{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:15:42Z","timestamp":1788347742479,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009657","name":"FSHD Global Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009657","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Methods & Clinical Development"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.omtm.2025.101546","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T23:01:20Z","timestamp":1754434880000},"page":"101546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["All-in-one vectors for epigenetic CRISPR inhibition of DUX4-fl in facioscapulohumeral muscular dystrophy"],"prefix":"10.1016","volume":"33","author":[{"given":"Charis L.","family":"Himeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako I.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-1016","authenticated-orcid":false,"given":"Peter L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtm.2025.101546_bib1","series-title":"Facioscapulohumeral Disease [thesis]","author":"Padberg","year":"1982"},{"key":"10.1016\/j.omtm.2025.101546_bib2","unstructured":"Orphanet (2024). Prevalence and incidence of rare diseases: Bibliographic data. http:\/\/www.orpha.net\/orphacom\/cahiers\/docs\/GB\/Prevalence_of_rare_diseases_by_alphabetical_list.pdf."},{"key":"10.1016\/j.omtm.2025.101546_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ng1262","article-title":"Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy","volume":"35","author":"van Overveld","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-genom-083118-014933","article-title":"The Genetics and Epigenetics of Facioscapulohumeral Muscular Dystrophy","volume":"20","author":"Himeda","year":"2019","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0140-6736(90)92148-B","article-title":"Location of facioscapulohumeral muscular dystrophy gene on chromosome 4","volume":"336","author":"Wijmenga","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.omtm.2025.101546_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ng0992-26","article-title":"Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy","volume":"2","author":"Wijmenga","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib7","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1093\/hmg\/2.12.2037","article-title":"FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit","volume":"2","author":"van Deutekom","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib8","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ng.2454","article-title":"Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2","volume":"44","author":"Lemmers","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib9","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.ajhg.2016.03.013","article-title":"Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy","volume":"98","author":"van den Boogaard","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001181","article-title":"Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene","volume":"6","author":"Snider","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2012.01647.x","article-title":"DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy?","volume":"17","author":"Tassin","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.omtm.2025.101546_bib12","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1093\/hmg\/ddy162","article-title":"Facioscapulohumeral dystrophy: Activating an early embryonic transcriptional program in human skeletal muscle","volume":"27","author":"Campbell","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(99)00267-X","article-title":"Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element","volume":"236","author":"Gabriels","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.omtm.2025.101546_bib14","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1189044","article-title":"A unifying genetic model for facioscapulohumeral muscular dystrophy","volume":"329","author":"Lemmers","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.omtm.2025.101546_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11010007","article-title":"Gene Editing Targeting the DUX4 Polyadenylation Signal: A Therapy for FSHD?","volume":"11","author":"Joubert","year":"2020","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.omtm.2025.101546_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92096-0","article-title":"CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy","volume":"11","author":"Das","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtm.2025.101546_bib17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.omtn.2021.05.020","article-title":"Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy","volume":"25","author":"Sikrova","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.omtm.2025.101546_bib18","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mt.2015.200","article-title":"CRISPR\/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy","volume":"24","author":"Himeda","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2025.101546_bib19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.omtm.2020.12.001","article-title":"Targeted epigenetic repression by CRISPR\/dSaCas9 suppresses pathogenic DUX4-fl expression in FSHD","volume":"20","author":"Himeda","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2025.101546_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/rmv.1762","article-title":"Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them","volume":"23","author":"Hareendran","year":"2013","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.omtm.2025.101546_bib21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/hum.2024.041","article-title":"Have a Little Heart (or Not): Highly Minimized Skeletal Muscle Regulatory Cassettes with Low or No Activity in the Heart","volume":"35","author":"Himeda","year":"2024","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.omtm.2025.101546_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-61737-982-6_1","article-title":"Design and testing of regulatory cassettes for optimal activity in skeletal and cardiac muscles","volume":"709","author":"Himeda","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtm.2025.101546_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.omtm.2021.05.014","article-title":"A consolidated AAV system for single-cut CRISPR correction of a common Duchenne muscular dystrophy mutation","volume":"22","author":"Zhang","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.omtm.2025.101546_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1566523221666211006120355","article-title":"CRISPR Systems Suitable for Single AAV Vector Delivery","volume":"22","author":"Stevanovic","year":"2022","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.omtm.2025.101546_bib25","article-title":"In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2025.101546_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jbiotec.2019.05.306","article-title":"Active fusions of Cas9 orthologs","volume":"301","author":"Josipovic","year":"2019","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.omtm.2025.101546_bib27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/35020506","article-title":"Regulation of chromatin structure by site-specific histone H3 methyltransferases","volume":"406","author":"Rea","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.omtm.2025.101546_bib28","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1093\/hmg\/ddu251","article-title":"DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle","volume":"23","author":"Yao","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib29","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/hmg\/ddy364","article-title":"MRI-informed muscle biopsies correlate MRI with pathology and DUX4 target gene expression in FSHD","volume":"28","author":"Wang","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib30","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/hmg\/ddaa031","article-title":"Longitudinal measures of RNA expression and disease activity in FSHD muscle