{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:21:58Z","timestamp":1774282918329,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["P30 DK065988"],"award-info":[{"award-number":["P30 DK065988"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000292","name":"Cystic Fibrosis Trust","doi-asserted-by":"publisher","award":["SRC 006"],"award-info":[{"award-number":["SRC 006"]}],"id":[{"id":"10.13039\/501100000292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.omtm.2023.08.006","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T20:48:35Z","timestamp":1691873315000},"page":"593-605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Expression of gain-of-function CFTR in cystic fibrosis airway cells restores epithelial function better than wild-type or codon-optimized CFTR"],"prefix":"10.1016","volume":"30","author":[{"given":"Maximillian","family":"Woodall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Tarran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhianna","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafssa","family":"Anfishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Prins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Counsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Vergani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-0244","authenticated-orcid":false,"given":"Deborah","family":"Baines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2023.08.006_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fphar.2012.00117","article-title":"Class 1 CF mutations","volume":"3","author":"Wilschanski","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.omtm.2023.08.006_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI115952","volume":"90","author":"Chu","year":"1992","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.omtm.2023.08.006_bib3","doi-asserted-by":"crossref","first-page":"e88564","DOI":"10.1371\/journal.pone.0088564","article-title":"A little CFTR goes a long way: CFTR-dependent sweat secretion from G551D and R117H-5T cystic fibrosis subjects taking ivacaftor","volume":"9","author":"Char","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2023.08.006_bib4","doi-asserted-by":"crossref","first-page":"e88730","DOI":"10.1172\/jci.insight.88730","article-title":"Lentiviral-mediated phenotypic correction of cystic fibrosis pigs","volume":"1","author":"Cooney","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.omtm.2023.08.006_bib5","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.3390\/ijms21113903","article-title":"Gene Therapy for Cystic Fibrosis: Progress and Challenges of Genome Editing","volume":"21","author":"Maule","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtm.2023.08.006_bib6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1165\/rcmb.2001-0004OC","article-title":"Five Percent of Normal Cystic Fibrosis Transmembrane Conductance Regulator mRNA Ameliorates the Severity of Pulmonary Disease in Cystic Fibrosis","volume":"27","author":"Ramalho","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib7","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1089\/hum.2020.160","article-title":"Correction of Airway Stem Cells: Genome Editing Approaches for the Treatment of Cystic Fibrosis","volume":"31","author":"King","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2023.08.006_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3390\/genes9110538","article-title":"Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward","volume":"9","author":"Cooney","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.omtm.2023.08.006_bib9","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1073\/pnas.1604905113","article-title":"Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies","volume":"113","author":"Shah","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.08.006_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1165\/rcmb.2008-0018OC","article-title":"Functional Properties of Mixed Cystic Fibrosis and Normal Bronchial Epithelial Cell Cultures","volume":"40","author":"Dannhoffer","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib11","doi-asserted-by":"crossref","first-page":"L1123","DOI":"10.1152\/ajplung.00049.2005","article-title":"Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl \u2212 transport and overexpression can generate basolateral CFTR","volume":"289","author":"Farmen","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng0992-21","article-title":"Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis","volume":"2","author":"Johnson","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2023.08.006_bib13","doi-asserted-by":"crossref","first-page":"e1000155","DOI":"10.1371\/journal.pbio.1000155","article-title":"CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium","volume":"7","author":"Zhang","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib14","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S2213-2600(15)00245-3","article-title":"Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial","volume":"3","author":"Alton","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.omtm.2023.08.006_bib15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/mt.2011.196","article-title":"Optimization of hCFTR lung expression in mice using DNA nanoparticles","volume":"20","author":"Padegimas","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2023.08.006_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1089\/10430349950019011","article-title":"Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes","volume":"10","author":"Yew","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2023.08.006_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s11658-016-0025-x","article-title":"Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator","volume":"21","author":"Bartoszewski","year":"2016","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.omtm.2023.08.006_bib18","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jmb.2015.02.003","article-title":"Synonymous