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Sci."},{"key":"10.1016\/j.omtm.2024.101398_bib91","article-title":"Recent advances in RNA therapeutics and RNA delivery systems based on nanoparticles","volume":"1","author":"Shin","year":"2018","journal-title":"Adv. Ther."},{"key":"10.1016\/j.omtm.2024.101398_bib92","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconrel.2017.01.024","article-title":"Mononuclear phagocytes as a target, not a barrier, for drug delivery","volume":"259","author":"Yong","year":"2017","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.omtm.2024.101398_bib93","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1039\/c2cs15309b","article-title":"Endocytosis at the nanoscale","volume":"41","author":"Canton","year":"2012","journal-title":"Chem. Soc. 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Rev."},{"key":"10.1016\/j.omtm.2024.101398_bib99","doi-asserted-by":"crossref","first-page":"1698.e1","DOI":"10.1016\/j.cmi.2021.06.007","article-title":"Reconstituted mRNA COVID-19 vaccines may maintain stability after continuous movement","volume":"27","author":"Grau","year":"2021","journal-title":"Clin. Microbiol. 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Biol."},{"key":"10.1016\/j.omtm.2024.101398_bib104","first-page":"1486","article-title":"Synthesis and properties of mRNAs containing the novel \u201canti-reverse\u201d cap analogs 7-methyl(3\u2019-O-methyl)GpppG and 7-methyl (3\u2019-deoxy)GpppG","volume":"7","author":"Stepinski","year":"2001","journal-title":"RNA"},{"key":"10.1016\/j.omtm.2024.101398_bib105","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1261\/rna.5430403","article-title":"Novel \u201canti-reverse\u201d cap analogs with superior translational properties","volume":"9","author":"Jemielity","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.omtm.2024.101398_bib106","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3762\/bjoc.13.274","article-title":"Synthetic mRNA capping","volume":"13","author":"Muttach","year":"2017","journal-title":"Beilstein J. Org. 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Microbiol."},{"key":"10.1016\/j.omtm.2024.101398_bib112","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1586\/erv.12.98","article-title":"Design and data analysis of experimental trials to test vaccine candidates against zoonotic pathogens in animals: the case of a clinical trial against campylobacter in broilers","volume":"11","author":"Garcia","year":"2012","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.omtm.2024.101398_bib113","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41594-020-0465-x","article-title":"Decoding mRNA translatability and stability from the 5\u2019 UTR","volume":"27","author":"Jia","year":"2020","journal-title":"Nat. Struct. Mol. 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Sci."},{"key":"10.1016\/j.omtm.2024.101398_bib126","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1093\/nar\/gki1012","article-title":"AU-rich elements and associated factors: are there unifying principles?","volume":"33","author":"Barreau","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtm.2024.101398_bib127","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.3390\/ijms21186582","article-title":"mRNA vaccine era-mechanisms, drug platform and clinical prospection","volume":"21","author":"Xu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtm.2024.101398_bib128","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41565-020-0669-6","article-title":"Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR\u2013cas gene editing","volume":"15","author":"Cheng","year":"2020","journal-title":"Nat. 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Soc. Gene Ther."},{"key":"10.1016\/j.omtm.2024.101398_bib132","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nsmb.2311","article-title":"Translational control by changes in poly(a) tail length: Recycling mRNAs","volume":"19","author":"Weill","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.omtm.2024.101398_bib133","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ymeth.2017.10.008","article-title":"Design, Assembly, Production, and Transfection of Synthetic Modified mRNA","volume":"133","author":"Oh","year":"2018","journal-title":"Methods"},{"key":"10.1016\/j.omtm.2024.101398_bib134","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm.2016.116","article-title":"Alternative polyadenylation of mRNA precursors","volume":"18","author":"Tian","year":"2017","journal-title":"Nat. Rev. Mol. 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Y.)"},{"key":"10.1016\/j.omtm.2024.101398_bib186","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijpharm.2017.10.030","article-title":"Cationic nanoemulsions as nucleic acids delivery systems","volume":"534","author":"Teixeira","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.omtm.2024.101398_bib187","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1038\/mt.2014.133","article-title":"A cationic nanoemulsion for the delivery of next-generation RNA vaccines","volume":"22","author":"Brito","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2024.101398_bib188","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Rev. 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Rev. Microbiol."},{"key":"10.1016\/j.omtm.2024.101398_bib200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1099\/vir.0.014506-0","article-title":"Genomics and evolution of aedes-borne flaviviruses","volume":"91","author":"Grard","year":"2010","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.omtm.2024.101398_bib201","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/j.semdp.2019.04.009","article-title":"Four human diseases with significant public health impact caused by mosquito-borne flaviviruses: west nile, zika, dengue and yellow fever","volume":"36","author":"Guarner","year":"2019","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.omtm.2024.101398_bib202","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1038\/nm1144","article-title":"Emerging flaviviruses: the spread and resurgence of japanese encephalitis, west nile and dengue viruses","volume":"10","author":"Mackenzie","year":"2004","journal-title":"Nat. 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Dis."},{"key":"10.1016\/j.omtm.2024.101398_bib218","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature21428","article-title":"Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination","volume":"543","author":"Pardi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2024.101398_bib219","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00289-22","article-title":"Interleukin-17 contributes to chikungunya virus-induced disease","volume":"13","author":"Liu","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.omtm.2024.101398_bib220","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.virs.2022.01.032","article-title":"An mRNA vaccine encoding chikungunya virus E2-E1 protein elicits robust neutralizing antibody responses and CTL immune responses","volume":"37","author":"Ge","year":"2022","journal-title":"Virol. 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