experimental middle cerebral artery occlusion rat models","volume":"54","author":"Wu","year":"2013","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib72","article-title":"Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte","volume":"6","author":"Gu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2023.07.005_bib73","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/sj.jcbfm.9600273","article-title":"Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex\u00a0vivo HGF gene transfer with HSV-1 vector","volume":"26","author":"Zhao","year":"2006","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.omtm.2023.07.005_bib74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ymthe.2004.09.020","article-title":"Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model","volume":"11","author":"Kurozumi","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib75","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/WNL.59.4.514","article-title":"Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery","volume":"59","author":"Li","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.omtm.2023.07.005_bib76","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3389\/fnins.2017.00590","article-title":"The role of SDF-1\/CXCR4\/CXCR7 in neuronal regeneration after cerebral ischemia","volume":"11","author":"Cheng","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.omtm.2023.07.005_bib77","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/00207454.2013.838236","article-title":"CXCL12 inhibits cortical neuron apoptosis by increasing the ratio of Bcl-2\/Bax after traumatic brain injury","volume":"124","author":"Mao","year":"2014","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.omtm.2023.07.005_bib78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2012.04.011","article-title":"Stromal cell-derived factor 1\u03b1 decreases \u03b2-amyloid deposition in Alzheimer's disease mouse model","volume":"1459","author":"Wang","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib79","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/bonekey.2013.34","article-title":"CXCL12\/CXCR4 signaling and other recruitment and homing pathways in fracture repair","volume":"2","author":"Yellowley","year":"2013","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.omtm.2023.07.005_bib80","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/sctm.17-0108","article-title":"Neurotrophically induced mesenchymal progenitor cells derived from induced pluripotent stem cells enhance neuritogenesis via neurotrophin and cytokine production","volume":"7","author":"Brick","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib81","doi-asserted-by":"crossref","first-page":"11946","DOI":"10.1073\/pnas.182296499","article-title":"Vascular endothelial growth factor (VEGF) stimulates neurogenesis in\u00a0vitro and in\u00a0vivo","volume":"99","author":"Jin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.07.005_bib82","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/ijmm.2013.1290","article-title":"Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model","volume":"31","author":"Bao","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib83","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/cmi.2009.28","article-title":"Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells","volume":"6","author":"Liu","year":"2009","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.omtm.2023.07.005_bib84","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.freeradbiomed.2014.01.024","article-title":"Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model","volume":"70","author":"Cali\u00f3","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib85","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/129145","article-title":"Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model","volume":"2014","author":"Jeong","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.omtm.2023.07.005_bib86","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","article-title":"Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression","volume":"4","author":"Doeppner","year":"2015","journal-title":"Stem Cells transl. med."},{"key":"10.1016\/j.omtm.2023.07.005_bib87","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1038\/s41598-017-07274-w","article-title":"Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice","volume":"7","author":"Sammali","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2023.07.005_bib88","doi-asserted-by":"crossref","first-page":"9011","DOI":"10.2147\/IJN.S271519","article-title":"In\u00a0vivo monitoring and assessment of exogenous mesenchymal stem cell-derived exosomes in mice with ischemic stroke by molecular imaging","volume":"15","author":"Xu","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.omtm.2023.07.005_bib89","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/jcbfm.2013.152","article-title":"Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats","volume":"33","author":"Xin","year":"2013","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.omtm.2023.07.005_bib90","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1182\/blood-2010-12-325324","article-title":"Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery","volume":"118","author":"Giuliani","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.omtm.2023.07.005_bib91","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/stcltm\/szab005","article-title":"Improved MSC minimal criteria to maximize patient safety: A call to embrace tissue factor and hemocompatibility assessment of MSC Products","volume":"11","author":"Moll","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib92","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fimmu.2020.01091","article-title":"MSC therapies for COVID-19: Importance of patient coagulopathy, thromboprophylaxis, cell product quality and mode of delivery for treatment safety and efficacy","volume":"11","author":"Moll","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.omtm.2023.07.005_bib93","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s13770-020-00306-z","article-title":"Influences of xeno-free media on mesenchymal stem cell expansion for clinical application","volume":"18","author":"Bui","year":"2021","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.omtm.2023.07.005_bib94","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13287-021-02273-1","article-title":"Mesenchymal stem cells cultured in serum-free medium ameliorate experimental peritoneal fibrosis","volume":"12","author":"Nagasaki","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042855","article-title":"Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector","volume":"7","author":"Ono","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2023.07.005_bib96","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.1073\/pnas.0803078105","article-title":"Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation","volume":"105","author":"Wataya","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.07.005_bib97","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.yexcr.2010.02.013","article-title":"Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors","volume":"316","author":"Colleoni","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib98","doi-asserted-by":"crossref","first-page":"19240","DOI":"10.1073\/pnas.1113746108","article-title":"Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells","volume":"108","author":"Menendez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.07.005_bib99","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/mt.2011.181","article-title":"Long-term engraftment of multipotent mesenchymal stromal cells that differentiate to form myogenic cells in dogs with Duchenne muscular dystrophy","volume":"20","author":"Nitahara-Kasahara","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2023.07.005_bib100","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1093\/hmg\/ddu113","article-title":"Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10","volume":"23","author":"Nitahara-Kasahara","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2023.07.005_bib101","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1179\/1743132811Y.0000000019","article-title":"FK506 ameliorates oxidative damage and protects rat brain following transient focal cerebral ischemia","volume":"33","author":"Nito","year":"2011","journal-title":"Neurol. Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib102","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/01.STR.24.1.117","article-title":"Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats","volume":"24","author":"Lin","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.omtm.2023.07.005_bib103","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/00004647-199810000-00006","article-title":"Evaluation of a motor deficit after chronic focal cerebral ischemia in rats","volume":"18","author":"Yonemori","year":"1998","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.omtm.2023.07.005_bib104","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1073\/pnas.050583697","article-title":"Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task","volume":"97","author":"McNay","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.07.005_bib105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.brainres.2015.02.011","article-title":"Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease","volume":"1605","author":"Kanamaru","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.omtm.2023.07.005_bib106","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13402-3","article-title":"Highly sensitive and specific Alu-based quantification of human cells among rodent cells","volume":"7","author":"Funakoshi","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050123001067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050123001067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T01:37:46Z","timestamp":1714786666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050123001067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":105,"alternative-id":["S2329050123001067"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2023.07.005","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2023.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}]}}