{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:10:35Z","timestamp":1790961035016,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016308","name":"Public Investment Bank France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-EURE-0029"],"award-info":[{"award-number":["ANR-17-EURE-0029"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE17-0023-01"],"award-info":[{"award-number":["ANR-18-CE17-0023-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010728","name":"Asahikawa Medical University","doi-asserted-by":"publisher","award":["AMX-19-IET-004"],"award-info":[{"award-number":["AMX-19-IET-004"]}],"id":[{"id":"10.13039\/100010728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015760","name":"Inserm Transfert","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Methods & Clinical Development"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.omtm.2024.101342","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T13:48:48Z","timestamp":1726494528000},"page":"101342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-6071","authenticated-orcid":false,"given":"St\u00e9phane J.","family":"Baudouin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April R.","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severine","family":"Deforges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxia","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Boileau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Partouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Borta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Gautron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Wartel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Bo\u010dkaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Scavarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Penchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Aupy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Danos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Mulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cr\u00e9pel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2024.101342_bib1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1528-1167.2010.02903.x","article-title":"Epilepsy in the WHO European region: Fostering epilepsy care in Europe","volume":"52","author":"Cross","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.omtm.2024.101342_bib2","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1212\/WNL.51.5.1256","article-title":"Is the underlying cause of epilepsy a major prognostic factor for recurrence?","volume":"51","author":"Semah","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.omtm.2024.101342_bib3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.wneu.2016.12.074","article-title":"Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States","volume":"99","author":"Asadi-Pooya","year":"2017","journal-title":"World Neurosurg."},{"key":"10.1016\/j.omtm.2024.101342_bib4","first-page":"1443","article-title":"Cognitive impairment in temporal lobe epilepsy: contributions of lesion, localization and lateralization","volume":"268","author":"Phuong","year":"2021","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.omtm.2024.101342_bib5","series-title":"Review: Neurodegenerative Processes in Temporal Lobe Epilepsy with Hippocampal Sclerosis: Clinical, Pathological and Neuroimaging Evidence","author":"Tai","year":"2018"},{"key":"10.1016\/j.omtm.2024.101342_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.eplepsyres.2017.09.012","article-title":"Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"137","author":"Pohlen","year":"2017","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.omtm.2024.101342_bib7","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1528-1167.2011.03157.x","article-title":"The cognitive consequence of resecting nonlesional tissues in epilepsy surgery-Results from MRI- and histopathology-negative patients with temporal lobe epilepsy","volume":"52","author":"Helmstaedter","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.omtm.2024.101342_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196274","article-title":"The long-term outcomes of epilepsy surgery","volume":"13","author":"Mohan","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.omtm.2024.101342_bib9","series-title":"Responsive cortical stimulation for the treatment of medically intractable partial epilepsy On behalf of the RNS System in Epilepsy Study Group","author":"Morrell","year":"2011"},{"key":"10.1016\/j.omtm.2024.101342_bib10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/jamaneurol.2023.0066","article-title":"Focal Cortex Stimulation with a Novel Implantable Device and Antiseizure Outcomes in 2 Prospective Multicenter Single-Arm Trials","volume":"80","author":"Schulze-Bonhage","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.omtm.2024.101342_bib11","series-title":"Learnings from 30 Years of Reported Efficacy and Safety of Vagus Nerve Stimulation (VNS) for Epilepsy Treatment: A Critical Review","author":"Toffa","year":"2020"},{"key":"10.1016\/j.omtm.2024.101342_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.tins.2010.12.002","article-title":"Kainate receptors coming of age: milestones of two decades of research","volume":"34","author":"Contractor","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.omtm.2024.101342_bib13","series-title":"Regulation and Dysregulation of Neuronal Circuits by KARs","author":"Mulle","year":"2021"},{"key":"10.1016\/j.omtm.2024.101342_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/cercor\/bhs022","article-title":"Selective Block of Postsynaptic Kainate Receptors Reveals Their Function at Hippocampal Mossy Fiber Synapses","volume":"23","author":"Pinheiro","year":"2013","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.omtm.2024.101342_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0304-3940(89)90472-2","article-title":"Hippocampal plasticity in childhood epilepsy","volume":"99","author":"Represa","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.omtm.2024.101342_bib16","doi-asserted-by":"crossref","first-page":"10416","DOI":"10.1523\/JNEUROSCI.2074-04.2004","article-title":"Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis","volume":"24","author":"Gabriel","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2024.101342_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ana.410260303","article-title":"Mossy fiber synaptic reorganization in the epileptic human temporal lobe","volume":"26","author":"Sutula","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.omtm.2024.101342_bib18","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1523\/JNEUROSCI.1469-05.2005","article-title":"Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats","volume":"25","author":"Epsztein","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2024.101342_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2014.06.032","article-title":"Contribution of Aberrant GluK2-Containing Kainate Receptors to Chronic Seizures in Temporal Lobe Epilepsy","volume":"8","author":"Peret","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.omtm.2024.101342_bib20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.neuron.2016.04.001","article-title":"Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins","volume":"90","author":"Matsuda","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.omtm.2024.101342_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-24722-3","article-title":"The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse","volume":"8","author":"Grosenbaugh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2024.101342_bib22","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.ajhg.2021.07.007","article-title":"Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders","volume":"108","author":"Stolz","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.omtm.2024.101342_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1115880","article-title":"An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission","volume":"16","author":"Daniel","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.omtm.2024.101342_bib24","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ana.26723","article-title":"GluK2 Is a Target for Gene Therapy in Drug-Resistant Temporal Lobe Epilepsy","volume":"94","author":"Boileau","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.omtm.2024.101342_bib25","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/sj.gt.3302924","article-title":"Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters","volume":"14","author":"Hioki","year":"2007","journal-title":"Gene Ther."