codon usage affects the expression of wild type and F508del CFTR","volume":"427","author":"Shah","year":"2015","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.omtm.2021.02.020","article-title":"Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy","volume":"21","author":"Marquez Loza","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2023.08.006_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.bbamem.2016.01.009","article-title":"Anion conductance selectivity mechanism of the CFTR chloride channel","volume":"1858","author":"Linsdell","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.omtm.2023.08.006_bib21","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1073\/pnas.0913001107","article-title":"ATP-independent CFTR channel gating and allosteric modulation by phosphorylation","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.08.006_bib22","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1073\/pnas.1215982110","article-title":"Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle","volume":"110","author":"Jih","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.08.006_bib23","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1085\/jgp.201912360","article-title":"Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770","volume":"151","author":"Yeh","year":"2019","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib24","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1113\/JP281499","article-title":"Human models for COVID-19 research","volume":"599","author":"Woodall","year":"2021","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib25","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3389\/fphar.2018.01429","article-title":"Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine","volume":"9","author":"Awatade","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.omtm.2023.08.006_bib26","doi-asserted-by":"crossref","first-page":"C954","DOI":"10.1152\/ajpcell.00234.2021","article-title":"Culture with apically applied healthy or disease sputum alters the airway surface liquid proteome and ion transport across human bronchial epithelial cells","volume":"321","author":"Woodall","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib27","doi-asserted-by":"crossref","first-page":"L258","DOI":"10.1152\/ajplung.00471.2016","article-title":"BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity","volume":"312","author":"Munye","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2818.2008.02059.x","article-title":"A short history of blebbing","volume":"231","author":"Charras","year":"2008","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.omtm.2023.08.006_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: Coping with stress","volume":"14","author":"Rutkowski","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nchembio.1648","article-title":"Death by ions","volume":"10","author":"Miura","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib31","doi-asserted-by":"crossref","first-page":"30364","DOI":"10.1074\/jbc.M114.595710","article-title":"An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening","volume":"289","author":"Wang","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2023.08.006_bib32","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1111\/bph.14475","article-title":"Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydro","volume":"175","author":"Langron","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.omtm.2023.08.006_bib33","doi-asserted-by":"crossref","first-page":"18825","DOI":"10.1073\/pnas.0904709106","article-title":"Rescue of CF airway epithelial cell function in\u00a0vitro by a CFTR potentiator, VX-770","volume":"106","author":"van Goor","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.08.006_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jcf.2011.12.005","article-title":"Ivacaftor potentiation of multiple CFTR channels with gating mutations","volume":"11","author":"Yu","year":"2012","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.omtm.2023.08.006_bib35","doi-asserted-by":"crossref","first-page":"19723","DOI":"10.1074\/jbc.M101892200","article-title":"Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds","volume":"276","author":"Galietta","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2023.08.006_bib36","doi-asserted-by":"crossref","first-page":"pdb.top90","DOI":"10.1101\/pdb.top90","article-title":"Fluorescence perturbation techniques to study mobility and molecular dynamics of proteins in live cells: FRAP, Photoactivation, Photoconversion, and FLIP","volume":"2010","author":"Bancaud","year":"2010","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.omtm.2023.08.006_bib37","doi-asserted-by":"crossref","first-page":"C310","DOI":"10.1152\/ajpcell.1998.274.2.C310","article-title":"Hyperexpression of recombinant CFTR in heterologous cells alters its physiological properties","volume":"274","author":"Mohammad-Panah","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib38","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/mthe.2001.0314","article-title":"Regulated Expression of the Human CFTR Gene in Epithelial Cells","volume":"3","author":"Ye","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2023.08.006_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s40259-018-0261-x","article-title":"Codon Optimization in the Production of Recombinant Biotherapeutics: Potential Risks and Considerations","volume":"32","author":"Mauro","year":"2018","journal-title":"BioDrugs"},{"key":"10.1016\/j.omtm.2023.08.006_bib40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1042\/BST20170469","article-title":"Non-coding RNA in cystic fibrosis","volume":"46","author":"Glasgow","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.omtm.2023.08.006_bib41","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.aaa3974","article-title":"Translational