{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:32:57Z","timestamp":1778841177474,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL077726"],"award-info":[{"award-number":["HL077726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UL1TR001417"],"award-info":[{"award-number":["UL1TR001417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI116985"],"award-info":[{"award-number":["AI116985"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103440"],"award-info":[{"award-number":["GM103440"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy - Nucleic Acids"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.omtn.2019.12.033","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:16:09Z","timestamp":1579047369000},"page":"1000-1014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma"],"prefix":"10.1016","volume":"19","author":[{"given":"Sabrina C.","family":"Ramelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Comer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared M.","family":"McLendon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia L.","family":"Sandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Barrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed","family":"Matar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Fewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Gerthoffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.omtn.2019.12.033_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1164\/rccm.201610-2074PP","article-title":"New therapies for asthma and chronic obstructive pulmonary disease","volume":"195","author":"Gross","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding asthma phenotypes, endotypes, and mechanisms of disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.omtn.2019.12.033_bib3","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.2147\/DDDT.S130743","article-title":"Targeted therapy in severe asthma today: focus on immunoglobulin E","volume":"11","author":"Pelaia","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.omtn.2019.12.033_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.coi.2015.07.006","article-title":"MicroRNA regulation of allergic inflammation and asthma","volume":"36","author":"Pua","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.omtn.2019.12.033_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2014.11.006","article-title":"Epigenetic targets for novel therapies of lung diseases","volume":"147","author":"Comer","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.omtn.2019.12.033_bib6","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2217\/epi.15.53","article-title":"Epigenome-modifying tools in asthma","volume":"7","author":"Brook","year":"2015","journal-title":"Epigenomics"},{"key":"10.1016\/j.omtn.2019.12.033_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MCP.0000000000000532","article-title":"Role of microRNAs and exosomes in asthma","volume":"25","author":"van den Berge","year":"2019","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib8","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1365-2222.2011.03854.x","article-title":"Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor","volume":"42","author":"Molfino","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.omtn.2019.12.033_bib9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jgm.2631","article-title":"Locally instilled tumor necrosis factor-\u03b1 antisense oligonucleotide inhibits allergic inflammation via the induction of Tregs","volume":"14","author":"Luo","year":"2012","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib10","first-page":"26","article-title":"Inhibition of allergic airway inflammation by antisense-induced blockade of STAT6 expression","volume":"124","author":"Tian","year":"2011","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.omtn.2019.12.033_bib11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1164\/rccm.200408-1006OC","article-title":"Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice","volume":"171","author":"Duan","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/thoraxjnl-2011-200532","article-title":"MicroRNAs in lung diseases","volume":"67","author":"Pagdin","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.omtn.2019.12.033_bib13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/imr.12058","article-title":"The emerging role of microRNAs in regulating immune and inflammatory responses in the lung","volume":"253","author":"Foster","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.omtn.2019.12.033_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/omi.2018.0112","article-title":"Asthma microRNA regulome development using validated miRNA-target interaction visualization","volume":"22","author":"Fekonja","year":"2018","journal-title":"OMICS"},{"key":"10.1016\/j.omtn.2019.12.033_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jaci.2011.04.005","article-title":"Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment","volume":"128","author":"Collison","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.omtn.2019.12.033_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jconrel.2011.11.006","article-title":"Versatile cationic lipids for siRNA delivery","volume":"158","author":"Sparks","year":"2012","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.omtn.2019.12.033_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/mt.2011.210","article-title":"Delivery of siRNA to the mouse lung via a functionalized lipopolyamine","volume":"20","author":"Polach","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.omtn.2019.12.033_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2015.05.261","article-title":"Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension","volume":"210","author":"McLendon","year":"2015","journal-title":"J.