},{"key":"10.1016\/j.omtm.2024.101342_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0092-8674(03)00759-1","article-title":"Asymmetry in the assembly of the RNAi enzyme complex","volume":"115","author":"Schwarz","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2024.101342_bib27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(03)00801-8","article-title":"Functional siRNAs and miRNAs exhibit strand bias","volume":"115","author":"Khvorova","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2024.101342_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1627","article-title":"microRNA strand selection: Unwinding the rules","volume":"12","author":"Medley","year":"2021","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.omtm.2024.101342_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2007.05.057","article-title":"Sorting of Drosophila Small Silencing RNAs","volume":"130","author":"Tomari","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2024.101342_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2005.08.044","article-title":"Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes","volume":"123","author":"Matranga","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2024.101342_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010204","article-title":"Hippocampal Sclerosis in Pilocarpine Epilepsy: Survival of Peptide-Containing Neurons and Learning and Memory Disturbances in the Adult NMRI Strain Mouse","volume":"23","author":"M\u00e1ty\u00e1s","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtm.2024.101342_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105547","article-title":"Substantial outcome improvement using a refined pilocarpine mouse model of temporal lobe epilepsy","volume":"161","author":"Vigier","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.omtm.2024.101342_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2009.07.020","article-title":"Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage","volume":"619","author":"M\u00fcller","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtm.2024.101342_bib34","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/med\/9780199746545.003.0072","article-title":"Cognitive and Behavioral Co-Morbidities of Epilepsy","author":"Kleen","year":"2012","journal-title":"Jasper\u2019s Basic Mech. Epilepsies"},{"key":"10.1016\/j.omtm.2024.101342_bib35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2012.04.011","article-title":"Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy","volume":"215","author":"Huang","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.omtm.2024.101342_bib36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1474-4422(15)00225-2","article-title":"Comorbidities of epilepsy: current concepts and future perspectives","volume":"15","author":"Keezer","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.omtm.2024.101342_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1167.2007.01397.x","article-title":"Long-term memory impairment in patients with focal epilepsy","volume":"48","author":"Hoppe","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.omtm.2024.101342_bib38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","article-title":"The mouse light\/dark box test","volume":"463","author":"Bourin","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtm.2024.101342_bib39","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3162","article-title":"Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice","volume":"9","author":"Prieur","year":"2019","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.omtm.2024.101342_bib40","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1093\/brain\/awq219","article-title":"Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures","volume":"133","author":"Woldbye","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.omtm.2024.101342_bib41","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809963","article-title":"Dynorphin-based \u201crelease on demand\u201d gene therapy for drug-resistant temporal lobe epilepsy","volume":"11","author":"Agostinho","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.omtm.2024.101342_bib42","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1523\/JNEUROSCI.1143-18.2019","article-title":"Epilepsy Gene Therapy Using an Engineered Potassium Channel","volume":"39","author":"Snowball","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.omtm.2024.101342_bib43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1126\/science.abq6656","article-title":"On-demand cell-autonomous gene therapy for brain circuit disorders","volume":"378","author":"Qiu","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.omtm.2024.101342_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107751","article-title":"Optogenetic and chemogenetic therapies for epilepsy","volume":"168","author":"Walker","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.omtm.2024.101342_bib45","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1016\/j.neuron.2022.07.020","article-title":"Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy","volume":"110","author":"Whitebirch","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.omtm.2024.101342_bib46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.yebeh.2005.11.014","article-title":"Role of interictal epileptiform abnormalities in cognitive impairment","volume":"8","author":"Holmes","year":"2006","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.omtm.2024.101342_bib47","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1212\/WNL.52.9.1870","article-title":"Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study","volume":"52","author":"Bernasconi","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.omtm.2024.101342_bib48","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/brain\/awg034","article-title":"Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala and parahippocampal region","volume":"126","author":"Bernasconi","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.omtm.2024.101342_bib49","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-4682-11-14","article-title":"The role of the entorhinal cortex in epileptiform activities of the hippocampus","volume":"11","author":"Ren","year":"2014","journal-title":"Theor. Biol. Med. Model."},{"key":"10.1016\/j.omtm.2024.101342_bib50","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1073\/pnas.242746599","article-title":"Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis","volume":"100","author":"Redwine","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtm.2024.101342_bib51","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1111\/j.1528-1167.2009.02243.x","article-title":"Hippocampal volume assessment in temporal lobe epilepsy: How good is automated segmentation?","volume":"50","author":"Pardoe","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.omtm.2024.101342_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb8920","article-title":"Widespread and sustained target engagement in Huntington\u2019s disease minipigs upon intrastriatal microRNA-based gene therapy","volume":"13","author":"Valles","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtm.2024.101342_bib53","series-title":"The Pilocarpine Model of Mesial Temporal Lobe Epilepsy: Over One Decade Later, with More Rodent Species and New Investigative Approaches","author":"L\u00e9vesque","year":"2021"},{"key":"10.1016\/j.omtm.2024.101342_bib54","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.molcel.2019.06.012","article-title":"High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2","volume":"75","author":"Becker","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.omtm.2024.101342_bib55","first-page":"5","article-title":"The era of RNA interference medicines: the clinical landscape of synthetic gene silencing drugs","volume":"21","author":"Godinho","year":"2019","journal-title":"Sa\u00fade & Tecnologia"}],"container-title":["Molecular Therapy - Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S232905012400158X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S232905012400158X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:55:37Z","timestamp":1778867737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S232905012400158X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S232905012400158X"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2024.101342","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2024.101342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 uniQure biopharma B.V. Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"101342"}}