biopsies","volume":"29","author":"Wong","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113011","article-title":"Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy","volume":"320","author":"Mueller","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.omtm.2025.101546_bib32","first-page":"14","article-title":"Neuromuscular electrical stimulation promotes development in mice of mature human muscle from immortalized human myoblasts","volume":"6","author":"Sakellariou","year":"2016","journal-title":"Skelet Muscle"},{"key":"10.1016\/j.omtm.2025.101546_bib33","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1093\/hmg\/dds284","article-title":"Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis","volume":"21","author":"Jones","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13148-015-0072-6","article-title":"Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy","volume":"7","author":"Jones","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.omtm.2025.101546_bib35","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/mt.2016.111","article-title":"Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics","volume":"24","author":"Chen","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2025.101546_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/jpet.119.259663","article-title":"Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy","volume":"370","author":"Oliva","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.omtm.2025.101546_bib37","article-title":"Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy","author":"Sasaki-Honda","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.omtm.2025.101546_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1868-7083-6-23","article-title":"Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing","volume":"6","author":"Jones","year":"2014","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.omtm.2025.101546_bib39","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3390\/diagnostics11081469","article-title":"Precise Epigenetic Analysis Using Targeted Bisulfite Genomic Sequencing Distinguishes FSHD1, FSHD2, and Healthy Subjects","volume":"11","author":"Gould","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.omtm.2025.101546_bib40","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1136\/jmedgenet-2019-106402","article-title":"Intronic SMCHD1 variants in FSHD: testing the potential for CRISPR-Cas9 genome editing","volume":"56","author":"Goossens","year":"2019","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/humu.24171","article-title":"Relationship of DUX4 and target gene expression in FSHD myocytes","volume":"42","author":"Chau","year":"2021","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.omtm.2025.101546_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008754","article-title":"Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei","volume":"16","author":"Jiang","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib43","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/nar\/gkw1112","article-title":"Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase","volume":"45","author":"Stepper","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtm.2025.101546_bib44","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cell.2024.01.042","article-title":"Past, present, and future of CRISPR genome editing technologies","volume":"187","author":"Pacesa","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.omtm.2025.101546_bib45","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41467-017-02708-5","article-title":"Genome-wide tracking of dCas9-methyltransferase footprints","volume":"9","author":"Galonska","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtm.2025.101546_bib46","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1101\/gr.233049.117","article-title":"A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs","volume":"28","author":"Pflueger","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.omtm.2025.101546_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/giy011","article-title":"Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases","volume":"7","author":"Lin","year":"2018","journal-title":"GigaScience"},{"key":"10.1016\/j.omtm.2025.101546_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020502","article-title":"Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects","volume":"21","author":"Hofacker","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtm.2025.101546_bib49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/12664","article-title":"Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation","volume":"23","author":"Wade","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib51","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/77124","article-title":"DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters","volume":"25","author":"Robertson","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.omtm.2025.101546_bib52","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1093\/nar\/gkm599","article-title":"MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation","volume":"35","author":"Agarwal","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtm.2025.101546_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-11454-0_1","article-title":"Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges","volume":"1389","author":"Jurkowska","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.omtm.2025.101546_bib54","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1080\/15592294.2015.1113798","article-title":"Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4","volume":"10","author":"Balog","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.omtm.2025.101546_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn7732","article-title":"DNMT3B splicing dysregulation mediated by SMCHD1 loss contributes to DUX4 overexpression and FSHD pathogenesis","volume":"10","author":"Engal","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.omtm.2025.101546_bib56","doi-asserted-by":"crossref","first-page":"7875","DOI":"10.1128\/JVI.00649-08","article-title":"Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle","volume":"82","author":"Penaud-Budloo","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.omtm.2025.101546_bib57","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1001\/jamaneurol.2020.1484","article-title":"Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial","volume":"77","author":"Mendell","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.omtm.2025.101546_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3233\/JND-190403","article-title":"AVXS-101 (Onasemnogene Abeparvovec) for SMA1: Comparative Study with a Prospective Natural History Cohort","volume":"6","author":"Al-Zaidy","year":"2019","journal-title":"J. Neuromuscul. Dis."},{"key":"10.1016\/j.omtm.2025.101546_bib59","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.mt.6300027","article-title":"Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle","volume":"15","author":"Salva","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtm.2025.101546_bib60","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature14299","article-title":"In vivo genome editing using Staphylococcus aureus Cas9","volume":"520","author":"Ran","year":"2015","journal-title":"Nature"}],"container-title":["Molecular Therapy Methods & Clinical Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S232905012500141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S232905012500141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T15:23:31Z","timestamp":1762615411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S232905012500141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S232905012500141X"],"URL":"https:\/\/doi.org\/10.1016\/j.omtm.2025.101546","relation":{},"ISSN":["2329-0501"],"issn-type":[{"value":"2329-0501","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"All-in-one vectors for epigenetic CRISPR inhibition of DUX4-fl in facioscapulohumeral muscular dystrophy","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Methods & Clinical Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtm.2025.101546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}],"article-number":"101546"}}