\u00a0Control. Release"},{"issue":"Suppl 1","key":"10.1016\/j.omtn.2019.12.033_bib19","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1513\/AnnalsATS.201507-414MG","article-title":"Antisense microRNA therapy of airway remodeling in house dust mite-sensitized mice","volume":"13","author":"Ramelli","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.omtn.2019.12.033_bib20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1165\/rcmb.2004-0060OC","article-title":"Mucin is produced by clara cells in the proximal airways of antigen-challenged mice","volume":"31","author":"Evans","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.omtn.2019.12.033_bib21","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1038\/ncomms7281","article-title":"The polymeric mucin Muc5ac is required for allergic airway hyperreactivity","volume":"6","author":"Evans","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.omtn.2019.12.033_bib22","doi-asserted-by":"crossref","first-page":"W145","DOI":"10.1093\/nar\/gkr294","article-title":"DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association","volume":"39","author":"Maragkakis","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2019.12.033_bib23","doi-asserted-by":"crossref","first-page":"15858","DOI":"10.1073\/pnas.0707413104","article-title":"Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids","volume":"104","author":"Woodruff","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2019.12.033_bib24","doi-asserted-by":"crossref","first-page":"301ra129","DOI":"10.1126\/scitranslmed.aab3142","article-title":"TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma","volume":"7","author":"Choy","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1242\/bio.014464","article-title":"Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma","volume":"5","author":"Piyadasa","year":"2016","journal-title":"Biol. Open"},{"key":"10.1016\/j.omtn.2019.12.033_bib26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jaci.2018.05.026","article-title":"Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation","volume":"143","author":"Jevnikar","year":"2019","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.omtn.2019.12.033_bib28","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1371\/journal.pgen.0010016","article-title":"Glucocorticoid receptor-dependent gene regulatory networks","volume":"1","author":"Phuc Le","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.omtn.2019.12.033_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12890-016-0356-4","article-title":"Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with idiopathic pulmonary fibrosis","volume":"17","author":"Vukmirovic","year":"2017","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-2828(03)00110-X","article-title":"Serum response factor: toggling between disparate programs of gene expression","volume":"35","author":"Miano","year":"2003","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.omtn.2019.12.033_bib31","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1101\/gr.1197303","article-title":"Prediction of cell type-specific gene modules: identification and initial characterization of a core set of smooth muscle-specific genes","volume":"13","author":"Nelander","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.omtn.2019.12.033_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00438-008-0349-y","article-title":"Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle?","volume":"280","author":"Larsson","year":"2008","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.omtn.2019.12.033_bib33","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/nar\/gku1343","article-title":"Sequence-dependent off-target inhibition of TLR7\/8 sensing by synthetic microRNA inhibitors","volume":"43","author":"Sarvestani","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2019.12.033_bib35","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biomaterials.2013.10.046","article-title":"The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus","volume":"35","author":"Look","year":"2014","journal-title":"Biomaterials"},{"issue":"3, Suppl","key":"10.1016\/j.omtn.2019.12.033_bib36","doi-asserted-by":"crossref","first-page":"405S","DOI":"10.1378\/chest.123.3_suppl.405S-a","article-title":"Severe\/fatal asthma","volume":"123","author":"Wenzel","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.omtn.2019.12.033_bib37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1513\/pats.200402-014MS","article-title":"Corticosteroid resistance in airway disease","volume":"1","author":"Barnes","year":"2004","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.omtn.2019.12.033_bib38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/all.12412","article-title":"Refractory asthma: mechanisms, targets, and therapy","volume":"69","author":"Trevor","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.omtn.2019.12.033_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri3786","article-title":"Type 2 inflammation in asthma--present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.omtn.2019.12.033_bib40","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.201504-0763PP","article-title":"Evolving concepts of asthma","volume":"192","author":"Gauthier","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib41","doi-asserted-by":"crossref","first-page":"1701108","DOI":"10.1183\/13993003.01108-2017","article-title":"Phase three studies of biologics for severe asthma: could do better?","volume":"50","author":"Robinson","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.omtn.2019.12.033_bib42","doi-asserted-by":"crossref","first-page":"e16509","DOI":"10.1371\/journal.pone.0016509","article-title":"MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets","volume":"6","author":"Garbacki","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2019.12.033_bib43","first-page":"993","article-title":"Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma","volume":"6","author":"Collison","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.omtn.2019.12.033_bib44","first-page":"38","article-title":"MicroRNAs in lung development and disease","volume":"22","author":"Ameis","year":"2017","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.omtn.2019.12.033_bib45","doi-asserted-by":"crossref","first-page":"e5889","DOI":"10.1371\/journal.pone.0005889","article-title":"MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy","volume":"4","author":"Williams","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2019.12.033_bib46","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nature08195","article-title":"miR-145 and miR-143 regulate smooth muscle cell fate and plasticity","volume":"460","author":"Cordes","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.omtn.2019.12.033_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-015-2519-7","article-title":"Effects of miRNA-145 on airway smooth muscle cells function","volume":"409","author":"Liu","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.omtn.2019.12.033_bib48","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1096\/fj.12-219493","article-title":"miR-145 regulates myofibroblast differentiation and lung fibrosis","volume":"27","author":"Yang","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.omtn.2019.12.033_bib49","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/1873-3468.12168","article-title":"Airway smooth muscle inflammation is regulated by microRNA-145 in COPD","volume":"590","author":"O\u2019Leary","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.omtn.2019.12.033_bib50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-8794-5-21","article-title":"Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers","volume":"5","author":"Wang","year":"2012","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.omtn.2019.12.033_bib51","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm1462","article-title":"Role