{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:56:17Z","timestamp":1790484977042,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006441","name":"Center for Outcomes Research and Evaluation, Yale School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009002","name":"Shanghai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy Nucleic Acids"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.omtn.2019.10.013","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T20:52:00Z","timestamp":1571777520000},"page":"863-870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Size Matters: Arginine-Derived Peptides Targeting the PSMA Receptor Can Efficiently Complex but Not Transfect siRNA"],"prefix":"10.1016","volume":"18","author":[{"given":"Christopher N.","family":"Cultrara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Antuono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia J.","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Samuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Zilberberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sabatino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2019.10.013_bib1","first-page":"1445","article-title":"Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells","volume":"2","author":"Pinto","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2019.10.013_bib2","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1091\/mbc.e02-11-0731","article-title":"A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen","volume":"14","author":"Rajasekaran","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.omtn.2019.10.013_bib3","first-page":"6357","article-title":"Correlation of primary tumor prostate-specific membrane antigen expression with disease recurrence in prostate cancer","volume":"9","author":"Ross","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2019.10.013_bib4","first-page":"81","article-title":"Prostate-specific membrane antigen expression in normal and malignant human tissues","volume":"3","author":"Silver","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.omtn.2019.10.013_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s40336-018-0270-2","article-title":"PSMA diagnostics and treatments of prostate cancer become mature","volume":"6","author":"von Eyben","year":"2018","journal-title":"Clin. Transl. Imaging"},{"key":"10.1016\/j.omtn.2019.10.013_bib6","doi-asserted-by":"crossref","first-page":"e68339","DOI":"10.1371\/journal.pone.0068339","article-title":"Evaluation of phage display discovered peptides as ligands for prostate-specific membrane antigen (PSMA)","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2019.10.013_bib7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijpharm.2016.08.048","article-title":"Discovery of PSMA-specific peptide ligands for targeted drug delivery","volume":"513","author":"Jin","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.omtn.2019.10.013_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/psc.968","article-title":"Live-cell analysis of cell penetration ability and toxicity of oligo-arginines","volume":"14","author":"T\u00fcnnemann","year":"2008","journal-title":"J.\u00a0Pept. Sci."},{"key":"10.1016\/j.omtn.2019.10.013_bib9","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","article-title":"Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery","volume":"276","author":"Futaki","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2019.10.013_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jbbm.2007.01.010","article-title":"An intracellular delivery method for siRNA by an arginine-rich peptide","volume":"70","author":"Wang","year":"2007","journal-title":"J.\u00a0Biochem. Biophys. Methods"},{"key":"10.1016\/j.omtn.2019.10.013_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jconrel.2010.01.009","article-title":"RNA interference in\u00a0vitro and in\u00a0vivo using an arginine peptide\/siRNA complex system","volume":"143","author":"Kim","year":"2010","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.omtn.2019.10.013_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrc3701","article-title":"Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential","volume":"14","author":"Lee","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.omtn.2019.10.013_bib13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1186\/s12885-018-5178-8","article-title":"GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines","volume":"18","author":"Cultrara","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.omtn.2019.10.013_bib14","doi-asserted-by":"crossref","first-page":"917296","DOI":"10.1155\/2013\/917296","article-title":"The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells","volume":"2013","author":"Zhang","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.omtn.2019.10.013_bib15","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1016\/j.bmcl.2013.08.033","article-title":"Solid-phase synthesis, characterization and RNAi activity of branch and hyperbranch siRNAs","volume":"23","author":"Maina","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.omtn.2019.10.013_bib16","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1021\/acs.nanolett.6b02274","article-title":"RNAi Screening of the glucose-regulated chaperones in cancer with self-assembled siRNA nanostructures","volume":"16","author":"Patel","year":"2016","journal-title":"Nano Lett."},{"key":"10.1016\/j.omtn.2019.10.013_bib17","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1021\/acs.bioconjchem.8b00580","article-title":"Direct transfection of fatty acid conjugated siRNAs and Knockdown of the glucose-regulated chaperones in prostate cancer cells","volume":"29","author":"Shah","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.omtn.2019.10.013_bib18","doi-asserted-by":"crossref","first-page":"12975","DOI":"10.1021\/acsomega.8b01999","article-title":"Enhanced cancer theranostics with self-assembled, multilabeled siRNAs","volume":"3","author":"Kozuch","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.omtn.2019.10.013_bib19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/cbdd.13448","article-title":"Solid phase synthesis and self-assembly of higher-order siRNAs and their bioconjugates","volume":"93","author":"Cultrara","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.omtn.2019.10.013_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/adma.200801393","article-title":"Size-dependent endoytosis of nanoparticles","volume":"21","author":"Zhang","year":"2009","journal-title":"Adv. Mater."},{"key":"10.1016\/j.omtn.2019.10.013_bib21","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1021\/nl103264u","article-title":"Sizing nanomatter in biological fluids by fluorescence single particle tracking","volume":"10","author":"Braeckmans","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.omtn.2019.10.013_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.omtn.2019.10.013_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-4939-9220-1_21","article-title":"Bioconjugated gold nanoparticles enhance siRNA delivery in prostate cancer cells","volume":"1974","author":"Rahme","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2019.10.013_bib24","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1039\/C6TB00082G","article-title":"Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer\u2014synthesis, physicochemical characterization and in\u00a0vitro evaluation","volume":"4","author":"Fitzgerald","year":"2016","journal-title":"J.\u00a0Mater. Chem. B Mater. Biol. Med."}],"container-title":["Molecular Therapy Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253119303105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253119303105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:39:07Z","timestamp":1784651947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253119303105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":24,"alternative-id":["S2162253119303105"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2019.10.013","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Size Matters: Arginine-Derived Peptides Targeting the PSMA Receptor Can Efficiently Complex but Not Transfect siRNA","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2019.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}