{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:56Z","timestamp":1791475436059,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Science Foundation for Young Scientists of China","award":["81501955"],"award-info":[{"award-number":["81501955"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.omtn.2019.08.002","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T19:54:27Z","timestamp":1565207667000},"page":"34-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["Exercise Reduces Insulin Resistance in Type 2 Diabetes Mellitus via Mediating the lncRNA MALAT1\/MicroRNA-382-3p\/Resistin Axis"],"prefix":"10.1016","volume":"18","author":[{"given":"Sui-Xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Ling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Rong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2019.08.002_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5001\/omj.2012.68","article-title":"Type 2 diabetes mellitus: a review of current trends","volume":"27","author":"Olokoba","year":"2012","journal-title":"Oman Med. J."},{"key":"10.1016\/j.omtn.2019.08.002_bib2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2605.2010.01117.x","article-title":"Type 2 diabetes mellitus and testosterone: a meta-analysis study","volume":"34","author":"Corona","year":"2011","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.omtn.2019.08.002_bib3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/dom.12054","article-title":"Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise","volume":"15","author":"Stenl\u00f6f","year":"2013","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.omtn.2019.08.002_bib4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2013.01.041","article-title":"The origins and drivers of insulin resistance","volume":"152","author":"Johnson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2019.08.002_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrendo.2011.138","article-title":"The role of mitochondria in insulin resistance and type 2 diabetes mellitus","volume":"8","author":"Szendroedi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.omtn.2019.08.002_bib6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.biopha.2017.06.040","article-title":"Tanshinone I alleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway","volume":"93","author":"Wei","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.omtn.2019.08.002_bib7","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/oby.2009.274","article-title":"A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents","volume":"18","author":"van der Heijden","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.omtn.2019.08.002_bib8","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3892\/ijmm.2014.1738","article-title":"Swimming improves high-fat induced insulin resistance by regulating lipid and energy metabolism and the insulin pathway in rats","volume":"33","author":"Song","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.omtn.2019.08.002_bib9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2015.11.048","article-title":"Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression","volume":"469","author":"Zhu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2019.08.002_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbacli.2015.09.001","article-title":"Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus","volume":"4","author":"Carter","year":"2015","journal-title":"BBA Clin."},{"key":"10.1016\/j.omtn.2019.08.002_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12265-018-9830-0","article-title":"Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance","volume":"11","author":"Liu","year":"2018","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.omtn.2019.08.002_bib12","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1261\/rna.033217.112","article-title":"Malat1 is not an essential component of nuclear speckles in mice","volume":"18","author":"Nakagawa","year":"2012","journal-title":"RNA"},{"key":"10.1016\/j.omtn.2019.08.002_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13578-017-0147-5","article-title":"Long non-coding RNA MALAT1 contributes to cell apoptosis by sponging miR-124 in Parkinson disease","volume":"7","author":"Liu","year":"2017","journal-title":"Cell Biosci."},{"key":"10.1016\/j.omtn.2019.08.002_bib14","doi-asserted-by":"crossref","first-page":"e1506","DOI":"10.1038\/cddis.2014.466","article-title":"Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.omtn.2019.08.002_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2018.04.027","article-title":"Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1\/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells","volume":"830","author":"Xia","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtn.2019.08.002_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.trsl.2011.01.009","article-title":"Diabetes mellitus, a microRNA-related disease?","volume":"157","author":"Guay","year":"2011","journal-title":"Transl. Res."},{"key":"10.1016\/j.omtn.2019.08.002_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.bbrc.2014.02.034","article-title":"MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells","volume":"445","author":"Wen","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.omtn.2019.08.002_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.15537\/1658-3175.5543","article-title":"Serum resistin levels in patients with type 2 diabetes mellitus and its relationship with body composition","volume":"33","author":"Habib","year":"2012","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.omtn.2019.08.002_bib19","doi-asserted-by":"crossref","first-page":"29370","DOI":"10.3390\/ijms161226174","article-title":"Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells","volume":"16","author":"Huang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2019.08.002_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2407-14-112","article-title":"Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin","volume":"14","author":"Yang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.omtn.2019.08.002_bib21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/ijcp.12868","article-title":"Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus living in hot climates","volume":"70","author":"John","year":"2016","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.omtn.2019.08.002_bib22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s12265-018-9828-7","article-title":"Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492\/Resistin Axis in Aortic Endothelium","volume":"11","author":"Cai","year":"2018","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.omtn.2019.08.002_bib23","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1111\/jcmm.13189","article-title":"LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with \u03b2-catenin","volume":"21","author":"Hu","year":"2017","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.omtn.2019.08.002_bib24","first-page":"552","article-title":"Relationship of Serum Resistin with Insulin Resistance and Obesity","volume":"27","author":"Zaidi","year":"2015","journal-title":"J.