tuning optimizes nascent protein folding in cells","volume":"348","author":"Kim","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.omtm.2023.08.006_bib42","doi-asserted-by":"crossref","first-page":"41069","DOI":"10.1074\/jbc.M111.266734","article-title":"Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells","volume":"286","author":"Garnett","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2023.08.006_bib43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.omtn.2021.06.010","article-title":"Lentiviral vectors transduce lung stem cells without disrupting plasticity","volume":"25","author":"Cooney","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtm.2023.08.006_bib44","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","article-title":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","volume":"560","author":"Montoro","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2023.08.006_bib45","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.3390\/cells9092090","article-title":"Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells","volume":"9","author":"Scudieri","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.omtm.2023.08.006_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","article-title":"A single cell atlas of the tracheal epithelium reveals the CFTR-rich pulmonary ionocyte","volume":"560","author":"Plasschaert","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2023.08.006_bib47","series-title":"Ionocyte-Specific Regulation of CFTR","author":"Sato","year":"2023"},{"key":"10.1016\/j.omtm.2023.08.006_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-62703-125-7_8","article-title":"Human Nasal and Tracheo-Bronchial Respiratory Epithelial Cell Culture","volume":"945","author":"Fulcher","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib49","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1164\/ajrccm.164.10.2104051","article-title":"Induced sputum derives from the central airways: Confirmation using a radiolabeled aerosol bolus delivery technique","volume":"164","author":"Alexis","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.omtm.2023.08.006_bib50","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4161\/chim.25400","article-title":"Detection and quantification of chimerism by droplet digital PCR","volume":"4","author":"George","year":"2013","journal-title":"Chimerism"},{"key":"10.1016\/j.omtm.2023.08.006_bib51","doi-asserted-by":"crossref","first-page":"L109","DOI":"10.1152\/ajplung.00027.2015","article-title":"Automated acquisition and analysis of airway surface liquid height by confocal microscopy","volume":"309","author":"Choi","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.omtm.2023.08.006_bib52","doi-asserted-by":"crossref","first-page":"15973","DOI":"10.1073\/pnas.1311999110","article-title":"Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways","volume":"110","author":"Garland","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2023.08.006_bib53","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtm.2023.08.006_bib54","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.ymthe.2017.04.028","article-title":"Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy","volume":"25","author":"Vink","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2023.08.006_bib55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/gt.2010.163","article-title":"Quantification of lentiviral vector copy numbers in individual hematopoietic colony-forming cells shows vector dose-dependent effects on the frequency and level of transduction","volume":"18","author":"Charrier","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.omtm.2023.08.006_bib56","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0014-5793(01)02561-3","article-title":"Green fluorescent protein-based halide indicators with improved chloride and iodide affinities","volume":"499","author":"Galietta","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.omtm.2023.08.006_bib57","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/bph.13715","article-title":"Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds","volume":"174","author":"Langron","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.omtm.2023.08.006_bib58","doi-asserted-by":"crossref","first-page":"16529","DOI":"10.1074\/jbc.RA120.014061","article-title":"Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity","volume":"295","author":"Prins","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtm.2023.08.006_bib59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-61779-117-8_2","article-title":"High-throughput screening of libraries of compounds to identify CFTR modulators","volume":"741","author":"Pedemonte","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtm.2023.08.006_bib60","doi-asserted-by":"crossref","first-page":"L957","DOI":"10.1152\/ajplung.00123.2020","article-title":"E-cigarette constituents propylene glycol and vegetable glycerin decrease glucose uptake and its metabolism in airway epithelial cells in\u00a0vitro","volume":"319","author":"Woodall","year":"2020","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050123001201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2329050123001201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T01:37:58Z","timestamp":1714786678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2329050123001201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":60,"alternative-id":["S2329050123001201"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2023.08.006","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of gain-of-function CFTR in cystic fibrosis airway cells restores epithelial function better than wild-type or codon-optimized CFTR","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2023.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}]}}