of deficient type III interferon-lambda production in asthma exacerbations","volume":"12","author":"Contoli","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.omtn.2019.12.033_bib52","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s11882-013-0344-1","article-title":"Virus\/allergen interactions in asthma","volume":"13","author":"Gavala","year":"2013","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.omtn.2019.12.033_bib53","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0192623308329342","article-title":"Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model","volume":"37","author":"Meyerholz","year":"2009","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.omtn.2019.12.033_bib54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.omtn.2019.12.033_bib55","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ab.2009.01.003","article-title":"Comparison and evaluation of RNA quantification methods using viral, prokaryotic, and eukaryotic RNA over a 10(4) concentration range","volume":"387","author":"Aranda","year":"2009","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.omtn.2019.12.033_bib56","doi-asserted-by":"crossref","first-page":"L1202","DOI":"10.1152\/ajplung.00053.2015","article-title":"Adapted approach to profile genes while reconciling Vegf-a mRNA expression in the developing and injured lung","volume":"308","author":"Lee","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.omtn.2019.12.033_bib57","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/cpe.3274","article-title":"Experiences building Globus Genomics: a next-generation sequencing analysis service using Galaxy, Globus, and Amazon web services","volume":"26","author":"Madduri","year":"2014","journal-title":"Concurr. Comput."},{"issue":"W1","key":"10.1016\/j.omtn.2019.12.033_bib58","doi-asserted-by":"crossref","first-page":"W537","DOI":"10.1093\/nar\/gky379","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update","volume":"46","author":"Afgan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2019.12.033_bib59","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.omtn.2019.12.033_bib60","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4939-3572-7_13","article-title":"Optimizing RNA-seq mapping with STAR","volume":"1415","author":"Dobin","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.omtn.2019.12.033_bib61","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.omtn.2019.12.033_bib62","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.omtn.2019.12.033_bib63","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1093\/nar\/gkq636","article-title":"Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures","volume":"38","author":"Plaisier","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.omtn.2019.12.033_bib64","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.omtn.2019.12.033_bib65","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.omtn.2019.12.033_bib66","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1083\/jcb.200912096","article-title":"MicroRNA control of podosome formation in vascular smooth muscle cells in\u00a0vivo and in\u00a0vitro","volume":"189","author":"Quintavalle","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.omtn.2019.12.033_bib67","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.bjc.6605570","article-title":"miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer","volume":"102","author":"Chiyomaru","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.omtn.2019.12.033_bib68","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/CIRCULATIONAHA.113.004149","article-title":"Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis","volume":"129","author":"Schmitt","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.omtn.2019.12.033_bib69","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.4049\/jimmunol.1202960","article-title":"Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in \u0394F508 cystic fibrosis airway epithelium","volume":"190","author":"Oglesby","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.omtn.2019.12.033_bib70","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1183\/09031936.00113214","article-title":"Transcription factors and miRNAs that regulate fetal to adult CFTR expression change are new targets for cystic fibrosis","volume":"45","author":"Viart","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.omtn.2019.12.033_bib71","doi-asserted-by":"crossref","first-page":"e109673","DOI":"10.1371\/journal.pone.0109673","article-title":"Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription","volume":"9","author":"Booiman","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.omtn.2019.12.033_bib72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cyto.2014.09.003","article-title":"Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology","volume":"71","author":"Zhou","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.omtn.2019.12.033_bib73","doi-asserted-by":"crossref","first-page":"9910","DOI":"10.1074\/jbc.M111.337154","article-title":"MicroRNA profile of circulating CD4-positive regulatory T\u00a0cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function","volume":"287","author":"Fayyad-Kazan","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.omtn.2019.12.033_bib74","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2009.02.038","article-title":"MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells","volume":"137","author":"Xu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.omtn.2019.12.033_bib75","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.1582-4934.2011.01385.x","article-title":"miR-145 is differentially regulated by TGF-\u03b21 and ischaemia and targets Disabled-2 expression and wnt\/\u03b2-catenin activity","volume":"16","author":"Mayorga","year":"2012","journal-title":"J.\u00a0Cell. Mol. Med."}],"container-title":["Molecular Therapy - Nucleic Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253120300172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2162253120300172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T02:13:38Z","timestamp":1715998418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2162253120300172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":75,"alternative-id":["S2162253120300172"],"URL":"https:\/\/doi.org\/10.1016\/j.omtn.2019.12.033","relation":{},"ISSN":["2162-2531"],"issn-type":[{"value":"2162-2531","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoparticle Delivery of Anti-inflammatory LNA Oligonucleotides Prevents Airway Inflammation in a HDM Model of Asthma","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy - Nucleic Acids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.omtn.2019.12.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}]}}