\u00a0Ayub Med. Coll. Abbottabad"},{"key":"10.1016\/j.omtn.2019.08.002_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/1753-0407.12143","article-title":"Type 2 diabetes mellitus-related genetic polymorphisms in microRNAs and microRNA target sites","volume":"6","author":"Gong","year":"2014","journal-title":"J.\u00a0Diabetes"},{"key":"10.1016\/j.omtn.2019.08.002_bib26","doi-asserted-by":"crossref","first-page":"e22839","DOI":"10.1371\/journal.pone.0022839","article-title":"MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus","volume":"6","author":"Karolina","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2019.08.002_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11010-014-1993-7","article-title":"MicroRNA-492 reverses high glucose-induced insulin resistance in HUVEC cells through targeting resistin","volume":"391","author":"Ying","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.omtn.2019.08.002_bib28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/dmrr.505","article-title":"Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance","volume":"20","author":"Hawley","year":"2004","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.omtn.2019.08.002_bib29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bcp.2018.03.019","article-title":"Long noncoding RNA MALAT1 regulates generation of reactive oxygen species and the insulin responses in male mice","volume":"152","author":"Chen","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.omtn.2019.08.002_bib30","doi-asserted-by":"crossref","first-page":"22640","DOI":"10.1038\/srep22640","article-title":"Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability","volume":"6","author":"Yan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.omtn.2019.08.002_bib31","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1160\/TH16-06-0471","article-title":"Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus","volume":"116","author":"Santilli","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.omtn.2019.08.002_bib32","first-page":"290","article-title":"Type 2 diabetes mellitus risk and exercise: is resistin involved?","volume":"59","author":"Cobbold","year":"2019","journal-title":"J.\u00a0Sports Med. Phys. Fitness"},{"key":"10.1016\/j.omtn.2019.08.002_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3892\/br.2017.972","article-title":"Exercise improves high fat diet-impaired vascular function","volume":"7","author":"Fang","year":"2017","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.omtn.2019.08.002_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ijms19113608","article-title":"Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity","volume":"19","author":"Improta Caria","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.omtn.2019.08.002_bib35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12872-015-0156-4","article-title":"Exercise training restores the cardiac microRNA-1 and -214 levels regulating Ca2+ handling after myocardial infarction","volume":"15","author":"Melo","year":"2015","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.omtn.2019.08.002_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2016.12.014","article-title":"MicroRNA-712 restrains macrophage pro-inflammatory responses by targeting LRRK2 leading to restoration of insulin stimulated glucose uptake by myoblasts","volume":"82","author":"Talari","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.omtn.2019.08.002_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00592-013-0543-1","article-title":"The inflammatory status score including IL-6, TNF-\u03b1, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus","volume":"51","author":"Daniele","year":"2014","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.omtn.2019.08.002_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1590\/2359-3997000000116","article-title":"Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus","volume":"60","author":"Polat","year":"2016","journal-title":"Arch. Endocrinol. Metab."},{"key":"10.1016\/j.omtn.2019.08.002_bib39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.atherosclerosis.2008.04.012","article-title":"Systemic and vascular markers of inflammation in relation to metabolic syndrome and insulin resistance in adults with elevated atherosclerosis risk","volume":"202","author":"Kressel","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.omtn.2019.08.002_bib40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejphar.2009.06.046","article-title":"Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels","volume":"617","author":"Wu","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.omtn.2019.08.002_bib41","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1016\/j.bmc.2010.03.056","article-title":"Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin","volume":"18","author":"Zou","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.omtn.2019.08.002_bib42","doi-asserted-by":"crossref","DOI":"10.1159\/000495665","article-title":"Beta Cell Functional Adaptation and Dysfunction in Insulin Resistance and the Role of Chronic Kidney Disease","author":"Sto\u017eer","year":"2019","journal-title":"Nephron."},{"key":"10.1016\/j.omtn.2019.08.002_bib43","doi-asserted-by":"crossref","first-page":"e2327","DOI":"10.1038\/cddis.2016.125","article-title":"Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253119302124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253119302124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:40:49Z","timestamp":1784652049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253119302124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":43,"alternative-id":["S2162253119302124"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2019.08.002","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise Reduces Insulin Resistance in Type 2 Diabetes Mellitus via Mediating the lncRNA MALAT1\/MicroRNA-382-3p\/Resistin Axis","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2019.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}